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Cui J, Muller MD, Blaha C, et al. Seasonal variation in muscle sympathetic nerve activity. Physiol Rep. 2015;3(8)doi: 10.14814/phy2.12492.
Cui, J., Muller, M. D., Blaha, C., Kunselman, A. R., & Sinoway, L. I. (2015). Seasonal variation in muscle sympathetic nerve activity. Physiological reports, 3(8), . https://doi.org/10.14814/phy2.12492
Cui, Jian, et al. "Seasonal variation in muscle sympathetic nerve activity." Physiological reports vol. 3,8 (2015). doi: https://doi.org/10.14814/phy2.12492
Cui J, Muller MD, Blaha C, Kunselman AR, Sinoway LI. Seasonal variation in muscle sympathetic nerve activity. Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12492. PMID: 26265752; PMCID: PMC4562578.
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Physiol Rep. 2015 Aug;3(8). doi: 10.14814/phy2.12492.

Seasonal variation in muscle sympathetic nerve activity.

Physiological reports

Jian Cui, Matthew D Muller, Cheryl Blaha, Allen R Kunselman, Lawrence I Sinoway

Affiliations

  1. Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  2. Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University College of Medicine Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  3. Penn State Hershey Heart and Vascular Institute, Pennsylvania State University College of Medicine Milton S. Hershey Medical Center, Hershey, Pennsylvania [email protected].

PMID: 26265752 PMCID: PMC4562578 DOI: 10.14814/phy2.12492

Abstract

Epidemiologic data suggest there are seasonal variations in the incidence of severe cardiac events with peak levels being evident in the winter. Whether autonomic indices including muscle sympathetic nerve activity (MSNA) vary with season remains unclear. In this report, we tested the hypothesis that resting MSNA varies with the seasons of the year with peak levels evident in the winter. We analyzed the supine resting MSNA in 60 healthy subjects. Each subject was studied during two, three, or four seasons (total 237 visits). MSNA burst rate in the winter (21.0 ± 6.8 burst/min, mean ± SD) was significantly greater than in the summer (13.5 ± 5.8 burst/min, P < 0.001), the spring (17.1 ± 9.0 burst/min, P = 0.03), and the fall (17.9 ± 7.7 burst/min, P = 0.002). There was no significant difference in MSNA for other seasonal comparisons. The results suggest that resting sympathetic nerve activity varies along the seasons, with peak levels evident in the winter. We speculate that the seasonal changes in sympathetic activity may be a contribution to the previously observed seasonal variations in cardiovascular morbidity and mortality.

© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

Keywords: Cardiovascular diseases; hemodynamic; nervous system; risk factors; sympathetic

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