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Showing 1 to 12 of 165 entries
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Long noncoding RNAs in cancer: from function to translation.

Trends in cancer

Sahu A, Singhal U, Chinnaiyan AM.
PMID: 26693181
Trends Cancer. 2015 Oct 01;1(2):93-109. doi: 10.1016/j.trecan.2015.08.010.

While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that...

Corrigendum: Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development.

Nature cell biology

Henninger J, Santoso B, Hans S, Durand E, Moore J, Mosimann C, Brand M, Traver D, Zon L.
PMID: 28139650
Nat Cell Biol. 2017 Jan 31;19(2):142. doi: 10.1038/ncb3462.

No abstract available.

Prospective Optimization.

Proceedings of the IEEE. Institute of Electrical and Electronics Engineers

Sejnowski TJ, Poizner H, Lynch G, Gepshtein S, Greenspan RJ.
PMID: 25328167
Proc IEEE Inst Electr Electron Eng. 2014 May;102(5). doi: 10.1109/JPROC.2014.2314297.

Human performance approaches that of an ideal observer and optimal actor in some perceptual and motor tasks. These optimal abilities depend on the capacity of the cerebral cortex to store an immense amount of information and to flexibly make...

Regulating Cortical Oscillations in an Inhibition-Stabilized Network.

Proceedings of the IEEE. Institute of Electrical and Electronics Engineers

Jadi MP, Sejnowski TJ.
PMID: 24966414
Proc IEEE Inst Electr Electron Eng. 2014 Apr 21;102(5). doi: 10.1109/JPROC.2014.2313113.

Understanding the anatomical and functional architecture of the brain is essential for designing neurally inspired intelligent systems. Theoretical and empirical studies suggest a role for narrowband oscillations in shaping the functional architecture of the brain through their role in...

Biocompatible and High Stiffness Nanophotonic Trap Array for Precise and Versatile Manipulation.

Nano letters

Ye F, Badman RP, Inman JT, Soltani M, Killian JL, Wang MD.
PMID: 27689302
Nano Lett. 2016 Oct 12;16(10):6661-6667. doi: 10.1021/acs.nanolett.6b03470. Epub 2016 Sep 30.

The advent of nanophotonic evanescent field trapping and transport platforms has permitted increasingly complex single molecule and single cell studies on-chip. Here, we present the next generation of nanophotonic Standing Wave Array Traps (nSWATs) representing a streamlined CMOS fabrication...

Efficient and direct estimation of a neural subunit model for sensory coding.

Advances in neural information processing systems

Vintch B, Zaharia AD, Movshon JA, Simoncelli EP.
PMID: 26273181
Adv Neural Inf Process Syst. 2012 Dec;25:3113-3121.

Many visual and auditory neurons have response properties that are well explained by pooling the rectified responses of a set of spatially shifted linear filters. These filters cannot be estimated using spike-triggered averaging (STA). Subspace methods such as spike-triggered...

A Bayesian Model of Conditioned Perception.

Advances in neural information processing systems

Stocker AA, Simoncelli EP.
PMID: 25328364
Adv Neural Inf Process Syst. 2007;2007:1409-1416.

We argue that in many circumstances, human observers evaluate sensory evidence simultaneously under multiple hypotheses regarding the physical process that has generated the sensory information. In such situations, inference can be optimal if an observer combines the evaluation results...

Insights from a Convocation: Integrating Discovery-Based Research into the Undergraduate Curriculum.

CBE life sciences education

Elgin SC, Bangera G, Decatur SM, Dolan EL, Guertin L, Newstetter WC, San Juan EF, Smith MA, Weaver GC, Wessler SR, Brenner KA, Labov JB.
PMID: 27146158
CBE Life Sci Educ. 2016;15(2). doi: 10.1187/cbe.16-03-0118.

No abstract available.

Visualizing a protein's sugars.

National science review

He C.
PMID: 26114009
Natl Sci Rev. 2014 Dec;1(4):480-481. doi: 10.1093/nsr/nwu046.

No abstract available.

Complex Cell-like Direction Selectivity through Spike-Timing Dependent Plasticity.

IETE journal of research

Rao RP, Sejnowski TJ.
PMID: 21057672
IETE J Res. 2003 Jan 01;49(2):97-111. doi: 10.1080/03772063.2003.11416329.

Complex cells in primary visual cortex exhibit highly nonlinear receptive field properties such as phase-invariant direction selectivity and antagonistic interactions between individually excitatory stimuli. Traditional models assume that these properties are governed by the outputs of antecedent simple cells,...

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.

Nature communications

Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE.
PMID: 21224844
Nat Commun. 2011 Jan 11;2:153. doi: 10.1038/ncomms1153.

Calcium signalling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca(2+). Cation channels of sperm proteins (CATSPERS1-4) form an alkalinization-activated Ca(2+)-selective channel required for the...

Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs.

Neurocomputing

Kretzberg J, Sejnowski T, Warzecha AK, Egelhaaf M.
PMID: 20871738
Neurocomputing. 2003 Jun 01;52:313-320. doi: 10.1016/S0925-2312(02)00797-X.

A conductance-based model for synaptic transmission and postsynaptic integration reveals how postsynaptic responses and their variability depend on the number of synaptic inputs. With increasing number of balanced stochastic excitatory and inhibitory inputs, the postsynaptic responses and their variance...

Showing 1 to 12 of 165 entries