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Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression.

PeerJ

Saeed MT, Ahmad J, Kanwal S, Holowatyj AN, Sheikh IA, Zafar Paracha R, Shafi A, Siddiqa A, Bibi Z, Khan M, Ali A.
PMID: 27703839
PeerJ. 2016 Sep 27;4:e2348. doi: 10.7717/peerj.2348. eCollection 2016.

The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP) drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation) and contributes to...

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Saeed MT, Ahmad J, Kanwal S, et al. Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. PeerJ. 2016;4:e2348doi: 10.7717/peerj.2348.
Saeed, M. T., Ahmad, J., Kanwal, S., Holowatyj, A. N., Sheikh, I. A., Zafar Paracha, R., Shafi, A., Siddiqa, A., Bibi, Z., Khan, M., & Ali, A. (2016). Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. PeerJ, 4e2348. https://doi.org/10.7717/peerj.2348
Saeed, Muhammad Tariq, et al. "Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression." PeerJ vol. 4 (2016): e2348. doi: https://doi.org/10.7717/peerj.2348
Saeed MT, Ahmad J, Kanwal S, Holowatyj AN, Sheikh IA, Zafar Paracha R, Shafi A, Siddiqa A, Bibi Z, Khan M, Ali A. Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression. PeerJ. 2016 Sep 27;4:e2348. doi: 10.7717/peerj.2348. eCollection 2016. PMID: 27703839; PMCID: PMC5047222.
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Chromosome imbalance as a driver of sex disparity in disease.

Journal of genomics

Abramowitz LK, Olivier-Van Stichelen S, Hanover JA.
PMID: 25031659
J Genomics. 2014 Apr 01;2:77-88. doi: 10.7150/jgen.8123. eCollection 2014.

It has long been recognized that men and women exhibit different risks for diverse disorders ranging from metabolic to autoimmune diseases. However, the underlying causes of these disparities remain obscure. Analysis of patients with chromosomal abnormalities, including Turner syndrome...

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Abramowitz LK, Olivier-Van Stichelen S, Hanover JA. Chromosome imbalance as a driver of sex disparity in disease. J Genomics. 2014;2:77-88doi: 10.7150/jgen.8123.
Abramowitz, L. K., Olivier-Van Stichelen, S., & Hanover, J. A. (2014). Chromosome imbalance as a driver of sex disparity in disease. Journal of genomics, 277-88. https://doi.org/10.7150/jgen.8123
Abramowitz, Lara K, et al. "Chromosome imbalance as a driver of sex disparity in disease." Journal of genomics vol. 2 (2014): 77-88. doi: https://doi.org/10.7150/jgen.8123
Abramowitz LK, Olivier-Van Stichelen S, Hanover JA. Chromosome imbalance as a driver of sex disparity in disease. J Genomics. 2014 Apr 01;2:77-88. doi: 10.7150/jgen.8123. eCollection 2014. PMID: 25031659; PMCID: PMC4091450.
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A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations.

Current biology : CB

Barnes TD, Wozniak DF, Gutierrez J, Han TU, Drayna D, Holy TE.
PMID: 27151663
Curr Biol. 2016 Apr 13; doi: 10.1016/j.cub.2016.02.068. Epub 2016 Apr 13.

A promising approach to understanding the mechanistic basis of speech is to study disorders that affect speech without compromising other cognitive or motor functions. Stuttering, also known as stammering, has been linked to mutations in the lysosomal enzyme-targeting pathway,...

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Barnes TD, Wozniak DF, Gutierrez J, et al. A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations. Curr Biol. 2016;doi: 10.1016/j.cub.2016.02.068.
Barnes, T. D., Wozniak, D. F., Gutierrez, J., Han, T. U., Drayna, D., & Holy, T. E. (2016). A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations. Current biology : CB, . https://doi.org/10.1016/j.cub.2016.02.068
Barnes, Terra D, et al. "A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations." Current biology : CB vol. (2016). doi: https://doi.org/10.1016/j.cub.2016.02.068
Barnes TD, Wozniak DF, Gutierrez J, Han TU, Drayna D, Holy TE. A Mutation Associated with Stuttering Alters Mouse Pup Ultrasonic Vocalizations. Curr Biol. 2016 Apr 13; doi: 10.1016/j.cub.2016.02.068. Epub 2016 Apr 13. PMID: 27151663; PMCID: PMC5063665.
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Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells.

Oncology letters

Qiao Z, Dang C, Zhou B, Li S, Zhang W, Jiang J, Zhang J, Ma Y, Kong R, Ma Z.
PMID: 27123109
Oncol Lett. 2016 May;11(5):3317-3323. doi: 10.3892/ol.2016.4428. Epub 2016 Apr 07.

O-linked N-acetylglucosamine transferase (OGT) catalyzes O-linked glycosylation (O-GlcNAcylation). O-GlcNAcylation is a post-translational carbohydrate modification of diverse nuclear and cytosolic proteins by the addition of O-linked β-N-acetylglucosamine. It was recently demonstrated that OGT and the level of O-GlcNAcylation are upregulated...

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Qiao Z, Dang C, Zhou B, et al. Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells. Oncol Lett. 2016;11(5):3317-3323doi: 10.3892/ol.2016.4428.
Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W., Jiang, J., Zhang, J., Ma, Y., Kong, R., & Ma, Z. (2016). Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells. Oncology letters, 11(5), 3317-3323. https://doi.org/10.3892/ol.2016.4428
Qiao, Zhe, et al. "Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells." Oncology letters vol. 11,5 (2016): 3317-3323. doi: https://doi.org/10.3892/ol.2016.4428
Qiao Z, Dang C, Zhou B, Li S, Zhang W, Jiang J, Zhang J, Ma Y, Kong R, Ma Z. Downregulation of O-linked N-acetylglucosamine transferase by RNA interference decreases MMP9 expression in human esophageal cancer cells. Oncol Lett. 2016 May;11(5):3317-3323. doi: 10.3892/ol.2016.4428. Epub 2016 Apr 07. PMID: 27123109; PMCID: PMC4840913.
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Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells.

Biology of reproduction

Wang X, Li D, Wu G, Bazer FW.
PMID: 27655785
Biol Reprod. 2016 Nov 01;95(5):102. doi: 10.1095/biolreprod.116.142281. Epub 2016 Sep 21.

During pregnancy, the placentae of ungulate mammals (e.g., cows, sheep, and pigs) convert glucose into fructose which is the most abundant hexose sugar in fetal fluids and blood. However, the role of fructose, the most enigmatic component of carbohydrate...

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Wang X, Li D, Wu G, et al. Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biol Reprod. 2016;95(5):102doi: 10.1095/biolreprod.116.142281.
Wang, X., Li, D., Wu, G., & Bazer, F. W. (2016). Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biology of reproduction, 95(5), 102. https://doi.org/10.1095/biolreprod.116.142281
Wang, Xiaoqiu, et al. "Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells." Biology of reproduction vol. 95,5 (2016): 102. doi: https://doi.org/10.1095/biolreprod.116.142281
Wang X, Li D, Wu G, Bazer FW. Functional Roles of Fructose: Crosstalk between O-Linked Glycosylation and Phosphorylation of Akt-TSC2-MTOR Cell Signaling Cascade in Ovine Trophectoderm Cells. Biol Reprod. 2016 Nov 01;95(5):102. doi: 10.1095/biolreprod.116.142281. Epub 2016 Sep 21. PMID: 27655785.
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Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway.

American journal of cancer research

Zhang B, Zhou P, Li X, Shi Q, Li D, Ju X.
PMID: 28670495
Am J Cancer Res. 2017 Jun 01;7(6):1337-1349. eCollection 2017.

Abnormal cellular energetics has emerged as a hallmark of cancer cells. Deregulating aerobic glycolysis can alter multiple metabolic and signaling pathways in cancer cells, and trigger unlimited growth and proliferation. Accumulating evidence suggests that elevated levels of protein modification...

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Zhang B, Zhou P, Li X, et al. Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. Am J Cancer Res. 2017;7(6):1337-1349
Zhang, B., Zhou, P., Li, X., Shi, Q., Li, D., & Ju, X. (2017). Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. American journal of cancer research, 7(6), 1337-1349.
Zhang, Bing, et al. "Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway." American journal of cancer research vol. 7,6 (2017): 1337-1349.
Zhang B, Zhou P, Li X, Shi Q, Li D, Ju X. Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway. Am J Cancer Res. 2017 Jun 01;7(6):1337-1349. eCollection 2017. PMID: 28670495; PMCID: PMC5489782.
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Temperature affects Vibrio cholerae O1 El Tor persistence in the aquatic environment via an enhanced expression of GbpA and MSHA adhesins.

Environmental microbiology reports

Stauder M, Vezzulli L, Pezzati E, Repetto B, Pruzzo C.
PMID: 23766009
Environ Microbiol Rep. 2010 Feb;2(1):140-4. doi: 10.1111/j.1758-2229.2009.00121.x. Epub 2010 Jan 05.

Vibrio cholerae O1 El Tor attachment to chitin and biofilm formation on polyvinylchloride surfaces via the N-acetylglucosamine-binding protein A (GbpA) and the mannose-sensitive haemagglutinin (MSHA) were investigated under different temperature and salinity conditions simulating those found in the aquatic...

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Stauder M, Vezzulli L, Pezzati E, et al. Temperature affects Vibrio cholerae O1 El Tor persistence in the aquatic environment via an enhanced expression of GbpA and MSHA adhesins. Environ Microbiol Rep. 2010;2(1):140-4doi: 10.1111/j.1758-2229.2009.00121.x.
Stauder, M., Vezzulli, L., Pezzati, E., Repetto, B., & Pruzzo, C. (2010). Temperature affects Vibrio cholerae O1 El Tor persistence in the aquatic environment via an enhanced expression of GbpA and MSHA adhesins. Environmental microbiology reports, 2(1), 140-4. https://doi.org/10.1111/j.1758-2229.2009.00121.x
Stauder, Monica, et al. "Temperature affects Vibrio cholerae O1 El Tor persistence in the aquatic environment via an enhanced expression of GbpA and MSHA adhesins." Environmental microbiology reports vol. 2,1 (2010): 140-4. doi: https://doi.org/10.1111/j.1758-2229.2009.00121.x
Stauder M, Vezzulli L, Pezzati E, Repetto B, Pruzzo C. Temperature affects Vibrio cholerae O1 El Tor persistence in the aquatic environment via an enhanced expression of GbpA and MSHA adhesins. Environ Microbiol Rep. 2010 Feb;2(1):140-4. doi: 10.1111/j.1758-2229.2009.00121.x. Epub 2010 Jan 05. PMID: 23766009.
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Ontogenetic changes of the soluble and membrane-bound D2 glycoprotein in rat forebrain.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Gennarini G, Corsi P, Pavia R, Vitiello F, Di Benedetta C.
PMID: 24873953
Int J Dev Neurosci. 1984;2(2):103-11. doi: 10.1016/0736-5748(84)90001-7.

A soluble form of the D2 glycoprotein, detected in the rat brain hypotonic extract, is described. Its specific relative concentration did not differ significantly in the three examined cerebral regions (forebrain, brainstem and cerebellum), while in the cerebellum the...

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Gennarini G, Corsi P, Pavia R, et al. Ontogenetic changes of the soluble and membrane-bound D2 glycoprotein in rat forebrain. Int J Dev Neurosci. 1984;2(2):103-11doi: 10.1016/0736-5748(84)90001-7.
Gennarini, G., Corsi, P., Pavia, R., Vitiello, F., & Di Benedetta, C. (1984). Ontogenetic changes of the soluble and membrane-bound D2 glycoprotein in rat forebrain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2(2), 103-11. https://doi.org/10.1016/0736-5748(84)90001-7
Gennarini, G, et al. "Ontogenetic changes of the soluble and membrane-bound D2 glycoprotein in rat forebrain." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 2,2 (1984): 103-11. doi: https://doi.org/10.1016/0736-5748(84)90001-7
Gennarini G, Corsi P, Pavia R, Vitiello F, Di Benedetta C. Ontogenetic changes of the soluble and membrane-bound D2 glycoprotein in rat forebrain. Int J Dev Neurosci. 1984;2(2):103-11. doi: 10.1016/0736-5748(84)90001-7. PMID: 24873953.
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Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance.

Frontiers in endocrinology

Wollaston-Hayden EE, Harris RB, Liu B, Bridger R, Xu Y, Wells L.
PMID: 25657638
Front Endocrinol (Lausanne). 2015 Jan 22;5:223. doi: 10.3389/fendo.2014.00223. eCollection 2014.

Increased flux through the hexosamine biosynthetic pathway and the corresponding increase in intracellular glycosylation of proteins via O-linked β-N-acetylglucosamine (O-GlcNAc) is sufficient to induce insulin resistance (IR) in multiple systems. Previously, our group used shotgun proteomics to identify multiple...

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Wollaston-Hayden EE, Harris RB, Liu B, et al. Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance. Front Endocrinol (Lausanne). 2015;5:223doi: 10.3389/fendo.2014.00223.
Wollaston-Hayden, E. E., Harris, R. B., Liu, B., Bridger, R., Xu, Y., & Wells, L. (2014). Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance. Frontiers in endocrinology, 5223. https://doi.org/10.3389/fendo.2014.00223
Wollaston-Hayden, Edith E, et al. "Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance." Frontiers in endocrinology vol. 5 (2014): 223. doi: https://doi.org/10.3389/fendo.2014.00223
Wollaston-Hayden EE, Harris RB, Liu B, Bridger R, Xu Y, Wells L. Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance. Front Endocrinol (Lausanne). 2015 Jan 22;5:223. doi: 10.3389/fendo.2014.00223. eCollection 2014. PMID: 25657638; PMCID: PMC4302944.
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A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods.

International journal of analytical chemistry

Kim HJ, Bae IK, Jeong MH, Park HJ, Jung JS, Kim JE.
PMID: 26788060
Int J Anal Chem. 2015;2015:892486. doi: 10.1155/2015/892486. Epub 2015 Dec 15.

A rapid high performance liquid chromatographic method with evaporative light scattering detection (HPLC-ELSD), using a carbohydrate column, was developed for simultaneous determination of N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) in dairy foods. Sample preparation was performed by precipitation using acetonitrile....

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Kim HJ, Bae IK, Jeong MH, et al. A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods. Int J Anal Chem. 2015;2015:892486doi: 10.1155/2015/892486.
Kim, H. J., Bae, I. K., Jeong, M. H., Park, H. J., Jung, J. S., & Kim, J. E. (2015). A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods. International journal of analytical chemistry, 2015892486. https://doi.org/10.1155/2015/892486
Kim, Ho Jin, et al. "A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods." International journal of analytical chemistry vol. 2015 (2015): 892486. doi: https://doi.org/10.1155/2015/892486
Kim HJ, Bae IK, Jeong MH, Park HJ, Jung JS, Kim JE. A New HPLC-ELSD Method for Simultaneous Determination of N-Acetylglucosamine and N-Acetylgalactosamine in Dairy Foods. Int J Anal Chem. 2015;2015:892486. doi: 10.1155/2015/892486. Epub 2015 Dec 15. PMID: 26788060; PMCID: PMC4693021.
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Involvements of Trp23 in the Chitin-binding and of Trp131 in the Chitinase Activity of Rye Seed Chitinase-a.

Bioscience, biotechnology, and biochemistry

Yamagami T, Funatsu G.
PMID: 27396734
Biosci Biotechnol Biochem. 1997 Jan;61(11):1819-25. doi: 10.1271/bbb.61.1819.

The oxidation of the tryptophan residues of rye seed chitinase-a (RSC-a) and its isolated catalytic (Cat) domain by N-bromosuccinimide (NBS) was investigated in the absence and presence of oligomers of N-acetylglucosamine (GlcNAc)n. Based on the reactivity toward NBS at...

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Yamagami T, Funatsu G. Involvements of Trp23 in the Chitin-binding and of Trp131 in the Chitinase Activity of Rye Seed Chitinase-a. Biosci Biotechnol Biochem. 1997;61(11):1819-25doi: 10.1271/bbb.61.1819.
Yamagami, T., & Funatsu, G. (1997). Involvements of Trp23 in the Chitin-binding and of Trp131 in the Chitinase Activity of Rye Seed Chitinase-a. Bioscience, biotechnology, and biochemistry, 61(11), 1819-25. https://doi.org/10.1271/bbb.61.1819
Yamagami, T, and Funatsu, G. "Involvements of Trp23 in the Chitin-binding and of Trp131 in the Chitinase Activity of Rye Seed Chitinase-a." Bioscience, biotechnology, and biochemistry vol. 61,11 (1997): 1819-25. doi: https://doi.org/10.1271/bbb.61.1819
Yamagami T, Funatsu G. Involvements of Trp23 in the Chitin-binding and of Trp131 in the Chitinase Activity of Rye Seed Chitinase-a. Biosci Biotechnol Biochem. 1997 Jan;61(11):1819-25. doi: 10.1271/bbb.61.1819. PMID: 27396734.
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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.

Diabetes & metabolism journal

Brahma MK, Pepin ME, Wende AR.
PMID: 28236380
Diabetes Metab J. 2017 Feb;41(1):1-9. doi: 10.4093/dmj.2017.41.1.1.

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying...

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Brahma MK, Pepin ME, Wende AR. My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy. Diabetes Metab J. 2017;41(1):1-9doi: 10.4093/dmj.2017.41.1.1.
Brahma, M. K., Pepin, M. E., & Wende, A. R. (2017). My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy. Diabetes & metabolism journal, 41(1), 1-9. https://doi.org/10.4093/dmj.2017.41.1.1
Brahma, Manoja K, et al. "My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy." Diabetes & metabolism journal vol. 41,1 (2017): 1-9. doi: https://doi.org/10.4093/dmj.2017.41.1.1
Brahma MK, Pepin ME, Wende AR. My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy. Diabetes Metab J. 2017 Feb;41(1):1-9. doi: 10.4093/dmj.2017.41.1.1. PMID: 28236380; PMCID: PMC5328690.
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