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Showing 1 to 12 of 17 entries
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Antimicrobial lactoferrin peptides: the hidden players in the protective function of a multifunctional protein.

International journal of peptides

Sinha M, Kaushik S, Kaur P, Sharma S, Singh TP.
PMID: 23554820
Int J Pept. 2013;2013:390230. doi: 10.1155/2013/390230. Epub 2013 Feb 13.

Lactoferrin is a multifunctional, iron-binding glycoprotein which displays a wide array of modes of action to execute its primary antimicrobial function. It contains various antimicrobial peptides which are released upon its hydrolysis by proteases. These peptides display a similarity...

A Bi-Functional Targeted P28-NRC Chimeric Protein with Enhanced Cytotoxic Effects on Breast Cancer Cell Lines.

Iranian journal of pharmaceutical research : IJPR

Soleimani M, Mirmohammmad Sadeghi H, Jahanian-Najafabadi A.
PMID: 31531057
Iran J Pharm Res. 2019;18(2):735-744. doi: 10.22037/ijpr.2019.2392.

One of the emerging therapeutic strategies for targeted therapy of cancer is the use of chimeric proteins. The p28 peptide has the ability of selective entrance and activating apoptosis in breast cancer cells. The NRC antimicrobial peptide showed cytotoxic...

Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship.

Leukemia

Ratajczak MZ, Kucia M.
PMID: 34853440
Leukemia. 2021 Dec 01; doi: 10.1038/s41375-021-01482-0. Epub 2021 Dec 01.

Hematopoietic and immune cells originate from a common hematopoietic/lymphopoietic stem cell what explains that these different cell types often share the same receptors and respond to similar factors. Moreover, the common goal of both lineages is to ensure tissue...

Combined Training Improves the Expression Profile of Inflammation-associated Antimicrobial Peptides, MicroRNAs, and TLR-4 in Patients with Multiple Sclerosis.

Iranian journal of allergy, asthma, and immunology

Yousefi Saqqezi S, Azamian Jazi A, Hemmati R, Jivad N.
PMID: 34418898
Iran J Allergy Asthma Immunol. 2021 Aug 07;20(4):441-452.

Some antimicrobial peptides (AMPs), microRNAs (miRs), and Toll-like receptor 4 (TLR-4) are involved in autoimmune diseases, which may be affected by exercise training. The purpose of this study was to investigate the effect of an eight-week combined exercise training...

A Fast Method for DEFB1 - 44C/G SNP Genotyping in Brazilian Patients with Periodontitis.

Acta stomatologica Croatica

Cimőes R, Cavalcanti de Siqueira RR, Crovella S, Eleutério de Souza PR, Donos N.
PMID: 27688368
Acta Stomatol Croat. 2014 Sep;48(3):208-15. doi: 10.15644/asc48/3/5.

AIM: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the...

From amino acids polymers, antimicrobial peptides, and histones, to their possible role in the pathogenesis of septic shock: a historical perspective.

Journal of inflammation research

Ginsburg I, van Heerden PV, Koren E.
PMID: 28203100
J Inflamm Res. 2017 Feb 01;10:7-15. doi: 10.2147/JIR.S126150. eCollection 2017.

This paper describes the evolution of our understanding of the biological role played by synthetic and natural antimicrobial cationic peptides and by the highly basic nuclear histones as modulators of infection, postinfectious sequelae, trauma, and coagulation phenomena. The authors...

Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells.

Frontiers in immunology

Baumann A, Kiener MS, Haigh B, Perreten V, Summerfield A.
PMID: 28203238
Front Immunol. 2017 Feb 01;8:59. doi: 10.3389/fimmu.2017.00059. eCollection 2017.

Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the sensing of nucleic acids by the innate immune system. The present study aimed to investigate the ability of...

Predicted regulatory SNPs reveal potential drug targets and novel companion diagnostics in psoriasis.

Journal of translational autoimmunity

Ruiz Ramírez AV, Flores-Saiffe Farías A, Chávez Álvarez RDC, Prado Montes de Oca E.
PMID: 33898962
J Transl Autoimmun. 2021 Apr 05;4:100096. doi: 10.1016/j.jtauto.2021.100096. eCollection 2021.

Psoriasis is an autoimmune disease associated with interleukins, their receptors, key transcription factors and more recently, antimicrobial peptides (AMPs). Cathelicidin LL-37 is an AMP proposed to play a fundamental role in psoriasis etiology. With our proprietary software SNPClinic v.1.0,...

Synthesis, Characterization, and Bactericidal Activity of a 4-Ammoniumbuthylstyrene-Based Random Copolymer.

Polymers

Alfei S, Piatti G, Caviglia D, Schito AM.
PMID: 33918374
Polymers (Basel). 2021 Apr 02;13(7). doi: 10.3390/polym13071140.

The growing resistance of bacteria to current chemotherapy is a global concern that urgently requires new and effective antimicrobial agents, aimed at curing untreatable infection, reducing unacceptable healthcare costs and human mortality. Cationic polymers, that mimic antimicrobial cationic peptides,...

The effects of Peptide Mel4-coated titanium plates on infection rabbits after internal fixation of open fractures.

Archives of orthopaedic and trauma surgery

Zhang S, Zhou X, Liu T, Huang Y, Li J.
PMID: 33386976
Arch Orthop Trauma Surg. 2021 Jan 02; doi: 10.1007/s00402-020-03694-y. Epub 2021 Jan 02.

INTRODUCTION: Infection after internal fixation surgery is an orthopedic serious complication which affect the fracture healing. The primary objective of this study was to verify the effects of a Peptide Mel4-coated titanium plate applied in the treatment of infection...

Bronchoalveolar Lavage and Plasma Cathelicidin Response to 25-Hydroxy Vitamin D Supplementation: A Pilot Study.

Chronic obstructive pulmonary diseases (Miami, Fla.)

Sanders EC, Burkes RM, Mock JR, Brown TT, Wise RA, Hansel NN, Liu MC, Drummond MB.
PMID: 34044475
Chronic Obstr Pulm Dis. 2021 Jul 28;8(3):371-381. doi: 10.15326/jcopdf.2021.0220.

INTRODUCTION: Cathelicidin is a vitamin D-regulated, antimicrobial peptide involved in the innate immune response of the airways. Reduced plasma cathelicidin concentrations are independently associated with worse pulmonary outcomes in current and former smokers. This study aimed to determine whether...

Antimicrobial peptide GH12 suppresses cariogenic virulence factors of .

Journal of oral microbiology

Wang Y, Wang X, Jiang W, Wang K, Luo J, Li W, Zhou X, Zhang L.
PMID: 29503706
J Oral Microbiol. 2018 Feb 26;10(1):1442089. doi: 10.1080/20002297.2018.1442089. eCollection 2018.

Cariogenic virulence factors of

Showing 1 to 12 of 17 entries