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Showing 1 to 12 of 14 entries
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Spherical Oligo-Silicic Acid SOSA Disclosed as Possible Endogenous Digitalis-Like Factor.

Frontiers in endocrinology

Kerek F, Voicu VA.
PMID: 25667581
Front Endocrinol (Lausanne). 2015 Jan 23;5:233. doi: 10.3389/fendo.2014.00233. eCollection 2014.

The Na(+)/K(+)-ATPase is a membrane ion-transporter protein, specifically inhibited by digitalis glycosides used in cardiac therapy. The existence in mammals of some endogenous digitalis-like factors (EDLFs) as presumed ATPase ligands is generally accepted. But the chemical structure of these...

Digoxin overdose: clinical features and management.

Emergency nurse : the journal of the RCN Accident and Emergency Nursing Association

Bara V.
PMID: 27731735
Emerg Nurse. 2001 Jun 01;9(3):16-21. doi: 10.7748/en.9.3.16.s14.

Digoxin is a digitalis glycoside extracted front the leaves of the plant Digitalis Lanata. more commonly known as Grecian foxglove. The digitalis glycosides are present in many plants including Digitalis purpura (foxglove), Nerium oleander (oleander) and Convallaria majalis (lily-of-the-valley)....

Risk of Hospitalization for Adverse Drug Events in Women and Men: A Post Hoc Analysis of an Active Pharmacovigilance Study in Italian Emergency Departments.

Pharmaceuticals (Basel, Switzerland)

Crescioli G, Boscia E, Bettiol A, Pagani S, Spada G, Vighi GV, Bonaiuti R, Venegoni M, Vighi GD, Vannacci A, Lombardi N, On Behalf Of The MEREAFaPS Study Group.
PMID: 34358104
Pharmaceuticals (Basel). 2021 Jul 15;14(7). doi: 10.3390/ph14070678.

This post hoc analysis of an Italian active pharmacovigilance study describes pharmacological differences of ADEs leading to emergency department (ED) visits and hospitalization in women and men. During the study period (January 2007-December 2018), 61,855 reports of ADEs leading...

Guideline Adherence and Associated Outcomes in the Treatment of Type 2 Diabetes Mellitus Patients With an Incident Cardiovascular Comorbidity: An Analysis Based on a Large German Claims Dataset.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Gabler M, Picker N, Geier S, Ley L, Aberle J, Lehrke M, Martin S, Riedl M, Wilke T.
PMID: 33710520
Diabetes Ther. 2021 Apr;12(4):1209-1226. doi: 10.1007/s13300-021-01024-y. Epub 2021 Mar 12.

INTRODUCTION: According to current guidelines, appropriate drug treatment is the backbone of the effective management of cardiovascular (CV) comorbidities in patients with type 2 diabetes mellitus (T2DM). The main objective of this study was to assess the degree of...

The use of digitalis glycosides in the dog and cat.

The Canadian veterinary journal = La revue veterinaire canadienne

Difruscia R.
PMID: 17422374
Can Vet J. 1984 Mar;25(3):135-7.

The author reviews the pharmacological properties of digitalis glycosides and their clinical use in the control of congestive heart failure in the dog and cat. Methods of digitalization, dosage for each drug, toxic effects and drug interactions are described.

Foxglove poisoning: diagnostic and therapeutic differences with medicinal digitalis glycosides overdose.

Acta clinica Belgica

Maes KR, Depuydt P, Vermassen J, De Paepe P, Buylaert W, Lyphout C.
PMID: 32496148
Acta Clin Belg. 2020 Jun 04;1-7. doi: 10.1080/17843286.2020.1773652. Epub 2020 Jun 04.

We report a case of a 19-year-old woman who ingested Digitalis purpurea leaves as a suicide attempt. She developed gastro-intestinal symptoms, loss of colour vision, cardiac conduction disturbances as well as an elevated serum potassium. Treatment was initiated in...

Myocardial Na,K-ATPase: Clinical aspects.

Experimental and clinical cardiology

Kjeldsen K.
PMID: 19641704
Exp Clin Cardiol. 2003;8(3):131-3.

The specific binding of digitalis glycosides to Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased by around 40%; a correlation...

Heart failure management in Poland: The National Cardiovascular Disease Prevention and Treatment Program POLKARD, edition 2003-2005.

Cardiology journal

Fedyk-Łukasik M, Zdrojewski T, Wizner B, Opolski G, Dubiel J, Stompór M, Wyrzykowski B, Mogilnaya I, Marchel M, Grodzicki T.
PMID: 18651521
Cardiol J. 2007;14(6):552-60.

BACKGROUND: The aim of this study was to assess actual management of heart failure (HF) in Poland, both in outpatient clinics and hospitals.METHODS AND RESULTS: The survey was undertaken between April 21 2005 and December 31 2005 in 796...

Diagnosis and Treatment of Systolic Heart Failure in the Elderly.

The American journal of geriatric cardiology

Frishman WH.
PMID: 11416476
Am J Geriatr Cardiol. 1998 Nov;7(6):10-16.

Appropriate therapy of systolic LV dysfunction in the elderly depends on the stage of the disease process. Evidence of systolic dysfunction is best detected by clinical assessment and echocardiographic exam. While one seeks to define and treat the factors...

Effects of digitoxigenin, digoxigenin, and various cardiac glycosides on cardenolide accumulation in shoot cultures of Digitalis lanata.

Planta medica

Theurer C, Kreis W, Reinhard E.
PMID: 17253315
Planta Med. 1998 Dec;64(8):705-10. doi: 10.1055/s-2006-957562.

Various cardenolide genins and cardenolide glycosides were administered to light-grown and dark-grown Digitalis lanata shoot cultures to investigate conversion reactions related to the formation and rearrangement of the sugar side chain of Digitalis glycosides. Digitoxigenin was converted to digitoxigen-3-one,...

Digitalis in the treatment of heart failure in the elderly. The GIFA study results.

Archives of gerontology and geriatrics

Carosella L, Pahor M, Pedone C, Manto A, Carbonin PU.
PMID: 15374150
Arch Gerontol Geriatr. 1996 Nov-Dec;23(3):299-311. doi: 10.1016/s0167-4943(96)00729-7.

Digitalis glycosides have played an important role in the treatment of patients with heart failure (HF) for more than two centuries. Despite the introduction of new therapeutic strategies in the treatment of HF, and controversies regarding the role of...

Digitalis and baroreflexes in heart failure.

Trends in cardiovascular medicine

Ferguson DW.
PMID: 21239284
Trends Cardiovasc Med. 1992 Jan-Feb;2(1):21-6. doi: 10.1016/1050-1738(92)90040-Y.

A physiologic hallmark of heart failure is neurohumoral excitation, due in large part to abnormalities in baroreflex control of the circulation. New experimental and clinical evidence suggests that digitalis glycosides, long considered important inotropic agents in the management of...

Showing 1 to 12 of 14 entries