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In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes.

Journal of drug assessment

Caggiano A, Blight A.
PMID: 27536444
J Drug Assess. 2013 Mar 26;2(1):106-16. doi: 10.3109/21556660.2013.818544. eCollection 2013.

BACKGROUND: Dalfampridine extended release tablets (dalfampridine-ER, known as prolonged-, modified, or sustained-release fampridine tablets in some countries) are approved for the improvement of walking in patients with multiple sclerosis (MS). Dalfampridine-ER is an extended release formulation of 4-aminopyridine (4-AP)....

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Caggiano A, Blight A. In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes. J Drug Assess. 2013;2(1):106-16doi: 10.3109/21556660.2013.818544.
Caggiano, A., & Blight, A. (2013). In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes. Journal of drug assessment, 2(1), 106-16. https://doi.org/10.3109/21556660.2013.818544
Caggiano, Anthony, and Blight, Andrew. "In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes." Journal of drug assessment vol. 2,1 (2013): 106-16. doi: https://doi.org/10.3109/21556660.2013.818544
Caggiano A, Blight A. In vitro evaluation of the effects of 4-aminopyridine on cytochrome P450 enzymes. J Drug Assess. 2013 Mar 26;2(1):106-16. doi: 10.3109/21556660.2013.818544. eCollection 2013. PMID: 27536444; PMCID: PMC4937660.
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[Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study].

Revista brasileira de anestesiologia

Braga Ade F, Carvalho VH, Braga FS, Potério GM, Santos FN.
PMID: 25666937
Rev Bras Anestesiol. 2015 Mar-Apr;65(2):136-40. doi: 10.1016/j.bjan.2013.10.020. Epub 2014 Nov 08.

BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this...

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Braga Ade F, Carvalho VH, Braga FS, et al. Efeito da associação ropivacaina-pancurônio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental. [Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study]. Rev Bras Anestesiol. 2014;65(2):136-40doi: 10.1016/j.bjan.2013.10.020.
Braga, A. d. e. . F., Carvalho, V. H., Braga, F. S., Potério, G. M., & Santos, F. N. (2015). Efeito da associação ropivacaina-pancurônio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental. [Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study]. Revista brasileira de anestesiologia, 65(2), 136-40. https://doi.org/10.1016/j.bjan.2013.10.020
Braga, Angélica de Fátima, et al. "Efeito da associação ropivacaina-pancurônio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental." [Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study]. Revista brasileira de anestesiologia vol. 65,2 (2015): 136-40. doi: https://doi.org/10.1016/j.bjan.2013.10.020
Braga Ade F, Carvalho VH, Braga FS, Potério GM, Santos FN. Efeito da associação ropivacaina-pancurônio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental. [Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study]. Rev Bras Anestesiol. 2015 Mar-Apr;65(2):136-40. doi: 10.1016/j.bjan.2013.10.020. Epub 2014 Nov 08. Portuguese. PMID: 25666937.
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Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats.

Iranian journal of basic medical sciences

Sadeghnia HR, Taji AR, Forouzanfar F, Hosseinzadeh H.
PMID: 28656093
Iran J Basic Med Sci. 2017 May;20(5):588-593. doi: 10.22038/IJBMS.2017.8756.

OBJECTIVES: K+ channel blocker 4-aminopyridine (4-AP) stimulates the release of glutamate from nerve terminals and induces seizures. Berberine as a potential herbal drug exerts several pharmacological actions on the central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The...

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Sadeghnia HR, Taji AR, Forouzanfar F, et al. Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats. Iran J Basic Med Sci. 2017;20(5):588-593doi: 10.22038/IJBMS.2017.8756.
Sadeghnia, H. R., Taji, A. R., Forouzanfar, F., & Hosseinzadeh, H. (2017). Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats. Iranian journal of basic medical sciences, 20(5), 588-593. https://doi.org/10.22038/IJBMS.2017.8756
Sadeghnia, Hamid Reza, et al. "Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats." Iranian journal of basic medical sciences vol. 20,5 (2017): 588-593. doi: https://doi.org/10.22038/IJBMS.2017.8756
Sadeghnia HR, Taji AR, Forouzanfar F, Hosseinzadeh H. Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats. Iran J Basic Med Sci. 2017 May;20(5):588-593. doi: 10.22038/IJBMS.2017.8756. PMID: 28656093; PMCID: PMC5478786.
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4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome.

International neurourology journal

Strupp M, Feil K, Bardins S, Waidelich R.
PMID: 25558420
Int Neurourol J. 2014 Dec;18(4):221-5. doi: 10.5213/inj.2014.18.4.221. Epub 2014 Dec 29.

Aminopyridines are potassium channel blockers that increase the excitability of nerve cells and axons; therefore, they are widely used to treat different neurological disorders. Here we present a patient with idiopathic downbeat nystagmus and lower urinary tract symptoms (LUTS)...

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Strupp M, Feil K, Bardins S, et al. 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. Int Neurourol J. 2014;18(4):221-5doi: 10.5213/inj.2014.18.4.221.
Strupp, M., Feil, K., Bardins, S., & Waidelich, R. (2014). 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. International neurourology journal, 18(4), 221-5. https://doi.org/10.5213/inj.2014.18.4.221
Strupp, Michael, et al. "4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome." International neurourology journal vol. 18,4 (2014): 221-5. doi: https://doi.org/10.5213/inj.2014.18.4.221
Strupp M, Feil K, Bardins S, Waidelich R. 4-aminopyridine improves lower urinary tract symptoms in a patient with benign prostatic hyperplasia and downbeat nystagmus syndrome. Int Neurourol J. 2014 Dec;18(4):221-5. doi: 10.5213/inj.2014.18.4.221. Epub 2014 Dec 29. PMID: 25558420; PMCID: PMC4280442.
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Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.

Frontiers in cellular neuroscience

Robinson SD, Lee TW, Christie DL, Birch NP.
PMID: 26500501
Front Cell Neurosci. 2015 Oct 09;9:404. doi: 10.3389/fncel.2015.00404. eCollection 2015.

NMDA receptors (NMDARs) play a critical role in neurotransmission, acting as essential mediators of many forms of synaptic plasticity, and also modulating aspects of development, synaptic transmission and cell death. NMDAR-induced responses are dependent on a range of factors...

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Robinson SD, Lee TW, Christie DL, et al. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Front Cell Neurosci. 2015;9:404doi: 10.3389/fncel.2015.00404.
Robinson, S. D., Lee, T. W., Christie, D. L., & Birch, N. P. (2015). Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Frontiers in cellular neuroscience, 9404. https://doi.org/10.3389/fncel.2015.00404
Robinson, Samuel D, et al. "Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons." Frontiers in cellular neuroscience vol. 9 (2015): 404. doi: https://doi.org/10.3389/fncel.2015.00404
Robinson SD, Lee TW, Christie DL, Birch NP. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons. Front Cell Neurosci. 2015 Oct 09;9:404. doi: 10.3389/fncel.2015.00404. eCollection 2015. PMID: 26500501; PMCID: PMC4598481.
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Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats.

ISRN pharmacology

Onsa-Ard A, Shimbhu D, Tocharus J, Sutheerawattananonda M, Pantan R, Tocharus C.
PMID: 24312733
ISRN Pharmacol. 2013 Nov 07;2013:717529. doi: 10.1155/2013/717529. eCollection 2013.

Sericin-derived oligopeptides obtained from silk cocoons were investigated for the in vivo hypotensive effect and investigated for the underlying mechanism involved in vasodilation in isolated rat thoracic aorta. In normotensive anesthetized rats, oligopeptides induced an immediate and transient hypotensive...

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Onsa-Ard A, Shimbhu D, Tocharus J, et al. Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN Pharmacol. 2013;2013:717529doi: 10.1155/2013/717529.
Onsa-Ard, A., Shimbhu, D., Tocharus, J., Sutheerawattananonda, M., Pantan, R., & Tocharus, C. (2013). Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN pharmacology, 2013717529. https://doi.org/10.1155/2013/717529
Onsa-Ard, Amnart, et al. "Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats." ISRN pharmacology vol. 2013 (2013): 717529. doi: https://doi.org/10.1155/2013/717529
Onsa-Ard A, Shimbhu D, Tocharus J, Sutheerawattananonda M, Pantan R, Tocharus C. Hypotensive and vasorelaxant effects of sericin-derived oligopeptides in rats. ISRN Pharmacol. 2013 Nov 07;2013:717529. doi: 10.1155/2013/717529. eCollection 2013. PMID: 24312733; PMCID: PMC3839117.
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Kinetic Studies of the Reactions of Pentacyanoferrate(II) Complexes with Peroxydisulfate.

Inorganic chemistry

Chen MH, Lee S, Liu S, Yeh A.
PMID: 11666479
Inorg Chem. 1996 Apr 24;35(9):2627-2629. doi: 10.1021/ic9505920.

Reactions of Fe(CN)(5)L(3-) (L = 4-aminopyridine (4-ampy), pyridine (py), 4,4'-bipyridine (4,4'-bpy), and pyrazine (pz)) with peroxydisulfate, Fe(CN)(5)L(3-) + S(2)O(8)(2-) right harpoon over left harpoon Fe(CN)(5)L(2-) + SO(4)(-) + SO(4)(2-), have been found to follow an outer-sphere electron transfer mechanism....

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Chen MH, Lee S, Liu S, et al. Kinetic Studies of the Reactions of Pentacyanoferrate(II) Complexes with Peroxydisulfate. Inorg Chem. 1996;35(9):2627-2629doi: 10.1021/ic9505920.
Chen, M. H., Lee, S., Liu, S., & Yeh, A. (1996). Kinetic Studies of the Reactions of Pentacyanoferrate(II) Complexes with Peroxydisulfate. Inorganic chemistry, 35(9), 2627-2629. https://doi.org/10.1021/ic9505920
Chen, Ming Hung, et al. "Kinetic Studies of the Reactions of Pentacyanoferrate(II) Complexes with Peroxydisulfate." Inorganic chemistry vol. 35,9 (1996): 2627-2629. doi: https://doi.org/10.1021/ic9505920
Chen MH, Lee S, Liu S, Yeh A. Kinetic Studies of the Reactions of Pentacyanoferrate(II) Complexes with Peroxydisulfate. Inorg Chem. 1996 Apr 24;35(9):2627-2629. doi: 10.1021/ic9505920. PMID: 11666479.
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Two-component molecular crystals composed of chloronitrobenzoic acids and 4-aminopyridine.

Acta crystallographica. Section C, Crystal structure communications

Sugiyama T, Meng J, Matsuura T.
PMID: 11932555
Acta Crystallogr C. 2002 Apr;58:O242-6. doi: 10.1107/s0108270102003657. Epub 2002 Mar 21.

The crystal structures of the four isomeric organic salts 4-aminopyridinium 2-chloro-4-nitrobenzoate, (I), 4-aminopyridinium 2-chloro-5-nitrobenzoate, (II), 4-aminopyridinium 5-chloro-2-nitrobenzoate, (III), and 4-aminopyridinium 4-chloro-2-nitrobenzoate, (IV), all C(5)H(7)N(2)+ x C(7)H(3)ClNO(4)-, are presented. Compound (I) has one intramolecular hydrogen bond, one intermolecular C-H* *...

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Sugiyama T, Meng J, Matsuura T. Two-component molecular crystals composed of chloronitrobenzoic acids and 4-aminopyridine. Acta Crystallogr C. 2002;58:O242-6doi: 10.1107/s0108270102003657.
Sugiyama, T., Meng, J., & Matsuura, T. (2002). Two-component molecular crystals composed of chloronitrobenzoic acids and 4-aminopyridine. Acta crystallographica. Section C, Crystal structure communications, 58O242-6. https://doi.org/10.1107/s0108270102003657
Sugiyama, Teruki, et al. "Two-component molecular crystals composed of chloronitrobenzoic acids and 4-aminopyridine." Acta crystallographica. Section C, Crystal structure communications vol. 58 (2002): O242-6. doi: https://doi.org/10.1107/s0108270102003657
Sugiyama T, Meng J, Matsuura T. Two-component molecular crystals composed of chloronitrobenzoic acids and 4-aminopyridine. Acta Crystallogr C. 2002 Apr;58:O242-6. doi: 10.1107/s0108270102003657. Epub 2002 Mar 21. PMID: 11932555.
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Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons.

The European journal of neuroscience

Neuman R, Ari YB, Cherubini E.
PMID: 12106484
Eur J Neurosci. 1991 Jun;3(6):523-530. doi: 10.1111/j.1460-9568.1991.tb00839.x.

Mast cell degranulating peptide (MCDP) is a neurotoxic agent isolated from bee venom. It produces a long-term potentiation in the hippocampus. We now report that MCDP, at nanomolar concentrations, induces a reduction of a transient voltage-dependent potassium current (ID)...

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Neuman R, Ari YB, Cherubini E. Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons. Eur J Neurosci. 1991;3(6):523-530doi: 10.1111/j.1460-9568.1991.tb00839.x.
Neuman, R., Ari, Y. B., & Cherubini, E. (1991). Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons. The European journal of neuroscience, 3(6), 523-530. https://doi.org/10.1111/j.1460-9568.1991.tb00839.x
Neuman, R., et al. "Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons." The European journal of neuroscience vol. 3,6 (1991): 523-530. doi: https://doi.org/10.1111/j.1460-9568.1991.tb00839.x
Neuman R, Ari YB, Cherubini E. Mast Cell Degranulating Peptide Increases the Frequency of Spontaneous Miniature Postsynaptic Currents in CA3 Rat Hippocampal Neurons. Eur J Neurosci. 1991 Jun;3(6):523-530. doi: 10.1111/j.1460-9568.1991.tb00839.x. PMID: 12106484.
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New nucleophilic catalysts for bright and fast peroxyoxalate chemiluminescence.

Analytical chemistry

Jonsson T, Irgum K.
PMID: 10763230
Anal Chem. 2000 Apr 01;72(7):1373-80. doi: 10.1021/ac991339a.

Miniaturized detection applications based on chemiluminescence require fast reaction kinetics for optimum performance. In this work, high-intensity light from the analytically useful peroxyoxalate chemiluminescence reaction has been generated at high rates by employing both single-component and dual-component nucleophilic catalysis....

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Jonsson T, Irgum K. New nucleophilic catalysts for bright and fast peroxyoxalate chemiluminescence. Anal Chem. 2000;72(7):1373-80doi: 10.1021/ac991339a.
Jonsson, T., & Irgum, K. (2000). New nucleophilic catalysts for bright and fast peroxyoxalate chemiluminescence. Analytical chemistry, 72(7), 1373-80. https://doi.org/10.1021/ac991339a
Jonsson, and Irgum. "New nucleophilic catalysts for bright and fast peroxyoxalate chemiluminescence." Analytical chemistry vol. 72,7 (2000): 1373-80. doi: https://doi.org/10.1021/ac991339a
Jonsson T, Irgum K. New nucleophilic catalysts for bright and fast peroxyoxalate chemiluminescence. Anal Chem. 2000 Apr 01;72(7):1373-80. doi: 10.1021/ac991339a. PMID: 10763230.
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Interaction of 2-Amino-, 3-Amino-, and 4-Aminopyridines with Chromium and Manganese Ferrocyanides.

Journal of colloid and interface science

Alam T, Tarannum H, Kumar N, Kamaluddin.
PMID: 10708502
J Colloid Interface Sci. 2000 Apr 01;224(1):133-139. doi: 10.1006/jcis.1999.6681.

The present investigation deals with the interaction of 2-aminopyridine, 3-aminopyridine, and 4-aminopyridine with chromium and manganese ferrocyanides. Chromium ferrocyanide possesses better adsorbing properties than manganese ferrocyanide. Maximum uptake was observed at neutral pH (pH 7.0). The adsorption data obtained...

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Alam T, Tarannum H, Kumar N, et al. Interaction of 2-Amino-, 3-Amino-, and 4-Aminopyridines with Chromium and Manganese Ferrocyanides. J Colloid Interface Sci. 2000;224(1):133-139doi: 10.1006/jcis.1999.6681.
Alam, T., Tarannum, H., Kumar, N., & Kamaluddin. (2000). Interaction of 2-Amino-, 3-Amino-, and 4-Aminopyridines with Chromium and Manganese Ferrocyanides. Journal of colloid and interface science, 224(1), 133-139. https://doi.org/10.1006/jcis.1999.6681
Alam, et al. "Interaction of 2-Amino-, 3-Amino-, and 4-Aminopyridines with Chromium and Manganese Ferrocyanides." Journal of colloid and interface science vol. 224,1 (2000): 133-139. doi: https://doi.org/10.1006/jcis.1999.6681
Alam T, Tarannum H, Kumar N, Kamaluddin. Interaction of 2-Amino-, 3-Amino-, and 4-Aminopyridines with Chromium and Manganese Ferrocyanides. J Colloid Interface Sci. 2000 Apr 01;224(1):133-139. doi: 10.1006/jcis.1999.6681. PMID: 10708502.
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Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals.

Neurotoxicity research

Amador FC, Santos MS, Oliveira CR.
PMID: 15111247
Neurotox Res. 2001 Jul;3(3):223-33. doi: 10.1007/BF03033261.

In the present study, we analyzed how aluminium and oxidative stress induced by ascorbate/Fe(2+) affect the mechanisms related with the cholinergic system in a crude synaptosomal fraction isolated from rat brain. [(3)H]Choline uptake, [(3)H]acetylcholine release, membrane potential and Na(+)/K(+)-ATPase...

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Amador FC, Santos MS, Oliveira CR. Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals. Neurotox Res. 2001;3(3):223-33doi: 10.1007/BF03033261.
Amador, F. C., Santos, M. S., & Oliveira, C. R. (2001). Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals. Neurotoxicity research, 3(3), 223-33. https://doi.org/10.1007/BF03033261
Amador, F C, et al. "Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals." Neurotoxicity research vol. 3,3 (2001): 223-33. doi: https://doi.org/10.1007/BF03033261
Amador FC, Santos MS, Oliveira CR. Lipid peroxidation and aluminium effects on the cholinergic system in nerve terminals. Neurotox Res. 2001 Jul;3(3):223-33. doi: 10.1007/BF03033261. PMID: 15111247.
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Showing 1 to 12 of 264 entries