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Showing 1 to 12 of 119 entries
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Long noncoding RNAs in cancer: from function to translation.

Trends in cancer

Sahu A, Singhal U, Chinnaiyan AM.
PMID: 26693181
Trends Cancer. 2015 Oct 01;1(2):93-109. doi: 10.1016/j.trecan.2015.08.010.

While our understanding of the molecular mechanisms underlying cancer has significantly improved, most of our knowledge focuses on protein-coding genes that make up a fraction of the genome. Recent studies have uncovered thousands of long noncoding RNAs (lncRNAs) that...

ONCOMINE: a cancer microarray database and integrated data-mining platform.

Neoplasia (New York, N.Y.)

Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM.
PMID: 15068665
Neoplasia. 2004 Jan-Feb;6(1):1-6. doi: 10.1016/s1476-5586(04)80047-2.

DNA microarray technology has led to an explosion of oncogenomic analyses, generating a wealth of data and uncovering the complex gene expression patterns of cancer. Unfortunately, due to the lack of a unifying bioinformatic resource, the majority of these...

Pathway analysis reveals functional convergence of gene expression profiles in breast cancer.

BMC medical genomics

Shen R, Chinnaiyan AM, Ghosh D.
PMID: 18588682
BMC Med Genomics. 2008 Jun 27;1:28. doi: 10.1186/1755-8794-1-28.

BACKGROUND: A recent study has shown high concordance of several breast-cancer gene signatures in predicting disease recurrence despite minimal overlap of the gene lists. It raises the question if there are common themes underlying such prediction concordance that are...

Hazards of contrast-induced acute kidney injury in elderly women.

Women's health (London, England)

McCullough PA, Chinnaiyan KM.
PMID: 19245350
Womens Health (Lond). 2009 Mar;5(2):123-5. doi: 10.2217/17455057.5.2.123.

No abstract available.

Subclinical coronary atherosclerosis identified by coronary computed tomographic angiography in asymptomatic morbidly obese patients.

Heart international

Lubanski MS, Vanhecke TE, Chinnaiyan KM, Franklin BA, McCullough PA.
PMID: 21977300
Heart Int. 2010 Dec 31;5(2):e15. doi: 10.4081/hi.2010.e15.

Obesity is a common public health problem and obese individuals in particular have a disproportionate incidence of acute coronary events. This study was undertaken to identify coronary artery lesions as well as associated clinical features, risk factors and demographics...

Metformin Use Is Not Associated With B.

Frontiers in endocrinology

Elhadd T, Ponirakis G, Dabbous Z, Siddique M, Chinnaiyan S, Malik RA.
PMID: 29887831
Front Endocrinol (Lausanne). 2018 May 25;9:248. doi: 10.3389/fendo.2018.00248. eCollection 2018.

BACKGROUND: Metformin may lead to BAIMS: Determine whether Metformin intake is associated with BMETHODS: Patients with type 2 diabetes mellitus (T2DM) (RESULTS: Comparing Metformin to non-Metformin users there were no differences in BCONCLUSION: Serum B

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.

The Journal of clinical investigation

Lin H, Wei S, Hurt EM, Green MD, Zhao L, Vatan L, Szeliga W, Herbst R, Harms PW, Fecher LA, Vats P, Chinnaiyan AM, Lao CD, Lawrence TS, Wicha M, Hamanishi J, Mandai M, Kryczek I, Zou W.
PMID: 29608143
J Clin Invest. 2018 Apr 02;128(4):1708. doi: 10.1172/JCI120803. Epub 2018 Apr 02.

No abstract available.

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy.

Oncotarget

Hovelson DH, Liu CJ, Wang Y, Kang Q, Henderson J, Gursky A, Brockman S, Ramnath N, Krauss JC, Talpaz M, Kandarpa M, Chugh R, Tuck M, Herman K, Grasso CS, Quist MJ, Feng FY, Haakenson C, Langmore J, Kamberov E, Tesmer T, Husain H, Lonigro RJ, Robinson D, Smith DC, Alva AS, Hussain MH, Chinnaiyan AM, Tewari M, Mills RE, Morgan TM, Tomlins SA.
PMID: 29163793
Oncotarget. 2017 Sep 22;8(52):89848-89866. doi: 10.18632/oncotarget.21163. eCollection 2017 Oct 27.

Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to...

Utility of ERG Immunohistochemistry for Evaluation of Lymphovascular Invasion in Testicular Germ Cell Tumors: A Retrospective Pilot Study.

Applied immunohistochemistry & molecular morphology : AIMM

Udager AM, McHugh JB, Morgan TM, Spratt DE, Chinnaiyan AM, Mehra R.
PMID: 28968266
Appl Immunohistochem Mol Morphol. 2019 May/Jun;27(5):392-401. doi: 10.1097/PAI.0000000000000597.

Lymphovascular invasion (LVI) of testicular germ cell tumors (GCT) is an important stage-determining variable in the evaluation of radical orchiectomy specimens. ERG endothelial cell expression, as detected by immunohistochemistry (IHC), robustly highlights lymphovascular spaces, and thus, we sought to...

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?.

Infectious agents and cancer

Kaplan MH, Contreras-Galindo R, Jiagge E, Merajver SD, Newman L, Bigman G, Dosik MH, Palapattu GS, Siddiqui J, Chinnaiyan AM, Adebamowo S, Adebamowo C.
PMID: 32165916
Infect Agent Cancer. 2020 Mar 07;15:19. doi: 10.1186/s13027-020-00284-w. eCollection 2020.

The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for...

The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development.

Clinical cancer research : an official journal of the American Association for Cancer Research

Palanisamy N, Yang J, Shepherd PDA, Li-Ning-Tapia EM, Labanca E, Manyam GC, Ravoori MK, Kundra V, Araujo JC, Efstathiou E, Pisters LL, Wan X, Wang X, Vazquez ES, Aparicio AM, Carskadon SL, Tomlins SA, Kunju LP, Chinnaiyan AM, Broom BM, Logothetis CJ, Troncoso P, Navone NM.
PMID: 32576626
Clin Cancer Res. 2020 Sep 15;26(18):4933-4946. doi: 10.1158/1078-0432.CCR-20-0479. Epub 2020 Jun 23.

PURPOSE: Advances in prostate cancer lag behind other tumor types partly due to the paucity of models reflecting key milestones in prostate cancer progression. Therefore, we develop clinically relevant prostate cancer models.EXPERIMENTAL DESIGN: Since 1996, we have generated clinically...

Publisher Correction: The long tail of oncogenic drivers in prostate cancer.

Nature genetics

Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE, Beltran H, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F, Kantoff PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM, Schultz N, Van Allen EM.
PMID: 31152158
Nat Genet. 2019 Jul;51(7):1194. doi: 10.1038/s41588-019-0451-6.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Showing 1 to 12 of 119 entries