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Allele-specific losses of heterozygosity on chromosomes 1 and 17 revealed by whole genome scan of ethylnitrosourea-induced gliomas of BDIX x BDIV hybrid rats.

Molecular carcinogenesis

Kindler-Rohrborn A, Kolsch BU, Buslei R, Zabel S, Wiestler OD, Rajewsky MF.
PMID: 10657907
Mol Carcinog. 2000 Feb;27(2):149. doi: 10.1002/(sici)1098-2744(200002)27:2<149::aid-mc10>3.0.co;2-3.

No abstract available.

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Kindler-Rohrborn A, Kolsch BU, Buslei R, et al. Allele-specific losses of heterozygosity on chromosomes 1 and 17 revealed by whole genome scan of ethylnitrosourea-induced gliomas of BDIX x BDIV hybrid rats. Mol Carcinog. 2000;27(2):149doi: 10.1002/(sici)1098-2744(200002)27:2<149::aid-mc10>3.0.co;2-3.
Kindler-Rohrborn, A., Kolsch, B. U., Buslei, R., Zabel, S., Wiestler, O. D., & Rajewsky, M. F. (2000). Allele-specific losses of heterozygosity on chromosomes 1 and 17 revealed by whole genome scan of ethylnitrosourea-induced gliomas of BDIX x BDIV hybrid rats. Molecular carcinogenesis, 27(2), 149. https://doi.org/10.1002/(sici)1098-2744(200002)27:2<149::aid-mc10>3.0.co;2-3
Kindler-Rohrborn, et al. "Allele-specific losses of heterozygosity on chromosomes 1 and 17 revealed by whole genome scan of ethylnitrosourea-induced gliomas of BDIX x BDIV hybrid rats." Molecular carcinogenesis vol. 27,2 (2000): 149. doi: https://doi.org/10.1002/(sici)1098-2744(200002)27:2<149::aid-mc10>3.0.co;2-3
Kindler-Rohrborn A, Kolsch BU, Buslei R, Zabel S, Wiestler OD, Rajewsky MF. Allele-specific losses of heterozygosity on chromosomes 1 and 17 revealed by whole genome scan of ethylnitrosourea-induced gliomas of BDIX x BDIV hybrid rats. Mol Carcinog. 2000 Feb;27(2):149. doi: 10.1002/(sici)1098-2744(200002)27:2<149::aid-mc10>3.0.co;2-3. PMID: 10657907.
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The medaka as a model for studying germ-cell mutagenesis and genomic instability.

Marine biotechnology (New York, N.Y.)

Shima A, Shimada A.
PMID: 14961312
Mar Biotechnol (NY). 2001 Jun;3:S162-7. doi: 10.1007/s10126-001-0038-x.

To study germ-cell mutagenesis from the viewpoint of biodiversity, we developed a nonmammalian specific-locus test system using the Japanese medaka, Oryzias latipes. The genetic end points available are dominant lethal mutations, total specific-locus mutations, and viable specific-locus mutations. We...

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Shima A, Shimada A. The medaka as a model for studying germ-cell mutagenesis and genomic instability. Mar Biotechnol (NY). 2001;3:S162-7doi: 10.1007/s10126-001-0038-x.
Shima, A., & Shimada, A. (2001). The medaka as a model for studying germ-cell mutagenesis and genomic instability. Marine biotechnology (New York, N.Y.), 3S162-7. https://doi.org/10.1007/s10126-001-0038-x
Shima, A, and Shimada, A. "The medaka as a model for studying germ-cell mutagenesis and genomic instability." Marine biotechnology (New York, N.Y.) vol. 3 (2001): S162-7. doi: https://doi.org/10.1007/s10126-001-0038-x
Shima A, Shimada A. The medaka as a model for studying germ-cell mutagenesis and genomic instability. Mar Biotechnol (NY). 2001 Jun;3:S162-7. doi: 10.1007/s10126-001-0038-x. PMID: 14961312.
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Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse.

Comparative and functional genomics

Tsipouri V, Curtin JA, Nolan PM, Vizor L, Parsons CA, Clapham CM, Latham ID, Rooke LJ, Martin JE, Peters J, Hunter AJ, Rogers D, Rastan S, Brown SD, Fisher EM, Spurr NK, Gray IC.
PMID: 18629060
Comp Funct Genomics. 2004;5(2):123-7. doi: 10.1002/cfg.382.

Three mutant mice with pigmentation phenotypes were recovered from a genomewide random mouse chemical mutagenesis study. White toes (Whto; MGI:1861986), Belly spot and white toes (Bswt; MGI:2152776) and Dark footpads 2 (Dfp2; MGI:1861991) were identified following visual inspection of...

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Tsipouri V, Curtin JA, Nolan PM, et al. Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse. Comp Funct Genomics. 2004;5(2):123-7doi: 10.1002/cfg.382.
Tsipouri, V., Curtin, J. A., Nolan, P. M., Vizor, L., Parsons, C. A., Clapham, C. M., Latham, I. D., Rooke, L. J., Martin, J. E., Peters, J., Hunter, A. J., Rogers, D., Rastan, S., Brown, S. D., Fisher, E. M., Spurr, N. K., & Gray, I. C. (2004). Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse. Comparative and functional genomics, 5(2), 123-7. https://doi.org/10.1002/cfg.382
Tsipouri, Vicky, et al. "Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse." Comparative and functional genomics vol. 5,2 (2004): 123-7. doi: https://doi.org/10.1002/cfg.382
Tsipouri V, Curtin JA, Nolan PM, Vizor L, Parsons CA, Clapham CM, Latham ID, Rooke LJ, Martin JE, Peters J, Hunter AJ, Rogers D, Rastan S, Brown SD, Fisher EM, Spurr NK, Gray IC. Three novel pigmentation mutants generated by genome-wide random ENU mutagenesis in the mouse. Comp Funct Genomics. 2004;5(2):123-7. doi: 10.1002/cfg.382. PMID: 18629060; PMCID: PMC2447344.
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The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas.

Pathobiology of aging & age related diseases

Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, Lee S, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y.
PMID: 22953030
Pathobiol Aging Age Relat Dis. 2011;1. doi: 10.3402/pba.v1i0.7189. Epub 2011 Jun 01.

The anti-tumor effects of calorie restriction (CR) and the possible underlying mechanisms were investigated using ethylnitrosourea (ENU)-induced glioma in rats. ENU was given transplacentally at gestational day 15, and male offspring were used in this experiment. The brain from...

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Mahlke MA, Cortez LA, Ortiz MA, et al. The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiol Aging Age Relat Dis. 2011;1doi: 10.3402/pba.v1i0.7189.
Mahlke, M. A., Cortez, L. A., Ortiz, M. A., Rodriguez, M., Uchida, K., Shigenaga, M. K., Lee, S., Zhang, Y., Tominaga, K., Hubbard, G. B., & Ikeno, Y. (2011). The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiology of aging & age related diseases, 1. https://doi.org/10.3402/pba.v1i0.7189
Mahlke, Megan A, et al. "The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas." Pathobiology of aging & age related diseases vol. 1 (2011). doi: https://doi.org/10.3402/pba.v1i0.7189
Mahlke MA, Cortez LA, Ortiz MA, Rodriguez M, Uchida K, Shigenaga MK, Lee S, Zhang Y, Tominaga K, Hubbard GB, Ikeno Y. The anti-tumor effects of calorie restriction are correlated with reduced oxidative stress in ENU-induced gliomas. Pathobiol Aging Age Relat Dis. 2011;1. doi: 10.3402/pba.v1i0.7189. Epub 2011 Jun 01. PMID: 22953030; PMCID: PMC3417672.
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Proprotein convertase furina is required for heart development in zebrafish.

Journal of cell science

Zhou Q, Lei L, Zhang H, Chiu SC, Gao L, Yang R, Wei W, Peng G, Zhu X, Xiong JW.
PMID: 34622921
J Cell Sci. 2021 Nov 01;134(21). doi: 10.1242/jcs.258432. Epub 2021 Nov 05.

Cardiac looping and trabeculation are key processes during cardiac chamber maturation. However, the underlying mechanisms remain incompletely understood. Here, we report the isolation, cloning and characterization of the proprotein convertase furina from the cardiovascular mutant loft in zebrafish. loft...

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Zhou Q, Lei L, Zhang H, et al. Proprotein convertase furina is required for heart development in zebrafish. J Cell Sci. 2021;134(21)doi: 10.1242/jcs.258432.
Zhou, Q., Lei, L., Zhang, H., Chiu, S. C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., & Xiong, J. W. (2021). Proprotein convertase furina is required for heart development in zebrafish. Journal of cell science, 134(21), . https://doi.org/10.1242/jcs.258432
Zhou, Qinchao, et al. "Proprotein convertase furina is required for heart development in zebrafish." Journal of cell science vol. 134,21 (2021). doi: https://doi.org/10.1242/jcs.258432
Zhou Q, Lei L, Zhang H, Chiu SC, Gao L, Yang R, Wei W, Peng G, Zhu X, Xiong JW. Proprotein convertase furina is required for heart development in zebrafish. J Cell Sci. 2021 Nov 01;134(21). doi: 10.1242/jcs.258432. Epub 2021 Nov 05. PMID: 34622921.
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Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society

Furihata C, Watanabe T, Suzuki T, Hamada S, Nakajima M.
PMID: 27482301
Genes Environ. 2016 Aug 01;38:15. doi: 10.1186/s41021-016-0041-0. eCollection 2016.

Toxicogenomics is a rapidly developing discipline focused on the elucidation of the molecular and cellular effects of chemicals on biological systems. As a collaborative study group of Toxicogenomics/JEMS·MMS, we conducted studies on hepatocarcinogens in rodent liver in which 100...

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Furihata C, Watanabe T, Suzuki T, et al. Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes Environ. 2016;38:15doi: 10.1186/s41021-016-0041-0.
Furihata, C., Watanabe, T., Suzuki, T., Hamada, S., & Nakajima, M. (2016). Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 3815. https://doi.org/10.1186/s41021-016-0041-0
Furihata, Chie, et al. "Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics." Genes and environment : the official journal of the Japanese Environmental Mutagen Society vol. 38 (2016): 15. doi: https://doi.org/10.1186/s41021-016-0041-0
Furihata C, Watanabe T, Suzuki T, Hamada S, Nakajima M. Collaborative studies in toxicogenomics in rodent liver in JEMS·MMS; a useful application of principal component analysis on toxicogenomics. Genes Environ. 2016 Aug 01;38:15. doi: 10.1186/s41021-016-0041-0. eCollection 2016. PMID: 27482301; PMCID: PMC4968012.
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Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas.

Brain research bulletin

Ramírez-Expósito MJ, Carrera-González MP, Martínez-Martos JM.
PMID: 33359638
Brain Res Bull. 2021 Mar;168:1-7. doi: 10.1016/j.brainresbull.2020.12.008. Epub 2020 Dec 26.

INTRODUCTION: The renin angiotensin system (RAS) is emerging as an important target for the treatment of glioma. We had described that the local RAS is involved in vivo in tumor growth in the rat model of experimental C6 glioma...

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Ramírez-Expósito MJ, Carrera-González MP, Martínez-Martos JM. Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas. Brain Res Bull. 2020;168:1-7doi: 10.1016/j.brainresbull.2020.12.008.
Ramírez-Expósito, M. J., Carrera-González, M. P., & Martínez-Martos, J. M. (2021). Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas. Brain research bulletin, 1681-7. https://doi.org/10.1016/j.brainresbull.2020.12.008
Ramírez-Expósito, M J, et al. "Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas." Brain research bulletin vol. 168 (2021): 1-7. doi: https://doi.org/10.1016/j.brainresbull.2020.12.008
Ramírez-Expósito MJ, Carrera-González MP, Martínez-Martos JM. Sex differences exist in brain renin-angiotensin system-regulating aminopeptidase activities in transplacental ethyl-nitrosourea-induced gliomas. Brain Res Bull. 2021 Mar;168:1-7. doi: 10.1016/j.brainresbull.2020.12.008. Epub 2020 Dec 26. PMID: 33359638.
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A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment.

SpringerPlus

El Hakam Kamareddin C, Magnol L, Blanquet V.
PMID: 26636018
Springerplus. 2015 Nov 25;4:730. doi: 10.1186/s40064-015-1537-y. eCollection 2015.

Approximately 10 % of the population worldwide suffers from hearing loss (HL) and about 60 % of persons with early onset HL have hereditary hearing loss due to genetic mutations. Highly efficient mutagenesis in mice with the chemical mutagen,...

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El Hakam Kamareddin C, Magnol L, Blanquet V. A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment. Springerplus. 2015;4:730doi: 10.1186/s40064-015-1537-y.
El Hakam Kamareddin, C., Magnol, L., & Blanquet, V. (2015). A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment. SpringerPlus, 4730. https://doi.org/10.1186/s40064-015-1537-y
El Hakam Kamareddin, Carole, et al. "A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment." SpringerPlus vol. 4 (2015): 730. doi: https://doi.org/10.1186/s40064-015-1537-y
El Hakam Kamareddin C, Magnol L, Blanquet V. A new Otogelin ENU mouse model for autosomal-recessive nonsyndromic moderate hearing impairment. Springerplus. 2015 Nov 25;4:730. doi: 10.1186/s40064-015-1537-y. eCollection 2015. PMID: 26636018; PMCID: PMC4659790.
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Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens.

Toxicologic pathology

Ito N, Tsuda H, Hasegawa R, Imaida K.
PMID: 28094708
Toxicol Pathol. 1982 Feb;10(2):37-47. doi: 10.1177/019262338201000207.

The aims of this study were 1) to observe the sequential development of hepatocellular carcinomas from preneoplastic lesions and to investigate hyperplastic (neoplastic) foci or nodules (HN) as an indicator of a preneoplastic population, and 2) to test the...

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Ito N, Tsuda H, Hasegawa R, et al. Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens. Toxicol Pathol. 1982;10(2):37-47doi: 10.1177/019262338201000207.
Ito, N., Tsuda, H., Hasegawa, R., & Imaida, K. (1982). Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens. Toxicologic pathology, 10(2), 37-47. https://doi.org/10.1177/019262338201000207
Ito, Nobuyuki, et al. "Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens." Toxicologic pathology vol. 10,2 (1982): 37-47. doi: https://doi.org/10.1177/019262338201000207
Ito N, Tsuda H, Hasegawa R, Imaida K. Sequential observation of pathomorphologic alterations in preneoplastic lesions during the promoting stage of hepatocarcinogenesis and the development of short-term test system for hepatopromoters and hepatocarcinogens. Toxicol Pathol. 1982 Feb;10(2):37-47. doi: 10.1177/019262338201000207. PMID: 28094708.
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The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus.

The EMBO journal

Florentz C, Briand JP, Romby P, Hirth L, Ebel JP, Glegé R.
PMID: 16453415
EMBO J. 1982;1(2):269-76.

The secondary structure of the isolated tRNA-like sequence (n=159) present at the 3' OH terminus of turnip yellow mosaic virus RNA has been established from partial nuclease digestion with S1 nuclease and T1, CL(3), and Naja oxiana RNases. The...

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Florentz C, Briand JP, Romby P, et al. The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus. EMBO J. 1982;1(2):269-76
Florentz, C., Briand, J. P., Romby, P., Hirth, L., Ebel, J. P., & Glegé, R. (1982). The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus. The EMBO journal, 1(2), 269-76.
Florentz, C, et al. "The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus." The EMBO journal vol. 1,2 (1982): 269-76.
Florentz C, Briand JP, Romby P, Hirth L, Ebel JP, Glegé R. The tRNA-like structure of turnip yellow mosaic virus RNA: structural organization of the last 159 nucleotides from the 3' OH terminus. EMBO J. 1982;1(2):269-76. PMID: 16453415; PMCID: PMC553031.
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Activating point mutations of the Neu oncogene in schwannomas induced by ethylnitrosourea exposure to day-15 and day-18 fetal rats.

International journal of oncology

Thomas R, Susil B, Kola I.
PMID: 21559701
Int J Oncol. 1994 Dec;5(6):1219-25. doi: 10.3892/ijo.5.6.1219.

Single transplacental exposure of day 15 fetal rats to the carcinogen ethylnitrosourea (ENU) primarily induces tumours of neuroectodermal origin, whereas exposure to ENU at neonatal and adult stages results in tumours arising predominantly from secretory epithelial tissue. Expression of...

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Thomas R, Susil B, Kola I. Activating point mutations of the Neu oncogene in schwannomas induced by ethylnitrosourea exposure to day-15 and day-18 fetal rats. Int J Oncol. 1994;5(6):1219-25doi: 10.3892/ijo.5.6.1219.
Thomas, R., Susil, B., & Kola, I. (1994). Activating point mutations of the Neu oncogene in schwannomas induced by ethylnitrosourea exposure to day-15 and day-18 fetal rats. International journal of oncology, 5(6), 1219-25. https://doi.org/10.3892/ijo.5.6.1219
Thomas, R, et al. "Activating point mutations of the Neu oncogene in schwannomas induced by ethylnitrosourea exposure to day-15 and day-18 fetal rats." International journal of oncology vol. 5,6 (1994): 1219-25. doi: https://doi.org/10.3892/ijo.5.6.1219
Thomas R, Susil B, Kola I. Activating point mutations of the Neu oncogene in schwannomas induced by ethylnitrosourea exposure to day-15 and day-18 fetal rats. Int J Oncol. 1994 Dec;5(6):1219-25. doi: 10.3892/ijo.5.6.1219. PMID: 21559701.
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Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by .

International journal of environmental health research

Bhattacharyya S, Law S.
PMID: 34420458
Int J Environ Health Res. 2021 Aug 22;1-15. doi: 10.1080/09603123.2021.1969341. Epub 2021 Aug 22.

Exposure to N-nitroso compounds (NOCs) in our environment via pesticides, tobacco, and smoked meat can be potentially carcinogenic. The induction of N-N' ethylnitrosourea (ENU), a genotoxic NOC, leads to leukemogenesis. The study aimed to explore the ameliorating effect of...

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Bhattacharyya S, Law S. Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by . Int J Environ Health Res. 2021;1-15doi: 10.1080/09603123.2021.1969341.
Bhattacharyya, S., & Law, S. (2021). Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by . International journal of environmental health research, 1-15. https://doi.org/10.1080/09603123.2021.1969341
Bhattacharyya, Subhashree, and Law, Sujata. "Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by ." International journal of environmental health research vol. (2021): 1-15. doi: https://doi.org/10.1080/09603123.2021.1969341
Bhattacharyya S, Law S. Environmental pollutant ENU induced leukemic NF-kB signaling amelioration by . Int J Environ Health Res. 2021 Aug 22;1-15. doi: 10.1080/09603123.2021.1969341. Epub 2021 Aug 22. PMID: 34420458.
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