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Mannich bases: an important pharmacophore in present scenario.

International journal of medicinal chemistry

Bala S, Sharma N, Kajal A, Kamboj S, Saini V.
PMID: 25478226
Int J Med Chem. 2014;2014:191072. doi: 10.1155/2014/191072. Epub 2014 Nov 12.

Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of...

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Bala S, Sharma N, Kajal A, et al. Mannich bases: an important pharmacophore in present scenario. Int J Med Chem. 2014;2014:191072doi: 10.1155/2014/191072.
Bala, S., Sharma, N., Kajal, A., Kamboj, S., & Saini, V. (2014). Mannich bases: an important pharmacophore in present scenario. International journal of medicinal chemistry, 2014191072. https://doi.org/10.1155/2014/191072
Bala, Suman, et al. "Mannich bases: an important pharmacophore in present scenario." International journal of medicinal chemistry vol. 2014 (2014): 191072. doi: https://doi.org/10.1155/2014/191072
Bala S, Sharma N, Kajal A, Kamboj S, Saini V. Mannich bases: an important pharmacophore in present scenario. Int J Med Chem. 2014;2014:191072. doi: 10.1155/2014/191072. Epub 2014 Nov 12. PMID: 25478226; PMCID: PMC4244926.
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Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode.

Pathophysiology : the official journal of the International Society for Pathophysiology

Ishida H, Hirota Y, Higashijima N, Ishiwata K, Chokoh G, Matsuyama S, Murakami E, Nakazawa H.
PMID: 15364117
Pathophysiology. 2004 Oct;11(2):77-80. doi: 10.1016/j.pathophys.2004.03.004.

BACKGROUND:: Nipradilol (3,4-dihydro-8-[2-hydroxy-3-isopropyl-amino]propoxy-3-nitroxy-2-H-1-benzopyran), a potent non-selective beta-adrenoceptor antagonist, has been shown to increase NO production. The mechanisms are up-regulation of nitric oxide synthase (NOS) and direct release of NO from nipradilol. The process of direct NO release from nipradilol...

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Ishida H, Hirota Y, Higashijima N, et al. Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode. Pathophysiology. 2004;11(2):77-80doi: 10.1016/j.pathophys.2004.03.004.
Ishida, H., Hirota, Y., Higashijima, N., Ishiwata, K., Chokoh, G., Matsuyama, S., Murakami, E., & Nakazawa, H. (2004). Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode. Pathophysiology : the official journal of the International Society for Pathophysiology, 11(2), 77-80. https://doi.org/10.1016/j.pathophys.2004.03.004
Ishida, Hideyuki, et al. "Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 11,2 (2004): 77-80. doi: https://doi.org/10.1016/j.pathophys.2004.03.004
Ishida H, Hirota Y, Higashijima N, Ishiwata K, Chokoh G, Matsuyama S, Murakami E, Nakazawa H. Direct nitric oxide release from nipradilol in human coronary arterial smooth muscle cells observed with fluorescent NO probe and NO-electrode. Pathophysiology. 2004 Oct;11(2):77-80. doi: 10.1016/j.pathophys.2004.03.004. PMID: 15364117.
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Properties of Single K and Cl Channels in Asclepias tuberosa Protoplasts.

Plant physiology

Schauf CL, Wilson KJ.
PMID: 16665712
Plant Physiol. 1987 Oct;85(2):413-8. doi: 10.1104/pp.85.2.413.

Potassium and chloride channels were characterized in Asclepias tuberosa suspension cell derived protoplasts by patch voltage-clamp. Whole-cell currents and single channels in excised patches had linear instantaneous current-voltage relations, reversing at the Nernst potentials for K(+) and Cl(-), respectively....

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Schauf CL, Wilson KJ. Properties of Single K and Cl Channels in Asclepias tuberosa Protoplasts. Plant Physiol. 1987;85(2):413-8doi: 10.1104/pp.85.2.413.
Schauf, C. L., & Wilson, K. J. (1987). Properties of Single K and Cl Channels in Asclepias tuberosa Protoplasts. Plant physiology, 85(2), 413-8. https://doi.org/10.1104/pp.85.2.413
Schauf, C L, and Wilson, K J. "Properties of Single K and Cl Channels in Asclepias tuberosa Protoplasts." Plant physiology vol. 85,2 (1987): 413-8. doi: https://doi.org/10.1104/pp.85.2.413
Schauf CL, Wilson KJ. Properties of Single K and Cl Channels in Asclepias tuberosa Protoplasts. Plant Physiol. 1987 Oct;85(2):413-8. doi: 10.1104/pp.85.2.413. PMID: 16665712; PMCID: PMC1054270.
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Characterization of glutathione S-transferases in needles of Norway spruce trees from a forest decline stand.

Tree physiology

Schröder P, Wolf AE.
PMID: 14871720
Tree Physiol. 1996 May;16(5):503-8. doi: 10.1093/treephys/16.5.503.

Glutathione S-transferases (GST) detoxify many electrophilic xenobiotics, including several volatile organic compounds and pesticides. The GST activity for the conjugation of several xenobiotic substances was isolated from needles of Norway spruce (Picea abies L. Karst.) trees from a forest...

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Schröder P, Wolf AE. Characterization of glutathione S-transferases in needles of Norway spruce trees from a forest decline stand. Tree Physiol. 1996;16(5):503-8doi: 10.1093/treephys/16.5.503.
Schröder, P., & Wolf, A. E. (1996). Characterization of glutathione S-transferases in needles of Norway spruce trees from a forest decline stand. Tree physiology, 16(5), 503-8. https://doi.org/10.1093/treephys/16.5.503
Schröder, P, and Wolf, A E. "Characterization of glutathione S-transferases in needles of Norway spruce trees from a forest decline stand." Tree physiology vol. 16,5 (1996): 503-8. doi: https://doi.org/10.1093/treephys/16.5.503
Schröder P, Wolf AE. Characterization of glutathione S-transferases in needles of Norway spruce trees from a forest decline stand. Tree Physiol. 1996 May;16(5):503-8. doi: 10.1093/treephys/16.5.503. PMID: 14871720.
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Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues.

Neurochemistry international

Yoneda Y, Ogita K, Nakamuta H, Koida M, Ohgaki T, Meguri H.
PMID: 20493157
Neurochem Int. 1986;9(4):521-31. doi: 10.1016/0197-0186(86)90145-2.

The effect of various ions on [(3)H]l-glutamic acid (Glu) binding was examined using crude synaptic membrane preparations from the rat brain. In vitro addition of sodium acetate (1-100 mM) exhibited a significant enhancement of the binding in a concentration...

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Yoneda Y, Ogita K, Nakamuta H, et al. Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues. Neurochem Int. 1986;9(4):521-31doi: 10.1016/0197-0186(86)90145-2.
Yoneda, Y., Ogita, K., Nakamuta, H., Koida, M., Ohgaki, T., & Meguri, H. (1986). Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues. Neurochemistry international, 9(4), 521-31. https://doi.org/10.1016/0197-0186(86)90145-2
Yoneda, Y, et al. "Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues." Neurochemistry international vol. 9,4 (1986): 521-31. doi: https://doi.org/10.1016/0197-0186(86)90145-2
Yoneda Y, Ogita K, Nakamuta H, Koida M, Ohgaki T, Meguri H. Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues. Neurochem Int. 1986;9(4):521-31. doi: 10.1016/0197-0186(86)90145-2. PMID: 20493157.
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Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats.

Environmental toxicology and pharmacology

Eke BC, Coban T, Vural N, Iscan M.
PMID: 21781847
Environ Toxicol Pharmacol. 1998 Jan;5(1):29-34. doi: 10.1016/s1382-6689(97)10003-5.

The adult male and female rats were exposed to cigarette smoke (CS) 5 times a day, with 1 h intervals, for 3 days in a chamber where smoke and fresh air lead alternatively and were killed 16 h after...

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Eke BC, Coban T, Vural N, et al. Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats. Environ Toxicol Pharmacol. 1998;5(1):29-34doi: 10.1016/s1382-6689(97)10003-5.
Eke, B. C., Coban, T., Vural, N., & Iscan, M. (1998). Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats. Environmental toxicology and pharmacology, 5(1), 29-34. https://doi.org/10.1016/s1382-6689(97)10003-5
Eke, B C, et al. "Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats." Environmental toxicology and pharmacology vol. 5,1 (1998): 29-34. doi: https://doi.org/10.1016/s1382-6689(97)10003-5
Eke BC, Coban T, Vural N, Iscan M. Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats. Environ Toxicol Pharmacol. 1998 Jan;5(1):29-34. doi: 10.1016/s1382-6689(97)10003-5. PMID: 21781847.
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Utilizing ethacrynic acid and ciclopirox olamine in liver cancer.

Oncology letters

Al-Dali AM, Weiher H, Schmidt-Wolf IGH.
PMID: 30405829
Oncol Lett. 2018 Nov;16(5):6854-6860. doi: 10.3892/ol.2018.9472. Epub 2018 Sep 20.

Once aberrantly activated, the Wnt/β-catenin pathway may result in uncontrolled proliferation and eventually cancer. Efforts to counter and inhibit this pathway are mainly directed against β-catenin, as it serves a role on the cytoplasm and the nucleus. In addition,...

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Al-Dali AM, Weiher H, Schmidt-Wolf IGH. Utilizing ethacrynic acid and ciclopirox olamine in liver cancer. Oncol Lett. 2018;16(5):6854-6860doi: 10.3892/ol.2018.9472.
Al-Dali, A. M., Weiher, H., & Schmidt-Wolf, I. G. H. (2018). Utilizing ethacrynic acid and ciclopirox olamine in liver cancer. Oncology letters, 16(5), 6854-6860. https://doi.org/10.3892/ol.2018.9472
Al-Dali, Ahmad M, et al. "Utilizing ethacrynic acid and ciclopirox olamine in liver cancer." Oncology letters vol. 16,5 (2018): 6854-6860. doi: https://doi.org/10.3892/ol.2018.9472
Al-Dali AM, Weiher H, Schmidt-Wolf IGH. Utilizing ethacrynic acid and ciclopirox olamine in liver cancer. Oncol Lett. 2018 Nov;16(5):6854-6860. doi: 10.3892/ol.2018.9472. Epub 2018 Sep 20. PMID: 30405829; PMCID: PMC6202527.
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Electrically gated nanoporous membranes for smart molecular flow control.

Nanoscale

Kim S, Ozalp EI, Darwish M, Weldon JA.
PMID: 30398271
Nanoscale. 2018 Nov 15;10(44):20740-20747. doi: 10.1039/c8nr05906c.

We report a novel conductive nanoporous membrane platform for a smart drug delivery system, which allows low-power electrically controlled delivery of therapeutic drug molecules via field-effect gating. The device was fabricated and tested with two oppositely charged drug molecules...

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Kim S, Ozalp EI, Darwish M, et al. Electrically gated nanoporous membranes for smart molecular flow control. Nanoscale. 2018;10(44):20740-20747doi: 10.1039/c8nr05906c.
Kim, S., Ozalp, E. I., Darwish, M., & Weldon, J. A. (2018). Electrically gated nanoporous membranes for smart molecular flow control. Nanoscale, 10(44), 20740-20747. https://doi.org/10.1039/c8nr05906c
Kim, Sungho, et al. "Electrically gated nanoporous membranes for smart molecular flow control." Nanoscale vol. 10,44 (2018): 20740-20747. doi: https://doi.org/10.1039/c8nr05906c
Kim S, Ozalp EI, Darwish M, Weldon JA. Electrically gated nanoporous membranes for smart molecular flow control. Nanoscale. 2018 Nov 15;10(44):20740-20747. doi: 10.1039/c8nr05906c. PMID: 30398271.
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Assessment of the Potential for Veverimer Drug-Drug Interactions.

Drug metabolism and disposition: the biological fate of chemicals

Parsell D, Shao J, Guttendorf R, Mathur V, Li E, Wu YS, Tsao L, Tabakman S, Stasiv Y, Lee A, Biyani K, Klaerner G.
PMID: 34031138
Drug Metab Dispos. 2021 Jul;49(7):490-500. doi: 10.1124/dmd.121.000366. Epub 2021 May 24.

Veverimer is a polymer being developed as a potential treatment of metabolic acidosis in patients with chronic kidney disease. Veverimer selectively binds and removes hydrochloric acid from the gastrointestinal tract, resulting in an increase in serum bicarbonate. Veverimer is...

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Parsell D, Shao J, Guttendorf R, et al. Assessment of the Potential for Veverimer Drug-Drug Interactions. Drug Metab Dispos. 2021;49(7):490-500doi: 10.1124/dmd.121.000366.
Parsell, D., Shao, J., Guttendorf, R., Mathur, V., Li, E., Wu, Y. S., Tsao, L., Tabakman, S., Stasiv, Y., Lee, A., Biyani, K., & Klaerner, G. (2021). Assessment of the Potential for Veverimer Drug-Drug Interactions. Drug metabolism and disposition: the biological fate of chemicals, 49(7), 490-500. https://doi.org/10.1124/dmd.121.000366
Parsell, Dawn, et al. "Assessment of the Potential for Veverimer Drug-Drug Interactions." Drug metabolism and disposition: the biological fate of chemicals vol. 49,7 (2021): 490-500. doi: https://doi.org/10.1124/dmd.121.000366
Parsell D, Shao J, Guttendorf R, Mathur V, Li E, Wu YS, Tsao L, Tabakman S, Stasiv Y, Lee A, Biyani K, Klaerner G. Assessment of the Potential for Veverimer Drug-Drug Interactions. Drug Metab Dispos. 2021 Jul;49(7):490-500. doi: 10.1124/dmd.121.000366. Epub 2021 May 24. PMID: 34031138.
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Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions.

Journal of pharmaceutical analysis

Potęga A, Kosno M, Mazerska Z.
PMID: 35028185
J Pharm Anal. 2021 Dec;11(6):791-798. doi: 10.1016/j.jpha.2021.03.014. Epub 2021 Apr 05.

Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with glutathione (GSH), which can be non-enzymatic and/or catalyzed by GSH-dependent enzymes. The aim of this work was...

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Potęga A, Kosno M, Mazerska Z. Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions. J Pharm Anal. 2021;11(6):791-798doi: 10.1016/j.jpha.2021.03.014.
Potęga, A., Kosno, M., & Mazerska, Z. (2021). Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions. Journal of pharmaceutical analysis, 11(6), 791-798. https://doi.org/10.1016/j.jpha.2021.03.014
Potęga, Agnieszka, et al. "Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions." Journal of pharmaceutical analysis vol. 11,6 (2021): 791-798. doi: https://doi.org/10.1016/j.jpha.2021.03.014
Potęga A, Kosno M, Mazerska Z. Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions. J Pharm Anal. 2021 Dec;11(6):791-798. doi: 10.1016/j.jpha.2021.03.014. Epub 2021 Apr 05. PMID: 35028185; PMCID: PMC8740389.
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Inhibitors of glutathione S-transferases as therapeutic agents.

Advanced drug delivery reviews

Tew KD, Dutta S, Schultz M.
PMID: 10837536
Adv Drug Deliv Rev. 1997 Jul 07;26(2):91-104. doi: 10.1016/s0169-409x(97)00029-x.

Glutathione S-transferases (GST) are a family of phase II detoxification enzymes with broad substrate specificities. They catalyze the conjugation of glutathione with many different types of xenobiotics, rendering the compound more water soluble and thus more easily eliminated. Resistance...

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Tew KD, Dutta S, Schultz M. Inhibitors of glutathione S-transferases as therapeutic agents. Adv Drug Deliv Rev. 1997;26(2):91-104doi: 10.1016/s0169-409x(97)00029-x.
Tew, K. D., Dutta, S., & Schultz, M. (1997). Inhibitors of glutathione S-transferases as therapeutic agents. Advanced drug delivery reviews, 26(2), 91-104. https://doi.org/10.1016/s0169-409x(97)00029-x
Tew, et al. "Inhibitors of glutathione S-transferases as therapeutic agents." Advanced drug delivery reviews vol. 26,2 (1997): 91-104. doi: https://doi.org/10.1016/s0169-409x(97)00029-x
Tew KD, Dutta S, Schultz M. Inhibitors of glutathione S-transferases as therapeutic agents. Adv Drug Deliv Rev. 1997 Jul 07;26(2):91-104. doi: 10.1016/s0169-409x(97)00029-x. PMID: 10837536.
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2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases.

Plant physiology

Droog F, Hooykaas P, Van Der Zaal BJ.
PMID: 12228421
Plant Physiol. 1995 Apr;107(4):1139-1146. doi: 10.1104/pp.107.4.1139.

Two auxin-inducible glutathione S-transferase (GST, EC 2.5.1.18) isozymes from tobacco (Nicotiana tabacum, White Burley) were partially characterized. GST1-1 and GST2-1 are members of a recently identified new type of plant GST isozymes that we will here refer to as...

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Droog F, Hooykaas P, Van Der Zaal BJ. 2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases. Plant Physiol. 1995;107(4):1139-1146doi: 10.1104/pp.107.4.1139.
Droog, F., Hooykaas, P., & Van Der Zaal, B. J. (1995). 2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases. Plant physiology, 107(4), 1139-1146. https://doi.org/10.1104/pp.107.4.1139
Droog, FNJ., et al. "2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases." Plant physiology vol. 107,4 (1995): 1139-1146. doi: https://doi.org/10.1104/pp.107.4.1139
Droog F, Hooykaas P, Van Der Zaal BJ. 2,4-Dichlorophenoxyacetic Acid and Related Chlorinated Compounds Inhibit Two Auxin-Regulated Type-III Tobacco Glutathione S-Transferases. Plant Physiol. 1995 Apr;107(4):1139-1146. doi: 10.1104/pp.107.4.1139. PMID: 12228421; PMCID: PMC157246.
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Showing 1 to 12 of 39 entries