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Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.

Cancer discovery

Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC.
PMID: 34244212
Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08.

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets containing free and esterified cholesterol; however, the functional significance of cholesterol accumulation in ccRCC cells is unknown. We demonstrate that, surprisingly, genes encoding cholesterol biosynthetic enzymes...

Cite
Riscal R, Bull CJ, Mesaros C, et al. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0211.
Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., Purdue, M. P., Chanock, S. J., Mariosa, D., Timpson, N. J., Vincent, E. E., Keith, B., Blair, I. A., Skuli, N., & Simon, M. C. (2021). Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal, Romain, et al. "Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08. PMID: 34244212; PMCID: PMC8741905.
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Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.

Cancer discovery

Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC.
PMID: 34244212
Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08.

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets containing free and esterified cholesterol; however, the functional significance of cholesterol accumulation in ccRCC cells is unknown. We demonstrate that, surprisingly, genes encoding cholesterol biosynthetic enzymes...

Cite
Riscal R, Bull CJ, Mesaros C, et al. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0211.
Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., Purdue, M. P., Chanock, S. J., Mariosa, D., Timpson, N. J., Vincent, E. E., Keith, B., Blair, I. A., Skuli, N., & Simon, M. C. (2021). Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal, Romain, et al. "Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08. PMID: 34244212; PMCID: PMC8741905.
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Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Tan VY, Bull CJ, Biernacka KM, Teumer A, Richardson TG, Sanderson E, Corbin LJ, Dudding T, Qi Q, Kaplan RC, Rotter JI, Friedrich N, Völker U, Mayerle J, Perks CM, Holly JMP, Timpson NJ.
PMID: 34583967
Cancer Epidemiol Biomarkers Prev. 2021 Dec;30(12):2207-2216. doi: 10.1158/1055-9965.EPI-21-0315. Epub 2021 Sep 28.

BACKGROUND: Circulating lipids and insulin-like growth factor 1 (IGF-I) have been reliably associated with breast cancer. Observational studies suggest an interplay between lipids and IGF-I, however, whether these relationships are causal and if pathways from these phenotypes to breast...

Cite
Tan VY, Bull CJ, Biernacka KM, et al. Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study. Cancer Epidemiol Biomarkers Prev. 2021;30(12):2207-2216doi: 10.1158/1055-9965.EPI-21-0315.
Tan, V. Y., Bull, C. J., Biernacka, K. M., Teumer, A., Richardson, T. G., Sanderson, E., Corbin, L. J., Dudding, T., Qi, Q., Kaplan, R. C., Rotter, J. I., Friedrich, N., Völker, U., Mayerle, J., Perks, C. M., Holly, J. M. P., & Timpson, N. J. (2021). Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(12), 2207-2216. https://doi.org/10.1158/1055-9965.EPI-21-0315
Tan, Vanessa Y, et al. "Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,12 (2021): 2207-2216. doi: https://doi.org/10.1158/1055-9965.EPI-21-0315
Tan VY, Bull CJ, Biernacka KM, Teumer A, Richardson TG, Sanderson E, Corbin LJ, Dudding T, Qi Q, Kaplan RC, Rotter JI, Friedrich N, Völker U, Mayerle J, Perks CM, Holly JMP, Timpson NJ. Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study. Cancer Epidemiol Biomarkers Prev. 2021 Dec;30(12):2207-2216. doi: 10.1158/1055-9965.EPI-21-0315. Epub 2021 Sep 28. PMID: 34583967; PMCID: PMC7612074.
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Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.

Cancer discovery

Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC.
PMID: 34244212
Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08.

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets containing free and esterified cholesterol; however, the functional significance of cholesterol accumulation in ccRCC cells is unknown. We demonstrate that, surprisingly, genes encoding cholesterol biosynthetic enzymes...

Cite
Riscal R, Bull CJ, Mesaros C, et al. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0211.
Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., Purdue, M. P., Chanock, S. J., Mariosa, D., Timpson, N. J., Vincent, E. E., Keith, B., Blair, I. A., Skuli, N., & Simon, M. C. (2021). Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal, Romain, et al. "Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08. PMID: 34244212; PMCID: PMC8741905.
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GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses.

The Journal of heredity

Hammons V, Ribeiro L, Munyard K, Sadeghi R, Miller D, Antczak D, Brooks SA.
PMID: 34343312
J Hered. 2021 Aug 25;112(5):443-446. doi: 10.1093/jhered/esab037.

Chestnut coat color in horses is determined by a missense mutation within the MC1R gene. However, the intensity of the chestnut color can vary widely within individuals possessing this genotype. Here, we investigated this variation using standardized photographs of...

Cite
Hammons V, Ribeiro L, Munyard K, et al. GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses. J Hered. 2021;112(5):443-446doi: 10.1093/jhered/esab037.
Hammons, V., Ribeiro, L., Munyard, K., Sadeghi, R., Miller, D., Antczak, D., & Brooks, S. A. (2021). GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses. The Journal of heredity, 112(5), 443-446. https://doi.org/10.1093/jhered/esab037
Hammons, Vada, et al. "GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses." The Journal of heredity vol. 112,5 (2021): 443-446. doi: https://doi.org/10.1093/jhered/esab037
Hammons V, Ribeiro L, Munyard K, Sadeghi R, Miller D, Antczak D, Brooks SA. GWAS Identifies a Region Containing the SALL1 Gene in Variation of Pigmentation Intensity Within the Chestnut Coat Color of Horses. J Hered. 2021 Aug 25;112(5):443-446. doi: 10.1093/jhered/esab037. PMID: 34343312; PMCID: PMC8386761.
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Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.

Cancer discovery

Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC.
PMID: 34244212
Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08.

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets containing free and esterified cholesterol; however, the functional significance of cholesterol accumulation in ccRCC cells is unknown. We demonstrate that, surprisingly, genes encoding cholesterol biosynthetic enzymes...

Cite
Riscal R, Bull CJ, Mesaros C, et al. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0211.
Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., Purdue, M. P., Chanock, S. J., Mariosa, D., Timpson, N. J., Vincent, E. E., Keith, B., Blair, I. A., Skuli, N., & Simon, M. C. (2021). Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal, Romain, et al. "Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08. PMID: 34244212.
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Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.

Diabetes

Li-Gao R, Hughes DA, van Klinken JB, de Mutsert R, Rosendaal FR, Mook-Kanamori DO, Timpson NJ, Willems van Dijk K.
PMID: 34610981
Diabetes. 2021 Dec;70(12):2932-2946. doi: 10.2337/db21-0397. Epub 2021 Oct 05.

Humans spend the greater part of the day in a postprandial state. However, the genetic basis of postprandial blood measures is relatively uncharted territory. We examined the genetics of variation in concentrations of postprandial metabolites (

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Li-Gao R, Hughes DA, van Klinken JB, et al. Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism. Diabetes. 2021;70(12):2932-2946doi: 10.2337/db21-0397.
Li-Gao, R., Hughes, D. A., van Klinken, J. B., de Mutsert, R., Rosendaal, F. R., Mook-Kanamori, D. O., Timpson, N. J., & Willems van Dijk, K. (2021). Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism. Diabetes, 70(12), 2932-2946. https://doi.org/10.2337/db21-0397
Li-Gao, Ruifang, et al. "Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism." Diabetes vol. 70,12 (2021): 2932-2946. doi: https://doi.org/10.2337/db21-0397
Li-Gao R, Hughes DA, van Klinken JB, de Mutsert R, Rosendaal FR, Mook-Kanamori DO, Timpson NJ, Willems van Dijk K. Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism. Diabetes. 2021 Dec;70(12):2932-2946. doi: 10.2337/db21-0397. Epub 2021 Oct 05. PMID: 34610981.
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Pleiotropic associations of heterozygosity for the .

ERJ open research

Fawcett KA, Song K, Qian G, Farmaki AE, Packer R, John C, Shrine N, Granell R, Ring S, Timpson NJ, Yerges-Armstrong LM, Eastell R, Wain LV, Scott RA, Tobin MD, Hall IP.
PMID: 33981765
ERJ Open Res. 2021 May 10;7(2). doi: 10.1183/23120541.00049-2021. eCollection 2021 Apr.

Homozygosity for the

Cite
Fawcett KA, Song K, Qian G, et al. Pleiotropic associations of heterozygosity for the . ERJ Open Res. 2021;7(2)doi: 10.1183/23120541.00049-2021.
Fawcett, K. A., Song, K., Qian, G., Farmaki, A. E., Packer, R., John, C., Shrine, N., Granell, R., Ring, S., Timpson, N. J., Yerges-Armstrong, L. M., Eastell, R., Wain, L. V., Scott, R. A., Tobin, M. D., & Hall, I. P. (2021). Pleiotropic associations of heterozygosity for the . ERJ open research, 7(2), . https://doi.org/10.1183/23120541.00049-2021
Fawcett, Katherine A, et al. "Pleiotropic associations of heterozygosity for the ." ERJ open research vol. 7,2 (2021). doi: https://doi.org/10.1183/23120541.00049-2021
Fawcett KA, Song K, Qian G, Farmaki AE, Packer R, John C, Shrine N, Granell R, Ring S, Timpson NJ, Yerges-Armstrong LM, Eastell R, Wain LV, Scott RA, Tobin MD, Hall IP. Pleiotropic associations of heterozygosity for the . ERJ Open Res. 2021 May 10;7(2). doi: 10.1183/23120541.00049-2021. eCollection 2021 Apr. PMID: 33981765; PMCID: PMC8107350.
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Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma.

Cancer discovery

Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC.
PMID: 34244212
Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08.

Clear cell renal cell carcinoma (ccRCC) is characterized by large intracellular lipid droplets containing free and esterified cholesterol; however, the functional significance of cholesterol accumulation in ccRCC cells is unknown. We demonstrate that, surprisingly, genes encoding cholesterol biosynthetic enzymes...

Cite
Riscal R, Bull CJ, Mesaros C, et al. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;doi: 10.1158/2159-8290.CD-21-0211.
Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., Purdue, M. P., Chanock, S. J., Mariosa, D., Timpson, N. J., Vincent, E. E., Keith, B., Blair, I. A., Skuli, N., & Simon, M. C. (2021). Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer discovery, . https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal, Romain, et al. "Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma." Cancer discovery vol. (2021). doi: https://doi.org/10.1158/2159-8290.CD-21-0211
Riscal R, Bull CJ, Mesaros C, Finan JM, Carens M, Ho ES, Xu JP, Godfrey J, Brennan P, Johansson M, Purdue MP, Chanock SJ, Mariosa D, Timpson NJ, Vincent EE, Keith B, Blair IA, Skuli N, Simon MC. Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021 Jul 08; doi: 10.1158/2159-8290.CD-21-0211. Epub 2021 Jul 08. PMID: 34244212.
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Showing 1 to 9 of 9 entries