Chembiochem : a European journal of chemical biology
Gu Y, Ni X, Ren J, Gao H, Wang D, Xia H.
Chembiochem. 2015 Sep 07;16(13):1933-1942. doi: 10.1002/cbic.201500258. Epub 2015 Jul 14.
Gentamicin is a broad-spectrum aminoglycoside antibiotic widely used to treat life-threatening bacterial infections. The gentamicin C complex consists of gentamicin C1, gentamicin C1a, and epimers gentamicin C2 and gentamicin C2a. At present there is a generally accepted pathway of...
Clinical and experimental otorhinolaryngology
Lee JY, Lee SH, Chang JW, Song JJ, Jung HH, Im GJ.
Clin Exp Otorhinolaryngol. 2014 Dec;7(4):286-94. doi: 10.3342/ceo.2014.7.4.286. Epub 2014 Nov 14.
OBJECTIVES: One of the antidiabetic drugs, metformin, have shown that it prevented oxidative stress-induced death in several cell types through a mechanism involving the opening of the permeability transition pore and cytochrome c release. Thus, it is possible that...
Korean journal of anesthesiology
Rhee WJ, Lee SY, Lee JH, Choi SR, Lee SC, Lee JH, Lee SI.
Korean J Anesthesiol. 2015 Feb;68(1):50-61. doi: 10.4097/kjae.2015.68.1.50. Epub 2015 Jan 28.
BACKGROUND: Magnesium, ropivacaine, gentamicin, and rocuronium block neuromuscular (NM) transmission by different mechanisms. Therefore, concurrent administration of these agents may induce prolonged muscle paralysis via synergistic interaction. This study investigated the efficacy and safety of NM block caused by...
Ibrahim MI, Abdelrahim HE, Ab Rahman AF.
Pharm Pract (Granada). 2014 Jan;12(1):372. doi: 10.4321/s1886-36552014000100006. Epub 2014 Mar 24.
BACKGROUND: Therapeutic drug monitoring (TDM) makes use of serum drug concentrations as an adjunct to decision-making. Preliminary data in our hospital showed that approximately one-fifth of all drugs monitored by TDM service were gentamicin.OBJECTIVE: In this study, we evaluated...
International journal of preventive medicine
Al-Kuraishy HM, Al-Gareeb AI, Al-Nami MS.
Int J Prev Med. 2019 Aug 12;10:142. doi: 10.4103/ijpvm.IJPVM_5_19. eCollection 2019.
BACKGROUND: Gentamicin-induced-acute kidney injury (AKI) is a multifaceted phenomenon which previously linked to the oxidative stress only. Vinpocetine prevents reactive free radical generation which contributed in reduction of damage. Therefore, objective of the present study was to investigate the...