Display options
Cite
Drew RC, Muller MD, Blaha CA, et al. Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease. Physiol Rep. 2013;1(6):e00154doi: 10.1002/phy2.154.
Drew, R. C., Muller, M. D., Blaha, C. A., Mast, J. L., Heffernan, M. J., Estep, L. E., Cui, J., Reed, A. B., & Sinoway, L. I. (2013). Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease. Physiological reports, 1(6), e00154. https://doi.org/10.1002/phy2.154
Drew, Rachel C, et al. "Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease." Physiological reports vol. 1,6 (2013): e00154. doi: https://doi.org/10.1002/phy2.154
Drew RC, Muller MD, Blaha CA, Mast JL, Heffernan MJ, Estep LE, Cui J, Reed AB, Sinoway LI. Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease. Physiol Rep. 2013 Nov;1(6):e00154. doi: 10.1002/phy2.154. Epub 2013 Nov 07. PMID: 24400156; PMCID: PMC3871469.
Copy Download .nbib Format: NLM
Share it on

Physiol Rep. 2013 Nov;1(6):e00154. doi: 10.1002/phy2.154. Epub 2013 Nov 07.

Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease.

Physiological reports

Rachel C Drew, Matthew D Muller, Cheryl A Blaha, Jessica L Mast, Matthew J Heffernan, Lauren E Estep, Jian Cui, Amy B Reed, Lawrence I Sinoway

Affiliations

  1. Penn State Hershey Heart and Vascular Institute, Penn State University College of Medicine Hershey, Pennsylvania.

PMID: 24400156 PMCID: PMC3871469 DOI: 10.1002/phy2.154

Abstract

Peripheral arterial disease (PAD) patients have augmented blood pressure increases during exercise, heightening their cardiovascular risk. However, it is unknown whether patients have exaggerated renal vasoconstriction during exercise and if oxidative stress contributes to this response. Eleven PAD patients and 10 controls (CON) performed 4-min mild, rhythmic, plantar flexion exercise of increasing intensity (0.5-2 kg) with each leg (most and least affected in PAD). Eight patients also exercised with their most affected leg during ascorbic acid (AA) infusion. Renal blood flow velocity (RBFV; Doppler ultrasound), mean arterial blood pressure (MAP; Finometer), and heart rate (HR; electrocardiogram [ECG]) were measured. Renal vascular resistance (RVR), an index of renal vasoconstriction, was calculated as MAP/RBFV. Baseline RVR and MAP were similar while HR was higher in PAD than CON (2.08 ± 0.23 vs. 1.87 ± 0.20 au, 94 ± 3 vs. 93 ± 3 mmHg, and 72 ± 3 vs. 59 ± 3 bpm [P < 0.05] for PAD and CON, respectively). PAD had greater RVR increases during exercise than CON, specifically during the first minute (PAD most: 26 ± 5% and PAD least: 17 ± 5% vs. CON: 3 ± 3%; P < 0.05). AA did not alter baseline RVR, MAP, or HR. AA attenuated the augmented RVR increase in PAD during the first minute of exercise (PAD most: 33 ± 4% vs. PAD most with AA: 21 ± 4%; P < 0.05). In conclusion, these findings suggest that PAD patients have augmented renal vasoconstriction during exercise, with oxidative stress contributing to this response.

Keywords: Exercise; oxidative stress; peripheral arterial disease; renal

References

  1. J Physiol. 2012 Dec 1;590(23):6237-46 - PubMed
  2. J Appl Physiol (1985). 2007 Oct;103(4):1257-62 - PubMed
  3. Circ Res. 1997 Jan;80(1):62-8 - PubMed
  4. Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H968-77 - PubMed
  5. Angiology. 1999 May;50(5):361-74 - PubMed
  6. J Appl Physiol (1985). 2001 May;90(5):1714-9 - PubMed
  7. Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1166-74 - PubMed
  8. Exp Physiol. 2006 Jan;91(1):37-49 - PubMed
  9. JAMA. 2001 Sep 19;286(11):1317-24 - PubMed
  10. Exp Physiol. 2006 Jan;91(1):111-9 - PubMed
  11. Exp Physiol. 2012 Aug;97(8):943-54 - PubMed
  12. BMJ. 2012 Aug 14;345:e5208 - PubMed
  13. J Appl Physiol (1985). 2011 Oct;111(4):971-9 - PubMed
  14. J Appl Physiol (1985). 2007 Jan;102(1):492-4; discussion 496 - PubMed
  15. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2113-7 - PubMed
  16. Am J Cardiol. 1988 Sep 9;62(8):2E-8E - PubMed
  17. Circulation. 2001 Apr 10;103(14):1863-8 - PubMed
  18. Circulation. 2000 Feb 22;101(7):784-9 - PubMed
  19. Eur J Vasc Endovasc Surg. 2007 Jan;33(1):20-5 - PubMed
  20. Med Sci Sports Exerc. 1982;14(5):377-81 - PubMed
  21. Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1247-53 - PubMed
  22. Circ Res. 2000 Nov 10;87(10):840-4 - PubMed
  23. Arch Intern Med. 2003 Apr 28;163(8):884-92 - PubMed
  24. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H311-21 - PubMed
  25. Eur Heart J. 2007 Mar;28(5):608-12 - PubMed
  26. Am J Cardiol. 2003 Feb 6;91(3A):7A-11A - PubMed
  27. J Physiol. 2009 Nov 1;587(Pt 21):5227-37 - PubMed
  28. Circulation. 1972 Aug;46(2):257-63 - PubMed
  29. J Vasc Surg. 2004 Oct;40(4):768-73 - PubMed
  30. Exp Physiol. 2006 Jan;91(1):89-102 - PubMed
  31. J Appl Physiol (1985). 2007 Jan;102(1):494-6; discussion 496-7 - PubMed

Publication Types

Grant support