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Pathophysiology and Treatment of Hyperhomocysteinemia in End-Stage Renal Disease Patients.

Hemodialysis international. International Symposium on Home Hemodialysis

Sunder-Plassmann G, Hörl WH.
PMID: 28452434
Hemodial Int. 2001 Jan;5(1):86-91. doi: 10.1111/hdi.2001.5.1.86.

The pathophysiology of hyperhomocysteinemia in end-stage renal disease (ESRD) patients includes impaired remethylation of homocysteine (Hcy) to methionine, inhibition of extrarenal Hcy metabolism by uremic solutes, a block in decarboxylation of cysteinesulfinic acid, impaired [adenosylmethionine]/[adenosylhomocysteine] ratio, and a probable...

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Sunder-Plassmann G, Hörl WH. Pathophysiology and Treatment of Hyperhomocysteinemia in End-Stage Renal Disease Patients. Hemodial Int. 2001;5(1):86-91doi: 10.1111/hdi.2001.5.1.86.
Sunder-Plassmann, G., & Hörl, W. H. (2001). Pathophysiology and Treatment of Hyperhomocysteinemia in End-Stage Renal Disease Patients. Hemodialysis international. International Symposium on Home Hemodialysis, 5(1), 86-91. https://doi.org/10.1111/hdi.2001.5.1.86
Sunder-Plassmann, G, and Hörl, Walter H. "Pathophysiology and Treatment of Hyperhomocysteinemia in End-Stage Renal Disease Patients." Hemodialysis international. International Symposium on Home Hemodialysis vol. 5,1 (2001): 86-91. doi: https://doi.org/10.1111/hdi.2001.5.1.86
Sunder-Plassmann G, Hörl WH. Pathophysiology and Treatment of Hyperhomocysteinemia in End-Stage Renal Disease Patients. Hemodial Int. 2001 Jan;5(1):86-91. doi: 10.1111/hdi.2001.5.1.86. PMID: 28452434.
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Selection and Characteristics of Fermented Salted Seafood (jeotgal)-Originated Strains with Excellent S-adenosyl-L-methionine (SAM) Production and Probiotics Efficacy.

Korean journal for food science of animal resources

Kim MJ, Park S, Lee RS, Lim SD, Kim HJ, Lee MK.
PMID: 26760747
Korean J Food Sci Anim Resour. 2014;34(1):65-72. doi: 10.5851/kosfa.2014.34.1.65. Epub 2014 Feb 28.

This study is executed to develop probiotics which produce S-adenosyl-L-methionine (SAM), a methyl group donor of the 5-methyltetrahydrofolate methylation reaction within the animal cell. SAM is an essential substance for the synthesis, activation, and metabolism of hormones, neurotransmitters, nucleic...

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Kim MJ, Park S, Lee RS, et al. Selection and Characteristics of Fermented Salted Seafood (jeotgal)-Originated Strains with Excellent S-adenosyl-L-methionine (SAM) Production and Probiotics Efficacy. Korean J Food Sci Anim Resour. 2014;34(1):65-72doi: 10.5851/kosfa.2014.34.1.65.
Kim, M. J., Park, S., Lee, R. S., Lim, S. D., Kim, H. J., & Lee, M. K. (2014). Selection and Characteristics of Fermented Salted Seafood (jeotgal)-Originated Strains with Excellent S-adenosyl-L-methionine (SAM) Production and Probiotics Efficacy. Korean journal for food science of animal resources, 34(1), 65-72. https://doi.org/10.5851/kosfa.2014.34.1.65
Kim, Min-Jeong, et al. "Selection and Characteristics of Fermented Salted Seafood (jeotgal)-Originated Strains with Excellent S-adenosyl-L-methionine (SAM) Production and Probiotics Efficacy." Korean journal for food science of animal resources vol. 34,1 (2014): 65-72. doi: https://doi.org/10.5851/kosfa.2014.34.1.65
Kim MJ, Park S, Lee RS, Lim SD, Kim HJ, Lee MK. Selection and Characteristics of Fermented Salted Seafood (jeotgal)-Originated Strains with Excellent S-adenosyl-L-methionine (SAM) Production and Probiotics Efficacy. Korean J Food Sci Anim Resour. 2014;34(1):65-72. doi: 10.5851/kosfa.2014.34.1.65. Epub 2014 Feb 28. PMID: 26760747; PMCID: PMC4597818.
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Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that .

Frontiers in microbiology

Kopp M, Dürr K, Steigleder M, Clavel T, Rychlik M.
PMID: 28377750
Front Microbiol. 2017 Mar 21;8:445. doi: 10.3389/fmicb.2017.00445. eCollection 2017.

Certain intestinal bifidobacteria have the ability to synthesize folates.

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Kopp M, Dürr K, Steigleder M, et al. Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that . Front Microbiol. 2017;8:445doi: 10.3389/fmicb.2017.00445.
Kopp, M., Dürr, K., Steigleder, M., Clavel, T., & Rychlik, M. (2017). Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that . Frontiers in microbiology, 8445. https://doi.org/10.3389/fmicb.2017.00445
Kopp, Markus, et al. "Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that ." Frontiers in microbiology vol. 8 (2017): 445. doi: https://doi.org/10.3389/fmicb.2017.00445
Kopp M, Dürr K, Steigleder M, Clavel T, Rychlik M. Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that . Front Microbiol. 2017 Mar 21;8:445. doi: 10.3389/fmicb.2017.00445. eCollection 2017. PMID: 28377750; PMCID: PMC5359228.
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Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B 12 had been excluded.

Advances in hematology

Sobczyńska-Malefora A, Harrington DJ, Voong K, Shearer MJ.
PMID: 24527038
Adv Hematol. 2014;2014:465623. doi: 10.1155/2014/465623. Epub 2014 Jan 15.

5-Methyltetrahydrofolate (5-MTHF) is the predominant form of folate and a strong determinant of homocysteine concentrations. There is evidence that suboptimal 5-MTHF availability is a risk factor for cardiovascular disease independent of homocysteine. The analysis of folates remains challenging and...

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Sobczyńska-Malefora A, Harrington DJ, Voong K, et al. Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B 12 had been excluded. Adv Hematol. 2014;2014:465623doi: 10.1155/2014/465623.
Sobczyńska-Malefora, A., Harrington, D. J., Voong, K., & Shearer, M. J. (2014). Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B 12 had been excluded. Advances in hematology, 2014465623. https://doi.org/10.1155/2014/465623
Sobczyńska-Malefora, Agata, et al. "Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B 12 had been excluded." Advances in hematology vol. 2014 (2014): 465623. doi: https://doi.org/10.1155/2014/465623
Sobczyńska-Malefora A, Harrington DJ, Voong K, Shearer MJ. Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B 12 had been excluded. Adv Hematol. 2014;2014:465623. doi: 10.1155/2014/465623. Epub 2014 Jan 15. PMID: 24527038; PMCID: PMC3914575.
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Serum homocysteine is associated with polycystic ovarian syndrome in Jordan.

Biomedical reports

Saadeh N, Alfaqih MA, Mansour H, Khader YS, Saadeh R, Al-Dwairi A, Nusier M.
PMID: 30402228
Biomed Rep. 2018 Nov;9(5):439-445. doi: 10.3892/br.2018.1149. Epub 2018 Sep 13.

Polycystic ovarian syndrome (PCOS) is a prevalent endocrinopathy among women of a reproductive age. Although not included in the diagnostic criteria, insulin resistance (IR) is a major characteristic of PCOS and may contribute to its development. The exact cause...

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Saadeh N, Alfaqih MA, Mansour H, et al. Serum homocysteine is associated with polycystic ovarian syndrome in Jordan. Biomed Rep. 2018;9(5):439-445doi: 10.3892/br.2018.1149.
Saadeh, N., Alfaqih, M. A., Mansour, H., Khader, Y. S., Saadeh, R., Al-Dwairi, A., & Nusier, M. (2018). Serum homocysteine is associated with polycystic ovarian syndrome in Jordan. Biomedical reports, 9(5), 439-445. https://doi.org/10.3892/br.2018.1149
Saadeh, Nesreen, et al. "Serum homocysteine is associated with polycystic ovarian syndrome in Jordan." Biomedical reports vol. 9,5 (2018): 439-445. doi: https://doi.org/10.3892/br.2018.1149
Saadeh N, Alfaqih MA, Mansour H, Khader YS, Saadeh R, Al-Dwairi A, Nusier M. Serum homocysteine is associated with polycystic ovarian syndrome in Jordan. Biomed Rep. 2018 Nov;9(5):439-445. doi: 10.3892/br.2018.1149. Epub 2018 Sep 13. PMID: 30402228; PMCID: PMC6200971.
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5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology.

International journal of environmental research and public health

Cirillo M, Fucci R, Rubini S, Coccia ME, Fatini C.
PMID: 34886014
Int J Environ Res Public Health. 2021 Nov 23;18(23). doi: 10.3390/ijerph182312280.

The homocysteine pathway in the preconception period should be evaluated to highlight micronutrient deficiencies and warrants optimal multivitamin supplementation, before Assisted Reproduction, as preconception care. We conducted a retrospective study aimed at investigating the role of vitamin B complex...

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Cirillo M, Fucci R, Rubini S, et al. 5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology. Int J Environ Res Public Health. 2021;18(23)doi: 10.3390/ijerph182312280.
Cirillo, M., Fucci, R., Rubini, S., Coccia, M. E., & Fatini, C. (2021). 5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology. International journal of environmental research and public health, 18(23), . https://doi.org/10.3390/ijerph182312280
Cirillo, Michela, et al. "5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology." International journal of environmental research and public health vol. 18,23 (2021). doi: https://doi.org/10.3390/ijerph182312280
Cirillo M, Fucci R, Rubini S, Coccia ME, Fatini C. 5-Methyltetrahydrofolate and Vitamin B12 Supplementation Is Associated with Clinical Pregnancy and Live Birth in Women Undergoing Assisted Reproductive Technology. Int J Environ Res Public Health. 2021 Nov 23;18(23). doi: 10.3390/ijerph182312280. PMID: 34886014.
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Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to .

Antimicrobial agents and chemotherapy

Yu JF, Xu JT, Yang SS, Gao MN, Si HR, Xiong DY, Gu J, Wu ZL, Zhou J, Deng JY.
PMID: 34780266
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0146521. doi: 10.1128/AAC.01465-21. Epub 2021 Nov 15.

Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the most fatal diseases in the world. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the production of 5-methyltetrahydrofolate (5-CH

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Yu JF, Xu JT, Yang SS, et al. Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to . Antimicrob Agents Chemother. 2021;66(1):e0146521doi: 10.1128/AAC.01465-21.
Yu, J. F., Xu, J. T., Yang, S. S., Gao, M. N., Si, H. R., Xiong, D. Y., Gu, J., Wu, Z. L., Zhou, J., & Deng, J. Y. (2022). Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to . Antimicrobial agents and chemotherapy, 66(1), e0146521. https://doi.org/10.1128/AAC.01465-21
Yu, Ji-Fang, et al. "Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to ." Antimicrobial agents and chemotherapy vol. 66,1 (2022): e0146521. doi: https://doi.org/10.1128/AAC.01465-21
Yu JF, Xu JT, Yang SS, Gao MN, Si HR, Xiong DY, Gu J, Wu ZL, Zhou J, Deng JY. Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to . Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0146521. doi: 10.1128/AAC.01465-21. Epub 2021 Nov 15. PMID: 34780266.
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The effect of trichloroethylene metabolites on the hepatic vitamin B.

Toxicology research

Yaqoob N, Bloch KM, Evans AR, Lock EA.
PMID: 32440343
Toxicol Res (Camb). 2020 Apr 24;9(2):117-126. doi: 10.1093/toxres/tfaa006. eCollection 2020 Apr.

The industrial solvent trichloroethylene (TCE) and its two major metabolites trichloroethanol (TCE-OH) and trichloroacetic acid (TCA) cause formic aciduria in male F344 rats. Prior treatment of male F344 rats with 1-aminobenzotriazole a cytochrome P450 inhibitor, followed by TCE (16mk/kg,...

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Yaqoob N, Bloch KM, Evans AR, et al. The effect of trichloroethylene metabolites on the hepatic vitamin B. Toxicol Res (Camb). 2020;9(2):117-126doi: 10.1093/toxres/tfaa006.
Yaqoob, N., Bloch, K. M., Evans, A. R., & Lock, E. A. (2020). The effect of trichloroethylene metabolites on the hepatic vitamin B. Toxicology research, 9(2), 117-126. https://doi.org/10.1093/toxres/tfaa006
Yaqoob, Noreen, et al. "The effect of trichloroethylene metabolites on the hepatic vitamin B." Toxicology research vol. 9,2 (2020): 117-126. doi: https://doi.org/10.1093/toxres/tfaa006
Yaqoob N, Bloch KM, Evans AR, Lock EA. The effect of trichloroethylene metabolites on the hepatic vitamin B. Toxicol Res (Camb). 2020 Apr 24;9(2):117-126. doi: 10.1093/toxres/tfaa006. eCollection 2020 Apr. PMID: 32440343; PMCID: PMC7233319.
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Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018.

The British journal of nutrition

Liu M, Zhou C, Zhang Z, Li Q, He P, Zhang Y, Li H, Liu C, Fan Hou F, Qin X.
PMID: 34016197
Br J Nutr. 2021 May 21;1-10. doi: 10.1017/S0007114521001665. Epub 2021 May 21.

We aim to examine the relation of several folate forms (5-methyltetrahydrofolate (5-mTHF), unmetabolised folic acid (UMFA) and MeFox) with kidney function and albuminuria, which remained uncertain. The cross-sectional study was conducted in 18 757 participants from National Health and...

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Liu M, Zhou C, Zhang Z, et al. Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018. Br J Nutr. 2021;1-10doi: 10.1017/S0007114521001665.
Liu, M., Zhou, C., Zhang, Z., Li, Q., He, P., Zhang, Y., Li, H., Liu, C., Fan Hou, F., & Qin, X. (2021). Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018. The British journal of nutrition, 1-10. https://doi.org/10.1017/S0007114521001665
Liu, Mengyi, et al. "Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018." The British journal of nutrition vol. (2021): 1-10. doi: https://doi.org/10.1017/S0007114521001665
Liu M, Zhou C, Zhang Z, Li Q, He P, Zhang Y, Li H, Liu C, Fan Hou F, Qin X. Relationship of several serum folate forms with kidney function and albuminuria: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018. Br J Nutr. 2021 May 21;1-10. doi: 10.1017/S0007114521001665. Epub 2021 May 21. PMID: 34016197.
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Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells.

Clinical and experimental rheumatology

Ravaei A, Rubini M.
PMID: 34665710
Clin Exp Rheumatol. 2021 Oct 19; Epub 2021 Oct 19.

OBJECTIVES: Methotrexate (MTX)is a folate antagonist that is administered in several conditions such as rheumatoid arthritis. Its use may associate with adverse effects presumably originating from folate deficiency. Although MTX side effects could be decreased by folate supplementation, the...

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Ravaei A, Rubini M. Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells. Clin Exp Rheumatol. 2021;
Ravaei, A., & Rubini, M. (2021). Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells. Clinical and experimental rheumatology, .
Ravaei, Amin, and Rubini, Michele. "Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells." Clinical and experimental rheumatology vol. (2021).
Ravaei A, Rubini M. Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells. Clin Exp Rheumatol. 2021 Oct 19; Epub 2021 Oct 19. PMID: 34665710.
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Vitamin B12 and Folate Markers Are Associated with Insulin Resistance During the Third Trimester of Pregnancy in South Asian Women, Living in the United Kingdom, with Gestational Diabetes and Normal Glucose Tolerance.

The Journal of nutrition

Sobczyńska-Malefora A, Yajnik CS, Harrington DJ, Hitman GA, Finer S.
PMID: 34601603
J Nutr. 2022 Jan 11;152(1):163-170. doi: 10.1093/jn/nxab352.

BACKGROUND: Gestational diabetes mellitus (GDM) can adversely affect the health of the developing fetus. Women of South Asian origin are particularly at risk of developing GDM. Insulin resistance (IR) contributes to the etiology of GDM, and although studies have...

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Sobczyńska-Malefora A, Yajnik CS, Harrington DJ, et al. Vitamin B12 and Folate Markers Are Associated with Insulin Resistance During the Third Trimester of Pregnancy in South Asian Women, Living in the United Kingdom, with Gestational Diabetes and Normal Glucose Tolerance. J Nutr. 2022;152(1):163-170doi: 10.1093/jn/nxab352.
Sobczyńska-Malefora, A., Yajnik, C. S., Harrington, D. J., Hitman, G. A., & Finer, S. (2022). Vitamin B12 and Folate Markers Are Associated with Insulin Resistance During the Third Trimester of Pregnancy in South Asian Women, Living in the United Kingdom, with Gestational Diabetes and Normal Glucose Tolerance. The Journal of nutrition, 152(1), 163-170. https://doi.org/10.1093/jn/nxab352
Sobczyńska-Malefora, Agata, et al. "Vitamin B12 and Folate Markers Are Associated with Insulin Resistance During the Third Trimester of Pregnancy in South Asian Women, Living in the United Kingdom, with Gestational Diabetes and Normal Glucose Tolerance." The Journal of nutrition vol. 152,1 (2022): 163-170. doi: https://doi.org/10.1093/jn/nxab352
Sobczyńska-Malefora A, Yajnik CS, Harrington DJ, Hitman GA, Finer S. Vitamin B12 and Folate Markers Are Associated with Insulin Resistance During the Third Trimester of Pregnancy in South Asian Women, Living in the United Kingdom, with Gestational Diabetes and Normal Glucose Tolerance. J Nutr. 2022 Jan 11;152(1):163-170. doi: 10.1093/jn/nxab352. PMID: 34601603; PMCID: PMC8754569.
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Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats.

The Journal of nutritional biochemistry

Hong KH, Keen CL, Mizuno Y, Johnston KE, Tamura T.
PMID: 10742662
J Nutr Biochem. 2000 Mar;11(3):165-9. doi: 10.1016/s0955-2863(99)00089-3.

In rats, zinc deficiency has been reported to result in elevated hepatic methionine synthase activity and alterations in folate metabolism. We investigated the effect of zinc deficiency on plasma homocysteine concentrations and the distribution of hepatic folates. Weanling male...

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Hong KH, Keen CL, Mizuno Y, et al. Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats. J Nutr Biochem. 2000;11(3):165-9doi: 10.1016/s0955-2863(99)00089-3.
Hong, K. H., Keen, C. L., Mizuno, Y., Johnston, K. E., & Tamura, T. (2000). Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats. The Journal of nutritional biochemistry, 11(3), 165-9. https://doi.org/10.1016/s0955-2863(99)00089-3
Hong, K H, et al. "Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats." The Journal of nutritional biochemistry vol. 11,3 (2000): 165-9. doi: https://doi.org/10.1016/s0955-2863(99)00089-3
Hong KH, Keen CL, Mizuno Y, Johnston KE, Tamura T. Effects of dietary zinc deficiency on homocysteine and folate metabolism in rats. J Nutr Biochem. 2000 Mar;11(3):165-9. doi: 10.1016/s0955-2863(99)00089-3. PMID: 10742662.
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Showing 1 to 12 of 70 entries