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Showing 1 to 6 of 6 entries
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Effect of devazepide reversed antagonism of CCK-8 against morphine on electrical and mechanical activities of rat duodenum in vitro.

World journal of gastroenterology

Xu MY, Lu HM, Wang SZ, Shi WY, Wang XC, Yang DX, Yang CX, Yang LZ.
PMID: 11819361
World J Gastroenterol. 1998 Dec;4(6):524-526. doi: 10.3748/wjg.v4.i6.524.

AIM:To study the antagonism of cholecystokinin octapeptide (CCK-8) against the effect of morphine and its mechanism.METHODS:The method of simultaneously recording the electrical and mechanical activities of rat duodenum in vitro was adopted.RESULTS:Acetylcholine (ACh) could increase the amplitude and the...

Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinoma.

Translational andrology and urology

Zhang H, Bao X, Zhang J, Hu Q, Wei B.
PMID: 34159092
Transl Androl Urol. 2021 May;10(5):2113-2121. doi: 10.21037/tau-21-409.

BACKGROUND: This study aimed to examine the effects of devazepide on the proliferation, migration, and apoptosis of human bladder cancer (BC) 5637 cells, and its mechanism.METHODS: A cell counting kit-8 (CCK-8) for cell viability assays, a colony formation assay,...

Cholecystokinin system is involved in the anorexigenic effect of peripherally applied palmitoylated prolactin-releasing peptide in fasted mice.

Physiological research

Pirník Z, Kořínková L, Osacká J, Železná B, Kuneš J, Maletínská L.
PMID: 34062082
Physiol Res. 2021 Aug 31;70(4):579-590. doi: 10.33549/physiolres.934694. Epub 2021 Jun 01.

Prolactin-releasing peptide (PrRP) has been proposed to mediate the central satiating effects of cholecystokinin (CCK) through the vagal CCK1 receptor. PrRP acts as an endogenous ligand of G protein-coupled receptor 10 (GPR10), which is expressed at the highest levels...

Dietary whey and egg proteins interact with inulin fiber to modulate energy balance and gut microbiota in obese rats.

The Journal of nutritional biochemistry

Avirineni BS, Singh A, Zapata RC, Phillips CD, Chelikani PK.
PMID: 34520853
J Nutr Biochem. 2022 Jan;99:108860. doi: 10.1016/j.jnutbio.2021.108860. Epub 2021 Sep 11.

Diets supplemented with protein and fiber are well known to reduce food intake and weight gain; however, less is known about the combined effects of protein and prebiotic fiber on energy balance and gut microbiota composition. We compared effects...

Opposing effects of CCK(A) and CCK(B) antagonists on the development of conditioned activity in rats.

Behavioural pharmacology

Josselyn SA, Vaccarino FJ.
PMID: 11224447
Behav Pharmacol. 1996 Nov;7(6):505-512.

Cholecystokinin (CCK) is co-localized with dopamine (DA) in portions of the mesolimbic system. Evidence suggests that CCK(B) receptor mechanisms mediate an inhibitory effect on DA function while CCK(A) receptor mechanisms mediate a facilitory effect on DA function. As DA...

Cholecystokinin and psychiatric disorders : role in aetiology and potential of receptor antagonists in therapy.

CNS drugs

Shlik J, Vasar E, Bradwejn J.
PMID: 23338219
CNS Drugs. 1997 Aug;8(2):134-52. doi: 10.2165/00023210-199708020-00005.

Cholecystokinin (CCK) is one of the most abundant neuropeptides in the brain. It is found in the highest levels in cortical and limbic structures and also in the basal ganglia. Two subtypes of CCK receptors have been described in...

Showing 1 to 6 of 6 entries