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Latest development in the synthesis of ursodeoxycholic acid (UDCA): a critical review.

Beilstein journal of organic chemistry

Tonin F, Arends IWCE.
PMID: 29520309
Beilstein J Org Chem. 2018 Feb 20;14:470-483. doi: 10.3762/bjoc.14.33. eCollection 2018.

Ursodeoxycholic acid (UDCA) is a pharmaceutical ingredient widely used in clinics. As bile acid it solubilizes cholesterol gallstones and improves the liver function in case of cholestatic diseases. UDCA can be obtained from cholic acid (CA), which is the...

Fluid Shear Stress Reduces 11ss-Hydroxysteroid Dehydrogenase Type 2.

Hypertension (Dallas, Tex. : 1979)

Lanz CB, Causevic M, Heiniger C, Frey FJ, Frey BM, Mohaupt MG.
PMID: 11208772
Hypertension. 2001 Jan;37(1):160-169. doi: 10.1161/01.hyp.37.1.160.

-In pregnancy, invading trophoblasts represent the inner vascular border of maternal spiral arteries and are exposed to elevated shear stress (ss) in hypertensive disorders. Intracellular cortisol availability is regulated by 11ss-hydroxysteroid dehydrogenases (11ss-HSDs), thus determining body fluid volume and...

11β-hydroxysteroid dehydrogenases as targets in the treatment of steroid-associated femoral head necrosis using antler extract.

Experimental and therapeutic medicine

Pu R, Peng H.
PMID: 29434691
Exp Ther Med. 2018 Jan;15(1):977-984. doi: 10.3892/etm.2017.5459. Epub 2017 Nov 07.

The aim of the present study was to investigate the therapeutic effect of deer antler extract on avascular necrosis of the femoral head (ANFH) induced by steroids, and to confirm that 11β-hydroxysteroid dehydrogenases (11β-HSD) are one of the targets...

Prenatal caffeine exposure-induced adrenal developmental abnormality in male offspring rats and its possible intrauterine programming mechanisms.

Toxicology research

He Z, Zhu C, Huang H, Liu L, Wang L, Chen L, Magdalou J, Wang H.
PMID: 30090354
Toxicol Res (Camb). 2016 Jan 15;5(2):388-398. doi: 10.1039/c5tx00265f. eCollection 2016 Mar 01.

Glucocorticoid (GC) is a major factor for fetal tissue maturation and fate decision after birth. We previously demonstrated that prenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in adrenal dysplasia. However, whether these changes play a role...

Sperm storage in the oviduct of the tropical rock lizard, Psammophilus dorsalis.

Journal of morphology

Srinivas SR, Hegde SN, Sarkar HBD, Shivanandappa T.
PMID: 29865339
J Morphol. 1995 Jun;224(3):293-301. doi: 10.1002/jmor.1052240304.

The female rock lizard, Psammophilus dorsalis (Agamidae), lays multiple clutches of eggs over a period of 6 months (June-December). The later clutches of eggs are presumably fertilized by sperm stored from earlier matings, since testes and epididymides are regressed...

Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper (.

Frontiers in genetics

Xiao L, Guo Y, Wang D, Zhao M, Hou X, Li S, Lin H, Zhang Y.
PMID: 32194632
Front Genet. 2020 Mar 04;11:161. doi: 10.3389/fgene.2020.00161. eCollection 2020.

Beta-hydroxysteroid dehydrogenases (β-HSDs) are a group of steroidogenic enzymes that are involved in steroid biosynthesis and metabolism, and play a crucial role in mammalian physiology and development, including sex determination and differentiation. In the present study, a genome-wide analysis...

Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole-intoxicated rats by conducting oxidative stress, apoptosis and proliferation.

Andrologia

Khwanes SA, Mohamed RA, Ibrahim KA, Abd El-Rahman HA.
PMID: 34519103
Andrologia. 2021 Sep 13;e14241. doi: 10.1111/and.14241. Epub 2021 Sep 13.

Difenoconazole, a triazole fungicide, can induce reproductive toxicity in aquatic species, but the probable mechanisms of this hazard in mammals are not formally reported. Here, we have examined the possible ameliorative efficiency of the ginger aqueous extract against the...

New insights into the roles of glucocorticoid signaling dysregulation in pathological cardiac hypertrophy.

Heart failure reviews

Yang J, Chen Y, Li X, Xu D.
PMID: 34455516
Heart Fail Rev. 2021 Aug 28; doi: 10.1007/s10741-021-10158-x. Epub 2021 Aug 28.

Pathological cardiac hypertrophy is a process of abnormal remodeling of the myocardium in response to stress overload or ischemia that results in myocardial injury, which is an independent risk factor for the increased morbidity and mortality of heart failure....

The effects of the standardized extracts of Ginkgo biloba on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells.

Environmental health and toxicology

Kim M, Park YJ, Ahn H, Moon B, Chung KH, Oh SM.
PMID: 27188280
Environ Health Toxicol. 2016 May 09;31:e2016010. doi: 10.5620/eht.e2016010. eCollection 2016.

OBJECTIVES: Aromatase inhibitors that block estrogen synthesis are a proven first-line hormonal therapy for postmenopausal breast cancer. Although it is known that standardized extract of Ginkgo biloba (EGb761) induces anti-carcinogenic effects like the aromatase inhibitors, the effects of EGb761...

Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary-gonadal axis of primates.

Endocrine connections

Bird AD, Greatorex S, Reser D, Lavery GG, Cole TJ.
PMID: 28871060
Endocr Connect. 2017 Oct;6(7):489-499. doi: 10.1530/EC-17-0119.

Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2) have key roles in the pre-receptor modification...

Histological, histochemical, and biochemical changes in the annual oviduct cycle of the agamid, Calotes versicolor.

Journal of morphology

Shanthakumari TR, Sarkar HBD, Shivanandappa T.
PMID: 29865573
J Morphol. 1992 Mar;211(3):295-306. doi: 10.1002/jmor.1052110307.

Histology, histochemistry, and biochemistry of the oviduct change seasonally in relationship to the annual ovarian cycle of Calotes versicolor. Histological changes show distinct changes in various components of the infundibulum, uterus and vagina of the oviduct. The active phase...

Ginger reserves testicular spermatogenesis and steroidogenesis in difenoconazole-intoxicated rats by conducting oxidative stress, apoptosis and proliferation.

Andrologia

Khwanes SA, Mohamed RA, Ibrahim KA, Abd El-Rahman HA.
PMID: 34519103
Andrologia. 2022 Feb;54(1):e14241. doi: 10.1111/and.14241. Epub 2021 Sep 13.

Difenoconazole, a triazole fungicide, can induce reproductive toxicity in aquatic species, but the probable mechanisms of this hazard in mammals are not formally reported. Here, we have examined the possible ameliorative efficiency of the ginger aqueous extract against the...

Showing 1 to 12 of 39 entries