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Showing 1 to 12 of 68 entries
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Urine creatinine concentration and clinical outcomes in older adults: The Cardiovascular Health Study.

Journal of the American Geriatrics Society

Barzilay JI, Buzkova P, Shlipak MG, Lyles MF, Bansal N, Garimella PS, Ix JH, Kizer JR, Strotmeyer ES, Djousse L, Biggs ML, Siscovick D, Mukamal KJ.
PMID: 34363689
J Am Geriatr Soc. 2021 Dec;69(12):3486-3496. doi: 10.1111/jgs.17388. Epub 2021 Aug 07.

PURPOSE: Loss of muscle mass and strength are associated with long-term adverse health outcomes in older adults. Urine creatinine concentrations (Ucr; mg/dl) are a measure of muscle tissue mass and turnover. This study assessed the associations of a spot...

Associations of body size and composition with subclinical cardiac dysfunction in older individuals: the cardiovascular health study.

International journal of obesity (2005)

Garg PK, Biggs ML, Kizer JR, Shah SJ, Djousse L, Mukamal KJ.
PMID: 34349227
Int J Obes (Lond). 2021 Dec;45(12):2539-2545. doi: 10.1038/s41366-021-00926-y. Epub 2021 Aug 04.

BACKGROUND: Focused studies in younger to middle-aged populations have demonstrated a relationship between obesity and adverse cardiac mechanics. We examined whether measures of overall and central adiposity are associated with cardiac mechanics, assessed by speckle-tracking echocardiography, in an older...

Serum Nonesterified Fatty Acids and Incident Stroke: The CHS.

Journal of the American Heart Association

Huang NK, Biggs ML, Matthan NR, Djoussé L, Longstreth WT, Mukamal KJ, Siscovick DS, Lichtenstein AH.
PMID: 34755529
J Am Heart Assoc. 2021 Nov 16;10(22):e022725. doi: 10.1161/JAHA.121.022725. Epub 2021 Nov 10.

Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and

Blood Pressure Levels in Young Adulthood and Midlife Stroke Incidence in a Diverse Cohort.

Hypertension (Dallas, Tex. : 1979)

Gerber Y, Rana JS, Jacobs DR, Yano Y, Levine DA, Nguyen-Huynh MN, Lima JAC, Reis JP, Zhao L, Liu K, Lewis CE, Sidney S.
PMID: 33775116
Hypertension. 2021 May 05;77(5):1683-1693. doi: 10.1161/HYPERTENSIONAHA.120.16535. Epub 2021 Mar 29.

[Figure: see text].

Serum Nonesterified Fatty Acids and Incident Stroke: The CHS.

Journal of the American Heart Association

Huang NK, Biggs ML, Matthan NR, Djoussé L, Longstreth WT, Mukamal KJ, Siscovick DS, Lichtenstein AH.
PMID: 34755529
J Am Heart Assoc. 2021 Nov 16;10(22):e022725. doi: 10.1161/JAHA.121.022725. Epub 2021 Nov 10.

Background Significant associations between total nonesterified fatty acid (NEFA) concentrations and incident stroke have been reported in some prospective cohort studies. We evaluated the associations between incident stroke and serum concentrations of nonesterified saturated, monounsaturated, polyunsaturated, and

Pre-Statistical Considerations for Harmonization of Cognitive Instruments: Harmonization of ARIC, CARDIA, CHS, FHS, MESA, and NOMAS.

Journal of Alzheimer's disease : JAD

Briceño EM, Gross AL, Giordani BJ, Manly JJ, Gottesman RF, Elkind MSV, Sidney S, Hingtgen S, Sacco RL, Wright CB, Fitzpatrick A, Fohner AE, Mosley TH, Yaffe K, Levine DA.
PMID: 34459397
J Alzheimers Dis. 2021;83(4):1803-1813. doi: 10.3233/JAD-210459.

BACKGROUND: Meta-analyses of individuals' cognitive data are increasing to investigate the biomedical, lifestyle, and sociocultural factors that influence cognitive decline and dementia risk. Pre-statistical harmonization of cognitive instruments is a critical methodological step for accurate cognitive data harmonization, yet...

Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.

Clinical epigenetics

Do WL, Nguyen S, Yao J, Guo X, Whitsel EA, Demerath E, Rotter JI, Rich SS, Lange L, Ding J, Van Den Berg D, Liu Y, Justice AE, Guan W, Horvath S, Assimes TL, Bhatti P, Jordahl K, Shadyab A, Valencia CI, Stein AD, Smith A, Staimez LR, Conneely K, Narayan KMV.
PMID: 34937574
Clin Epigenetics. 2021 Dec 22;13(1):230. doi: 10.1186/s13148-021-01194-3.

BACKGROUND: Body mass index (BMI), a well-known risk factor for poor cardiovascular outcomes, is associated with differential DNA methylation (DNAm). Similarly, metabolic health has also been associated with changes in DNAm. It is unclear how overall metabolic health outside...

Blood cancer discovery

Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Gallì A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Desai P, Cho MH, Johnson AD, Loos R, MacArthur DG, Lek M, Neuberg DS, Lage K, Carr SA, Hellstrom-Lindberg E, Malcovati L, Papaemmanuil E, Stewart C, Getz G, Bradley RK, Jaiswal S, Ebert BL.
PMID: 34568833
Blood Cancer Discov. 2021 Sep;2(5):500-517. doi: 10.1158/2643-3230.BCD-20-0224. Epub 2021 Jul 14.

Clonal hematopoiesis results from somatic mutations in cancer driver genes in hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis of sequencing data from 84,683 persons and identified common mutations in the...

Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation.

Blood

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook-Kanamori DO, Deleuze JF, Johnson A, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Trégouët DA, Morange PE.
PMID: 33512453
Blood. 2021 Apr 29;137(17):2394-2402. doi: 10.1182/blood.2020008997.

Genetic risk score (GRS) analysis is a popular approach to derive individual risk prediction models for complex diseases. In venous thrombosis (VT), such type of analysis shall integrate information at the ABO blood group locus, which is one of...

Comparison of whole genome sequencing and targeted sequencing for mitochondrial DNA.

Mitochondrion

Chen R, Aldred MA, Xu W, Zein J, Bazeley P, Comhair SAA, Meyers DA, Bleecker ER, Liu C, Erzurum SC, Hu B.
PMID: 33513442
Mitochondrion. 2021 May;58:303-310. doi: 10.1016/j.mito.2021.01.006. Epub 2021 Jan 26.

Mitochondrial dysfunction has emerged to be associated with a broad spectrum of diseases, and there is an increasing demand for accurate detection of mitochondrial DNA (mtDNA) variants. Whole genome sequencing (WGS) has been the dominant sequencing approach to identify...

Effect of Sickle Cell Trait and .

Clinical journal of the American Society of Nephrology : CJASN

Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N.
PMID: 33268503
Clin J Am Soc Nephrol. 2021 Feb 08;16(2):287-289. doi: 10.2215/CJN.12100720. Epub 2020 Dec 02.

No abstract available.

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women.

Circulation

Honigberg MC, Zekavat SM, Niroula A, Griffin GK, Bick AG, Pirruccello JP, Nakao T, Whitsel EA, Farland LV, Laurie C, Kooperberg C, Manson JE, Gabriel S, Libby P, Reiner AP, Ebert BL, Natarajan P.
PMID: 33161765
Circulation. 2021 Feb 02;143(5):410-423. doi: 10.1161/CIRCULATIONAHA.120.051775. Epub 2020 Nov 09.

BACKGROUND: Premature menopause is an independent risk factor for cardiovascular disease in women, but mechanisms underlying this association remain unclear. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of hematopoietic cells with leukemogenic mutations without detectable malignancy, is...

Showing 1 to 12 of 68 entries