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Therapeutic promise maintained.

Immunology today

Green C.
PMID: 25291644
Immunol Today. 1982 May;3(5):121-3. doi: 10.1016/0167-5699(82)90066-4.

Cyclosporin A (CS-A) is a fungal metabolite, one of many cyclosporins with a narrow spectrum of antibiotic activity, but one with profound immunosuppressive effects on cell-mediated cytolysis in vitro, graft v. host reactions and delayed-type hypersensitivity. An international symposium...

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Green C. Therapeutic promise maintained. Immunol Today. 1982;3(5):121-3doi: 10.1016/0167-5699(82)90066-4.
Green, C. (1982). Therapeutic promise maintained. Immunology today, 3(5), 121-3. https://doi.org/10.1016/0167-5699(82)90066-4
Green, C. "Therapeutic promise maintained." Immunology today vol. 3,5 (1982): 121-3. doi: https://doi.org/10.1016/0167-5699(82)90066-4
Green C. Therapeutic promise maintained. Immunol Today. 1982 May;3(5):121-3. doi: 10.1016/0167-5699(82)90066-4. PMID: 25291644.
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An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A.

Amino acids

Jegorov A, Havlíček V, Sedmera P.
PMID: 24178476
Amino Acids. 1996 Jun;10(2):145-51. doi: 10.1007/BF00806587.

The mixture of products obtained by alkaline treatment of cyclosporin A was analyzed by HPLC-continuous-flow-FAB/MS. The changes involve the atypical amino acid (4R)-4-((E)-2-butenyl)-4,N-dimethyl-L-threonine (MeBmt) without affecting the cyclic structure. The main degradation pathway is dehydration producing all four possible...

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Jegorov A, Havlíček V, Sedmera P. An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A. Amino Acids. 1996;10(2):145-51doi: 10.1007/BF00806587.
Jegorov, A., Havlíček, V., & Sedmera, P. (1996). An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A. Amino acids, 10(2), 145-51. https://doi.org/10.1007/BF00806587
Jegorov, A, et al. "An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A." Amino acids vol. 10,2 (1996): 145-51. doi: https://doi.org/10.1007/BF00806587
Jegorov A, Havlíček V, Sedmera P. An unusual side chain C-C cleavage at the MeBmt amino acid in cyclosporin A. Amino Acids. 1996 Jun;10(2):145-51. doi: 10.1007/BF00806587. PMID: 24178476.
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Type 1 diabetes in India: Overall insights.

Indian journal of endocrinology and metabolism

Das AK.
PMID: 25941645
Indian J Endocrinol Metab. 2015 Apr;19:S31-3. doi: 10.4103/2230-8210.155372.

Type 1 diabetes mellitus (T1DM) is also on increase like type 2 diabetes, even though not in the same proportion, but still with a trend of 3-5% increase/year. India has three new cases of T1DM/100,000 children of 0-14 years....

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Das AK. Type 1 diabetes in India: Overall insights. Indian J Endocrinol Metab. 2015;19:S31-3doi: 10.4103/2230-8210.155372.
Das, A. K. (2015). Type 1 diabetes in India: Overall insights. Indian journal of endocrinology and metabolism, 19S31-3. https://doi.org/10.4103/2230-8210.155372
Das, Ashok Kumar. "Type 1 diabetes in India: Overall insights." Indian journal of endocrinology and metabolism vol. 19 (2015): S31-3. doi: https://doi.org/10.4103/2230-8210.155372
Das AK. Type 1 diabetes in India: Overall insights. Indian J Endocrinol Metab. 2015 Apr;19:S31-3. doi: 10.4103/2230-8210.155372. PMID: 25941645; PMCID: PMC4413384.
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Separating Isomers, Conformers, and Analogues of Cyclosporin using Differential Mobility Spectroscopy, Mass Spectrometry, and Hydrogen-Deuterium Exchange.

Analytical chemistry

Lam KHB, Le Blanc JCY, Campbell JL.
PMID: 32698568
Anal Chem. 2020 Aug 18;92(16):11053-11061. doi: 10.1021/acs.analchem.0c00191. Epub 2020 Aug 06.

Cyclosporins are an invaluable class of drug used to prevent the rejection of transplanted tissue. While the most popular drug in this group is cyclosporin A, several other analogues are available, including some enantiomeric and structurally isomeric forms. Unfortunately,...

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Lam KHB, Le Blanc JCY, Campbell JL. Separating Isomers, Conformers, and Analogues of Cyclosporin using Differential Mobility Spectroscopy, Mass Spectrometry, and Hydrogen-Deuterium Exchange. Anal Chem. 2020;92(16):11053-11061doi: 10.1021/acs.analchem.0c00191.
Lam, K. H. B., Le Blanc, J. C. Y., & Campbell, J. L. (2020). Separating Isomers, Conformers, and Analogues of Cyclosporin using Differential Mobility Spectroscopy, Mass Spectrometry, and Hydrogen-Deuterium Exchange. Analytical chemistry, 92(16), 11053-11061. https://doi.org/10.1021/acs.analchem.0c00191
Lam, K H Brian, et al. "Separating Isomers, Conformers, and Analogues of Cyclosporin using Differential Mobility Spectroscopy, Mass Spectrometry, and Hydrogen-Deuterium Exchange." Analytical chemistry vol. 92,16 (2020): 11053-11061. doi: https://doi.org/10.1021/acs.analchem.0c00191
Lam KHB, Le Blanc JCY, Campbell JL. Separating Isomers, Conformers, and Analogues of Cyclosporin using Differential Mobility Spectroscopy, Mass Spectrometry, and Hydrogen-Deuterium Exchange. Anal Chem. 2020 Aug 18;92(16):11053-11061. doi: 10.1021/acs.analchem.0c00191. Epub 2020 Aug 06. PMID: 32698568.
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Cyclosporin Structure and Permeability: From A to Z and Beyond.

Journal of medicinal chemistry

Corbett KM, Ford L, Warren DB, Pouton CW, Chalmers DK.
PMID: 34478303
J Med Chem. 2021 Sep 23;64(18):13131-13151. doi: 10.1021/acs.jmedchem.1c00580. Epub 2021 Sep 03.

Cyclosporins are natural or synthetic undecapeptides with a wide range of actual and potential pharmaceutical applications. Several members of the cyclosporin compound family have remarkably high passive membrane permeabilities that are not well-described by simple structural metrics. Here we...

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Corbett KM, Ford L, Warren DB, et al. Cyclosporin Structure and Permeability: From A to Z and Beyond. J Med Chem. 2021;64(18):13131-13151doi: 10.1021/acs.jmedchem.1c00580.
Corbett, K. M., Ford, L., Warren, D. B., Pouton, C. W., & Chalmers, D. K. (2021). Cyclosporin Structure and Permeability: From A to Z and Beyond. Journal of medicinal chemistry, 64(18), 13131-13151. https://doi.org/10.1021/acs.jmedchem.1c00580
Corbett, Karen M, et al. "Cyclosporin Structure and Permeability: From A to Z and Beyond." Journal of medicinal chemistry vol. 64,18 (2021): 13131-13151. doi: https://doi.org/10.1021/acs.jmedchem.1c00580
Corbett KM, Ford L, Warren DB, Pouton CW, Chalmers DK. Cyclosporin Structure and Permeability: From A to Z and Beyond. J Med Chem. 2021 Sep 23;64(18):13131-13151. doi: 10.1021/acs.jmedchem.1c00580. Epub 2021 Sep 03. PMID: 34478303.
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Showing 1 to 5 of 5 entries