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NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines.

Clinical pharmacology : advances and applications

North WG, Liu F, Tian R, Abbasi H, Akerman B.
PMID: 26566373
Clin Pharmacol. 2015 Oct 23;7:111-7. doi: 10.2147/CPAA.S90367. eCollection 2015.

We have earlier demonstrated that breast cancer and small-cell lung cancer express functional NMDA receptors that can be targeted to promote cancer cell death. Human ovarian cancer tissues and human ovarian cancer cell lines (SKOV3, A2008, and A2780) have...

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North WG, Liu F, Tian R, et al. NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines. Clin Pharmacol. 2015;7:111-7doi: 10.2147/CPAA.S90367.
North, W. G., Liu, F., Tian, R., Abbasi, H., & Akerman, B. (2015). NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines. Clinical pharmacology : advances and applications, 7111-7. https://doi.org/10.2147/CPAA.S90367
North, William G, et al. "NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines." Clinical pharmacology : advances and applications vol. 7 (2015): 111-7. doi: https://doi.org/10.2147/CPAA.S90367
North WG, Liu F, Tian R, Abbasi H, Akerman B. NMDA receptors are expressed in human ovarian cancer tissues and human ovarian cancer cell lines. Clin Pharmacol. 2015 Oct 23;7:111-7. doi: 10.2147/CPAA.S90367. eCollection 2015. PMID: 26566373; PMCID: PMC4627399.
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Maternal treatment with NMDA receptor antagonist (MK-801) attenuates delayed mitochondrial dysfunction after transient intrauterine ischemia in the neonatal rat brain.

Journal of anesthesia

Nakai A, Shibazaki Y, Taniuchi Y, Koshino T, Yokoyama K.
PMID: 14569439
J Anesth. 2001;15(4):217-22. doi: 10.1007/s005400170006.

PURPOSE: Mitochondrial respiratory activities were measured in neonatal rat brains to evaluate the influence of transient intrauterine ischemia on the near-term fetus and to assess the effect of dizocilpine maleate (MK-801), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist.METHODS: Transient intrauterine...

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Nakai A, Shibazaki Y, Taniuchi Y, et al. Maternal treatment with NMDA receptor antagonist (MK-801) attenuates delayed mitochondrial dysfunction after transient intrauterine ischemia in the neonatal rat brain. J Anesth. 2001;15(4):217-22doi: 10.1007/s005400170006.
Nakai, A., Shibazaki, Y., Taniuchi, Y., Koshino, T., & Yokoyama, K. (2001). Maternal treatment with NMDA receptor antagonist (MK-801) attenuates delayed mitochondrial dysfunction after transient intrauterine ischemia in the neonatal rat brain. Journal of anesthesia, 15(4), 217-22. https://doi.org/10.1007/s005400170006
Nakai, A, et al. "Maternal treatment with NMDA receptor antagonist (MK-801) attenuates delayed mitochondrial dysfunction after transient intrauterine ischemia in the neonatal rat brain." Journal of anesthesia vol. 15,4 (2001): 217-22. doi: https://doi.org/10.1007/s005400170006
Nakai A, Shibazaki Y, Taniuchi Y, Koshino T, Yokoyama K. Maternal treatment with NMDA receptor antagonist (MK-801) attenuates delayed mitochondrial dysfunction after transient intrauterine ischemia in the neonatal rat brain. J Anesth. 2001;15(4):217-22. doi: 10.1007/s005400170006. PMID: 14569439.
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NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment.

Clinical pharmacology : advances and applications

North WG, Liu F, Lin LZ, Tian R, Akerman B.
PMID: 28761381
Clin Pharmacol. 2017 Jul 17;9:79-86. doi: 10.2147/CPAA.S140057. eCollection 2017.

Pancreatic cancer, particularly adenocarcinoma of the pancreas, is a common disease with a poor prognosis. In this study, the importance of N-methyl-D-aspartate (NMDA) receptors for the growth and survival of pancreatic cancer was investigated. Immunohistochemistry performed with antibodies against...

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North WG, Liu F, Lin LZ, et al. NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment. Clin Pharmacol. 2017;9:79-86doi: 10.2147/CPAA.S140057.
North, W. G., Liu, F., Lin, L. Z., Tian, R., & Akerman, B. (2017). NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment. Clinical pharmacology : advances and applications, 979-86. https://doi.org/10.2147/CPAA.S140057
North, William G, et al. "NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment." Clinical pharmacology : advances and applications vol. 9 (2017): 79-86. doi: https://doi.org/10.2147/CPAA.S140057
North WG, Liu F, Lin LZ, Tian R, Akerman B. NMDA receptors are important regulators of pancreatic cancer and are potential targets for treatment. Clin Pharmacol. 2017 Jul 17;9:79-86. doi: 10.2147/CPAA.S140057. eCollection 2017. PMID: 28761381; PMCID: PMC5522667.
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MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis.

Neural regeneration research

Yi NX, Zhou LY, Wang XY, Song YJ, Han HH, Zhang TS, Wang YJ, Shi Q, Xu H, Liang QQ, Zhang T.
PMID: 31290450
Neural Regen Res. 2019 Nov;14(11):1919-1931. doi: 10.4103/1673-5374.259619.

OBJECTIVE: To evaluate the efficacy and safety of MK-801 and its effect on lesion volume in rat models of acute brain injury.DATA SOURCES: Key terms were "stroke", "brain diseases", "brain injuries", "brain hemorrhage, traumatic", "acute brain injury", "dizocilpine maleate",...

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Yi NX, Zhou LY, Wang XY, et al. MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis. Neural Regen Res. 2019;14(11):1919-1931doi: 10.4103/1673-5374.259619.
Yi, N. X., Zhou, L. Y., Wang, X. Y., Song, Y. J., Han, H. H., Zhang, T. S., Wang, Y. J., Shi, Q., Xu, H., Liang, Q. Q., & Zhang, T. (2019). MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis. Neural regeneration research, 14(11), 1919-1931. https://doi.org/10.4103/1673-5374.259619
Yi, Nan-Xing, et al. "MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis." Neural regeneration research vol. 14,11 (2019): 1919-1931. doi: https://doi.org/10.4103/1673-5374.259619
Yi NX, Zhou LY, Wang XY, Song YJ, Han HH, Zhang TS, Wang YJ, Shi Q, Xu H, Liang QQ, Zhang T. MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis. Neural Regen Res. 2019 Nov;14(11):1919-1931. doi: 10.4103/1673-5374.259619. PMID: 31290450; PMCID: PMC6676887.
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Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats.

Journal of neurosurgical anesthesiology

Shapira Y, Artru AA, Lam AM.
PMID: 15815471
J Neurosurg Anesthesiol. 1992 Oct;4(4):231-40. doi: 10.1097/00008506-199210000-00001.

In brain injury, concentrations of extracellular excitatory amino acids are increased and stimulate glutamate receptors in general and the N-methyl-D-aspartate (NMDA)-preferring subtype in particular. That stimulation causes substantial calcium influx, which appears to initiate a cascade of events leading...

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Shapira Y, Artru AA, Lam AM. Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats. J Neurosurg Anesthesiol. 1992;4(4):231-40doi: 10.1097/00008506-199210000-00001.
Shapira, Y., Artru, A. A., & Lam, A. M. (1992). Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats. Journal of neurosurgical anesthesiology, 4(4), 231-40. https://doi.org/10.1097/00008506-199210000-00001
Shapira, Y, et al. "Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats." Journal of neurosurgical anesthesiology vol. 4,4 (1992): 231-40. doi: https://doi.org/10.1097/00008506-199210000-00001
Shapira Y, Artru AA, Lam AM. Ketamine decreases cerebral infarct volume and improves neurological outcome following experimental head trauma in rats. J Neurosurg Anesthesiol. 1992 Oct;4(4):231-40. doi: 10.1097/00008506-199210000-00001. PMID: 15815471.
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Long-lasting dephosphorylation of connexin 43 in acute seizures is regulated by NMDA receptors in the rat cerebral cortex.

Molecular medicine reports

Zádor Z, Weiczner R, Mihály A.
PMID: 21479476
Mol Med Rep. 2008 Sep-Oct;1(5):721-7. doi: 10.3892/mmr_00000019.

Gap junctions consisting of connexin 43 subunits provide intercellular communication between astrocytes, contributing to their function of maintaining the central nervous system (CNS) microenvironment. Magnetic resonance imaging (MRI) studies demonstrate prolonged astrocyte swelling related to seizures, while in vitro...

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Zádor Z, Weiczner R, Mihály A. Long-lasting dephosphorylation of connexin 43 in acute seizures is regulated by NMDA receptors in the rat cerebral cortex. Mol Med Rep. 2008;1(5):721-7doi: 10.3892/mmr_00000019.
Zádor, Z., Weiczner, R., & Mihály, A. (2008). Long-lasting dephosphorylation of connexin 43 in acute seizures is regulated by NMDA receptors in the rat cerebral cortex. Molecular medicine reports, 1(5), 721-7. https://doi.org/10.3892/mmr_00000019
Zádor, Z, et al. "Long-lasting dephosphorylation of connexin 43 in acute seizures is regulated by NMDA receptors in the rat cerebral cortex." Molecular medicine reports vol. 1,5 (2008): 721-7. doi: https://doi.org/10.3892/mmr_00000019
Zádor Z, Weiczner R, Mihály A. Long-lasting dephosphorylation of connexin 43 in acute seizures is regulated by NMDA receptors in the rat cerebral cortex. Mol Med Rep. 2008 Sep-Oct;1(5):721-7. doi: 10.3892/mmr_00000019. PMID: 21479476.
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How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms.

Journal of neuroscience research

Benvenutti R, Gallas-Lopes M, Sachett A, Marcon M, Strogulski NR, Reis CG, Chitolina R, Piato A, Herrmann AP.
PMID: 34496062
J Neurosci Res. 2021 Nov;99(11):2844-2859. doi: 10.1002/jnr.24948. Epub 2021 Sep 08.

Schizophrenia pathophysiology has been associated with dopaminergic hyperactivity, NMDA receptor hypofunction, and redox dysregulation. Most behavioral assays and animal models to study this condition were developed in rodents, leaving room for species-specific biases that could be avoided by cross-species...

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Benvenutti R, Gallas-Lopes M, Sachett A, et al. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. J Neurosci Res. 2021;99(11):2844-2859doi: 10.1002/jnr.24948.
Benvenutti, R., Gallas-Lopes, M., Sachett, A., Marcon, M., Strogulski, N. R., Reis, C. G., Chitolina, R., Piato, A., & Herrmann, A. P. (2021). How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. Journal of neuroscience research, 99(11), 2844-2859. https://doi.org/10.1002/jnr.24948
Benvenutti, Radharani, et al. "How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms." Journal of neuroscience research vol. 99,11 (2021): 2844-2859. doi: https://doi.org/10.1002/jnr.24948
Benvenutti R, Gallas-Lopes M, Sachett A, Marcon M, Strogulski NR, Reis CG, Chitolina R, Piato A, Herrmann AP. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. J Neurosci Res. 2021 Nov;99(11):2844-2859. doi: 10.1002/jnr.24948. Epub 2021 Sep 08. PMID: 34496062.
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The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae.

International journal of comparative psychology

Chen J, Patel R, Friedman TC, Jones KS.
PMID: 21278812
Int J Comp Psychol. 2010;23(1):82-90.

Dizocilpine maleate (MK-801) is one of several NMDA receptor antagonists that is widely used to pharmacologically model the symptoms of psychosis and schizophrenia in animals. MK-801 elicits behaviors in adult zebrafish (Danio rerio) that are phenotypically consistent with behaviors...

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Chen J, Patel R, Friedman TC, et al. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010;23(1):82-90
Chen, J., Patel, R., Friedman, T. C., & Jones, K. S. (2010). The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. International journal of comparative psychology, 23(1), 82-90.
Chen, John, et al. "The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae." International journal of comparative psychology vol. 23,1 (2010): 82-90.
Chen J, Patel R, Friedman TC, Jones KS. The Behavioral and Pharmacological Actions of NMDA Receptor Antagonism are Conserved in Zebrafish Larvae. Int J Comp Psychol. 2010;23(1):82-90. PMID: 21278812; PMCID: PMC3027073.
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How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms.

Journal of neuroscience research

Benvenutti R, Gallas-Lopes M, Sachett A, Marcon M, Strogulski NR, Reis CG, Chitolina R, Piato A, Herrmann AP.
PMID: 34496062
J Neurosci Res. 2021 Nov;99(11):2844-2859. doi: 10.1002/jnr.24948. Epub 2021 Sep 08.

Schizophrenia pathophysiology has been associated with dopaminergic hyperactivity, NMDA receptor hypofunction, and redox dysregulation. Most behavioral assays and animal models to study this condition were developed in rodents, leaving room for species-specific biases that could be avoided by cross-species...

Cite
Benvenutti R, Gallas-Lopes M, Sachett A, et al. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. J Neurosci Res. 2021;99(11):2844-2859doi: 10.1002/jnr.24948.
Benvenutti, R., Gallas-Lopes, M., Sachett, A., Marcon, M., Strogulski, N. R., Reis, C. G., Chitolina, R., Piato, A., & Herrmann, A. P. (2021). How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. Journal of neuroscience research, 99(11), 2844-2859. https://doi.org/10.1002/jnr.24948
Benvenutti, Radharani, et al. "How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms." Journal of neuroscience research vol. 99,11 (2021): 2844-2859. doi: https://doi.org/10.1002/jnr.24948
Benvenutti R, Gallas-Lopes M, Sachett A, Marcon M, Strogulski NR, Reis CG, Chitolina R, Piato A, Herrmann AP. How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. J Neurosci Res. 2021 Nov;99(11):2844-2859. doi: 10.1002/jnr.24948. Epub 2021 Sep 08. PMID: 34496062.
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Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment.

Biomedical reports

Chen G, Lin X, Li G, Jiang D, Lib Z, Jiang R, Zhuo C.
PMID: 28451387
Biomed Rep. 2017 Mar;6(3):285-290. doi: 10.3892/br.2017.850. Epub 2017 Jan 27.

The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute...

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Chen G, Lin X, Li G, et al. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomed Rep. 2017;6(3):285-290doi: 10.3892/br.2017.850.
Chen, G., Lin, X., Li, G., Jiang, D., Lib, Z., Jiang, R., & Zhuo, C. (2017). Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomedical reports, 6(3), 285-290. https://doi.org/10.3892/br.2017.850
Chen, Guangdong, et al. "Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment." Biomedical reports vol. 6,3 (2017): 285-290. doi: https://doi.org/10.3892/br.2017.850
Chen G, Lin X, Li G, Jiang D, Lib Z, Jiang R, Zhuo C. Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment. Biomed Rep. 2017 Mar;6(3):285-290. doi: 10.3892/br.2017.850. Epub 2017 Jan 27. PMID: 28451387; PMCID: PMC5403402.
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Showing 1 to 10 of 10 entries