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Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1.

Frontiers in pharmacology

Smith NJ.
PMID: 26635605
Front Pharmacol. 2015 Nov 17;6:275. doi: 10.3389/fphar.2015.00275. eCollection 2015.

Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery. Two promising orphan GPCRs are the endothelin B receptor-like proteins, GPR37 [ET(B)R-LP, Pael-R] and GPR37L1...

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Smith NJ. Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1. Front Pharmacol. 2015;6:275doi: 10.3389/fphar.2015.00275.
Smith, N. J. (2015). Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1. Frontiers in pharmacology, 6275. https://doi.org/10.3389/fphar.2015.00275
Smith, Nicola J. "Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1." Frontiers in pharmacology vol. 6 (2015): 275. doi: https://doi.org/10.3389/fphar.2015.00275
Smith NJ. Drug Discovery Opportunities at the Endothelin B Receptor-Related Orphan G Protein-Coupled Receptors, GPR37 and GPR37L1. Front Pharmacol. 2015 Nov 17;6:275. doi: 10.3389/fphar.2015.00275. eCollection 2015. PMID: 26635605; PMCID: PMC4648071.
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Central mediators involved in the febrile response: effects of antipyretic drugs.

Temperature (Austin, Tex.)

Zampronio AR, Soares DM, Souza GE.
PMID: 27227071
Temperature (Austin). 2015 Oct 13;2(4):506-21. doi: 10.1080/23328940.2015.1102802. eCollection 2015.

Fever is a complex signal of inflammatory and infectious diseases. It is generally initiated when peripherally produced endogenous pyrogens reach areas that surround the hypothalamus. These peripheral endogenous pyrogens are cytokines that are produced by leukocytes and other cells,...

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Zampronio AR, Soares DM, Souza GE. Central mediators involved in the febrile response: effects of antipyretic drugs. Temperature (Austin). 2015;2(4):506-21doi: 10.1080/23328940.2015.1102802.
Zampronio, A. R., Soares, D. M., & Souza, G. E. (2015). Central mediators involved in the febrile response: effects of antipyretic drugs. Temperature (Austin, Tex.), 2(4), 506-21. https://doi.org/10.1080/23328940.2015.1102802
Zampronio, Aleksander R, et al. "Central mediators involved in the febrile response: effects of antipyretic drugs." Temperature (Austin, Tex.) vol. 2,4 (2015): 506-21. doi: https://doi.org/10.1080/23328940.2015.1102802
Zampronio AR, Soares DM, Souza GE. Central mediators involved in the febrile response: effects of antipyretic drugs. Temperature (Austin). 2015 Oct 13;2(4):506-21. doi: 10.1080/23328940.2015.1102802. eCollection 2015. PMID: 27227071; PMCID: PMC4843933.
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Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway.

Physiological reports

Ortiz-Capisano MC.
PMID: 25524278
Physiol Rep. 2014 Dec 18;2(12). doi: 10.14814/phy2.12240. Print 2014 Dec 01.

Renin is the rate-limiting step in the production of angiotensin II: a critical element in the regulation of blood pressure and in the pathogenesis of hypertension. Renin release from the juxtaglomerular (JG) cell is stimulated by the second messenger...

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Ortiz-Capisano MC. Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway. Physiol Rep. 2014;2(12)doi: 10.14814/phy2.12240.
Ortiz-Capisano, M. C. (2014). Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway. Physiological reports, 2(12), . https://doi.org/10.14814/phy2.12240
Ortiz-Capisano, M Cecilia. "Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway." Physiological reports vol. 2,12 (2014). doi: https://doi.org/10.14814/phy2.12240
Ortiz-Capisano MC. Endothelin inhibits renin release from juxtaglomerular cells via endothelin receptors A and B via a transient receptor potential canonical-mediated pathway. Physiol Rep. 2014 Dec 18;2(12). doi: 10.14814/phy2.12240. Print 2014 Dec 01. PMID: 25524278; PMCID: PMC4332218.
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Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study.

Annals of rehabilitation medicine

Shakouri SK, Razavi Z, Eslamian F, Sadeghi-Bazargani H, Ghaffari S, Babaei-Ghazani A.
PMID: 25932415
Ann Rehabil Med. 2015 Apr;39(2):191-8. doi: 10.5535/arm.2015.39.2.191. Epub 2015 Apr 24.

OBJECTIVE: To investigate the effect of enhanced external counterpulsation (EECP) on plasma nitric oxide (NO), Endothelin 1 (ET1), high sensitive C-reactive protein (HSCRP) and quality of life (QoL) in patients with coronary artery disease (CAD).METHODS: We conducted a pilot...

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Shakouri SK, Razavi Z, Eslamian F, et al. Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study. Ann Rehabil Med. 2015;39(2):191-8doi: 10.5535/arm.2015.39.2.191.
Shakouri, S. K., Razavi, Z., Eslamian, F., Sadeghi-Bazargani, H., Ghaffari, S., & Babaei-Ghazani, A. (2015). Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study. Annals of rehabilitation medicine, 39(2), 191-8. https://doi.org/10.5535/arm.2015.39.2.191
Shakouri, Seyed Kazem, et al. "Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study." Annals of rehabilitation medicine vol. 39,2 (2015): 191-8. doi: https://doi.org/10.5535/arm.2015.39.2.191
Shakouri SK, Razavi Z, Eslamian F, Sadeghi-Bazargani H, Ghaffari S, Babaei-Ghazani A. Effect of Enhanced External Counterpulsation and Cardiac Rehabilitation on Quality of Life, Plasma Nitric Oxide, Endothelin 1 and High Sensitive CRP in Patients With Coronary Artery Disease: A Pilot Study. Ann Rehabil Med. 2015 Apr;39(2):191-8. doi: 10.5535/arm.2015.39.2.191. Epub 2015 Apr 24. PMID: 25932415; PMCID: PMC4414965.
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Acute Meningitis.

Current infectious disease reports

Pfister HW, Koedel U, Paul R.
PMID: 11095782
Curr Infect Dis Rep. 1999 Jun;1(2):153-159. doi: 10.1007/s11908-996-0023-7.

Recent major epidemiologic trends in bacterial meningitis include a dramatic decline in the incidence of Haemophilus influenzae meningitis since the introduction of the protein-conjugated H. influenzae vaccines, and a worldwide increase in infections with antibiotic-resistant strains of bacterial pathogens....

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Pfister HW, Koedel U, Paul R. Acute Meningitis. Curr Infect Dis Rep. 1999;1(2):153-159doi: 10.1007/s11908-996-0023-7.
Pfister, H. W., Koedel, U., & Paul, R. (1999). Acute Meningitis. Current infectious disease reports, 1(2), 153-159. https://doi.org/10.1007/s11908-996-0023-7
Pfister, et al. "Acute Meningitis." Current infectious disease reports vol. 1,2 (1999): 153-159. doi: https://doi.org/10.1007/s11908-996-0023-7
Pfister HW, Koedel U, Paul R. Acute Meningitis. Curr Infect Dis Rep. 1999 Jun;1(2):153-159. doi: 10.1007/s11908-996-0023-7. PMID: 11095782.
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The endothelins.

Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners

Mekel JM.
PMID: 11447473
Cardiovasc J S Afr. 2000 Apr;11(2):107-115.

No abstract available.

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Mekel JM. The endothelins. Cardiovasc J S Afr. 2000;11(2):107-115
Mekel, J. M. (2000). The endothelins. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners, 11(2), 107-115.
Mekel, J. M.. "The endothelins." Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners vol. 11,2 (2000): 107-115.
Mekel JM. The endothelins. Cardiovasc J S Afr. 2000 Apr;11(2):107-115. PMID: 11447473.
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Endothelin-1 production by normal human cultured keratinocytes and its regulation.

Mediators of inflammation

Inoue H, Wakisaka N, Tane N, Ando K, Isono E, Yamanaka M, Aihara M, Ishida H.
PMID: 18475592
Mediators Inflamm. 1994;3(6):433-7. doi: 10.1155/S096293519400061X.

The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the medium. As...

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Inoue H, Wakisaka N, Tane N, et al. Endothelin-1 production by normal human cultured keratinocytes and its regulation. Mediators Inflamm. 1994;3(6):433-7doi: 10.1155/S096293519400061X.
Inoue, H., Wakisaka, N., Tane, N., Ando, K., Isono, E., Yamanaka, M., Aihara, M., & Ishida, H. (1994). Endothelin-1 production by normal human cultured keratinocytes and its regulation. Mediators of inflammation, 3(6), 433-7. https://doi.org/10.1155/S096293519400061X
Inoue, H, et al. "Endothelin-1 production by normal human cultured keratinocytes and its regulation." Mediators of inflammation vol. 3,6 (1994): 433-7. doi: https://doi.org/10.1155/S096293519400061X
Inoue H, Wakisaka N, Tane N, Ando K, Isono E, Yamanaka M, Aihara M, Ishida H. Endothelin-1 production by normal human cultured keratinocytes and its regulation. Mediators Inflamm. 1994;3(6):433-7. doi: 10.1155/S096293519400061X. PMID: 18475592; PMCID: PMC2365585.
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Activity of endothelial factors on myocardial inotropy.

Minerva cardioangiologica

Folino A, Rastaldo R, Cappello S, Chiribiri A, Pagliaro P, Losano G.
PMID: 21285922
Minerva Cardioangiol. 2011 Feb 01; Epub 2011 Feb 01.

Both nitric oxide (NO) and endothelins can either increase or decrease myocardial contractility. A positive inotropic effect occurs in response to low NO concentrations, whereas a negative effect is brought about by high concentrations. Activation of protein kinase A...

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Folino A, Rastaldo R, Cappello S, et al. Activity of endothelial factors on myocardial inotropy. Minerva Cardioangiol. 2011;
Folino, A., Rastaldo, R., Cappello, S., Chiribiri, A., Pagliaro, P., & Losano, G. (2011). Activity of endothelial factors on myocardial inotropy. Minerva cardioangiologica, .
Folino, A, et al. "Activity of endothelial factors on myocardial inotropy." Minerva cardioangiologica vol. (2011).
Folino A, Rastaldo R, Cappello S, Chiribiri A, Pagliaro P, Losano G. Activity of endothelial factors on myocardial inotropy. Minerva Cardioangiol. 2011 Feb 01; Epub 2011 Feb 01. PMID: 21285922.
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Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats.

World journal of gastrointestinal pathophysiology

Câmara PR, Ferraz GJ, Velloso LA, Zeitune JM, Suassuna FA, Ferraz JG.
PMID: 23293745
World J Gastrointest Pathophysiol. 2012 Aug 15;3(4):85-91. doi: 10.4291/wjgp.v3.i4.85.

AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats.METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls...

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Câmara PR, Ferraz GJ, Velloso LA, et al. Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats. World J Gastrointest Pathophysiol. 2012;3(4):85-91doi: 10.4291/wjgp.v3.i4.85.
Câmara, P. R., Ferraz, G. J., Velloso, L. A., Zeitune, J. M., Suassuna, F. A., & Ferraz, J. G. (2012). Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats. World journal of gastrointestinal pathophysiology, 3(4), 85-91. https://doi.org/10.4291/wjgp.v3.i4.85
Câmara, Paula Rs, et al. "Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats." World journal of gastrointestinal pathophysiology vol. 3,4 (2012): 85-91. doi: https://doi.org/10.4291/wjgp.v3.i4.85
Câmara PR, Ferraz GJ, Velloso LA, Zeitune JM, Suassuna FA, Ferraz JG. Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats. World J Gastrointest Pathophysiol. 2012 Aug 15;3(4):85-91. doi: 10.4291/wjgp.v3.i4.85. PMID: 23293745; PMCID: PMC3536844.
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Regulation of cerebral blood flow.

International journal of vascular medicine

Peterson EC, Wang Z, Britz G.
PMID: 21808738
Int J Vasc Med. 2011;2011:823525. doi: 10.1155/2011/823525. Epub 2011 Jul 25.

The control of cerebral blood flow is complex, and only beginning to be elucidated. Studies have identified three key regulatory paradigms. The first is cerebral pressure autoregulation, which maintains a constant flow in the face of changing cerebral perfusion...

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Peterson EC, Wang Z, Britz G. Regulation of cerebral blood flow. Int J Vasc Med. 2011;2011:823525doi: 10.1155/2011/823525.
Peterson, E. C., Wang, Z., & Britz, G. (2011). Regulation of cerebral blood flow. International journal of vascular medicine, 2011823525. https://doi.org/10.1155/2011/823525
Peterson, Eric C, et al. "Regulation of cerebral blood flow." International journal of vascular medicine vol. 2011 (2011): 823525. doi: https://doi.org/10.1155/2011/823525
Peterson EC, Wang Z, Britz G. Regulation of cerebral blood flow. Int J Vasc Med. 2011;2011:823525. doi: 10.1155/2011/823525. Epub 2011 Jul 25. PMID: 21808738; PMCID: PMC3144666.
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Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells.

Journal of Cancer

Halaka M, Hired ZA, Rutledge GE, Hedgepath CM, Anderson MP, St John H, Do JM, Majmudar PR, Walker C, Alawawdeh A, Stephen HM, Reagor CC, Adereti J, Jamison K, Iglesias KP, Kirmani KZ, Conway RE.
PMID: 32201539
J Cancer. 2020 Feb 19;11(9):2688-2701. doi: 10.7150/jca.41004. eCollection 2020.

The endothelins and their receptors are best known for their regulation of the vascular system. Their widespread expression in epithelial cells and their overexpression in some tumors has prompted investigation into their ability to regulate cancer progression. In this...

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Halaka M, Hired ZA, Rutledge GE, et al. Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells. J Cancer. 2020;11(9):2688-2701doi: 10.7150/jca.41004.
Halaka, M., Hired, Z. A., Rutledge, G. E., Hedgepath, C. M., Anderson, M. P., St John, H., Do, J. M., Majmudar, P. R., Walker, C., Alawawdeh, A., Stephen, H. M., Reagor, C. C., Adereti, J., Jamison, K., Iglesias, K. P., Kirmani, K. Z., & Conway, R. E. (2020). Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells. Journal of Cancer, 11(9), 2688-2701. https://doi.org/10.7150/jca.41004
Halaka, Meena, et al. "Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells." Journal of Cancer vol. 11,9 (2020): 2688-2701. doi: https://doi.org/10.7150/jca.41004
Halaka M, Hired ZA, Rutledge GE, Hedgepath CM, Anderson MP, St John H, Do JM, Majmudar PR, Walker C, Alawawdeh A, Stephen HM, Reagor CC, Adereti J, Jamison K, Iglesias KP, Kirmani KZ, Conway RE. Differences in Endothelin B Receptor Isoforms Expression and Function in Breast Cancer Cells. J Cancer. 2020 Feb 19;11(9):2688-2701. doi: 10.7150/jca.41004. eCollection 2020. PMID: 32201539; PMCID: PMC7066022.
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The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment.

Pigment cell & melanoma research

Freitas JT, Lopez J, Llorian C, Boroni M, Kos L.
PMID: 34288510
Pigment Cell Melanoma Res. 2021 Nov;34(6):1084-1093. doi: 10.1111/pcmr.13002. Epub 2021 Jul 29.

Endothelins are cytokines expressed in the microenvironment of several tumors. To identify which stromal cells in the melanoma microenvironment respond to endothelin, we injected murine melanoma cell lines B16F10, YUMM1.7, and YUMMER1.7 in a transgenic mouse that overexpresses endothelin...

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Freitas JT, Lopez J, Llorian C, et al. The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. Pigment Cell Melanoma Res. 2021;34(6):1084-1093doi: 10.1111/pcmr.13002.
Freitas, J. T., Lopez, J., Llorian, C., Boroni, M., & Kos, L. (2021). The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. Pigment cell & melanoma research, 34(6), 1084-1093. https://doi.org/10.1111/pcmr.13002
Freitas, Juliano T, et al. "The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment." Pigment cell & melanoma research vol. 34,6 (2021): 1084-1093. doi: https://doi.org/10.1111/pcmr.13002
Freitas JT, Lopez J, Llorian C, Boroni M, Kos L. The immunosuppressive role of Edn3 overexpression in the melanoma microenvironment. Pigment Cell Melanoma Res. 2021 Nov;34(6):1084-1093. doi: 10.1111/pcmr.13002. Epub 2021 Jul 29. PMID: 34288510.
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Showing 1 to 12 of 52 entries