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Showing 1 to 12 of 12 entries
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Short-term Effects of Ethanol Intoxication on Ascorbic Acid and Lipid Metabolism and on Drug-metabolizing Enzymes in Liver of Rats.

Bioscience, biotechnology, and biochemistry

Mochizuki S, Oda H, Yoshida A.
PMID: 27280650
Biosci Biotechnol Biochem. 1992 Jan;56(4):576-9. doi: 10.1271/bbb.56.576.

The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v)...

Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats.

Environmental toxicology and pharmacology

Eke BC, Coban T, Vural N, Iscan M.
PMID: 21781847
Environ Toxicol Pharmacol. 1998 Jan;5(1):29-34. doi: 10.1016/s1382-6689(97)10003-5.

The adult male and female rats were exposed to cigarette smoke (CS) 5 times a day, with 1 h intervals, for 3 days in a chamber where smoke and fresh air lead alternatively and were killed 16 h after...

Comparison of effects of xenobiotics on extrahepatic and hepatic microsomal drug-metabolizing enzymes in mice.

Environmental toxicology and pharmacology

Huang R, Okuno H, Takasu M, Shiozaki Y, Inoue K.
PMID: 21781672
Environ Toxicol Pharmacol. 1996 Apr 15;1(2):123-30. doi: 10.1016/1382-6689(95)00018-6.

The content of microsomal protein is the same in both kidneys and small intestine, corresponding to 57% of the control value expressed as 100% in the untreated liver. The contents of P450 and cytochrome b(5), and the activity of...

Effects of simultaneous repeated exposure at high levels of arsenic and malathion on hepatic drug-biotransforming enzymes in broiler chickens.

Environmental toxicology and pharmacology

Naraharisetti SB, Aggarwal M, Ranganathan V, Sarkar SN, Kataria M, Malik JK.
PMID: 21784005
Environ Toxicol Pharmacol. 2009 Sep;28(2):213-8. doi: 10.1016/j.etap.2009.04.006. Epub 2009 Apr 15.

Groundwater contamination with arsenic is a major global health concern. The organophosphorus insecticide malathion has gained significance as an environmental pollutant due to its widespread use in agriculture, grain storage, ectoparasite control and public health management. The deleterious effects...

Effect of methomyl on hepatic mixed function oxidases in rats.

Indian journal of pharmacology

Patil JA, Patil AJ, Sontakke AV, Govindwar SP.
PMID: 20040949
Indian J Pharmacol. 2008 Aug;40(4):158-63. doi: 10.4103/0253-7613.43162.

OBJECTIVE: To study the effect of the methomyl on mixed function oxidase system in rats.MATERIALS AND METHODS: The effect of the methomyl on mixed function oxidase was studied using different dosages, durations and sex. Microsomes were isolated using the...

Effects of a Single Large Dose of Ethanol on Tissue Ascorbic Acid, Drug-Metabolizing Enzymes in the Liver, and Serum and Liver Lipids in Rats Fed with a PCB-containing Diet.

Bioscience, biotechnology, and biochemistry

Mochizuki S, Kato K, Watanabe Y, Yoshida A.
PMID: 27316864
Biosci Biotechnol Biochem. 1993 Jan;57(1):12-6. doi: 10.1271/bbb.57.12.

The effects of a single administration of ethanol after feeding a PCB-containing diet on tissue ascorbic acid, drug-metabolizing enzymes in the liver, and serum and liver lipids of rats were investigated. Male Donryu and Wistar rats that had been...

Alteration of drug metabolizing enzymes in sulphite oxidase deficiency.

Journal of clinical biochemistry and nutrition

Tutuncu B, Kuçukatay V, Arslan S, Sahin B, Semiz A, Sen A.
PMID: 22798713
J Clin Biochem Nutr. 2012 Jul;51(1):50-4. doi: 10.3164/jcbn.11-79. Epub 2012 Mar 30.

The aim of this study was to investigate the possible effects of sulphite oxidase (SOX, E.C. 1.8.3.1) deficiency on xenobiotic metabolism. For this purpose, SOX deficiency was produced in rats by the administration of a low molybdenum diet with...

In vivo effects of Faizol Ubat Batuk, a herbal product on aminopyrine metabolism in rat hepatocytes.

The Libyan journal of medicine

Taher YA, Hussin AH.
PMID: 21977110
Libyan J Med. 2011;6. doi: 10.3402/ljm.v6i0.5439. Epub 2011 Sep 28.

Traditional medicines, in particular herbal products, have been used abundantly over the years in curing several diseases. Pharmacological interactions of herbal products with modern drugs, however, remain to some extent unknown. Herein, we examined whether co-administration of Faizol Ubat...

Influence of growth hormone on the hepatic mixed function oxidase and transferase systems of rainbow trout.

Fish physiology and biochemistry

Cravedi JP, Paris A, Perdu-Durand E, Prunet P.
PMID: 24197494
Fish Physiol Biochem. 1995 Aug;14(4):259-66. doi: 10.1007/BF00004064.

The effect of GH treatment on hepatic cytochrome P450 content, aryl hydrocarbon hydroxylase (AHH), aminopyrine-N-demethylase (AND), testosterone hydroxylase, testosterone 5α- and 5β-reductase, UDP-glucuronyl transferase (UDPGT) and glutathione S-transferase (GST) activities in immature rainbow trout were investigated. Hepatic cytochrome P450...

The role of 3-methylsulfonyl-2,2',4',5,5'-pentachlorobiphenyl, a metabolite of 2,2',4,5,5'-pentachlorobiphenyl, in the induction of hepatic microsomal drug-metabolizing enzymes by 2,2',4,5,5'-pentachlorobiphenyl in rats.

Environmental toxicology and pharmacology

Kato Y, Haraguchi K, Tomiyasu K, Saito H, Shibahara T, Masuda Y, Kimura R.
PMID: 21781940
Environ Toxicol Pharmacol. 1999 Dec;8(1):39-47. doi: 10.1016/s1382-6689(99)00028-9.

After the administration of 2,2',4,5,5'-pentachlorobiphenyl (2,2',4,5,5'-pentaCB) to intact rats, the concentration of 2,2',4,5,5'-pentaCB in liver gradually decreased, whereas 3-methylsulfonyl (3-MeSO(2))-2,2',4',5,5'-pentaCB appeared in liver and remained detectable in liver for 6 weeks. A single injection of 2,2',4,5,5'-pentaCB (342 μmol/kg) or...

Biodegradation of Green HE4B: Co-substrate effect, biotransformation enzymes and metabolite toxicity analysis.

Indian journal of microbiology

Kalme SD, Jadhav SU, Parshetti GK, Govindwar SP.
PMID: 23100822
Indian J Microbiol. 2010 Jun;50(2):156-64. doi: 10.1007/s12088-010-0001-5. Epub 2010 Mar 05.

A high exhaust reactive dye, Green HE4B (GHE4B) was 98% degraded in nutrient medium by Pseudomonas desmolyticum NCIM 2112 (pd2112) within 72 h at static condition. Decolorization time in synthetic 10 g/l molasses. Addition of 5 g/l peptone to...

Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats.

Journal of biochemical and molecular toxicology

Adeleke GE, Adaramoye OA.
PMID: 34472159
J Biochem Mol Toxicol. 2021 Nov;35(11):e22901. doi: 10.1002/jbt.22901. Epub 2021 Sep 02.

N-nitrosamines have been linked with cancer in humans due to their presence in drinking water and diets. This study evaluated the role of betulinic acid (BA) in abating oxidative stress, inflammation, and hyperlipidemia in rats treated with N-nitrosodimethylamine (NDMA)....

Showing 1 to 12 of 12 entries