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Ethylenediamine derivatives efficiently react with oxidized RNA 3' ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation.

Nucleic acids research

Mamot A, Sikorski PJ, Siekierska A, de Witte P, Kowalska J, Jemielity J.
PMID: 34591964
Nucleic Acids Res. 2022 Jan 11;50(1):e3. doi: 10.1093/nar/gkab867.

Development of RNA-based technologies relies on the ability to detect, manipulate, and modify RNA. Efficient, selective and scalable covalent modification of long RNA molecules remains a challenge. We report a chemical method for modification of RNA 3'-end based on...

Ethylenediamine derivatives efficiently react with oxidized RNA 3' ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation.

Nucleic acids research

Mamot A, Sikorski PJ, Siekierska A, de Witte P, Kowalska J, Jemielity J.
PMID: 34591964
Nucleic Acids Res. 2022 Jan 11;50(1):e3. doi: 10.1093/nar/gkab867.

Development of RNA-based technologies relies on the ability to detect, manipulate, and modify RNA. Efficient, selective and scalable covalent modification of long RNA molecules remains a challenge. We report a chemical method for modification of RNA 3'-end based on...

Ethylenediamine derivatives efficiently react with oxidized RNA 3' ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation.

Nucleic acids research

Mamot A, Sikorski PJ, Siekierska A, de Witte P, Kowalska J, Jemielity J.
PMID: 34591964
Nucleic Acids Res. 2021 Sep 30; doi: 10.1093/nar/gkab867. Epub 2021 Sep 30.

Development of RNA-based technologies relies on the ability to detect, manipulate, and modify RNA. Efficient, selective and scalable covalent modification of long RNA molecules remains a challenge. We report a chemical method for modification of RNA 3'-end based on...

Showing 1 to 3 of 3 entries