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Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.

World journal of gastrointestinal pharmacology and therapeutics

Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE.
PMID: 26558155
World J Gastrointest Pharmacol Ther. 2015 Nov 06;6(4):213-22. doi: 10.4292/wjgpt.v6.i4.213.

AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate (cGMP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma...

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Shailubhai K, Palejwala V, Arjunan KP, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015;6(4):213-22doi: 10.4292/wjgpt.v6.i4.213.
Shailubhai, K., Palejwala, V., Arjunan, K. P., Saykhedkar, S., Nefsky, B., Foss, J. A., Comiskey, S., Jacob, G. S., & Plevy, S. E. (2015). Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World journal of gastrointestinal pharmacology and therapeutics, 6(4), 213-22. https://doi.org/10.4292/wjgpt.v6.i4.213
Shailubhai, Kunwar, et al. "Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis." World journal of gastrointestinal pharmacology and therapeutics vol. 6,4 (2015): 213-22. doi: https://doi.org/10.4292/wjgpt.v6.i4.213
Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 06;6(4):213-22. doi: 10.4292/wjgpt.v6.i4.213. PMID: 26558155; PMCID: PMC4635161.
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Methylene blue treatment for cytokine release syndrome-associated vasoplegia following a renal transplant with rATG infusion: A case report and literature review.

Experimental and therapeutic medicine

Denny JT, Burr AT, Balzer F, Tse JT, Denny JE, Chyu D.
PMID: 26136914
Exp Ther Med. 2015 May;9(5):1915-1920. doi: 10.3892/etm.2015.2349. Epub 2015 Mar 12.

Rabbit anti-thymocyte globulin (rATG) is an infusion of polyclonal rabbit-derived antibodies against human thymocyte markers, which can be used to prevent and treat acute rejection following organ transplantation. However, the product monograph issued by the manufacturer (Sanofi Canada) reports...

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Denny JT, Burr AT, Balzer F, et al. Methylene blue treatment for cytokine release syndrome-associated vasoplegia following a renal transplant with rATG infusion: A case report and literature review. Exp Ther Med. 2015;9(5):1915-1920doi: 10.3892/etm.2015.2349.
Denny, J. T., Burr, A. T., Balzer, F., Tse, J. T., Denny, J. E., & Chyu, D. (2015). Methylene blue treatment for cytokine release syndrome-associated vasoplegia following a renal transplant with rATG infusion: A case report and literature review. Experimental and therapeutic medicine, 9(5), 1915-1920. https://doi.org/10.3892/etm.2015.2349
Denny, John T, et al. "Methylene blue treatment for cytokine release syndrome-associated vasoplegia following a renal transplant with rATG infusion: A case report and literature review." Experimental and therapeutic medicine vol. 9,5 (2015): 1915-1920. doi: https://doi.org/10.3892/etm.2015.2349
Denny JT, Burr AT, Balzer F, Tse JT, Denny JE, Chyu D. Methylene blue treatment for cytokine release syndrome-associated vasoplegia following a renal transplant with rATG infusion: A case report and literature review. Exp Ther Med. 2015 May;9(5):1915-1920. doi: 10.3892/etm.2015.2349. Epub 2015 Mar 12. PMID: 26136914; PMCID: PMC4471690.
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Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges.

Pulmonary circulation

Lajoie AC, Bonnet S, Provencher S.
PMID: 28597774
Pulm Circ. 2017 Apr-Jun;7(2):312-325. doi: 10.1177/2045893217710639. Epub 2017 May 30.

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by a progressive increase in pulmonary vascular resistance, ultimately leading to right heart failure and death. Throughout the past 20 years, numerous specific pharmacologic agents, including phosphodiesterase-5 inhibitors, endothelin receptor...

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Lajoie AC, Bonnet S, Provencher S. Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges. Pulm Circ. 2017;7(2):312-325doi: 10.1177/2045893217710639.
Lajoie, A. C., Bonnet, S., & Provencher, S. (2017). Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges. Pulmonary circulation, 7(2), 312-325. https://doi.org/10.1177/2045893217710639
Lajoie, Annie-Christine, et al. "Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges." Pulmonary circulation vol. 7,2 (2017): 312-325. doi: https://doi.org/10.1177/2045893217710639
Lajoie AC, Bonnet S, Provencher S. Combination therapy in pulmonary arterial hypertension: recent accomplishments and future challenges. Pulm Circ. 2017 Apr-Jun;7(2):312-325. doi: 10.1177/2045893217710639. Epub 2017 May 30. PMID: 28597774; PMCID: PMC5467950.
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Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, Lim I.
PMID: 27162486
Korean J Physiol Pharmacol. 2016 May;20(3):315-24. doi: 10.4196/kjpp.2016.20.3.315. Epub 2016 Apr 26.

Human cardiac fibroblasts (HCFs) have various voltage-dependent K(+) channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac injury and cardiac remodeling. We investigated whether H2O2 could...

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Bae H, Lee D, Kim YW, et al. Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways. Korean J Physiol Pharmacol. 2016;20(3):315-24doi: 10.4196/kjpp.2016.20.3.315.
Bae, H., Lee, D., Kim, Y. W., Choi, J., Lee, H. J., Kim, S. W., Kim, T., Noh, Y. H., Ko, J. H., Bang, H., & Lim, I. (2016). Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(3), 315-24. https://doi.org/10.4196/kjpp.2016.20.3.315
Bae, Hyemi, et al. "Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 20,3 (2016): 315-24. doi: https://doi.org/10.4196/kjpp.2016.20.3.315
Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, Lim I. Effects of hydrogen peroxide on voltage-dependent K(+) currents in human cardiac fibroblasts through protein kinase pathways. Korean J Physiol Pharmacol. 2016 May;20(3):315-24. doi: 10.4196/kjpp.2016.20.3.315. Epub 2016 Apr 26. PMID: 27162486; PMCID: PMC4860374.
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Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521).

Pulmonary circulation

Frey R, Saleh S, Becker C, Mück W.
PMID: 27162629
Pulm Circ. 2016 Mar;6:S58-65. doi: 10.1086/685019.

Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). This randomized, double-blind, placebo-controlled study investigated the pharmacokinetics of riociguat and its metabolite M1 in young (18-45...

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Frey R, Saleh S, Becker C, et al. Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521). Pulm Circ. 2016;6:S58-65doi: 10.1086/685019.
Frey, R., Saleh, S., Becker, C., & Mück, W. (2016). Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521). Pulmonary circulation, 6S58-65. https://doi.org/10.1086/685019
Frey, Reiner, et al. "Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)." Pulmonary circulation vol. 6 (2016): S58-65. doi: https://doi.org/10.1086/685019
Frey R, Saleh S, Becker C, Mück W. Effects of age and sex on the pharmacokinetics of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521). Pulm Circ. 2016 Mar;6:S58-65. doi: 10.1086/685019. PMID: 27162629; PMCID: PMC4860529.
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The role of nitric oxide in pre-synaptic plasticity and homeostasis.

Frontiers in cellular neuroscience

Hardingham N, Dachtler J, Fox K.
PMID: 24198758
Front Cell Neurosci. 2013 Oct 31;7:190. doi: 10.3389/fncel.2013.00190.

Since the observation that nitric oxide (NO) can act as an intercellular messenger in the brain, the past 25 years have witnessed the steady accumulation of evidence that it acts pre-synaptically at both glutamatergic and GABAergic synapses to alter...

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Hardingham N, Dachtler J, Fox K. The role of nitric oxide in pre-synaptic plasticity and homeostasis. Front Cell Neurosci. 2013;7:190doi: 10.3389/fncel.2013.00190.
Hardingham, N., Dachtler, J., & Fox, K. (2013). The role of nitric oxide in pre-synaptic plasticity and homeostasis. Frontiers in cellular neuroscience, 7190. https://doi.org/10.3389/fncel.2013.00190
Hardingham, Neil, et al. "The role of nitric oxide in pre-synaptic plasticity and homeostasis." Frontiers in cellular neuroscience vol. 7 (2013): 190. doi: https://doi.org/10.3389/fncel.2013.00190
Hardingham N, Dachtler J, Fox K. The role of nitric oxide in pre-synaptic plasticity and homeostasis. Front Cell Neurosci. 2013 Oct 31;7:190. doi: 10.3389/fncel.2013.00190. PMID: 24198758; PMCID: PMC3813972.
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Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center.

Cardiology and therapy

Sulica R, Fenton R, Cefali F.
PMID: 26411969
Cardiol Ther. 2015 Dec;4(2):209-18. doi: 10.1007/s40119-015-0046-y. Epub 2015 Sep 28.

INTRODUCTION: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are rare, life-threatening diseases in which chronically elevated pressure in the pulmonary arteries results in vascular remodeling and right heart failure. Treatment goals are to improve patient functioning,...

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Sulica R, Fenton R, Cefali F. Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center. Cardiol Ther. 2015;4(2):209-18doi: 10.1007/s40119-015-0046-y.
Sulica, R., Fenton, R., & Cefali, F. (2015). Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center. Cardiology and therapy, 4(2), 209-18. https://doi.org/10.1007/s40119-015-0046-y
Sulica, Roxana, et al. "Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center." Cardiology and therapy vol. 4,2 (2015): 209-18. doi: https://doi.org/10.1007/s40119-015-0046-y
Sulica R, Fenton R, Cefali F. Early Observations on the Use of Riociguat in a Large, Metropolitan Pulmonary Arterial Hypertension/Chronic Thromboembolic Pulmonary Hypertension Treatment Center. Cardiol Ther. 2015 Dec;4(2):209-18. doi: 10.1007/s40119-015-0046-y. Epub 2015 Sep 28. PMID: 26411969; PMCID: PMC4675747.
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Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries.

Pharmacology research & perspectives

Tawa M, Okamura T.
PMID: 27713826
Pharmacol Res Perspect. 2016 Sep 16;4(5):e00261. doi: 10.1002/prp2.261. eCollection 2016 Oct.

Coronary artery disease is associated with oxidative stress due to the excessive generation of free radicals in the vascular wall. This study investigated the impact of tert-butyl hydroperoxide (t-BuOOH), a peroxyl radical generator, on the redox state of soluble...

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Tawa M, Okamura T. Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries. Pharmacol Res Perspect. 2016;4(5):e00261doi: 10.1002/prp2.261.
Tawa, M., & Okamura, T. (2016). Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries. Pharmacology research & perspectives, 4(5), e00261. https://doi.org/10.1002/prp2.261
Tawa, Masashi, and Okamura, Tomio. "Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries." Pharmacology research & perspectives vol. 4,5 (2016): e00261. doi: https://doi.org/10.1002/prp2.261
Tawa M, Okamura T. Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteries. Pharmacol Res Perspect. 2016 Sep 16;4(5):e00261. doi: 10.1002/prp2.261. eCollection 2016 Oct. PMID: 27713826; PMCID: PMC5045941.
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Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications.

Healthcare (Basel, Switzerland)

McCarty MF.
PMID: 28335416
Healthcare (Basel). 2017 Mar 14;5(1). doi: 10.3390/healthcare5010015.

Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine...

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McCarty MF. Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare (Basel). 2017;5(1)doi: 10.3390/healthcare5010015.
McCarty, M. F. (2017). Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare (Basel, Switzerland), 5(1), . https://doi.org/10.3390/healthcare5010015
McCarty, Mark F. "Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications." Healthcare (Basel, Switzerland) vol. 5,1 (2017). doi: https://doi.org/10.3390/healthcare5010015
McCarty MF. Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin-Potential for Preventing or Slowing the Progression of Diabetic Complications. Healthcare (Basel). 2017 Mar 14;5(1). doi: 10.3390/healthcare5010015. PMID: 28335416; PMCID: PMC5371921.
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Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency.

Asian Pacific journal of tropical medicine

Liu XX, Shi Y.
PMID: 25902033
Asian Pac J Trop Med. 2015 Feb;8(2):162-8. doi: 10.1016/S1995-7645(14)60309-6.

OBJECTIVE: To investigate effects of herbal compound Yi Tang Kang on the spleen deficiency metabolic syndrome.METHODS: Forty male Wistar rats were randomly divided into two groups: the normal control group and the MS spleen deficiency syndrome group. The control...

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Liu XX, Shi Y. Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency. Asian Pac J Trop Med. 2015;8(2):162-8doi: 10.1016/S1995-7645(14)60309-6.
Liu, X. X., & Shi, Y. (2015). Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency. Asian Pacific journal of tropical medicine, 8(2), 162-8. https://doi.org/10.1016/S1995-7645(14)60309-6
Liu, Xiao-Xi, and Shi, Yan. "Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency." Asian Pacific journal of tropical medicine vol. 8,2 (2015): 162-8. doi: https://doi.org/10.1016/S1995-7645(14)60309-6
Liu XX, Shi Y. Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency. Asian Pac J Trop Med. 2015 Feb;8(2):162-8. doi: 10.1016/S1995-7645(14)60309-6. PMID: 25902033.
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7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice.

Drug target insights

Mutlu O, Akar F, Celikyurt IK, Tanyeri P, Ulak G, Erden F.
PMID: 25788830
Drug Target Insights. 2015 Mar 04;9:1-8. doi: 10.4137/DTI.S23378. eCollection 2015.

Nitric oxide (NO) is an atypical neurotransmitter that causes changes in cognition. Nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibitors have been shown to exert some effects on cognition in previous studies; however, the findings have been controversial....

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Mutlu O, Akar F, Celikyurt IK, et al. 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug Target Insights. 2015;9:1-8doi: 10.4137/DTI.S23378.
Mutlu, O., Akar, F., Celikyurt, I. K., Tanyeri, P., Ulak, G., & Erden, F. (2015). 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug target insights, 91-8. https://doi.org/10.4137/DTI.S23378
Mutlu, Oguz, et al. "7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice." Drug target insights vol. 9 (2015): 1-8. doi: https://doi.org/10.4137/DTI.S23378
Mutlu O, Akar F, Celikyurt IK, Tanyeri P, Ulak G, Erden F. 7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice. Drug Target Insights. 2015 Mar 04;9:1-8. doi: 10.4137/DTI.S23378. eCollection 2015. PMID: 25788830; PMCID: PMC4354329.
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Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles.

Pathophysiology : the official journal of the International Society for Pathophysiology

Domali A, Gourgoulianis KI, Molyvdas PA.
PMID: 10825681
Pathophysiology. 2000 Apr;7(1):21-23. doi: 10.1016/s0928-4680(99)00032-2.

The objective of the study was to investigate the effect of endothelin-1 (ET-1) on KCl-induced contractions. Tracheal strips were obtained from 12 male rabbits, perfused with Krebs solution and aerated continuously by bubbling with a mixture of 95% O(2)-5%...

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Domali A, Gourgoulianis KI, Molyvdas PA. Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles. Pathophysiology. 2000;7(1):21-23doi: 10.1016/s0928-4680(99)00032-2.
Domali, A., Gourgoulianis, K. I., & Molyvdas, P. A. (2000). Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles. Pathophysiology : the official journal of the International Society for Pathophysiology, 7(1), 21-23. https://doi.org/10.1016/s0928-4680(99)00032-2
Domali, et al. "Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 7,1 (2000): 21-23. doi: https://doi.org/10.1016/s0928-4680(99)00032-2
Domali A, Gourgoulianis KI, Molyvdas PA. Effects of endothelin-1 on KCl-induced contractions of airway smooth muscles. Pathophysiology. 2000 Apr;7(1):21-23. doi: 10.1016/s0928-4680(99)00032-2. PMID: 10825681.
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Showing 1 to 12 of 354 entries