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Li J, Cui J. Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease. Intern Med Rev (Wash D C). 2016;2(10)doi: 10.18103/imr.v2i10.259.
Li, J., & Cui, J. (2016). Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease. Internal medicine review (Washington, D.C. : Online), 2(10), . https://doi.org/10.18103/imr.v2i10.259
Li, Jianhua, and Cui, Jian. "Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease." Internal medicine review (Washington, D.C. : Online) vol. 2,10 (2016). doi: https://doi.org/10.18103/imr.v2i10.259
Li J, Cui J. Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease. Intern Med Rev (Wash D C). 2016 Nov;2(10). doi: 10.18103/imr.v2i10.259. PMID: 29862378; PMCID: PMC5984049.
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Intern Med Rev (Wash D C). 2016 Nov;2(10). doi: 10.18103/imr.v2i10.259.

Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.

Internal medicine review (Washington, D.C. : Online)

Jianhua Li, Jian Cui

Affiliations

  1. Heart & Vascular Institute, The Penn State University College of Medicine, Hershey, PA 17033.

PMID: 29862378 PMCID: PMC5984049 DOI: 10.18103/imr.v2i10.259

Abstract

Arterial blood pressure (BP) and vasoconstriction regulated by sympathetic nerve activity (SNA) are heightened during exercise in patients with peripheral artery disease (PAD). The exercise pressor reflex is considered as a neural mechanism responsible for the exaggerated autonomic responses to exercise in PAD. A series of studies have employed a rat model of PAD to examine signal pathways at receptor and cellular levels by which the exercise pressor reflex is amplified. This review will summarize results obtained from recent human and animal studies with respect to contribution of muscle afferents to augmented SNA and BP responses in PAD. The role played by adenosine triphosphate (ATP) and ATP sensitive purinergic P2X receptors will be emphasized.

Keywords: P2X; blood pressure; bradykinin; muscle temperature; nerve growth factor; peripheral artery disease; static exercise; sympathetic nerve activity

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