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Showing 1 to 12 of 87 entries
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Alveolar Rhabdomyosarcoma in a 69-Year-Old Woman Receiving Glucagon-Like Peptide-2 Therapy.

Case reports in oncological medicine

Zyczynski LE, McHugh JB, Gribbin TE, Schuetze SM.
PMID: 26266067
Case Rep Oncol Med. 2015;2015:107479. doi: 10.1155/2015/107479. Epub 2015 Jul 22.

A 69-year-old woman was diagnosed with alveolar rhabdomyosarcoma (ARMS) of the nasopharynx. She has a history of catastrophic thromboembolic event in the abdomen that caused short-gut syndrome and dependence on total parenteral nutrition (TPN) twelve hours per day. She...

Effects of benzoic acid (VevoVitall®) on the performance and jejunal digestive physiology in young pigs.

Journal of animal science and biotechnology

Diao H, Gao Z, Yu B, Zheng P, He J, Yu J, Huang Z, Chen D, Mao X.
PMID: 27239300
J Anim Sci Biotechnol. 2016 May 28;7:32. doi: 10.1186/s40104-016-0091-y. eCollection 2016.

BACKGROUND: As a organic acid, benzoic acid has become one of the most important alternatives for antibiotics, and its beneficial effect on performance in animals has been proven for a decade. However, knowledge of the effects of benzoic acid...

New advances in the molecular and cellular biology of the small intestine.

Current opinion in gastroenterology

Walters JR.
PMID: 17033281
Curr Opin Gastroenterol. 2002 Mar;18(2):161-7. doi: 10.1097/00001574-200203000-00002.

Research into the structure and function of the small intestinal mucosa is becoming increasingly focused on the molecular and cellular biology of this fascinating tissue. There is a growing understanding of the factors determining the expression of specific genes...

Short bowel syndrome.

Current treatment options in gastroenterology

Parekh NR, Steiger E.
PMID: 17298760
Curr Treat Options Gastroenterol. 2007 Feb;10(1):10-23. doi: 10.1007/s11938-007-0052-9.

Treatment of short bowel syndrome (SBS) is often a difficult endeavor due to the high variability among patients with SBS in regard to remaining anatomical structure and functional capacity. Research efforts to substantiate the use of existing therapies in...

The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing.

Gastroenterology research and practice

Redstone HA, Buie WD, Hart DA, Wallace L, Hornby PJ, Sague S, Holst JJ, Sigalet DL.
PMID: 20953406
Gastroenterol Res Pract. 2010;2010. doi: 10.1155/2010/672453. Epub 2010 Oct 04.

Background. Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown. We used a rat model of colonic healing, under normoxic, and stress (hypoxic) conditions to examine the effect...

Short bowel patients treated for two years with glucagon-like Peptide 2: effects on intestinal morphology and absorption, renal function, bone and body composition, and muscle function.

Gastroenterology research and practice

Jeppesen PB, Lund P, Gottschalck IB, Nielsen HB, Holst JJ, Mortensen J, Poulsen SS, Quistorff B, Mortensen PB.
PMID: 19707516
Gastroenterol Res Pract. 2009;2009:616054. doi: 10.1155/2009/616054. Epub 2009 Aug 20.

BACKGROUND AND AIMS: In a short-term study, Glucagon-like peptide 2 (GLP-2) has been shown to improve intestinal absorption in short bowel syndrome (SBS) patients. This study describes longitudinal changes in relation to GLP-2 treatment for two years.METHODS: GLP-2, 400...

Glucagon-like Peptide 2.

Trends in endocrinology and metabolism: TEM

Drucker DJ.
PMID: 10322410
Trends Endocrinol Metab. 1999 May;10(4):153-156. doi: 10.1016/s1043-2760(98)00136-2.

Glucagon-like peptide 2 (GLP-2) is secreted in a nutrient-dependent manner from enteroendocrine cells throughout the gastrointestinal tract and is trophic to the intestinal epithelial mucosa. GLP-2 acts via stimulation of crypt cell proliferation and inhibition of cell death. GLP-2...

Glucagon-Like Peptide-2 and the Enteric Nervous System Are Components of Cell-Cell Communication Pathway Regulating Intestinal Na.

Frontiers in nutrition

Moran AW, Al-Rammahi MA, Batchelor DJ, Bravo DM, Shirazi-Beechey SP.
PMID: 30416998
Front Nutr. 2018 Oct 26;5:101. doi: 10.3389/fnut.2018.00101. eCollection 2018.

The Na

GLP-2 administration in ovariectomized mice enhances collagen maturity but did not improve bone strength.

Bone reports

Gobron B, Bouvard B, Legrand E, Chappard D, Mabilleau G.
PMID: 32071954
Bone Rep. 2020 Feb 05;12:100251. doi: 10.1016/j.bonr.2020.100251. eCollection 2020 Jun.

Osteoporosis and bone fragility are progressing worldwide. Previous published literature reported a possible beneficial role of gut hormones, and especially glucagon-like peptide-2 (GLP-2), in modulating bone remodeling. As now (Gly

The roles of the glucagon-like peptide-2 and the serum TGF-β1 levels in the intestinal barrier and immune functions in rats with obstructive jaundice.

American journal of translational research

Wang C, Fan W, Feng X, Zhang Y, Liu C, Liu Z.
PMID: 34650714
Am J Transl Res. 2021 Sep 15;13(9):10449-10458. eCollection 2021.

OBJECTIVE: To determine the mechanisms by which glucagon-like peptide-2 (GLP-2) impacts the intestinal barrier function, the immune function, and the serum transforming growth factor-β1 (TGF-β1) levels in rats with obstructive jaundice.METHODS: Overall, 72 SPF-grade healthy Wistar rats were randomly...

The Discovery of GLP-2 and Development of Teduglutide for Short Bowel Syndrome.

ACS pharmacology & translational science

Drucker DJ.
PMID: 32219218
ACS Pharmacol Transl Sci. 2019 Mar 01;2(2):134-142. doi: 10.1021/acsptsci.9b00016. eCollection 2019 Apr 12.

The proglucagon gene encodes multiple structurally related peptides with overlapping actions promoting the absorption and assimilation of ingested energy. Notably, glucagon has been developed pharmaceutically to treat hypoglycemia, and glucagon-like peptide-1 (GLP-1) receptor agonists are used for the therapy...

Comments on "Pharmacological Characterization of Apraglutide a Novel Long-Acting Peptidic Glucagon-Like Peptide-2 Agonist for the Treatment of Short Bowel Syndrome".

The Journal of pharmacology and experimental therapeutics

Skarbaliene J, Larsen BD, Berner-Hansen M, Steensberg A.
PMID: 34039655
J Pharmacol Exp Ther. 2021 Jun;377(3):369. doi: 10.1124/jpet.120.000426.

No abstract available.

Showing 1 to 12 of 87 entries