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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2021). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2021): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2021). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2021): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2022 Jan;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2022). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2022): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2022 Jan;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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The cholesterol side-chain cleavage complex in human brain white matter.

Journal of neuroendocrinology

Goascogne C, Gouézou M, Robel P, Defaye G, Chambaz E, Waterman MR, Baulieu EE.
PMID: 19210447
J Neuroendocrinol. 1989 Jun 01;1(3):153-6. doi: 10.1111/j.1365-2826.1989.tb00095.x.

Abstract Specific antibodies obtained in rabbits after injection of bovine cholesterol side-chain cleavage enzymes cytochrome P-450scc, adrenodoxin and adrenodoxin-reductase were used for immunohistochemical studies in human brain. The three enzymes were co-localized in the white matter of the cerebellum....

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Goascogne C, Gouézou M, Robel P, et al. The cholesterol side-chain cleavage complex in human brain white matter. J Neuroendocrinol. 1989;1(3):153-6doi: 10.1111/j.1365-2826.1989.tb00095.x.
Goascogne, C., Gouézou, M., Robel, P., Defaye, G., Chambaz, E., Waterman, M. R., & Baulieu, E. E. (1989). The cholesterol side-chain cleavage complex in human brain white matter. Journal of neuroendocrinology, 1(3), 153-6. https://doi.org/10.1111/j.1365-2826.1989.tb00095.x
Goascogne, C, et al. "The cholesterol side-chain cleavage complex in human brain white matter." Journal of neuroendocrinology vol. 1,3 (1989): 153-6. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00095.x
Goascogne C, Gouézou M, Robel P, Defaye G, Chambaz E, Waterman MR, Baulieu EE. The cholesterol side-chain cleavage complex in human brain white matter. J Neuroendocrinol. 1989 Jun 01;1(3):153-6. doi: 10.1111/j.1365-2826.1989.tb00095.x. PMID: 19210447.
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Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin.

Archives of biochemistry and biophysics

Glass SM, Webb SN, Guengerich FP.
PMID: 34732331
Arch Biochem Biophys. 2021 Dec 15;714:109076. doi: 10.1016/j.abb.2021.109076. Epub 2021 Oct 31.

Of the 57 human cytochrome P450 (P450) enzymes, seven are mitochondrial: 11A1, 11B1, 11B2, 24A1, 27A1, 27B1, and 27C1. Mitochondrial P450s utilize an electron transport system with adrenodoxin (Adx) and NADPH-adrenodoxin reductase (AdR). AdR reduces Adx, which then transfers...

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Glass SM, Webb SN, Guengerich FP. Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. Arch Biochem Biophys. 2021;714:109076doi: 10.1016/j.abb.2021.109076.
Glass, S. M., Webb, S. N., & Guengerich, F. P. (2021). Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. Archives of biochemistry and biophysics, 714109076. https://doi.org/10.1016/j.abb.2021.109076
Glass, Sarah M, et al. "Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin." Archives of biochemistry and biophysics vol. 714 (2021): 109076. doi: https://doi.org/10.1016/j.abb.2021.109076
Glass SM, Webb SN, Guengerich FP. Binding of cytochrome P450 27C1, a retinoid desaturase, to its accessory protein adrenodoxin. Arch Biochem Biophys. 2021 Dec 15;714:109076. doi: 10.1016/j.abb.2021.109076. Epub 2021 Oct 31. PMID: 34732331; PMCID: PMC8629852.
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Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins.

ChemPlusChem

Kubeil C, Yeung JCI, Tuckey RC, Rodgers RJ, Martin LL.
PMID: 31968797
Chempluschem. 2016 Sep;81(9):995-1002. doi: 10.1002/cplu.201600272. Epub 2016 Jul 22.

Cytochrome P450scc (P450scc or CYP11A1) catalyses the first enzymatic step of steroid biosynthesis, the cleavage of the side chain of cholesterol to produce pregnenolone in the mitochondrion. The activity of P450scc is dependent upon electron delivery from NADPH-dependent adrenodoxin...

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Kubeil C, Yeung JCI, Tuckey RC, et al. Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins. Chempluschem. 2016;81(9):995-1002doi: 10.1002/cplu.201600272.
Kubeil, C., Yeung, J. C. I., Tuckey, R. C., Rodgers, R. J., & Martin, L. L. (2016). Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins. ChemPlusChem, 81(9), 995-1002. https://doi.org/10.1002/cplu.201600272
Kubeil, Clemens, et al. "Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins." ChemPlusChem vol. 81,9 (2016): 995-1002. doi: https://doi.org/10.1002/cplu.201600272
Kubeil C, Yeung JCI, Tuckey RC, Rodgers RJ, Martin LL. Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins. Chempluschem. 2016 Sep;81(9):995-1002. doi: 10.1002/cplu.201600272. Epub 2016 Jul 22. PMID: 31968797.
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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2021). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2021): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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Underestimated reactions and regulation patterns of adrenal cytochromes P450.

Molecular and cellular endocrinology

Bernhardt R, Neunzig J.
PMID: 33722664
Mol Cell Endocrinol. 2021 Jun 15;530:111237. doi: 10.1016/j.mce.2021.111237. Epub 2021 Mar 13.

Although cytochrome P450 (CYP) systems including the adrenal ones are being investigated since many years, there are still reactions and regulation patterns that have been underestimated ever since. This review discusses neglected ones to bring them into the focus...

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Bernhardt R, Neunzig J. Underestimated reactions and regulation patterns of adrenal cytochromes P450. Mol Cell Endocrinol. 2021;530:111237doi: 10.1016/j.mce.2021.111237.
Bernhardt, R., & Neunzig, J. (2021). Underestimated reactions and regulation patterns of adrenal cytochromes P450. Molecular and cellular endocrinology, 530111237. https://doi.org/10.1016/j.mce.2021.111237
Bernhardt, Rita, and Neunzig, Jens. "Underestimated reactions and regulation patterns of adrenal cytochromes P450." Molecular and cellular endocrinology vol. 530 (2021): 111237. doi: https://doi.org/10.1016/j.mce.2021.111237
Bernhardt R, Neunzig J. Underestimated reactions and regulation patterns of adrenal cytochromes P450. Mol Cell Endocrinol. 2021 Jun 15;530:111237. doi: 10.1016/j.mce.2021.111237. Epub 2021 Mar 13. PMID: 33722664.
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Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding.

Biochemistry

Jay N, Duffy SR, Estrada DF.
PMID: 34979083
Biochemistry. 2022 Jan 03; doi: 10.1021/acs.biochem.1c00770. Epub 2022 Jan 03.

The improper maintenance of the bioactivated form of vitamin-D (1α,25(OH)

Cite
Jay N, Duffy SR, Estrada DF. Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding. Biochemistry. 2022;doi: 10.1021/acs.biochem.1c00770.
Jay, N., Duffy, S. R., & Estrada, D. F. (2022). Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding. Biochemistry, . https://doi.org/10.1021/acs.biochem.1c00770
Jay, Natalie, et al. "Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding." Biochemistry vol. (2022). doi: https://doi.org/10.1021/acs.biochem.1c00770
Jay N, Duffy SR, Estrada DF. Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding. Biochemistry. 2022 Jan 03; doi: 10.1021/acs.biochem.1c00770. Epub 2022 Jan 03. PMID: 34979083.
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Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Yang C, Zhang Y, Li J, Song Z, Yi Z, Li F, Xue J, Zhang W, Wang C.
PMID: 33742450
Int J Dev Neurosci. 2021 Jun;81(4):364-369. doi: 10.1002/jdn.10104. Epub 2021 Mar 26.

Ferredoxin reductase (FDXR), located in 17q25.1, encodes for a mitochondrial NADPH: adrenodoxin oxidoreductase or ferredoxin reductase, the sole human ferredoxin reductase involved in the biosynthesis of iron-sulfur (Fe-S) clusters and heme formation. Iron-sulfur (Fe-S) clusters are involved in enzymatic...

Cite
Yang C, Zhang Y, Li J, et al. Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation. Int J Dev Neurosci. 2021;81(4):364-369doi: 10.1002/jdn.10104.
Yang, C., Zhang, Y., Li, J., Song, Z., Yi, Z., Li, F., Xue, J., Zhang, W., & Wang, C. (2021). Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 81(4), 364-369. https://doi.org/10.1002/jdn.10104
Yang, Chengqing, et al. "Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 81,4 (2021): 364-369. doi: https://doi.org/10.1002/jdn.10104
Yang C, Zhang Y, Li J, Song Z, Yi Z, Li F, Xue J, Zhang W, Wang C. Report of a case with ferredoxin reductase (FDXR) gene variants in a Chinese boy exhibiting hearing loss, visual impairment, and motor retardation. Int J Dev Neurosci. 2021 Jun;81(4):364-369. doi: 10.1002/jdn.10104. Epub 2021 Mar 26. PMID: 33742450.
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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2021). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2021): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism.

Insect biochemistry and molecular biology

Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y.
PMID: 34800643
Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17.

Insect CYP2 and mitochondrial clan P450s are relatively conserved genes encoding enzymes generally thought to be involved in biosynthesis or metabolism of endobiotics. However, emerging evidence argues they have potential roles in chemical defense as well, but their actual...

Cite
Shi Y, Qu Q, Wang C, et al. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021;140:103696doi: 10.1016/j.ibmb.2021.103696.
Shi, Y., Qu, Q., Wang, C., He, Y., Yang, Y., & Wu, Y. (2021). Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect biochemistry and molecular biology, 140103696. https://doi.org/10.1016/j.ibmb.2021.103696
Shi, Yu, et al. "Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism." Insect biochemistry and molecular biology vol. 140 (2021): 103696. doi: https://doi.org/10.1016/j.ibmb.2021.103696
Shi Y, Qu Q, Wang C, He Y, Yang Y, Wu Y. Involvement of CYP2 and mitochondrial clan P450s of Helicoverpa armigera in xenobiotic metabolism. Insect Biochem Mol Biol. 2021 Nov 17;140:103696. doi: 10.1016/j.ibmb.2021.103696. Epub 2021 Nov 17. PMID: 34800643.
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Showing 1 to 12 of 15 entries