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Targeting metabolism to regulate immune responses in autoimmunity and cancer

interventions

Patel CH.
GSID: WSL070LNqeYJ
CH Patel, RD Leone, MR Horton… - Nature Reviews Drug …, 2019 - nature.com

Metabolic programming is emerging as a critical mechanism to alter immune cell activation, differentiation and function. Targeting metabolism does not completely suppress or activate …

A study of bone mineral density and its determinants in type 1 diabetes mellitus.

Journal of osteoporosis

Joshi A, Varthakavi P, Chadha M, Bhagwat N.
PMID: 23607045
J Osteoporos. 2013;2013:397814. doi: 10.1155/2013/397814. Epub 2013 Mar 31.

Type 1 diabetes mellitus (T1DM) has been inconsistently associated with low bone mineral density (BMD) and increased fracture risk. 86 consecutive T1DM cases and 140 unrelated age and sex matched healthy nondiabetic controls were included in the study. After...

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Joshi A, Varthakavi P, Chadha M, et al. A study of bone mineral density and its determinants in type 1 diabetes mellitus. J Osteoporos. 2013;2013:397814doi: 10.1155/2013/397814.
Joshi, A., Varthakavi, P., Chadha, M., & Bhagwat, N. (2013). A study of bone mineral density and its determinants in type 1 diabetes mellitus. Journal of osteoporosis, 2013397814. https://doi.org/10.1155/2013/397814
Joshi, Ameya, et al. "A study of bone mineral density and its determinants in type 1 diabetes mellitus." Journal of osteoporosis vol. 2013 (2013): 397814. doi: https://doi.org/10.1155/2013/397814
Joshi A, Varthakavi P, Chadha M, Bhagwat N. A study of bone mineral density and its determinants in type 1 diabetes mellitus. J Osteoporos. 2013;2013:397814. doi: 10.1155/2013/397814. Epub 2013 Mar 31. PMID: 23607045; PMCID: PMC3628496.
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Reactive oxygen species in organ-specific autoimmunity.

Auto- immunity highlights

Di Dalmazi G, Hirshberg J, Lyle D, Freij JB, Caturegli P.
PMID: 27491295
Auto Immun Highlights. 2016 Dec;7(1):11. doi: 10.1007/s13317-016-0083-0. Epub 2016 Aug 04.

Reactive oxygen species (ROS) have been extensively studied in the induction of inflammation and tissue damage, especially as it relates to aging. In more recent years, ROS have been implicated in the pathogenesis of autoimmune diseases. Here, ROS accumulation...

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Di Dalmazi G, Hirshberg J, Lyle D, et al. Reactive oxygen species in organ-specific autoimmunity. Auto Immun Highlights. 2016;7(1):11doi: 10.1007/s13317-016-0083-0.
Di Dalmazi, G., Hirshberg, J., Lyle, D., Freij, J. B., & Caturegli, P. (2016). Reactive oxygen species in organ-specific autoimmunity. Auto- immunity highlights, 7(1), 11. https://doi.org/10.1007/s13317-016-0083-0
Di Dalmazi, Giulia, et al. "Reactive oxygen species in organ-specific autoimmunity." Auto- immunity highlights vol. 7,1 (2016): 11. doi: https://doi.org/10.1007/s13317-016-0083-0
Di Dalmazi G, Hirshberg J, Lyle D, Freij JB, Caturegli P. Reactive oxygen species in organ-specific autoimmunity. Auto Immun Highlights. 2016 Dec;7(1):11. doi: 10.1007/s13317-016-0083-0. Epub 2016 Aug 04. PMID: 27491295; PMCID: PMC4974204.
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Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells.

Frontiers in immunology

Laffont S, Blanquart E, Guéry JC.
PMID: 28912783
Front Immunol. 2017 Aug 31;8:1069. doi: 10.3389/fimmu.2017.01069. eCollection 2017.

Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in...

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Laffont S, Blanquart E, Guéry JC. Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells. Front Immunol. 2017;8:1069doi: 10.3389/fimmu.2017.01069.
Laffont, S., Blanquart, E., & Guéry, J. C. (2017). Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells. Frontiers in immunology, 81069. https://doi.org/10.3389/fimmu.2017.01069
Laffont, Sophie, et al. "Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells." Frontiers in immunology vol. 8 (2017): 1069. doi: https://doi.org/10.3389/fimmu.2017.01069
Laffont S, Blanquart E, Guéry JC. Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells. Front Immunol. 2017 Aug 31;8:1069. doi: 10.3389/fimmu.2017.01069. eCollection 2017. PMID: 28912783; PMCID: PMC5583151.
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Ceramide synthesis regulates T cell activity and GVHD development.

JCI insight

Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ.
PMID: 28515365
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.91701. eCollection 2017 May 18.

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapy for a variety of hematologic malignances, yet its efficacy is impeded by the development of graft-versus-host disease (GVHD). GVHD is characterized by activation, expansion, cytokine production, and migration of alloreactive...

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Sofi MH, Heinrichs J, Dany M, et al. Ceramide synthesis regulates T cell activity and GVHD development. JCI Insight. 2017;2(10)doi: 10.1172/jci.insight.91701.
Sofi, M. H., Heinrichs, J., Dany, M., Nguyen, H., Dai, M., Bastian, D., Schutt, S., Wu, Y., Daenthanasanmak, A., Gencer, S., Zivkovic, A., Szulc, Z., Stark, H., Liu, C., Chang, Y. J., Ogretmen, B., & Yu, X. Z. (2017). Ceramide synthesis regulates T cell activity and GVHD development. JCI insight, 2(10), . https://doi.org/10.1172/jci.insight.91701
Sofi, M Hanief, et al. "Ceramide synthesis regulates T cell activity and GVHD development." JCI insight vol. 2,10 (2017). doi: https://doi.org/10.1172/jci.insight.91701
Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ. Ceramide synthesis regulates T cell activity and GVHD development. JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.91701. eCollection 2017 May 18. PMID: 28515365; PMCID: PMC5436544.
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Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

JCI insight

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.
PMID: 28515366
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.92920. eCollection 2017 May 18.

Many effector mechanisms of neutrophils have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Neutrophil extracellular traps (NETs) have been assigned a particularly detrimental role. Here we investigated the functional impact of neutrophils and NETs on a...

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Kienhöfer D, Hahn J, Stoof J, et al. Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps. JCI Insight. 2017;2(10)doi: 10.1172/jci.insight.92920.
Kienhöfer, D., Hahn, J., Stoof, J., Csepregi, J. Z., Reinwald, C., Urbonaviciute, V., Johnsson, C., Maueröder, C., Podolska, M. J., Biermann, M. H., Leppkes, M., Harrer, T., Hultqvist, M., Olofsson, P., Munoz, L. E., Mocsai, A., Herrmann, M., Schett, G., Holmdahl, R., & Hoffmann, M. H. (2017). Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps. JCI insight, 2(10), . https://doi.org/10.1172/jci.insight.92920
Kienhöfer, Deborah, et al. "Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps." JCI insight vol. 2,10 (2017). doi: https://doi.org/10.1172/jci.insight.92920
Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH. Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps. JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.92920. eCollection 2017 May 18. PMID: 28515366; PMCID: PMC5436535.
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Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.

ACS medicinal chemistry letters

Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ.
PMID: 28947948
ACS Med Chem Lett. 2017 Sep 01;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14.

No abstract available.

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Kindon N, Andrews G, Baxter A, et al. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017;8(9):981-986doi: 10.1021/acsmedchemlett.7b00315.
Kindon, N., Andrews, G., Baxter, A., Cheshire, D., Hemsley, P., Johnson, T., Liu, Y. Z., McGinnity, D., McHale, M., Mete, A., Reuberson, J., Roberts, B., Steele, J., Teobald, B., Unitt, J., Vaughan, D., Walters, I., & Stocks, M. J. (2017). Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS medicinal chemistry letters, 8(9), 981-986. https://doi.org/10.1021/acsmedchemlett.7b00315
Kindon, Nicholas, et al. "Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists." ACS medicinal chemistry letters vol. 8,9 (2017): 981-986. doi: https://doi.org/10.1021/acsmedchemlett.7b00315
Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists. ACS Med Chem Lett. 2017 Sep 01;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14. PMID: 28947948; PMCID: PMC5601455.
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Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy.

Journal for immunotherapy of cancer

Koelzer VH, Buser T, Willi N, Rothschild SI, Wicki A, Schiller P, Cathomas G, Zippelius A, Mertz KD.
PMID: 27532022
J Immunother Cancer. 2016 Aug 16;4:47. doi: 10.1186/s40425-016-0151-z. eCollection 2016.

BACKGROUND: Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (PD-L1). Skin toxicity most commonly includes a maculopapular erythematous rash...

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Koelzer VH, Buser T, Willi N, et al. Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. J Immunother Cancer. 2016;4:47doi: 10.1186/s40425-016-0151-z.
Koelzer, V. H., Buser, T., Willi, N., Rothschild, S. I., Wicki, A., Schiller, P., Cathomas, G., Zippelius, A., & Mertz, K. D. (2016). Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. Journal for immunotherapy of cancer, 447. https://doi.org/10.1186/s40425-016-0151-z
Koelzer, Viktor H, et al. "Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy." Journal for immunotherapy of cancer vol. 4 (2016): 47. doi: https://doi.org/10.1186/s40425-016-0151-z
Koelzer VH, Buser T, Willi N, Rothschild SI, Wicki A, Schiller P, Cathomas G, Zippelius A, Mertz KD. Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. J Immunother Cancer. 2016 Aug 16;4:47. doi: 10.1186/s40425-016-0151-z. eCollection 2016. PMID: 27532022; PMCID: PMC4986338.
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Temporal lobe epilepsy associated with GAD autoimmunity.

Acta diabetologica

Obata A, Kutoku Y, Sunada Y, Okauchi S, Kimura T, Hirukawa H, Tanabe A, Kinoshita T, Kohara K, Tatsumi F, Shimoda M, Kamei S, Nakanishi S, Mune T, Kaku K, Kaneto H.
PMID: 27638303
Acta Diabetol. 2017 Mar;54(3):321-323. doi: 10.1007/s00592-016-0910-9. Epub 2016 Sep 08.

No abstract available.

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Obata A, Kutoku Y, Sunada Y, et al. Temporal lobe epilepsy associated with GAD autoimmunity. Acta Diabetol. 2016;54(3):321-323doi: 10.1007/s00592-016-0910-9.
Obata, A., Kutoku, Y., Sunada, Y., Okauchi, S., Kimura, T., Hirukawa, H., Tanabe, A., Kinoshita, T., Kohara, K., Tatsumi, F., Shimoda, M., Kamei, S., Nakanishi, S., Mune, T., Kaku, K., & Kaneto, H. (2017). Temporal lobe epilepsy associated with GAD autoimmunity. Acta diabetologica, 54(3), 321-323. https://doi.org/10.1007/s00592-016-0910-9
Obata, Atsushi, et al. "Temporal lobe epilepsy associated with GAD autoimmunity." Acta diabetologica vol. 54,3 (2017): 321-323. doi: https://doi.org/10.1007/s00592-016-0910-9
Obata A, Kutoku Y, Sunada Y, Okauchi S, Kimura T, Hirukawa H, Tanabe A, Kinoshita T, Kohara K, Tatsumi F, Shimoda M, Kamei S, Nakanishi S, Mune T, Kaku K, Kaneto H. Temporal lobe epilepsy associated with GAD autoimmunity. Acta Diabetol. 2017 Mar;54(3):321-323. doi: 10.1007/s00592-016-0910-9. Epub 2016 Sep 08. PMID: 27638303; PMCID: PMC5329084.
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Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis.

Rare diseases (Austin, Tex.)

Braun CJ, Witzel M, Paruzynski A, Boztug K, von Kalle C, Schmidt M, Klein C.
PMID: 26942098
Rare Dis. 2014 Oct 30;2(1):e947749. doi: 10.4161/21675511.2014.947749. eCollection 2014.

Wiskott-Aldrich-Syndrome (WAS) is a rare X-linked recessive disease caused by mutations of the WAS gene. It is characterized by immunodeficiency, autoimmunity, low numbers of small platelets (microthrombocytopenia) and a high risk of cancer, especially B cell lymphoma and leukemia.

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Braun CJ, Witzel M, Paruzynski A, et al. Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis. Rare Dis. 2014;2(1):e947749doi: 10.4161/21675511.2014.947749.
Braun, C. J., Witzel, M., Paruzynski, A., Boztug, K., von Kalle, C., Schmidt, M., & Klein, C. (2014). Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis. Rare diseases (Austin, Tex.), 2(1), e947749. https://doi.org/10.4161/21675511.2014.947749
Braun, Christian Joerg, et al. "Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis." Rare diseases (Austin, Tex.) vol. 2,1 (2014): e947749. doi: https://doi.org/10.4161/21675511.2014.947749
Braun CJ, Witzel M, Paruzynski A, Boztug K, von Kalle C, Schmidt M, Klein C. Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis. Rare Dis. 2014 Oct 30;2(1):e947749. doi: 10.4161/21675511.2014.947749. eCollection 2014. PMID: 26942098; PMCID: PMC4755244.
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Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins.

Frontiers in immunology

Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P.
PMID: 28861084
Front Immunol. 2017 Aug 16;8:976. doi: 10.3389/fimmu.2017.00976. eCollection 2017.

High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for...

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Fishman D, Kisand K, Hertel C, et al. Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 2017;8:976doi: 10.3389/fimmu.2017.00976.
Fishman, D., Kisand, K., Hertel, C., Rothe, M., Remm, A., Pihlap, M., Adler, P., Vilo, J., Peet, A., Meloni, A., Podkrajsek, K. T., Battelino, T., Bruserud, �. �., Wolff, A. S. B., Husebye, E. S., Kluger, N., Krohn, K., Ranki, A., Peterson, H., Hayday, A., & Peterson, P. (2017). Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Frontiers in immunology, 8976. https://doi.org/10.3389/fimmu.2017.00976
Fishman, Dmytro, et al. "Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins." Frontiers in immunology vol. 8 (2017): 976. doi: https://doi.org/10.3389/fimmu.2017.00976
Fishman D, Kisand K, Hertel C, Rothe M, Remm A, Pihlap M, Adler P, Vilo J, Peet A, Meloni A, Podkrajsek KT, Battelino T, Bruserud Ø, Wolff ASB, Husebye ES, Kluger N, Krohn K, Ranki A, Peterson H, Hayday A, Peterson P. Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Front Immunol. 2017 Aug 16;8:976. doi: 10.3389/fimmu.2017.00976. eCollection 2017. PMID: 28861084; PMCID: PMC5561390.
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Worms and Humans: A Happy Divorce?.

Forum on immunopathological diseases and therapeutics

Akuffo H, Britton S, Schön T.
PMID: 28392966
For Immunopathol Dis Therap. 2015;6(1):27-32. doi: 10.1615/ForumImmunDisTher.2015015300.

Chronic asymptomatic worm infection, often in combination with tuberculosis (TB), is common in low-income countries. Indeed, a life without worm infestation, as is now the case in most high-income countries, is a recent condition for humankind. Worms and

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Akuffo H, Britton S, Schön T. Worms and Humans: A Happy Divorce?. For Immunopathol Dis Therap. 2015;6(1):27-32doi: 10.1615/ForumImmunDisTher.2015015300.
Akuffo, H., Britton, S., & Schön, T. (2015). Worms and Humans: A Happy Divorce?. Forum on immunopathological diseases and therapeutics, 6(1), 27-32. https://doi.org/10.1615/ForumImmunDisTher.2015015300
Akuffo, Hannah, et al. "Worms and Humans: A Happy Divorce?." Forum on immunopathological diseases and therapeutics vol. 6,1 (2015): 27-32. doi: https://doi.org/10.1615/ForumImmunDisTher.2015015300
Akuffo H, Britton S, Schön T. Worms and Humans: A Happy Divorce?. For Immunopathol Dis Therap. 2015;6(1):27-32. doi: 10.1615/ForumImmunDisTher.2015015300. PMID: 28392966; PMCID: PMC5381959.
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