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Showing 1 to 11 of 11 entries
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Ascorbic acid does not enhance hypoxia-induced vasodilation in healthy older men.

Physiological reports

Pollock JP, Patel HM, Randolph BJ, Heffernan MJ, Leuenberger UA, Muller MD.
PMID: 25052494
Physiol Rep. 2014 Jul 22;2(7). doi: 10.14814/phy2.12091. Print 2014 Jul 01.

In response to hypoxia, a net vasodilation occurs in the limb vasculature in young healthy humans and this is referred to as "hypoxia-induced vasodilation". We performed two separate experiments to determine (1) if hypoxia-induced forearm vasodilation is impaired in...

Muscle afferent receptors engaged in augmented sympathetic responsiveness in peripheral artery disease.

Frontiers in physiology

Li J, Xing J.
PMID: 22934005
Front Physiol. 2012 Jul 10;3:247. doi: 10.3389/fphys.2012.00247. eCollection 2012.

The exercise pressor reflex (EPR) is a neural control mechanism responsible for the cardiovascular responses to exercise. As exercise is initiated, thin fiber muscle afferent nerves are activated by mechanical and metabolic stimuli arising in the contracting muscles. This...

Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.

Internal medicine review (Washington, D.C. : Online)

Li J, Cui J.
PMID: 29862378
Intern Med Rev (Wash D C). 2016 Nov;2(10). doi: 10.18103/imr.v2i10.259.

Arterial blood pressure (BP) and vasoconstriction regulated by sympathetic nerve activity (SNA) are heightened during exercise in patients with peripheral artery disease (PAD). The exercise pressor reflex is considered as a neural mechanism responsible for the exaggerated autonomic responses...

Effect of oxidative stress on sympathetic and renal vascular responses to ischemic exercise.

Physiological reports

Muller MD, Drew RC, Cui J, Blaha CA, Mast JL, Sinoway LI.
PMID: 24098855
Physiol Rep. 2013 Aug;1(3). doi: 10.1002/phy2.47.

Reactive oxygen species (ROS), produced acutely during skeletal muscle contraction, are known to stimulate group IV muscle afferents and accentuate the exercise pressor reflex (EPR) in rodents. The effect of ROS on the EPR in humans is unknown. We...

Do peripheral and/or central chemoreflexes influence skin blood flow in humans?.

Physiological reports

Heffernan MJ, Muller MD.
PMID: 25344478
Physiol Rep. 2014 Oct 24;2(10). doi: 10.14814/phy2.12181. Print 2014 Oct 01.

Voluntary apnea activates the central and peripheral chemoreceptors, leading to a rise in sympathetic nerve activity and limb vasoconstriction (i.e., brachial blood flow velocity and forearm cutaneous vascular conductance decrease to a similar extent). Whether peripheral and/or central chemoreceptors...

Femoral Artery Occlusion Increases Muscle Pressor Reflex and Expression of Hypoxia-Inducible Factor-1α in Sensory Neurons.

Journal of cardiovascular disease

Gao W, Li J.
PMID: 25346936
J Cardiovasc Dis. 2013 Oct;1(2):34-40.

Hypoxia inducible factor-1 (HIF-1) has an important contribution to pathophysiological changes of homeostasis under conditions of oxygen deprivation as well as ischemia. We examined the effects of femoral artery occlusion on HIF-1α expression in sensory dorsal root ganglion (DRG)...

Renal vasoconstriction is augmented during exercise in patients with peripheral arterial disease.

Physiological reports

Drew RC, Muller MD, Blaha CA, Mast JL, Heffernan MJ, Estep LE, Cui J, Reed AB, Sinoway LI.
PMID: 24400156
Physiol Rep. 2013 Nov;1(6):e00154. doi: 10.1002/phy2.154. Epub 2013 Nov 07.

Peripheral arterial disease (PAD) patients have augmented blood pressure increases during exercise, heightening their cardiovascular risk. However, it is unknown whether patients have exaggerated renal vasoconstriction during exercise and if oxidative stress contributes to this response. Eleven PAD patients...

Forearm vascular responses to mental stress in healthy older adults.

Physiological reports

Heffernan MJ, Patel HM, Muller MD.
PMID: 24744859
Physiol Rep. 2013 Dec 05;1(7):e00180. doi: 10.1002/phy2.180. eCollection 2013 Dec 01.

Forearm vascular conductance (FVC) increases in response to mental stress (verbal mental arithmetic) in young people. However, the effect of healthy aging and mental stress on FVC is unknown. In this study, we tested the hypothesis that FVC and...

Hindlimb venous distention evokes a pressor reflex in decerebrated rats.

Physiological reports

Yamauchi K, Stone AJ, Kaufman MP.
PMID: 24907299
Physiol Rep. 2014 Jun 06;2(6). doi: 10.14814/phy2.12036. Print 2014 Jun 01.

The distention of small vessels caused by an increase in blood flow to dynamically exercising muscles has been proposed as a stimulus that activates the thin fiber (groups III and IV) afferents evoking the exercise pressor reflex. This theory...

Seasonal variation in muscle sympathetic nerve activity.

Physiological reports

Cui J, Muller MD, Blaha C, Kunselman AR, Sinoway LI.
PMID: 26265752
Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12492.

Epidemiologic data suggest there are seasonal variations in the incidence of severe cardiac events with peak levels being evident in the winter. Whether autonomic indices including muscle sympathetic nerve activity (MSNA) vary with season remains unclear. In this report,...

Nerve Growth Factor, Muscle Afferent Receptors and Autonomic Responsiveness with Femoral Artery Occlusion.

Journal of modern physiological research

Li J, Xing J, Lu J.
PMID: 25346945
J Mod Physiol Res. 2014;1(1):1-18.

The exercise pressor reflex is a neural control mechanism responsible for the cardiovascular responses to exercise. As exercise is initiated, thin fiber muscle afferent nerves are activated by mechanical and metabolic stimuli arising in the contracting muscles. This leads...

Showing 1 to 11 of 11 entries