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Showing 1 to 10 of 10 entries
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Effect of oxidative stress on sympathetic and renal vascular responses to ischemic exercise.

Physiological reports

Muller MD, Drew RC, Cui J, Blaha CA, Mast JL, Sinoway LI.
PMID: 24098855
Physiol Rep. 2013 Aug;1(3). doi: 10.1002/phy2.47.

Reactive oxygen species (ROS), produced acutely during skeletal muscle contraction, are known to stimulate group IV muscle afferents and accentuate the exercise pressor reflex (EPR) in rodents. The effect of ROS on the EPR in humans is unknown. We...

Genetic Ancestry, Skin Reflectance and Pigmentation Genotypes in Association with Serum Vitamin D Metabolite Balance.

Hormone molecular biology and clinical investigation

Wilson RT, Roff AN, Dai PJ, Fortugno T, Douds J, Chen G, Grove GL, Nikiforova SO, Barnholtz-Sloan J, Frudakis T, Chinchilli VM, Hartman TJ, Demers LM, Shriver MD, Canfield VA, Cheng KC.
PMID: 23525585
Horm Mol Biol Clin Investig. 2011 Sep;7(1):279-293. doi: 10.1515/HMBCI.2011.021.

BACKGROUND: Lower serum vitamin D (25(OH)D) among individuals with African ancestry is attributed primarily to skin pigmentation. However, the influence of genetic polymorphisms controlling for skin melanin content has not been investigated. Therefore, we investigated differences in non-summer serum...

Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action.

Dermato-endocrinology

Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM.
PMID: 20436886
Dermatoendocrinol. 2009 May;1(3):177-87. doi: 10.4161/derm.1.3.8258.

Isotretinoin (13-cis RA) is the most potent agent in the treatment of acne. Insights into its mechanism of action can lead to drug discovery of alternative compounds with comparable efficacy but improved safety. The goal of this study is...

Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease.

Physiological reports

Drew RC, Muller MD, Blaha CA, Mast JL, Heffernan MJ, Estep LE, Cui J, Reed AB, Sinoway LI.
PMID: 24400156
Physiol Rep. 2013 Nov;1(6):e00154. doi: 10.1002/phy2.154. Epub 2013 Nov 07.

Peripheral arterial disease (PAD) patients have augmented blood pressure increases during exercise, heightening their cardiovascular risk. However, it is unknown whether patients have exaggerated renal vasoconstriction during exercise and if oxidative stress contributes to this response. Eleven PAD patients...

Forearm vascular responses to mental stress in healthy older adults.

Physiological reports

Heffernan MJ, Patel HM, Muller MD.
PMID: 24744859
Physiol Rep. 2013 Dec 05;1(7):e00180. doi: 10.1002/phy2.180. eCollection 2013 Dec 01.

Forearm vascular conductance (FVC) increases in response to mental stress (verbal mental arithmetic) in young people. However, the effect of healthy aging and mental stress on FVC is unknown. In this study, we tested the hypothesis that FVC and...

Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease.

Journal of neurology and neurobiology

Tekin I, Vgontzas A, Lewis MM, Kothari S, Kong L, Lu Y, Vrana KE, Huang X.
PMID: 26937489
J Neurol Neurobiol. 2015 Jul;1(3). doi: 10.16966/2379-7150.109. Epub 2015 Jul 25.

BACKGROUND: Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear.OBJECTIVE: To explore whether peripheral injury and associated chronic limb pain may influence the side of onset.METHODS: We administered a...

Insomnia Phenotypes Based on Objective Sleep Duration in Adolescents: Depression Risk and Differential Behavioral Profiles.

Brain sciences

Fernandez-Mendoza J, Calhoun SL, Vgontzas AN, Li Y, Gaines J, Liao D, Bixler EO.
PMID: 27983580
Brain Sci. 2016 Dec 13;6(4). doi: 10.3390/brainsci6040059.

Based on previous studies on the role of objective sleep duration in predicting morbidity in individuals with insomnia, we examined the role of objective sleep duration in differentiating behavioral profiles in adolescents with insomnia symptoms. Adolescents from the Penn...

Effect of acute hyperthyroidism on blood flow, muscle oxygenation, and sympathetic nerve activity during dynamic handgrip.

Physiological reports

Ray CA, Sauder CL, Ray DM, Nishida Y.
PMID: 24303102
Physiol Rep. 2013 Jun;1(1):e00011. doi: 10.1002/phy2.11. Epub 2013 Jun 12.

Hyperthyroidism induces marked changes in hemodynamics. Although considerable research has been done to study the effect of hyperthyroidism on the cardiovascular system, few studies have isolated the short-term, nongenomic effects of thyroid hormone on cardiovascular responses to exercise. We...

Infants' Transitions out of a Fussing/Crying State Are Modifiable and Are Related to Weight Status.

Infancy : the official journal of the International Society on Infant Studies

Anzman-Frasca S, Liu S, Gates KM, Paul IM, Rovine MJ, Birch LL.
PMID: 25302052
Infancy. 2013;18(5):662-686. doi: 10.1111/infa.12002.

Currently, about 10% of infants have a weight for length greater than the 95th percentile for their age and sex, which puts them at risk for obesity as they grow. In a pilot obesity prevention study, primiparous mothers and...

Opioid growth factor improves clinical benefit and survival in patients with advanced pancreatic cancer.

Open access journal of clinical trials

Smith JP, Bingaman SI, Mauger DT, Harvey HH, Demers LM, Zagon IS.
PMID: 20890374
Open Access J Clin Trials. 2010 Mar 01;2010(2):37-48. doi: 10.2147/oajct.s8270.

BACKGROUND: Advanced pancreatic cancer carries the poorest prognosis of all gastrointestinal malignancies. Once the tumor has spread beyond the margins of the pancreas, chemotherapy is the major treatment modality offered to patients; however, chemotherapy does not significantly improve survival....

Showing 1 to 10 of 10 entries