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Sahu A, Singhal U, Chinnaiyan AM. Long noncoding RNAs in cancer: from function to translation. Trends Cancer. 2015;1(2):93-109doi: 10.1016/j.trecan.2015.08.010.
Sahu, A., Singhal, U., & Chinnaiyan, A. M. (2015). Long noncoding RNAs in cancer: from function to translation. Trends in cancer, 1(2), 93-109. https://doi.org/10.1016/j.trecan.2015.08.010
Sahu, Anirban, et al. "Long noncoding RNAs in cancer: from function to translation." Trends in cancer vol. 1,2 (2015): 93-109. doi: https://doi.org/10.1016/j.trecan.2015.08.010
Sahu A, Singhal U, Chinnaiyan AM. Long noncoding RNAs in cancer: from function to translation. Trends Cancer. 2015 Oct 01;1(2):93-109. doi: 10.1016/j.trecan.2015.08.010. PMID: 26693181; PMCID: PMC4672369.
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Trends Cancer. 2015 Oct 01;1(2):93-109. doi: 10.1016/j.trecan.2015.08.010.

Long noncoding RNAs in cancer: from function to translation.

Trends in cancer

Anirban Sahu, Udit Singhal, Arul M Chinnaiyan

Affiliations

  1. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan USA. ; Department of Pathology, University of Michigan, Ann Arbor, Michigan USA.
  2. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan USA. ; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan USA.
  3. Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan USA. ; Department of Pathology, University of Michigan, Ann Arbor, Michigan USA. ; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, Michigan USA. ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan USA. ; Department of Urology, University of Michigan, Ann Arbor, Michigan USA.

PMID: 26693181 PMCID: PMC4672369 DOI: 10.1016/j.trecan.2015.08.010

Abstract

While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that populate the cancer genome. A subset of these molecules shows striking cancer- and lineage-specific expression patterns, suggesting they may be potential drivers of cancer biology and have utility as clinical biomarkers. Here, we discuss emerging modalities of lncRNA biology and their interplay with cancer-associated concepts, including epigenetic regulation, DNA damage and cell cycle control, microRNA silencing, signal transduction pathways, and hormone-driven disease. Additionally, we highlight the translational impact of lncRNAs, tools for their mechanistic investigation, and directions for future lncRNA research.

References

  1. Adv Drug Deliv Rev. 2015 Jun 29;87:46-51 - PubMed
  2. Nat Genet. 2013 Jun;45(6):592-601 - PubMed
  3. Oncogene. 2009 Apr 9;28(14 ):1653-68 - PubMed
  4. Nat Struct Mol Biol. 2013 Jul;20(7):908-13 - PubMed
  5. Nat Methods. 2013 Dec;10(12):1177-84 - PubMed
  6. Biomed Res Int. 2013;2013:136106 - PubMed
  7. Oncotarget. 2014 Apr 30;5(8):2276-92 - PubMed
  8. Nature. 2001 May 17;411(6835):349-54 - PubMed
  9. Nat Rev Cancer. 2011 Jun 09;11(7):481-92 - PubMed
  10. Nature. 2014 Jan 16;505(7483):344-52 - PubMed
  11. Oncotarget. 2014 Mar 30;5(6):1434-8 - PubMed
  12. Mol Med Rep. 2013 Mar;7(3):761-6 - PubMed
  13. Cancer Cell. 2014 May 12;25(5):666-81 - PubMed
  14. PLoS One. 2013 Sep 17;8(9):e73991 - PubMed
  15. Mol Cell. 2011 Sep 16;43(6):904-14 - PubMed
  16. Med Oncol. 2014 Dec;31(12):346 - PubMed
  17. Nature. 2011 Apr 7;472(7341):120-4 - PubMed
  18. Int J Clin Exp Pathol. 2014 May 15;7(6):3174-81 - PubMed
  19. Trends Biotechnol. 2013 Jul;31(7):397-405 - PubMed
  20. Nature. 2011 Jan 20;469(7330):343-9 - PubMed
  21. Tumour Biol. 2015 May;36(5):3355-9 - PubMed
  22. Elife. 2014 Aug 14;3:e03058 - PubMed
  23. Nat Rev Genet. 2013 Dec;14(12):853-64 - PubMed
  24. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-9 - PubMed
  25. Genes Dev. 2011 Sep 15;25(18):1915-27 - PubMed
  26. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5633-8 - PubMed
  27. Neoplasia. 2014 Dec;16(12):1121-7 - PubMed
  28. Hepatology. 2011 Nov;54(5):1679-89 - PubMed
  29. J Clin Oncol. 2005 Nov 10;23(32):8253-61 - PubMed
  30. Cell. 2008 Jul 25;134(2):215-30 - PubMed
  31. Mol Cell. 2009 Mar 27;33(6):717-26 - PubMed
  32. Mol Cancer Res. 2015 May;13(5):828-38 - PubMed
  33. Cell. 2012 Mar 30;149(1):22-35 - PubMed
  34. Cancer Res. 2015 Apr 1;75(7):1322-31 - PubMed
  35. Nat Commun. 2014 Nov 19;5:5323 - PubMed
  36. Cancer Cell. 2014 Sep 8;26(3):344-57 - PubMed
  37. J Am Heart Assoc. 2014 Jul 10;3(4):null - PubMed
  38. EMBO J. 2013 Jun 12;32(12 ):1665-80 - PubMed
  39. Elife. 2014 Feb 12;3:e02046 - PubMed
  40. Mol Cell. 2014 Jun 5;54(5):766-76 - PubMed
  41. Nature. 2009 Mar 12;458(7235):223-7 - PubMed
  42. N Engl J Med. 2015 Jan 15;372(3):232-40 - PubMed
  43. Nat Struct Mol Biol. 2013 Nov;20(11):1250-7 - PubMed
  44. Nature. 2011 Feb 10;470(7333):284-8 - PubMed
  45. Cell Res. 2014 May;24(5):513-31 - PubMed
  46. Nat Genet. 2013 Nov;45(11):1392-8 - PubMed
  47. Cancer Res. 2014 Dec 1;74(23):6890-902 - PubMed
  48. Nature. 2014 Oct 2;514(7520):102-6 - PubMed
  49. Eur J Cancer. 2013 Sep;49(13):2949-59 - PubMed
  50. Tumour Biol. 2015 Apr;36(4):2947-55 - PubMed
  51. Carcinogenesis. 2010 Mar;31(3):350-8 - PubMed
  52. Mol Cell. 2013 Mar 28;49(6):1083-96 - PubMed
  53. Carcinogenesis. 2010 Jan;31(1):27-36 - PubMed
  54. Nature. 2015 Feb 19;518(7539):409-12 - PubMed
  55. Neoplasia. 2014 Nov 20;16(11):900-8 - PubMed
  56. Nat Genet. 1995 Apr;9(4):401-6 - PubMed
  57. Genome Res. 2013 Sep;23 (9):1446-61 - PubMed
  58. Nat Biotechnol. 2011 Jul 31;29(8):742-9 - PubMed
  59. Nat Biotechnol. 2013 Jan;31(1):46-53 - PubMed
  60. Trends Cell Biol. 2008 Oct;18(10):505-16 - PubMed
  61. Nucleic Acids Res. 2010 Sep;38(16):5366-83 - PubMed
  62. Oncotarget. 2013 Oct;4(10):1748-62 - PubMed
  63. Biochem Biophys Res Commun. 2014 Jun 6;448(3):315-22 - PubMed
  64. PLoS One. 2013;8(1):e55119 - PubMed
  65. N Engl J Med. 2008 Mar 13;358(11):1148-59 - PubMed
  66. Endocr Rev. 2004 Apr;25(2):276-308 - PubMed
  67. Nature. 2011 Aug 28;477(7364):295-300 - PubMed
  68. Cancer Res. 2011 Oct 15;71(20):6320-6 - PubMed
  69. Hepatology. 2014 Mar;59(3):911-23 - PubMed
  70. Nucleic Acids Res. 2015 May 19;43(9):4447-62 - PubMed
  71. Nature. 2000 Nov 23;408(6811):433-9 - PubMed
  72. Cell. 2011 Mar 4;144(5):646-74 - PubMed
  73. Mol Cell. 2014 Aug 21;55(4):604-14 - PubMed
  74. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72 - PubMed
  75. Mol Cancer Res. 2006 Jun;4(6):379-86 - PubMed
  76. Science. 1998 Apr 24;280(5363):585-90 - PubMed
  77. PLoS One. 2014 Jan 23;9(1):e86295 - PubMed
  78. Cancer Res. 2012 Mar 1;72(5):1126-36 - PubMed
  79. Nat Rev Genet. 2011 Nov 18;12(12):861-74 - PubMed
  80. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11606-11 - PubMed
  81. Mod Pathol. 2013 Feb;26(2):155-65 - PubMed
  82. Genome Res. 2012 Jun;22(6):1006-14 - PubMed
  83. EMBO J. 2012 Nov 28;31(23):4415-27 - PubMed
  84. Nature. 2012 Sep 6;489(7414):101-8 - PubMed
  85. Cancer Res. 2014 Mar 15;74(6):1651-60 - PubMed
  86. EMBO Mol Med. 2012 Mar;4(3):143-59 - PubMed
  87. Science. 2008 Dec 12;322(5908):1717-20 - PubMed
  88. Genome Res. 2012 Sep;22(9):1760-74 - PubMed
  89. Oncotarget. 2015 Feb 28;6(6):4036-50 - PubMed
  90. Cell Rep. 2014 Sep 11;8(5):1365-79 - PubMed
  91. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18697-702 - PubMed
  92. Nature. 2014 Aug 7;512(7512):82-6 - PubMed
  93. Inhal Toxicol. 2014 Jul;26(8):452-63 - PubMed
  94. Mol Cell. 2008 Oct 24;32(2):232-46 - PubMed
  95. Nat Genet. 2015 Mar;47(3):199-208 - PubMed
  96. Nat Cell Biol. 2013 Jan;15(1):2-8 - PubMed
  97. Eur Urol. 2003 Jul;44(1):8-15; discussion 15-6 - PubMed
  98. Cell. 2011 Aug 5;146(3):353-8 - PubMed
  99. Nature. 2012 Jul 12;487(7406):239-43 - PubMed
  100. Mol Cell. 2013 Oct 10;52(1):101-12 - PubMed
  101. Tumour Biol. 2014 Nov;35(11):11541-9 - PubMed
  102. Cancer. 2014 Nov 1;120(21):3320-8 - PubMed
  103. Nature. 2002 Oct 10;419(6907):624-9 - PubMed
  104. Cancer Res. 2010 Mar 15;70(6):2350-8 - PubMed
  105. Oncogene. 2014 Oct 2;33(40):4857-66 - PubMed
  106. Cancer Discov. 2011 Oct;1(5):391-407 - PubMed
  107. Science. 2008 Oct 31;322(5902):750-6 - PubMed
  108. Tumour Biol. 2014 Jun;35(6):5375-80 - PubMed
  109. Cell. 2013 Feb 14;152(4):727-42 - PubMed
  110. Nat Rev Drug Discov. 2008 Dec;7(12):979-87 - PubMed
  111. Cancer Res. 2002 Nov 15;62(22):6442-6 - PubMed
  112. Int J Clin Exp Pathol. 2014 Dec 01;7(12):8471-9 - PubMed
  113. Ann Surg Oncol. 2011 May;18(5):1243-50 - PubMed
  114. Nature. 2013 Aug 29;500(7464):598-602 - PubMed
  115. JAMA. 2005 Jul 13;294(2):238-44 - PubMed
  116. Nat Genet. 2011 Jun 05;43(7):621-9 - PubMed
  117. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4173-8 - PubMed
  118. J Cell Physiol. 2011 Jul;226(7):1741-9 - PubMed
  119. Cell. 2014 Jun 5;157(6):1262-78 - PubMed
  120. BMC Cancer. 2014 May 06;14:319 - PubMed
  121. Nat Commun. 2015 Apr 24;6:6967 - PubMed
  122. Science. 2012 Dec 14;338(6113):1435-9 - PubMed
  123. Cancer Res. 2007 Apr 15;67(8):3963-9 - PubMed
  124. N Engl J Med. 2001 Jan 25;344(4):276-85 - PubMed
  125. Cancer Res. 2014 Sep 15;74(18):5103-17 - PubMed
  126. Annu Rev Biochem. 2012;81:145-66 - PubMed
  127. Cell Stem Cell. 2015 Apr 2;16(4):413-25 - PubMed
  128. Mol Cell. 2013 Jan 24;49(2):298-309 - PubMed
  129. Methods Mol Biol. 2011;714:3-13 - PubMed
  130. Annu Rev Pharmacol Toxicol. 2010;50:259-93 - PubMed
  131. Nucleus. 2013 Sep-Oct;4(5):374-8 - PubMed
  132. Mol Cancer. 2015 Feb 21;14:46 - PubMed
  133. Mol Cell. 2010 Jun 11;38(5):662-74 - PubMed
  134. Cell. 2014 Sep 25;159(1):188-99 - PubMed
  135. N Engl J Med. 2014 Dec 4;371(23):2200-6 - PubMed
  136. Mol Cancer. 2014 Mar 21;13:68 - PubMed
  137. Mol Cell. 2014 Jun 5;54(5):777-90 - PubMed
  138. Cell. 2014 Nov 20;159(5):1110-25 - PubMed
  139. Tumour Biol. 2015 Jul;36(7):5523-8 - PubMed
  140. Mol Cell. 2011 Nov 18;44(4):667-78 - PubMed
  141. Nat Rev Genet. 2014 Mar;15(3):193-204 - PubMed
  142. Cancer Res. 2013 Feb 1;73(3):1180-9 - PubMed
  143. Cancer Cell. 2015 Mar 9;27(3):370-81 - PubMed
  144. Cell. 2006 Nov 3;127(3):469-80 - PubMed
  145. Nat Commun. 2014 Nov 21;5:5383 - PubMed
  146. Mol Cell. 2015 Feb 5;57(3):552-8 - PubMed
  147. Nat Commun. 2014 Nov 07;5:5395 - PubMed
  148. Lancet Oncol. 2014 Dec;15(13):1469-80 - PubMed
  149. Genes Dev. 2009 Aug 15;23(16):1831-42 - PubMed
  150. Mol Cancer Res. 2014 Aug;12(8):1081-7 - PubMed
  151. Cell Death Dis. 2014 May 22;5:e1243 - PubMed
  152. BMC Cancer. 2013 Oct 07;13:461 - PubMed
  153. Nature. 2010 Jun 24;465(7301):1033-8 - PubMed
  154. Nat Commun. 2015 Mar 27;6:6520 - PubMed
  155. Cell. 2007 Jun 29;129(7):1311-23 - PubMed
  156. Nature. 2010 Apr 15;464(7291):1071-6 - PubMed
  157. Cell. 2010 Aug 6;142(3):409-19 - PubMed
  158. Nature. 2015 Mar 26;519(7544):486-90 - PubMed
  159. Cancer Cell. 2014 Nov 10;26(5):722-37 - PubMed
  160. Virchows Arch. 2005 May;446(5):475-82 - PubMed

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