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The Hepatocyte nuclear factor-1 alpha ( HNF1A) gene is associated with fatness and loin muscle area in the pig.

Animal : an international journal of animal bioscience

Fan B, Du ZQ, Rothschild MF.
PMID: 22445113
Animal. 2010 Oct;4(10):1619-27. doi: 10.1017/S175173111000087X.

The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY). Common Hepatocyte nuclear factor-1 alpha (HNF1A),...

The Hepatocyte nuclear factor-1 alpha ( HNF1A) gene is associated with fatness and loin muscle area in the pig.

Animal : an international journal of animal bioscience

Fan B, Du ZQ, Rothschild MF.
PMID: 22445113
Animal. 2010 Oct;4(10):1619-27. doi: 10.1017/S175173111000087X.

The significance of hepatocyte nuclear factors (HNFs) in β-cell development and function has been generally recognized in humans, as evidenced by their associations with cases of maturity onset diabetes of the young (MODY). Common Hepatocyte nuclear factor-1 alpha (HNF1A),...

Effects of C2-Ceramide and Oltipraz on Hepatocyte Nuclear Factor-1 and Glutathione S-Transferase A1 in Acetaminophen-Mediated Acute Mice Liver Injury.

Frontiers in pharmacology

Ma X, Chang Y, Zhang Y, Muhammad I, Shi C, Li R, Li C, Li Z, Lin Y, Han Q, Liu F.
PMID: 30254584
Front Pharmacol. 2018 Sep 11;9:1009. doi: 10.3389/fphar.2018.01009. eCollection 2018.

In this study, acetaminophen (APAP)-induced acute liver injury mice model was used to investigate the effects of C2-ceramide and oltipraz on hepatocyte nuclear factor 1 (HNF-1) and glutathione S-transferase A1 (GSTA1). Notably, C2-ceramide caused alteration in mice serum transaminases...

Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis.

FEBS letters

Cai C, Bi D, Bick G, Wei Q, Liu H, Lu L, Zhang X, Qin H.
PMID: 34719039
FEBS Lett. 2021 Oct 31; doi: 10.1002/1873-3468.14219. Epub 2021 Oct 31.

Super-enhancers (SEs) play essential roles in colorectal cancer (CRC) progression. However, how the SE landscape is orchestrated by transcriptional regulators and evolves is not clear. Using de novo motif analysis, we show that the hepatocyte nuclear factor 1 (HNF1)-binding...

Molecular diagnosis of maturity onset diabetes of the young in Iranian patients: improving management.

Journal of diabetes and metabolic disorders

Davoudi F, Aminzadeh M, Shahbazian HB, Bijanzadeh M, Ghadiri AA, Ghandil P.
PMID: 34900788
J Diabetes Metab Disord. 2021 Aug 19;20(2):1369-1374. doi: 10.1007/s40200-021-00870-8. eCollection 2021 Dec.

BACKGROUND: The purpose of this study is to identify the mutations of the most common form of maturity-onset diabetes of the young (MODY), also known as MODY3, in diabetic patients suspected of MODY. This can recommend appropriate medical surveillance...

Maturity-onset diabetes of the young type 5, presenting as diabetic ketoacidosis with alkalemia: A report of a case.

Journal of diabetes investigation

Hayakawa-Iwamoto A, Aotani D, Shimizu Y, Kakoi S, Hasegawa C, Itoh S, Fujii A, Takeda K, Yagi T, Koyama H, Imaeda K, Nozu K, Nagano C, Kataoka H, Tanaka T.
PMID: 34931465
J Diabetes Investig. 2021 Dec 20; doi: 10.1111/jdi.13737. Epub 2021 Dec 20.

A 34-year-old man visited our Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, because of dry mouth and weight loss. His plasma glucose level was 32.8 mmol/L and serum levels of ketone...

Clinicopathological features and post-resection outcomes of hepatocellular adenoma.

Annals of hepato-biliary-pancreatic surgery

Kim SM, Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Park GC, Hong SM.
PMID: 33649251
Ann Hepatobiliary Pancreat Surg. 2021 Feb 28;25(1):25-33. doi: 10.14701/ahbps.2021.25.1.25.

BACKGROUNDS/AIMS: Hepatocellular adenomas (HCA) are rare benign liver tumors with the potential of malignant transformation and risk of bleeding. We investigated the clinicopathological features and outcomes of HCA in 19 patients who underwent surgical resection.METHODS: This retrospective observational study...

Hepatocyte nuclear factor HNF1A is a potential regulator in shaping the super-enhancer landscape in colorectal cancer liver metastasis.

FEBS letters

Cai C, Bi D, Bick G, Wei Q, Liu H, Lu L, Zhang X, Qin H.
PMID: 34719039
FEBS Lett. 2021 Dec;595(24):3056-3071. doi: 10.1002/1873-3468.14219. Epub 2021 Nov 22.

Super-enhancers (SEs) play essential roles in colorectal cancer (CRC) progression. However, how the SE landscape is orchestrated by transcriptional regulators and evolves is not clear. Using de novo motif analysis, we show that the hepatocyte nuclear factor 1 (HNF1)-binding...

Maturity-onset diabetes of the young (MODY) type 5, presenting as diabetic ketoacidosis with alkalemia - A report of a case.

Journal of diabetes investigation

Hayakawa-Iwamoto A, Aotani D, Shimizu Y, Kakoi S, Hasegawa C, Itoh S, Fujii A, Takeda K, Yagi T, Koyama H, Imaeda K, Nozu K, Nagano C, Kataoka H, Tanaka T.
PMID: 34931465
J Diabetes Investig. 2021 Dec 20; doi: 10.1111/jdi.13737. Epub 2021 Dec 20.

A 34-year-old man visited our hospital because of dry mouth and weight loss. His plasma glucose level was 32.8 mmol/L and serum levels of ketone bodies were increased, but with metabolic alkalemia. He was also suffering from renal tubular...

Hepatocyte Nuclear Factor 1 Beta Mutation-associated Newborn Onset of Glomerulocystic Kidney Disease: A Case Presentation.

Medeniyet medical journal

Goknar N, Ekici Avci M, Uckardes D, Kelesoglu E, Tekkus Ermis K, Candan C.
PMID: 34939403
Medeni Med J. 2021 Dec 19;36(4):352-355. doi: 10.4274/MMJ.galenos.2021.02686.

Mutations in hepatocyte nuclear factor-1 beta (

HNF1A-AS1 Regulates Cell Migration, Invasion and Glycolysis via Modulating miR-124/MYO6 in Colorectal Cancer Cells.

OncoTargets and therapy

Guo X, Zhang Y, Liu L, Yang W, Zhang Q.
PMID: 32110048
Onco Targets Ther. 2020 Feb 18;13:1507-1518. doi: 10.2147/OTT.S231249. eCollection 2020.

BACKGROUND: Accumulating evidence determined that lncRNAs play multiple roles in cell progression in colorectal cancer (CRC). Long noncoding RNA (lncRNA) hepatocyte nuclear factor 1 homeobox A (HNF1A)-antisense RNA 1 (AS1) has been identified to affect cell growth and disease...

Genetic markers of inflammation may not contribute to metabolic traits in Mexican children.

PeerJ

Vashi N, Stryjecki C, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D.
PMID: 27366637
PeerJ. 2016 Jun 23;4:e2090. doi: 10.7717/peerj.2090. eCollection 2016.

BACKGROUND: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity rates in...

Showing 1 to 12 of 42 entries