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Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects.

Evidence-based complementary and alternative medicine : eCAM

Galhena PB, Samarakoon SR, Thabrew MI, Weerasinghe GA, Thammitiyagodage MG, Ratnasooriya WD, Tennekoon KH.
PMID: 23243426
Evid Based Complement Alternat Med. 2012;2012:108626. doi: 10.1155/2012/108626. Epub 2012 Nov 13.

The present study investigated the anti-inflammatory effects of a polyherbal decoction comprised of Nigella sativa, Hemidesmus indicus, and Smilax glabra in order to justify its claimed antihepatocarcinogenic activity. Activation of hepatic nuclear factor-kappa B (NF-κB), IκB kinase (IKK α/β)...

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Galhena PB, Samarakoon SR, Thabrew MI, et al. Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects. Evid Based Complement Alternat Med. 2012;2012:108626doi: 10.1155/2012/108626.
Galhena, P. B., Samarakoon, S. R., Thabrew, M. I., Weerasinghe, G. A., Thammitiyagodage, M. G., Ratnasooriya, W. D., & Tennekoon, K. H. (2012). Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects. Evidence-based complementary and alternative medicine : eCAM, 2012108626. https://doi.org/10.1155/2012/108626
Galhena, Prasanna B, et al. "Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects." Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 108626. doi: https://doi.org/10.1155/2012/108626
Galhena PB, Samarakoon SR, Thabrew MI, Weerasinghe GA, Thammitiyagodage MG, Ratnasooriya WD, Tennekoon KH. Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects. Evid Based Complement Alternat Med. 2012;2012:108626. doi: 10.1155/2012/108626. Epub 2012 Nov 13. PMID: 23243426; PMCID: PMC3517268.
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Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model.

American journal of translational research

Liu T, Zhu K, Ke C, Yang S, Yang F, Li Z, Zhang Z.
PMID: 28670377
Am J Transl Res. 2017 Jun 15;9(6):2891-2900. eCollection 2017.

Mesenchymal stem cells (MSCs) may play a significant role in carcinogenesis; however, data have shown that MSCs can both promote and inhibit tumor growth. We investigated the effect of MSCs on the development of lung cancer in a rat...

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Liu T, Zhu K, Ke C, et al. Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model. Am J Transl Res. 2017;9(6):2891-2900
Liu, T., Zhu, K., Ke, C., Yang, S., Yang, F., Li, Z., & Zhang, Z. (2017). Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model. American journal of translational research, 9(6), 2891-2900.
Liu, Tonggang, et al. "Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model." American journal of translational research vol. 9,6 (2017): 2891-2900.
Liu T, Zhu K, Ke C, Yang S, Yang F, Li Z, Zhang Z. Mesenchymal stem cells inhibited development of lung cancer induced by chemical carcinogens in a rat model. Am J Transl Res. 2017 Jun 15;9(6):2891-2900. eCollection 2017. PMID: 28670377; PMCID: PMC5489889.
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Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma.

Oncology letters

Xin B, Cui Y, Wang Y, Wang L, Yin J, Zhang L, Pang H, Zhang H, Wang RA.
PMID: 29085472
Oncol Lett. 2017 Oct;14(4):4722-4728. doi: 10.3892/ol.2017.6800. Epub 2017 Aug 23.

Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present study evaluated the effects...

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Xin B, Cui Y, Wang Y, et al. Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncol Lett. 2017;14(4):4722-4728doi: 10.3892/ol.2017.6800.
Xin, B., Cui, Y., Wang, Y., Wang, L., Yin, J., Zhang, L., Pang, H., Zhang, H., & Wang, R. A. (2017). Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncology letters, 14(4), 4722-4728. https://doi.org/10.3892/ol.2017.6800
Xin, Bo, et al. "Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma." Oncology letters vol. 14,4 (2017): 4722-4728. doi: https://doi.org/10.3892/ol.2017.6800
Xin B, Cui Y, Wang Y, Wang L, Yin J, Zhang L, Pang H, Zhang H, Wang RA. Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma. Oncol Lett. 2017 Oct;14(4):4722-4728. doi: 10.3892/ol.2017.6800. Epub 2017 Aug 23. PMID: 29085472; PMCID: PMC5649534.
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Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions.

Hepatobiliary surgery and nutrition

Melendez-Martinez AJ, Nascimento AF, Wang Y, Liu C, Mao Y, Wang XD.
PMID: 24273751
Hepatobiliary Surg Nutr. 2013 Aug;2(4):198-208. doi: 10.3978/j.issn.2304-3881.2013.07.04.

Higher intake of tomatoes or tomato-based products has been associated with lower risk for liver cancer. In this study, we investigated the effects of supplementing tomato extract (TE), which contains mainly lycopene (LY) and less amounts of its precursors,...

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Melendez-Martinez AJ, Nascimento AF, Wang Y, et al. Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary Surg Nutr. 2013;2(4):198-208doi: 10.3978/j.issn.2304-3881.2013.07.04.
Melendez-Martinez, A. J., Nascimento, A. F., Wang, Y., Liu, C., Mao, Y., & Wang, X. D. (2013). Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary surgery and nutrition, 2(4), 198-208. https://doi.org/10.3978/j.issn.2304-3881.2013.07.04
Melendez-Martinez, Antonio J, et al. "Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions." Hepatobiliary surgery and nutrition vol. 2,4 (2013): 198-208. doi: https://doi.org/10.3978/j.issn.2304-3881.2013.07.04
Melendez-Martinez AJ, Nascimento AF, Wang Y, Liu C, Mao Y, Wang XD. Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary Surg Nutr. 2013 Aug;2(4):198-208. doi: 10.3978/j.issn.2304-3881.2013.07.04. PMID: 24273751; PMCID: PMC3834971.
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Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice.

Journal of diabetes investigation

Zolzaya K, Nakamura A, Tajima K, Terauchi Y.
PMID: 24843733
J Diabetes Investig. 2014 Feb 12;5(1):27-30. doi: 10.1111/jdi.12128. Epub 2013 Aug 28.

We investigated the role of insulin receptor substrate (Irs)-1 for diethylnitrosamine (DEN) plus high-fat (HF) diet-induced hepatic tumorigenesis in mice. We gave DEN by intraperitoneal injection at the dose of 80 mg/kg to 18-week-old wild-type (WT) and Irs1-knockout (Irs1...

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Zolzaya K, Nakamura A, Tajima K, et al. Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice. J Diabetes Investig. 2013;5(1):27-30doi: 10.1111/jdi.12128.
Zolzaya, K., Nakamura, A., Tajima, K., & Terauchi, Y. (2014). Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice. Journal of diabetes investigation, 5(1), 27-30. https://doi.org/10.1111/jdi.12128
Zolzaya, Khadbaatar, et al. "Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice." Journal of diabetes investigation vol. 5,1 (2014): 27-30. doi: https://doi.org/10.1111/jdi.12128
Zolzaya K, Nakamura A, Tajima K, Terauchi Y. Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice. J Diabetes Investig. 2014 Feb 12;5(1):27-30. doi: 10.1111/jdi.12128. Epub 2013 Aug 28. PMID: 24843733; PMCID: PMC4025237.
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Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats.

Yonago acta medica

Sawada S, Okano J, Imamoto R, Yasunaka Y, Abe R, Koda M, Murawaki Y, Isomoto H.
PMID: 27046949
Yonago Acta Med. 2016 Mar;59(1):37-43. Epub 2016 Apr 01.

BACKGROUND: Geraniol is a plant-derived phytochemical possessing anti-cancer action. The anti-carcinogenic effect of geraniol was investigated in the diethylnitrosamine (DEN)-induced hepatocarcinogenic rat model.METHODS: Male Wistar rats were intraperitoneally injected with 300 μL of phosphate-buffered saline (PBS) (G1; n =...

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Sawada S, Okano J, Imamoto R, et al. Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats. Yonago Acta Med. 2016;59(1):37-43
Sawada, S., Okano, J., Imamoto, R., Yasunaka, Y., Abe, R., Koda, M., Murawaki, Y., & Isomoto, H. (2016). Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats. Yonago acta medica, 59(1), 37-43.
Sawada, Shintaro, et al. "Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats." Yonago acta medica vol. 59,1 (2016): 37-43.
Sawada S, Okano J, Imamoto R, Yasunaka Y, Abe R, Koda M, Murawaki Y, Isomoto H. Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats. Yonago Acta Med. 2016 Mar;59(1):37-43. Epub 2016 Apr 01. PMID: 27046949; PMCID: PMC4816747.
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Hydroxylation and sulfation of sex steroid hormones in inflammatory liver.

Journal of biomedical research

Lee SR, Lee SY, Kim SY, Ryu SY, Park BK, Hong EJ.
PMID: 28866654
J Biomed Res. 2017 Sep 26;31(5):437-444. doi: 10.7555/JBR.31.20170031.

Sex steroids, also known as gonadal steroids, are oxidized with hydroxylation by cytochrome P450, glucuronidation by UDP-glucuronosyltransferase, sulfation by sulfotransferase, andO-methylation by catechol O-methyltransferase. Thus, it is important to determine the process by which inflammation influences metabolism of gonadal...

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Lee SR, Lee SY, Kim SY, et al. Hydroxylation and sulfation of sex steroid hormones in inflammatory liver. J Biomed Res. 2017;31(5):437-444doi: 10.7555/JBR.31.20170031.
Lee, S. R., Lee, S. Y., Kim, S. Y., Ryu, S. Y., Park, B. K., & Hong, E. J. (2017). Hydroxylation and sulfation of sex steroid hormones in inflammatory liver. Journal of biomedical research, 31(5), 437-444. https://doi.org/10.7555/JBR.31.20170031
Lee, Sang R, et al. "Hydroxylation and sulfation of sex steroid hormones in inflammatory liver." Journal of biomedical research vol. 31,5 (2017): 437-444. doi: https://doi.org/10.7555/JBR.31.20170031
Lee SR, Lee SY, Kim SY, Ryu SY, Park BK, Hong EJ. Hydroxylation and sulfation of sex steroid hormones in inflammatory liver. J Biomed Res. 2017 Sep 26;31(5):437-444. doi: 10.7555/JBR.31.20170031. PMID: 28866654; PMCID: PMC5706436.
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Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats.

Toxicology reports

Moreira AJ, Rodrigues G, Bona S, Cerski CT, Marroni CA, Mauriz JL, González-Gallego J, Marroni NP.
PMID: 28962366
Toxicol Rep. 2014 Nov 28;2:333-340. doi: 10.1016/j.toxrep.2014.11.015. eCollection 2015.

Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths throughout the world. This study was aimed to analyze oxidative stress and cell damage in a multistage model of liver carcinogenesis induced by diethylnitrosamine (DEN) in rats....

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Moreira AJ, Rodrigues G, Bona S, et al. Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats. Toxicol Rep. 2014;2:333-340doi: 10.1016/j.toxrep.2014.11.015.
Moreira, A. J., Rodrigues, G., Bona, S., Cerski, C. T., Marroni, C. A., Mauriz, J. L., González-Gallego, J., & Marroni, N. P. (2015). Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats. Toxicology reports, 2333-340. https://doi.org/10.1016/j.toxrep.2014.11.015
Moreira, Andrea J, et al. "Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats." Toxicology reports vol. 2 (2015): 333-340. doi: https://doi.org/10.1016/j.toxrep.2014.11.015
Moreira AJ, Rodrigues G, Bona S, Cerski CT, Marroni CA, Mauriz JL, González-Gallego J, Marroni NP. Oxidative stress and cell damage in a model of precancerous lesions and advanced hepatocellular carcinoma in rats. Toxicol Rep. 2014 Nov 28;2:333-340. doi: 10.1016/j.toxrep.2014.11.015. eCollection 2015. PMID: 28962366; PMCID: PMC5598147.
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Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice.

Hepatology research : the official journal of the Japan Society of Hepatology

Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
PMID: 26147624
Hepatol Res. 2016 Mar;46(3):E201-9. doi: 10.1111/hepr.12550. Epub 2015 Jul 27.

AIM: Obesity and its related metabolic abnormalities, including oxidative stress and adipokine imbalance, are involved in liver carcinogenesis. The aim of the present study was to examine the effects of astaxanthin, a powerful biological antioxidant, on the development of...

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Ohno T, Shimizu M, Shirakami Y, et al. Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice. Hepatol Res. 2015;46(3):E201-9doi: 10.1111/hepr.12550.
Ohno, T., Shimizu, M., Shirakami, Y., Miyazaki, T., Ideta, T., Kochi, T., Kubota, M., Sakai, H., Tanaka, T., & Moriwaki, H. (2016). Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice. Hepatology research : the official journal of the Japan Society of Hepatology, 46(3), E201-9. https://doi.org/10.1111/hepr.12550
Ohno, Tomohiko, et al. "Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice." Hepatology research : the official journal of the Japan Society of Hepatology vol. 46,3 (2016): E201-9. doi: https://doi.org/10.1111/hepr.12550
Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H. Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice. Hepatol Res. 2016 Mar;46(3):E201-9. doi: 10.1111/hepr.12550. Epub 2015 Jul 27. PMID: 26147624.
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DNA adducts as early bioindicators of chemical exposure.

Environmental monitoring and assessment

Giam CS, Holliday TL, Zheng Y, Williams JL, Ahmed MS.
PMID: 24233950
Environ Monit Assess. 1991 Oct;19(1):335-40. doi: 10.1007/BF00401322.

Sensitive analytical methods indicate the presence of hundreds of chemical contaminants in our environment. However, concentration of these pollutants is usually at the low parts per million or parts per billion level. At such low levels, toxicants induce long-term...

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Giam CS, Holliday TL, Zheng Y, et al. DNA adducts as early bioindicators of chemical exposure. Environ Monit Assess. 1991;19(1):335-40doi: 10.1007/BF00401322.
Giam, C. S., Holliday, T. L., Zheng, Y., Williams, J. L., & Ahmed, M. S. (1991). DNA adducts as early bioindicators of chemical exposure. Environmental monitoring and assessment, 19(1), 335-40. https://doi.org/10.1007/BF00401322
Giam, C S, et al. "DNA adducts as early bioindicators of chemical exposure." Environmental monitoring and assessment vol. 19,1 (1991): 335-40. doi: https://doi.org/10.1007/BF00401322
Giam CS, Holliday TL, Zheng Y, Williams JL, Ahmed MS. DNA adducts as early bioindicators of chemical exposure. Environ Monit Assess. 1991 Oct;19(1):335-40. doi: 10.1007/BF00401322. PMID: 24233950.
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Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats.

Journal of clinical and experimental hepatology

Ishizaki S, Nishiyama M, Hagiwara A.
PMID: 25755500
J Clin Exp Hepatol. 2013 Sep;3(3):192-7. doi: 10.1016/j.jceh.2013.08.008. Epub 2013 Sep 06.

BACKGROUND: Obesity increases the risk of fatty liver disease and liver cancer. There are several models of obesity-associated hepatocellular carcinoma, but tumor development in these models is slow.MATERIALS AND METHODS: We investigated Zucker fatty rats, a model of obesity...

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Ishizaki S, Nishiyama M, Hagiwara A. Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. J Clin Exp Hepatol. 2013;3(3):192-7doi: 10.1016/j.jceh.2013.08.008.
Ishizaki, S., Nishiyama, M., & Hagiwara, A. (2013). Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. Journal of clinical and experimental hepatology, 3(3), 192-7. https://doi.org/10.1016/j.jceh.2013.08.008
Ishizaki, Sonoko, et al. "Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats." Journal of clinical and experimental hepatology vol. 3,3 (2013): 192-7. doi: https://doi.org/10.1016/j.jceh.2013.08.008
Ishizaki S, Nishiyama M, Hagiwara A. Long-term Branched Chain Amino Acid Supplementation Ameliorates Diethylnitrosamine-induced Liver Glutathione S-transferase-p Positivity in Zucker Fatty Rats. J Clin Exp Hepatol. 2013 Sep;3(3):192-7. doi: 10.1016/j.jceh.2013.08.008. Epub 2013 Sep 06. PMID: 25755500; PMCID: PMC3940393.
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Cessation of Long-term Alcohol Administration and Two-day Cycling of Exposure Respectively Promote and Inhibit Hepatocarcinogenesis in Rats.

Asian Pacific journal of cancer prevention : APJCP

Tanaka T, Hirota Y, Kuriyama M, Nishiguchi S, Otani S.
PMID: 12716308
Asian Pac J Cancer Prev. 2000;1(4):325-328.

The effects of different patterns of alcohol administration on hepatocarcinogenesis induced by diethylnitrosamine (DEN) in male Wistar rats were assessed using a modified Ito's medium-term bioassay system. Carcinogenic potential was scored by comparing numbers and areas of glutathione S...

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Tanaka T, Hirota Y, Kuriyama M, et al. Cessation of Long-term Alcohol Administration and Two-day Cycling of Exposure Respectively Promote and Inhibit Hepatocarcinogenesis in Rats. Asian Pac J Cancer Prev. 2000;1(4):325-328
Tanaka, T., Hirota, Y., Kuriyama, M., Nishiguchi, S., & Otani, S. (2000). Cessation of Long-term Alcohol Administration and Two-day Cycling of Exposure Respectively Promote and Inhibit Hepatocarcinogenesis in Rats. Asian Pacific journal of cancer prevention : APJCP, 1(4), 325-328.
Tanaka, Takashi, et al. "Cessation of Long-term Alcohol Administration and Two-day Cycling of Exposure Respectively Promote and Inhibit Hepatocarcinogenesis in Rats." Asian Pacific journal of cancer prevention : APJCP vol. 1,4 (2000): 325-328.
Tanaka T, Hirota Y, Kuriyama M, Nishiguchi S, Otani S. Cessation of Long-term Alcohol Administration and Two-day Cycling of Exposure Respectively Promote and Inhibit Hepatocarcinogenesis in Rats. Asian Pac J Cancer Prev. 2000;1(4):325-328. PMID: 12716308.
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Showing 1 to 12 of 361 entries