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Showing 1 to 12 of 763 entries
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Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease.

Clinical and translational medicine

Pule GD, Mowla S, Novitzky N, Wonkam A.
PMID: 27056246
Clin Transl Med. 2016 Mar;5(1):15. doi: 10.1186/s40169-016-0092-7. Epub 2016 Apr 07.

BACKGROUND: The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant reduction of morbidity and mortality. However, potential adverse effects such...

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Pule GD, Mowla S, Novitzky N, et al. Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease. Clin Transl Med. 2016;5(1):15doi: 10.1186/s40169-016-0092-7.
Pule, G. D., Mowla, S., Novitzky, N., & Wonkam, A. (2016). Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease. Clinical and translational medicine, 5(1), 15. https://doi.org/10.1186/s40169-016-0092-7
Pule, Gift Dineo, et al. "Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease." Clinical and translational medicine vol. 5,1 (2016): 15. doi: https://doi.org/10.1186/s40169-016-0092-7
Pule GD, Mowla S, Novitzky N, Wonkam A. Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease. Clin Transl Med. 2016 Mar;5(1):15. doi: 10.1186/s40169-016-0092-7. Epub 2016 Apr 07. PMID: 27056246; PMCID: PMC4824700.
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A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells.

Cell & bioscience

Han SH, Hahm SH, Tran AH, Chung JH, Hong MK, Paik HD, Kim KS, Han YS.
PMID: 26312135
Cell Biosci. 2015 Aug 27;5:50. doi: 10.1186/s13578-015-0042-x. eCollection 2015.

BACKGROUND: Human DNA topoisomerase II-binding protein 1 (hTopBP1) plays an important role in DNA replication and the DNA damage checkpoint pathway. The human mutY homolog (hMYH) is a base excision repair DNA glycosylase that excises adenines or 2-hydroxyadenines that...

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Han SH, Hahm SH, Tran AH, et al. A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells. Cell Biosci. 2015;5:50doi: 10.1186/s13578-015-0042-x.
Han, S. H., Hahm, S. H., Tran, A. H., Chung, J. H., Hong, M. K., Paik, H. D., Kim, K. S., & Han, Y. S. (2015). A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells. Cell & bioscience, 550. https://doi.org/10.1186/s13578-015-0042-x
Han, Se Hee, et al. "A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells." Cell & bioscience vol. 5 (2015): 50. doi: https://doi.org/10.1186/s13578-015-0042-x
Han SH, Hahm SH, Tran AH, Chung JH, Hong MK, Paik HD, Kim KS, Han YS. A physical association between the human mutY homolog (hMYH) and DNA topoisomerase II-binding protein 1 (hTopBP1) regulates Chk1-induced cell cycle arrest in HEK293 cells. Cell Biosci. 2015 Aug 27;5:50. doi: 10.1186/s13578-015-0042-x. eCollection 2015. PMID: 26312135; PMCID: PMC4550056.
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ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs.

Hospital pharmacy

Cohen MR, Smetzer JL.
PMID: 28515501
Hosp Pharm. 2017 Apr;52(4):249-252. doi: 10.1310/hpj5204-249.

These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors...

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Cohen MR, Smetzer JL. ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hosp Pharm. 2017;52(4):249-252doi: 10.1310/hpj5204-249.
Cohen, M. R., & Smetzer, J. L. (2017). ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hospital pharmacy, 52(4), 249-252. https://doi.org/10.1310/hpj5204-249
Cohen, Michael R, and Smetzer, Judy L. "ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs." Hospital pharmacy vol. 52,4 (2017): 249-252. doi: https://doi.org/10.1310/hpj5204-249
Cohen MR, Smetzer JL. ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hosp Pharm. 2017 Apr;52(4):249-252. doi: 10.1310/hpj5204-249. PMID: 28515501; PMCID: PMC5424826.
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Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia.

Journal of blood medicine

Lebensburger JD, Patel RJ, Palabindela P, Bemrich-Stolz CJ, Howard TH, Hilliard LM.
PMID: 26719735
J Blood Med. 2015 Dec 15;6:285-90. doi: 10.2147/JBM.S97405. eCollection 2015.

PURPOSE: Patients with hemoglobin SC (Hb SC) and hemoglobin SB+ (Hb SB+) thalassemia suffer from frequent hospitalizations yet strong evidence of a clinical benefit of hydroxyurea (HU) in this population is lacking. Patients with recurrent hospitalizations for pain crisis...

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Lebensburger JD, Patel RJ, Palabindela P, et al. Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia. J Blood Med. 2015;6:285-90doi: 10.2147/JBM.S97405.
Lebensburger, J. D., Patel, R. J., Palabindela, P., Bemrich-Stolz, C. J., Howard, T. H., & Hilliard, L. M. (2015). Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia. Journal of blood medicine, 6285-90. https://doi.org/10.2147/JBM.S97405
Lebensburger, Jeffrey D, et al. "Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia." Journal of blood medicine vol. 6 (2015): 285-90. doi: https://doi.org/10.2147/JBM.S97405
Lebensburger JD, Patel RJ, Palabindela P, Bemrich-Stolz CJ, Howard TH, Hilliard LM. Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia. J Blood Med. 2015 Dec 15;6:285-90. doi: 10.2147/JBM.S97405. eCollection 2015. PMID: 26719735; PMCID: PMC4687721.
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Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase.

OncoTargets and therapy

Asuncion Valenzuela MM, Castro I, Gonda A, Diaz Osterman CJ, Jutzy JM, Aspe JR, Khan S, Neidigh JW, Wall NR.
PMID: 25767396
Onco Targets Ther. 2015 Feb 26;8:495-507. doi: 10.2147/OTT.S79647. eCollection 2015.

New agent development, mechanistic understanding, and combinatorial partnerships with known and novel modalities continue to be important in the study of pancreatic cancer and its improved treatment. In this study, known antimetabolite drugs such as gemcitabine (ribonucleotide reductase inhibitor)...

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Asuncion Valenzuela MM, Castro I, Gonda A, et al. Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase. Onco Targets Ther. 2015;8:495-507doi: 10.2147/OTT.S79647.
Asuncion Valenzuela, M. M., Castro, I., Gonda, A., Diaz Osterman, C. J., Jutzy, J. M., Aspe, J. R., Khan, S., Neidigh, J. W., & Wall, N. R. (2015). Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase. OncoTargets and therapy, 8495-507. https://doi.org/10.2147/OTT.S79647
Asuncion Valenzuela, Malyn M, et al. "Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase." OncoTargets and therapy vol. 8 (2015): 495-507. doi: https://doi.org/10.2147/OTT.S79647
Asuncion Valenzuela MM, Castro I, Gonda A, Diaz Osterman CJ, Jutzy JM, Aspe JR, Khan S, Neidigh JW, Wall NR. Cell death in response to antimetabolites directed at ribonucleotide reductase and thymidylate synthase. Onco Targets Ther. 2015 Feb 26;8:495-507. doi: 10.2147/OTT.S79647. eCollection 2015. PMID: 25767396; PMCID: PMC4354452.
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Spinal epidural extramedullary hematopoiesis during the complicated course of polycythemia vera.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Tufan A, Koca E, Önal İ, Haznedaroğlu İC, Üner A, Özcebe OI.
PMID: 27263958
Turk J Haematol. 2007 Dec 05;24(4):177-80.

Extramedullary hematopoiesis (EMH) may uncommonly develop during the course of polycythemia vera (PV). We herein present a 57-year-old patient with spinal epidural EMH that developed during the complicated course of PV and his outcome under different treatment modalities including...

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Tufan A, Koca E, Önal İ, et al. Polisitemi veranın karmaşık seyri sırasında spinal epidural ekstramedüller hematopoiez. Spinal epidural extramedullary hematopoiesis during the complicated course of polycythemia vera. Turk J Haematol. 2007;24(4):177-80
Tufan, A., Koca, E., Önal, �. �., Haznedaroğlu, �. �. C., Üner, A., & Özcebe, O. I. (2007). Polisitemi veranın karmaşık seyri sırasında spinal epidural ekstramedüller hematopoiez. Spinal epidural extramedullary hematopoiesis during the complicated course of polycythemia vera. Turkish journal of haematology : official journal of Turkish Society of Haematology, 24(4), 177-80.
Tufan, Abdurrahman, et al. "Polisitemi veranın karmaşık seyri sırasında spinal epidural ekstramedüller hematopoiez." Spinal epidural extramedullary hematopoiesis during the complicated course of polycythemia vera. Turkish journal of haematology : official journal of Turkish Society of Haematology vol. 24,4 (2007): 177-80.
Tufan A, Koca E, Önal İ, Haznedaroğlu İC, Üner A, Özcebe OI. Polisitemi veranın karmaşık seyri sırasında spinal epidural ekstramedüller hematopoiez. Spinal epidural extramedullary hematopoiesis during the complicated course of polycythemia vera. Turk J Haematol. 2007 Dec 05;24(4):177-80. PMID: 27263958.
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Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin.

Oman medical journal

Aladily TN, Mohammad RS, Al-Khader A, Awidi AS.
PMID: 28584607
Oman Med J. 2017 May;32(3):243-246. doi: 10.5001/omj.2017.45.

Essential thrombocythemia (ET) is a myeloproliferative neoplasm that occurs mostly in patients above the age of 50 years. Its incidence in children is very rare, with around 100 cases reported in the literature. High-risk patients are defined by previous...

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Aladily TN, Mohammad RS, Al-Khader A, et al. Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin. Oman Med J. 2017;32(3):243-246doi: 10.5001/omj.2017.45.
Aladily, T. N., Mohammad, R. S., Al-Khader, A., & Awidi, A. S. (2017). Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin. Oman medical journal, 32(3), 243-246. https://doi.org/10.5001/omj.2017.45
Aladily, Tariq N, et al. "Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin." Oman medical journal vol. 32,3 (2017): 243-246. doi: https://doi.org/10.5001/omj.2017.45
Aladily TN, Mohammad RS, Al-Khader A, Awidi AS. Essential Thrombocythemia in a Two-year-old Child, Responsive to Hydroxyurea but Not Aspirin. Oman Med J. 2017 May;32(3):243-246. doi: 10.5001/omj.2017.45. PMID: 28584607; PMCID: PMC5447791.
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Cytological and molecular relationships between Larix decidua, L. leptolepis and Larix x eurolepis: identification of species-specific Chromosoms and synchronization of mitotic cells.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Nkongolo KK, Klimaszewska K.
PMID: 24172925
Theor Appl Genet. 1995 May;90(6):827-34. doi: 10.1007/BF00222018.

The effects of different concentrations of hydroxyurea (HU) and aphidicolin (APH) on the mitotic index (MI) were compared in cells of embryogenic cultures of Larix decidua, L. leptolepis, and L. decidua x L. leptolepis (Larix x eurolepis). The highest...

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Nkongolo KK, Klimaszewska K. Cytological and molecular relationships between Larix decidua, L. leptolepis and Larix x eurolepis: identification of species-specific Chromosoms and synchronization of mitotic cells. Theor Appl Genet. 1995;90(6):827-34doi: 10.1007/BF00222018.
Nkongolo, K. K., & Klimaszewska, K. (1995). Cytological and molecular relationships between Larix decidua, L. leptolepis and Larix x eurolepis: identification of species-specific Chromosoms and synchronization of mitotic cells. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 90(6), 827-34. https://doi.org/10.1007/BF00222018
Nkongolo, K K, and Klimaszewska, K. "Cytological and molecular relationships between Larix decidua, L. leptolepis and Larix x eurolepis: identification of species-specific Chromosoms and synchronization of mitotic cells." TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik vol. 90,6 (1995): 827-34. doi: https://doi.org/10.1007/BF00222018
Nkongolo KK, Klimaszewska K. Cytological and molecular relationships between Larix decidua, L. leptolepis and Larix x eurolepis: identification of species-specific Chromosoms and synchronization of mitotic cells. Theor Appl Genet. 1995 May;90(6):827-34. doi: 10.1007/BF00222018. PMID: 24172925.
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RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.

Breast cancer : basic and clinical research

Lee PS, Fang J, Jessop L, Myers T, Raj P, Hu N, Wang C, Taylor PR, Wang J, Khan J, Jasin M, Chanock SJ.
PMID: 25368520
Breast Cancer (Auckl). 2014 Oct 12;8:135-44. doi: 10.4137/BCBCR.S17766. eCollection 2014.

Common genetic variants mapping to two distinct regions of RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies (GWAS). RAD51B is a plausible candidate gene because of its established role in the...

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Lee PS, Fang J, Jessop L, et al. RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2014;8:135-44doi: 10.4137/BCBCR.S17766.
Lee, P. S., Fang, J., Jessop, L., Myers, T., Raj, P., Hu, N., Wang, C., Taylor, P. R., Wang, J., Khan, J., Jasin, M., & Chanock, S. J. (2014). RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines. Breast cancer : basic and clinical research, 8135-44. https://doi.org/10.4137/BCBCR.S17766
Lee, Phoebe S, et al. "RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines." Breast cancer : basic and clinical research vol. 8 (2014): 135-44. doi: https://doi.org/10.4137/BCBCR.S17766
Lee PS, Fang J, Jessop L, Myers T, Raj P, Hu N, Wang C, Taylor PR, Wang J, Khan J, Jasin M, Chanock SJ. RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2014 Oct 12;8:135-44. doi: 10.4137/BCBCR.S17766. eCollection 2014. PMID: 25368520; PMCID: PMC4213955.
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Deafness and sickle cell disease: three case reports and review of the literature.

Journal of clinical medicine research

Desai P, Dejoie-Brewer M, Ballas SK.
PMID: 25584106
J Clin Med Res. 2015 Mar;7(3):189-92. doi: 10.14740/jocmr2028w. Epub 2014 Dec 29.

The otological complications of sickle cell disease (SCD) in general and the audiological complications in particular are not well documented and studied. Because the general management of patients with SCD has improved after the advent of newborn screening, antibiotic...

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Desai P, Dejoie-Brewer M, Ballas SK. Deafness and sickle cell disease: three case reports and review of the literature. J Clin Med Res. 2014;7(3):189-92doi: 10.14740/jocmr2028w.
Desai, P., Dejoie-Brewer, M., & Ballas, S. K. (2015). Deafness and sickle cell disease: three case reports and review of the literature. Journal of clinical medicine research, 7(3), 189-92. https://doi.org/10.14740/jocmr2028w
Desai, Payal, et al. "Deafness and sickle cell disease: three case reports and review of the literature." Journal of clinical medicine research vol. 7,3 (2015): 189-92. doi: https://doi.org/10.14740/jocmr2028w
Desai P, Dejoie-Brewer M, Ballas SK. Deafness and sickle cell disease: three case reports and review of the literature. J Clin Med Res. 2015 Mar;7(3):189-92. doi: 10.14740/jocmr2028w. Epub 2014 Dec 29. PMID: 25584106; PMCID: PMC4285067.
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Painful Leg Ulcers: A Misdiagnosed Case Report With Literature Review.

Wounds : a compendium of clinical research and practice

Lu YM, Zhao WJ, Zheng YH, Fan BG.
PMID: 26110307
Wounds. 2007 May;19(5):124-7.

A 56-year-old man presented with painful leg ulcers located on the left malleolus, tibia, the dorsal aspect of the feet and calves. He was initially treated with wound dressings, antibiotics, and other surgical debridement-'but these treatments were not effective....

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Lu YM, Zhao WJ, Zheng YH, et al. Painful Leg Ulcers: A Misdiagnosed Case Report With Literature Review. Wounds. 2007;19(5):124-7
Lu, Y. M., Zhao, W. J., Zheng, Y. H., & Fan, B. G. (2007). Painful Leg Ulcers: A Misdiagnosed Case Report With Literature Review. Wounds : a compendium of clinical research and practice, 19(5), 124-7.
Lu, Yong-Ming, et al. "Painful Leg Ulcers: A Misdiagnosed Case Report With Literature Review." Wounds : a compendium of clinical research and practice vol. 19,5 (2007): 124-7.
Lu YM, Zhao WJ, Zheng YH, Fan BG. Painful Leg Ulcers: A Misdiagnosed Case Report With Literature Review. Wounds. 2007 May;19(5):124-7. PMID: 26110307.
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Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae.

Genomics data

Rossi SE, Carotenuto W, Giannattasio M.
PMID: 26981397
Genom Data. 2015 Dec 01;7:162-5. doi: 10.1016/j.gdata.2015.11.024. eCollection 2016 Mar.

The genome of the budding yeast Saccharomyces cerevisiae is sequenced and the location and dynamic of activation of DNA replication origins are known. G1 synchronized yeast cells can be released into S-phase in the presence of hydroxyurea (HU) (1),...

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Rossi SE, Carotenuto W, Giannattasio M. Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae. Genom Data. 2015;7:162-5doi: 10.1016/j.gdata.2015.11.024.
Rossi, S. E., Carotenuto, W., & Giannattasio, M. (2016). Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae. Genomics data, 7162-5. https://doi.org/10.1016/j.gdata.2015.11.024
Rossi, Silvia Emma, et al. "Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae." Genomics data vol. 7 (2016): 162-5. doi: https://doi.org/10.1016/j.gdata.2015.11.024
Rossi SE, Carotenuto W, Giannattasio M. Genome-wide localization of Rrm3 and Pif1 DNA helicases at stalled active and inactive DNA replication forks of Saccharomyces cerevisiae. Genom Data. 2015 Dec 01;7:162-5. doi: 10.1016/j.gdata.2015.11.024. eCollection 2016 Mar. PMID: 26981397; PMCID: PMC4778647.
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Showing 1 to 12 of 763 entries