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Exploiting an intramolecular Diels-Alder cyclization/dehydro-aromatization sequence for the total syntheses of ellipticines and calothrixin B.

Organic & biomolecular chemistry

Deng C, Liu Y, Xu M, Xie K, Liu S.
PMID: 33491728
Org Biomol Chem. 2021 Feb 18;19(6):1395-1403. doi: 10.1039/d0ob02527e.

The tetracyclic and pentacyclic skeletons of pyrido and quinolinocarbazole alkaloids have been synthesized via a unified strategy. The prominent key step involved a Diels-Alder intramolecular cyclization/dehydro-aromatization sequence. From these carbazole-lactam cores, linear syntheses have been developed for ellipticines and...

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Deng C, Liu Y, Xu M, et al. Exploiting an intramolecular Diels-Alder cyclization/dehydro-aromatization sequence for the total syntheses of ellipticines and calothrixin B. Org Biomol Chem. 2021;19(6):1395-1403doi: 10.1039/d0ob02527e.
Deng, C., Liu, Y., Xu, M., Xie, K., & Liu, S. (2021). Exploiting an intramolecular Diels-Alder cyclization/dehydro-aromatization sequence for the total syntheses of ellipticines and calothrixin B. Organic & biomolecular chemistry, 19(6), 1395-1403. https://doi.org/10.1039/d0ob02527e
Deng, Chengdan, et al. "Exploiting an intramolecular Diels-Alder cyclization/dehydro-aromatization sequence for the total syntheses of ellipticines and calothrixin B." Organic & biomolecular chemistry vol. 19,6 (2021): 1395-1403. doi: https://doi.org/10.1039/d0ob02527e
Deng C, Liu Y, Xu M, Xie K, Liu S. Exploiting an intramolecular Diels-Alder cyclization/dehydro-aromatization sequence for the total syntheses of ellipticines and calothrixin B. Org Biomol Chem. 2021 Feb 18;19(6):1395-1403. doi: 10.1039/d0ob02527e. PMID: 33491728.
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Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of .

Pathogens (Basel, Switzerland)

McKee ML, Zheng L, O'Sullivan EC, Kehoe RA, Doyle Prestwich BM, Mackrill JJ, McCarthy FO.
PMID: 32664299
Pathogens. 2020 Jul 10;9(7). doi: 10.3390/pathogens9070558.

The pathogen

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McKee ML, Zheng L, O'Sullivan EC, et al. Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of . Pathogens. 2020;9(7)doi: 10.3390/pathogens9070558.
McKee, M. L., Zheng, L., O'Sullivan, E. C., Kehoe, R. A., Doyle Prestwich, B. M., Mackrill, J. J., & McCarthy, F. O. (2020). Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of . Pathogens (Basel, Switzerland), 9(7), . https://doi.org/10.3390/pathogens9070558
McKee, Mary L, et al. "Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of ." Pathogens (Basel, Switzerland) vol. 9,7 (2020). doi: https://doi.org/10.3390/pathogens9070558
McKee ML, Zheng L, O'Sullivan EC, Kehoe RA, Doyle Prestwich BM, Mackrill JJ, McCarthy FO. Synthesis and Evaluation of Novel Ellipticines and Derivatives as Inhibitors of . Pathogens. 2020 Jul 10;9(7). doi: 10.3390/pathogens9070558. PMID: 32664299; PMCID: PMC7400634.
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Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells.

Pharmaceuticals (Basel, Switzerland)

Miller CM, O'Sullivan EC, McCarthy FO.
PMID: 31207878
Pharmaceuticals (Basel). 2019 Jun 14;12(2). doi: 10.3390/ph12020090.

Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been...

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Miller CM, O'Sullivan EC, McCarthy FO. Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells. Pharmaceuticals (Basel). 2019;12(2)doi: 10.3390/ph12020090.
Miller, C. M., O'Sullivan, E. C., & McCarthy, F. O. (2019). Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells. Pharmaceuticals (Basel, Switzerland), 12(2), . https://doi.org/10.3390/ph12020090
Miller, Charlotte M, et al. "Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells." Pharmaceuticals (Basel, Switzerland) vol. 12,2 (2019). doi: https://doi.org/10.3390/ph12020090
Miller CM, O'Sullivan EC, McCarthy FO. Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells. Pharmaceuticals (Basel). 2019 Jun 14;12(2). doi: 10.3390/ph12020090. PMID: 31207878; PMCID: PMC6631919.
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Showing 1 to 3 of 3 entries