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Showing 1 to 12 of 49 entries
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Long-term tocotrienol supplementation and glutathione-dependent enzymes during hepatocarcinogenesis in the rat.

Asia Pacific journal of clinical nutrition

Rahmat A, Wan Ngah WZ, Gapor A, Khalid BA.
PMID: 24352144
Asia Pac J Clin Nutr. 1993 Sep;2(3):129-34.

The effects of long-term administration of tocotrienol on hepatocarcinogenesis in rats induced by diethyl nitrosamine (DEN) and 2-acetylaminofluorene (AAF) were investigated by the determination of plasma and liver gamma-glutamyl transpeptidase (GGT), cytosolic glutathione reductase (GSSG-Rx), glutathione peroxidase (GSH-Px) and...

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Rahmat A, Wan Ngah WZ, Gapor A, et al. Long-term tocotrienol supplementation and glutathione-dependent enzymes during hepatocarcinogenesis in the rat. Asia Pac J Clin Nutr. 1993;2(3):129-34
Rahmat, A., Wan Ngah, W. Z., Gapor, A., & Khalid, B. A. (1993). Long-term tocotrienol supplementation and glutathione-dependent enzymes during hepatocarcinogenesis in the rat. Asia Pacific journal of clinical nutrition, 2(3), 129-34.
Rahmat, A, et al. "Long-term tocotrienol supplementation and glutathione-dependent enzymes during hepatocarcinogenesis in the rat." Asia Pacific journal of clinical nutrition vol. 2,3 (1993): 129-34.
Rahmat A, Wan Ngah WZ, Gapor A, Khalid BA. Long-term tocotrienol supplementation and glutathione-dependent enzymes during hepatocarcinogenesis in the rat. Asia Pac J Clin Nutr. 1993 Sep;2(3):129-34. PMID: 24352144.
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Interaction between dietary selenium and 2-acetylaminofluorene in the rat.

Biological trace element research

Cohen AM.
PMID: 24263569
Biol Trace Elem Res. 1983 Aug;5(4):307-15. doi: 10.1007/BF02987216.

The effect of dietary selenium on the metabolism of 2-acetylaminofluorene (AAF) and on its interaction with hepatic DNA was studied in male, Charles River rats. All studies were commenced at least 3 weeks after placing weanling rats on a...

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Cohen AM. Interaction between dietary selenium and 2-acetylaminofluorene in the rat. Biol Trace Elem Res. 1983;5(4):307-15doi: 10.1007/BF02987216.
Cohen, A. M. (1983). Interaction between dietary selenium and 2-acetylaminofluorene in the rat. Biological trace element research, 5(4), 307-15. https://doi.org/10.1007/BF02987216
Cohen, A M. "Interaction between dietary selenium and 2-acetylaminofluorene in the rat." Biological trace element research vol. 5,4 (1983): 307-15. doi: https://doi.org/10.1007/BF02987216
Cohen AM. Interaction between dietary selenium and 2-acetylaminofluorene in the rat. Biol Trace Elem Res. 1983 Aug;5(4):307-15. doi: 10.1007/BF02987216. PMID: 24263569.
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Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1).

The Journal of nutritional biochemistry

Naves MM, Silveira ER, Dagli ML, Moreno FS.
PMID: 12031251
J Nutr Biochem. 2001 Dec;12(12):685-692. doi: 10.1016/s0955-2863(01)00187-5.

The effects of beta-carotene and vitamin A administrations were evaluated in an in vivo model of hepatic cell differentiation. For this purpose, male Wistar rats received beta-carotene (70 mg/kg of body weight), vitamin A (10 mg/kg of body weight)...

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Naves MM, Silveira ER, Dagli ML, et al. Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1). J Nutr Biochem. 2001;12(12):685-692doi: 10.1016/s0955-2863(01)00187-5.
Naves, M. M., Silveira, E. R., Dagli, M. L., & Moreno, F. S. (2001). Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1). The Journal of nutritional biochemistry, 12(12), 685-692. https://doi.org/10.1016/s0955-2863(01)00187-5
Naves, Maria Margareth V., et al. "Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1)." The Journal of nutritional biochemistry vol. 12,12 (2001): 685-692. doi: https://doi.org/10.1016/s0955-2863(01)00187-5
Naves MM, Silveira ER, Dagli ML, Moreno FS. Effects of beta-carotene and vitamin A on oval cell proliferation and connexin 43 expression during hepatic differentiation in the rat(1). J Nutr Biochem. 2001 Dec;12(12):685-692. doi: 10.1016/s0955-2863(01)00187-5. PMID: 12031251.
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Inter-species variation in hepatocyte activation of 2-acetylaminofluorene in salmonella mutagenicity assays with TA98 and TA98/1,8DNP(6).

Toxicology in vitro : an international journal published in association with BIBRA

Smith AJ, Chipman JK.
PMID: 20702323
Toxicol In Vitro. 1989;3(1):45-52. doi: 10.1016/0887-2333(89)90023-4.

In Salmonella typhimurium mutagenicity assays the metabolic activation of 2-acetylaminofluorene (2AAF) was greater by isolated hepatocytes from two species resistant to 2AAF-induced hepatocarcinogenesis, the guinea-pig and rabbit, than by hepatocytes from the highly susceptible rat liver. S. typhimurium strain...

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Smith AJ, Chipman JK. Inter-species variation in hepatocyte activation of 2-acetylaminofluorene in salmonella mutagenicity assays with TA98 and TA98/1,8DNP(6). Toxicol In Vitro. 1989;3(1):45-52doi: 10.1016/0887-2333(89)90023-4.
Smith, A. J., & Chipman, J. K. (1989). Inter-species variation in hepatocyte activation of 2-acetylaminofluorene in salmonella mutagenicity assays with TA98 and TA98/1,8DNP(6). Toxicology in vitro : an international journal published in association with BIBRA, 3(1), 45-52. https://doi.org/10.1016/0887-2333(89)90023-4
Smith, A J, and Chipman, J K. "Inter-species variation in hepatocyte activation of 2-acetylaminofluorene in salmonella mutagenicity assays with TA98 and TA98/1,8DNP(6)." Toxicology in vitro : an international journal published in association with BIBRA vol. 3,1 (1989): 45-52. doi: https://doi.org/10.1016/0887-2333(89)90023-4
Smith AJ, Chipman JK. Inter-species variation in hepatocyte activation of 2-acetylaminofluorene in salmonella mutagenicity assays with TA98 and TA98/1,8DNP(6). Toxicol In Vitro. 1989;3(1):45-52. doi: 10.1016/0887-2333(89)90023-4. PMID: 20702323.
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Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens.

Toxicology in vitro : an international journal published in association with BIBRA

Gebhardt R, Fischer S.
PMID: 20650111
Toxicol In Vitro. 1995 Aug;9(4):445-51. doi: 10.1016/0887-2333(95)00050-i.

Comparison of stationary cultivation (repeated changes of medium) with perifusion (continuous flow of medium) revealed that perifused hepatocytes show enhanced basal proliferation and are more sensitive to insulin and EGF. Similarly, the sensitivity of bromodeoxyuridine incorporation to inhibition by...

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Gebhardt R, Fischer S. Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens. Toxicol In Vitro. 1995;9(4):445-51doi: 10.1016/0887-2333(95)00050-i.
Gebhardt, R., & Fischer, S. (1995). Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens. Toxicology in vitro : an international journal published in association with BIBRA, 9(4), 445-51. https://doi.org/10.1016/0887-2333(95)00050-i
Gebhardt, R, and Fischer, S. "Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens." Toxicology in vitro : an international journal published in association with BIBRA vol. 9,4 (1995): 445-51. doi: https://doi.org/10.1016/0887-2333(95)00050-i
Gebhardt R, Fischer S. Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens. Toxicol In Vitro. 1995 Aug;9(4):445-51. doi: 10.1016/0887-2333(95)00050-i. PMID: 20650111.
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Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum.

Applied and environmental microbiology

Lindmark DG.
PMID: 16345775
Appl Environ Microbiol. 1981 May;41(5):1238-42. doi: 10.1128/aem.41.5.1238-1242.1981.

The marine ciliate Parauronema acutum converted 2-aminofluorene and 2-acetylaminofluorene to compounds with mutagenic activity in the Ames Salmonella test. The ciliate, however, did not activate benzo (alpha)pyrene or benzanthracene or destroy the mutagenic properties of nitrosoguanidine. Homogenates, when substituted...

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Lindmark DG. Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum. Appl Environ Microbiol. 1981;41(5):1238-42doi: 10.1128/aem.41.5.1238-1242.1981.
Lindmark, D. G. (1981). Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum. Applied and environmental microbiology, 41(5), 1238-42. https://doi.org/10.1128/aem.41.5.1238-1242.1981
Lindmark, D G. "Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum." Applied and environmental microbiology vol. 41,5 (1981): 1238-42. doi: https://doi.org/10.1128/aem.41.5.1238-1242.1981
Lindmark DG. Activation of Polynuclear Aromatic Hydrocarbons to Mutagens by the Marine Ciliate Parauronema acutum. Appl Environ Microbiol. 1981 May;41(5):1238-42. doi: 10.1128/aem.41.5.1238-1242.1981. PMID: 16345775; PMCID: PMC243895.
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Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis.

Nutrition research and practice

Kim HS, Kim HS, Choi H.
PMID: 20016724
Nutr Res Pract. 2008;2(4):234-9. doi: 10.4162/nrp.2008.2.4.234. Epub 2008 Dec 30.

The purpose of this study was to investigate the effects of green tea ingestion on hepatocarcinogenesis before and after its initiation. Male Sprague-Dawley rats were fed an AIN76A diet with or without green tea. Initiation was induced by a...

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Kim HS, Kim HS, Choi H. Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis. Nutr Res Pract. 2008;2(4):234-9doi: 10.4162/nrp.2008.2.4.234.
Kim, H. S., Kim, H. S., & Choi, H. (2008). Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis. Nutrition research and practice, 2(4), 234-9. https://doi.org/10.4162/nrp.2008.2.4.234
Kim, Hyung-Sook, et al. "Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis." Nutrition research and practice vol. 2,4 (2008): 234-9. doi: https://doi.org/10.4162/nrp.2008.2.4.234
Kim HS, Kim HS, Choi H. Pre- and post-initiation modulating effects of green tea ingestion on rat hepatocarcinogenesis. Nutr Res Pract. 2008;2(4):234-9. doi: 10.4162/nrp.2008.2.4.234. Epub 2008 Dec 30. PMID: 20016724; PMCID: PMC2788192.
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Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas.

International journal of oncology

Kitamura K, Mizuno Y, Hatayama I, Sato K, Kikuchi K.
PMID: 21573543
Int J Oncol. 1993 Feb;2(2):237-40. doi: 10.3892/ijo.2.2.237.

We have examined the mRNA levels for the catalytic subunits of three phosphoseryl/phosphothreonyl protein phosphatases PP1alpha, PP2Aalpha and PP2C by Northern blot analysis in the three primary hepatomas and the three poorly differentiated ascites hepatomas. The mRNA levels were...

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Kitamura K, Mizuno Y, Hatayama I, et al. Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas. Int J Oncol. 1993;2(2):237-40doi: 10.3892/ijo.2.2.237.
Kitamura, K., Mizuno, Y., Hatayama, I., Sato, K., & Kikuchi, K. (1993). Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas. International journal of oncology, 2(2), 237-40. https://doi.org/10.3892/ijo.2.2.237
Kitamura, K, et al. "Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas." International journal of oncology vol. 2,2 (1993): 237-40. doi: https://doi.org/10.3892/ijo.2.2.237
Kitamura K, Mizuno Y, Hatayama I, Sato K, Kikuchi K. Selective high expression of protein phosphatase pp1-alpha messenger-RNA in rat poorly differentiated ascites hepatomas. Int J Oncol. 1993 Feb;2(2):237-40. doi: 10.3892/ijo.2.2.237. PMID: 21573543.
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Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis.

Drug and chemical toxicology

Ahmed OM, Ahmed AA, Fahim HI, Zaky MY.
PMID: 31665932
Drug Chem Toxicol. 2019 Oct 31;1-12. doi: 10.1080/01480545.2019.1683187. Epub 2019 Oct 31.

This study was designed to assess the preventive effects and to suggest the probable mechanisms of action of quercetin and naringein in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis in Wistar male rats. The chemical-induction of hepatocarcinogenesis was performed by injection of...

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Ahmed OM, Ahmed AA, Fahim HI, et al. Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis. Drug Chem Toxicol. 2019;1-12doi: 10.1080/01480545.2019.1683187.
Ahmed, O. M., Ahmed, A. A., Fahim, H. I., & Zaky, M. Y. (2019). Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis. Drug and chemical toxicology, 1-12. https://doi.org/10.1080/01480545.2019.1683187
Ahmed, Osama M, et al. "Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis." Drug and chemical toxicology vol. (2019): 1-12. doi: https://doi.org/10.1080/01480545.2019.1683187
Ahmed OM, Ahmed AA, Fahim HI, Zaky MY. Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis. Drug Chem Toxicol. 2019 Oct 31;1-12. doi: 10.1080/01480545.2019.1683187. Epub 2019 Oct 31. PMID: 31665932.
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Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor.

Archives of medical research

Patel S, Nanavati P, Sharma J, Chavda V, Savjani J.
PMID: 33551224
Arch Med Res. 2021 Jul;52(5):483-493. doi: 10.1016/j.arcmed.2021.01.005. Epub 2021 Feb 05.

BACKGROUND: Several studies suggested anticancer potential of NSAIDs. Therefore, we aimed to evaluate novel indomethacin derivatives for the treatment of hepatocellular carcinoma.METHODS: The molecular docking of derivatives was carried out for prediction of inhibitory effect on PDGFR-α using pass...

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Patel S, Nanavati P, Sharma J, et al. Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor. Arch Med Res. 2021;52(5):483-493doi: 10.1016/j.arcmed.2021.01.005.
Patel, S., Nanavati, P., Sharma, J., Chavda, V., & Savjani, J. (2021). Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor. Archives of medical research, 52(5), 483-493. https://doi.org/10.1016/j.arcmed.2021.01.005
Patel, Snehal, et al. "Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor." Archives of medical research vol. 52,5 (2021): 483-493. doi: https://doi.org/10.1016/j.arcmed.2021.01.005
Patel S, Nanavati P, Sharma J, Chavda V, Savjani J. Functional Role of Novel Indomethacin Derivatives for the Treatment of Hepatocellular Carcinoma Through Inhibition of Platelet-Derived Growth Factor. Arch Med Res. 2021 Jul;52(5):483-493. doi: 10.1016/j.arcmed.2021.01.005. Epub 2021 Feb 05. PMID: 33551224.
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Kinetics of DNA Repair in Ultraviolet-Irradiated and N-acetoxy-2-acetylaminofluorene-Treated Mammalian Cells.

Biophysical journal

Ahmed FE, Setlow RB.
PMID: 19431355
Biophys J. 1978 Dec;24(3):665-75. doi: 10.1016/S0006-3495(78)85412-5.

Repair kinetics after saturating doses of ultraviolet radiation (UV), N-acetoxy-2-acetylaminofluorene (AAAF), and combinations of both agents were studied in human fibroblasts proficient and deficient in excision repair, and in Chinese hamster cells (V-79) deficient in excision repair. Three techniques...

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Ahmed FE, Setlow RB. Kinetics of DNA Repair in Ultraviolet-Irradiated and N-acetoxy-2-acetylaminofluorene-Treated Mammalian Cells. Biophys J. 1978;24(3):665-75doi: 10.1016/S0006-3495(78)85412-5.
Ahmed, F. E., & Setlow, R. B. (1978). Kinetics of DNA Repair in Ultraviolet-Irradiated and N-acetoxy-2-acetylaminofluorene-Treated Mammalian Cells. Biophysical journal, 24(3), 665-75. https://doi.org/10.1016/S0006-3495(78)85412-5
Ahmed, F E, and Setlow, R B. "Kinetics of DNA Repair in Ultraviolet-Irradiated and N-acetoxy-2-acetylaminofluorene-Treated Mammalian Cells." Biophysical journal vol. 24,3 (1978): 665-75. doi: https://doi.org/10.1016/S0006-3495(78)85412-5
Ahmed FE, Setlow RB. Kinetics of DNA Repair in Ultraviolet-Irradiated and N-acetoxy-2-acetylaminofluorene-Treated Mammalian Cells. Biophys J. 1978 Dec;24(3):665-75. doi: 10.1016/S0006-3495(78)85412-5. PMID: 19431355; PMCID: PMC1473494.
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Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society

Furihata C, Watanabe T, Suzuki T, Hamada S, Nakajima M.
PMID: 27482301
Genes Environ. 2016 Aug 01;38:15. doi: 10.1186/s41021-016-0041-0. eCollection 2016.

Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS, we conducted studies on hepatocarcinogens in rodent liver in which 100...

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Furihata C, Watanabe T, Suzuki T, et al. Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes Environ. 2016;38:15doi: 10.1186/s41021-016-0041-0.
Furihata, C., Watanabe, T., Suzuki, T., Hamada, S., & Nakajima, M. (2016). Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 3815. https://doi.org/10.1186/s41021-016-0041-0
Furihata, Chie, et al. "Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics." Genes and environment : the official journal of the Japanese Environmental Mutagen Society vol. 38 (2016): 15. doi: https://doi.org/10.1186/s41021-016-0041-0
Furihata C, Watanabe T, Suzuki T, Hamada S, Nakajima M. Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes Environ. 2016 Aug 01;38:15. doi: 10.1186/s41021-016-0041-0. eCollection 2016. PMID: 27482301; PMCID: PMC4968012.
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Showing 1 to 12 of 49 entries