Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 18 entries
Sorted by: Best Match Show Resources per page
A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation.

Frontiers in immunology

Leighton PA, Schusser B, Yi H, Glanville J, Harriman W.
PMID: 25852694
Front Immunol. 2015 Mar 20;6:126. doi: 10.3389/fimmu.2015.00126. eCollection 2015.

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species. For discovery of a diverse panel of unique therapeutic antibody candidates, chickens therefore represent an attractive host...

Cite
Leighton PA, Schusser B, Yi H, et al. A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation. Front Immunol. 2015;6:126doi: 10.3389/fimmu.2015.00126.
Leighton, P. A., Schusser, B., Yi, H., Glanville, J., & Harriman, W. (2015). A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation. Frontiers in immunology, 6126. https://doi.org/10.3389/fimmu.2015.00126
Leighton, Philip A, et al. "A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation." Frontiers in immunology vol. 6 (2015): 126. doi: https://doi.org/10.3389/fimmu.2015.00126
Leighton PA, Schusser B, Yi H, Glanville J, Harriman W. A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation. Front Immunol. 2015 Mar 20;6:126. doi: 10.3389/fimmu.2015.00126. eCollection 2015. PMID: 25852694; PMCID: PMC4367436.
Copy Download .nbib Format: NLM
Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry.

Frontiers in oncology

Vázquez AM, Rodrèguez-Zhurbenko N, López AM.
PMID: 23181219
Front Oncol. 2012 Nov 20;2:170. doi: 10.3389/fonc.2012.00170. eCollection 2012.

Surgery, chemotherapy, and radiation therapy are standard modalities for cancer treatment, but the effectiveness of these treatments has reached a plateau. Thus, other strategies are being explored to combine with the current treatment paradigms in order to reach better...

Cite
Vázquez AM, Rodrèguez-Zhurbenko N, López AM. Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry. Front Oncol. 2012;2:170doi: 10.3389/fonc.2012.00170.
Vázquez, A. M., Rodrèguez-Zhurbenko, N., & López, A. M. (2012). Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry. Frontiers in oncology, 2170. https://doi.org/10.3389/fonc.2012.00170
Vázquez, Ana M H, et al. "Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry." Frontiers in oncology vol. 2 (2012): 170. doi: https://doi.org/10.3389/fonc.2012.00170
Vázquez AM, Rodrèguez-Zhurbenko N, López AM. Anti-ganglioside anti-idiotypic vaccination: more than molecular mimicry. Front Oncol. 2012 Nov 20;2:170. doi: 10.3389/fonc.2012.00170. eCollection 2012. PMID: 23181219; PMCID: PMC3501824.
Copy Download .nbib Format: NLM
Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas.

Methods in molecular medicine

Breitling F, Dübel S.
PMID: 21390867
Methods Mol Med. 1998;13:581-91. doi: 10.1385/0-89603-485-2:581.

For cloning and expressing the antigen-binding variable (Fv) portion of an antibody in Escherzchia coli, vectors have been constructed that combine the two variable regions (V(H) and V(L)) with a peptide linker (1-3). The genetic information for V(H) and...

Cite
Breitling F, Dübel S. Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas. Methods Mol Med. 1998;13:581-91doi: 10.1385/0-89603-485-2:581.
Breitling, F., & Dübel, S. (1998). Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas. Methods in molecular medicine, 13581-91. https://doi.org/10.1385/0-89603-485-2:581
Breitling, F, and Dübel, S. "Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas." Methods in molecular medicine vol. 13 (1998): 581-91. doi: https://doi.org/10.1385/0-89603-485-2:581
Breitling F, Dübel S. Cloning and Expression of Single-Chain Fragments (scFv) from Mouse and Rat Hybridomas. Methods Mol Med. 1998;13:581-91. doi: 10.1385/0-89603-485-2:581. PMID: 21390867.
Copy Download .nbib Format: NLM
Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development.

iScience

Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman BP, Armstrong SA.
PMID: 32169821
iScience. 2020 Mar 27;23(3):100941. doi: 10.1016/j.isci.2020.100941. Epub 2020 Feb 27.

Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically been centered on the study of RAG1/2 recombinases...

Cite
Chu SH, Chabon JR, Matovina CN, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23(3):100941doi: 10.1016/j.isci.2020.100941.
Chu, S. H., Chabon, J. R., Matovina, C. N., Minehart, J. C., Chen, B. R., Zhang, J., Kumar, V., Xiong, Y., Callen, E., Hung, P. J., Feng, Z., Koche, R. P., Liu, X. S., Chaudhuri, J., Nussenzweig, A., Sleckman, B. P., & Armstrong, S. A. (2020). Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience, 23(3), 100941. https://doi.org/10.1016/j.isci.2020.100941
Chu, S Haihua, et al. "Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development." iScience vol. 23,3 (2020): 100941. doi: https://doi.org/10.1016/j.isci.2020.100941
Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman BP, Armstrong SA. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020 Mar 27;23(3):100941. doi: 10.1016/j.isci.2020.100941. Epub 2020 Feb 27. PMID: 32169821; PMCID: PMC7066224.
Copy Download .nbib Format: NLM
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions.

Proceedings of the National Academy of Sciences of the United States of America

Yu G, Zhang Y, Gupta V, Zhang J, MacCarthy T, Duan Z, Scharff MD.
PMID: 34873043
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). doi: 10.1073/pnas.2114743118.

The H3.3 histone variant and its chaperone HIRA are involved in active transcription, but their detailed roles in regulating somatic hypermutation (SHM) of immunoglobulin variable regions in human B cells are not yet fully understood. In this study, we...

Cite
Yu G, Zhang Y, Gupta V, et al. The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proc Natl Acad Sci U S A. 2021;118(50)doi: 10.1073/pnas.2114743118.
Yu, G., Zhang, Y., Gupta, V., Zhang, J., MacCarthy, T., Duan, Z., & Scharff, M. D. (2021). The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proceedings of the National Academy of Sciences of the United States of America, 118(50), . https://doi.org/10.1073/pnas.2114743118
Yu, Guojun, et al. "The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions." Proceedings of the National Academy of Sciences of the United States of America vol. 118,50 (2021). doi: https://doi.org/10.1073/pnas.2114743118
Yu G, Zhang Y, Gupta V, Zhang J, MacCarthy T, Duan Z, Scharff MD. The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). doi: 10.1073/pnas.2114743118. PMID: 34873043.
Copy Download .nbib Format: NLM
Origin and Function of Circulating Plasmablasts during Acute Viral Infections.

Frontiers in immunology

Fink K.
PMID: 22566959
Front Immunol. 2012 Apr 17;3:78. doi: 10.3389/fimmu.2012.00078. eCollection 2012.

Activated B cells proliferate and differentiate into antibody-producing cells, long-lived plasma cells, and memory B cells after immunization or infection. Repeated encounter of the same antigen triggers the rapid re-activation of pre-existing specific memory B cells, which then potentially...

Cite
Fink K. Origin and Function of Circulating Plasmablasts during Acute Viral Infections. Front Immunol. 2012;3:78doi: 10.3389/fimmu.2012.00078.
Fink, K. (2012). Origin and Function of Circulating Plasmablasts during Acute Viral Infections. Frontiers in immunology, 378. https://doi.org/10.3389/fimmu.2012.00078
Fink, Katja. "Origin and Function of Circulating Plasmablasts during Acute Viral Infections." Frontiers in immunology vol. 3 (2012): 78. doi: https://doi.org/10.3389/fimmu.2012.00078
Fink K. Origin and Function of Circulating Plasmablasts during Acute Viral Infections. Front Immunol. 2012 Apr 17;3:78. doi: 10.3389/fimmu.2012.00078. eCollection 2012. PMID: 22566959; PMCID: PMC3341968.
Copy Download .nbib Format: NLM
Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes.

Frontiers in immunology

Detanico T, Phillips M, Wysocki LJ.
PMID: 27920779
Front Immunol. 2016 Nov 22;7:525. doi: 10.3389/fimmu.2016.00525. eCollection 2016.

In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are...

Cite
Detanico T, Phillips M, Wysocki LJ. Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes. Front Immunol. 2016;7:525doi: 10.3389/fimmu.2016.00525.
Detanico, T., Phillips, M., & Wysocki, L. J. (2016). Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes. Frontiers in immunology, 7525. https://doi.org/10.3389/fimmu.2016.00525
Detanico, Thiago, et al. "Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes." Frontiers in immunology vol. 7 (2016): 525. doi: https://doi.org/10.3389/fimmu.2016.00525
Detanico T, Phillips M, Wysocki LJ. Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes. Front Immunol. 2016 Nov 22;7:525. doi: 10.3389/fimmu.2016.00525. eCollection 2016. PMID: 27920779; PMCID: PMC5118421.
Copy Download .nbib Format: NLM
Inflammatory Infiltrate and Angiogenesis in Mantle Cell Lymphoma.

Translational oncology

Annese T, Ingravallo G, Tamma R, De Giorgis M, Maiorano E, Perrone T, Albano F, Specchia G, Ribatti D.
PMID: 32120334
Transl Oncol. 2020 Mar;13(3):100744. doi: 10.1016/j.tranon.2020.100744. Epub 2020 Feb 29.

Mantle cell lymphoma (MCL) is an aggressive and rare B-cell non-Hodgkin lymphoma classified in two clinicopathological subtypes according to SOX11 expression and mutation state of immunoglobulin variable region heavy chain (IgVH) gene. The transcription factor SOX11, overexpressed in 78%-93%...

Cite
Annese T, Ingravallo G, Tamma R, et al. Inflammatory Infiltrate and Angiogenesis in Mantle Cell Lymphoma. Transl Oncol. 2020;13(3):100744doi: 10.1016/j.tranon.2020.100744.
Annese, T., Ingravallo, G., Tamma, R., De Giorgis, M., Maiorano, E., Perrone, T., Albano, F., Specchia, G., & Ribatti, D. (2020). Inflammatory Infiltrate and Angiogenesis in Mantle Cell Lymphoma. Translational oncology, 13(3), 100744. https://doi.org/10.1016/j.tranon.2020.100744
Annese, Tiziana, et al. "Inflammatory Infiltrate and Angiogenesis in Mantle Cell Lymphoma." Translational oncology vol. 13,3 (2020): 100744. doi: https://doi.org/10.1016/j.tranon.2020.100744
Annese T, Ingravallo G, Tamma R, De Giorgis M, Maiorano E, Perrone T, Albano F, Specchia G, Ribatti D. Inflammatory Infiltrate and Angiogenesis in Mantle Cell Lymphoma. Transl Oncol. 2020 Mar;13(3):100744. doi: 10.1016/j.tranon.2020.100744. Epub 2020 Feb 29. PMID: 32120334; PMCID: PMC7052512.
Copy Download .nbib Format: NLM
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions.

Proceedings of the National Academy of Sciences of the United States of America

Yu G, Zhang Y, Gupta V, Zhang J, MacCarthy T, Duan Z, Scharff MD.
PMID: 34873043
Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). doi: 10.1073/pnas.2114743118.

The H3.3 histone variant and its chaperone HIRA are involved in active transcription, but their detailed roles in regulating somatic hypermutation (SHM) of immunoglobulin variable regions in human B cells are not yet fully understood. In this study, we...

Cite
Yu G, Zhang Y, Gupta V, et al. The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proc Natl Acad Sci U S A. 2021;118(50)doi: 10.1073/pnas.2114743118.
Yu, G., Zhang, Y., Gupta, V., Zhang, J., MacCarthy, T., Duan, Z., & Scharff, M. D. (2021). The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proceedings of the National Academy of Sciences of the United States of America, 118(50), . https://doi.org/10.1073/pnas.2114743118
Yu, Guojun, et al. "The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions." Proceedings of the National Academy of Sciences of the United States of America vol. 118,50 (2021). doi: https://doi.org/10.1073/pnas.2114743118
Yu G, Zhang Y, Gupta V, Zhang J, MacCarthy T, Duan Z, Scharff MD. The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50). doi: 10.1073/pnas.2114743118. PMID: 34873043; PMCID: PMC8685899.
Copy Download .nbib Format: NLM
Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self.

Frontiers in immunology

Bremel RD, Homan EJ.
PMID: 26557118
Front Immunol. 2015 Oct 22;6:538. doi: 10.3389/fimmu.2015.00538. eCollection 2015.

T-cell receptor binding to MHC-bound peptides plays a key role in discrimination between self and non-self. Only a subset, typically a pentamer, of amino acids in a MHC-bound peptide form the motif exposed to the T-cell receptor. We categorize...

Cite
Bremel RD, Homan EJ. Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self. Front Immunol. 2015;6:538doi: 10.3389/fimmu.2015.00538.
Bremel, R. D., & Homan, E. J. (2015). Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self. Frontiers in immunology, 6538. https://doi.org/10.3389/fimmu.2015.00538
Bremel, Robert D, and Homan, E Jane. "Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self." Frontiers in immunology vol. 6 (2015): 538. doi: https://doi.org/10.3389/fimmu.2015.00538
Bremel RD, Homan EJ. Extensive T-Cell Epitope Repertoire Sharing among Human Proteome, Gastrointestinal Microbiome, and Pathogenic Bacteria: Implications for the Definition of Self. Front Immunol. 2015 Oct 22;6:538. doi: 10.3389/fimmu.2015.00538. eCollection 2015. PMID: 26557118; PMCID: PMC4617169.
Copy Download .nbib Format: NLM
Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia.

Hematology (Amsterdam, Netherlands)

Stewart AK, Gupta H, Cappe D, Sutherland DR.
PMID: 11399561
Hematology. 1999;4(2):165-178. doi: 10.1080/10245332.1999.11746440.

An absolute requirement for the V(H(4-34) ) immunoglobulin (Ig) variable (V) region heavy chain (V(H) ) gene has been demonstrated in pathogenic cold agglutinin autoantibodies. Investigation of IgG binding anti-Rhesus (Rh) alloantibodies provides further evidence of V gene restriction...

Cite
Stewart AK, Gupta H, Cappe D, et al. Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia. Hematology. 1999;4(2):165-178doi: 10.1080/10245332.1999.11746440.
Stewart, A. K., Gupta, H., Cappe, D., & Sutherland, D. R. (1999). Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia. Hematology (Amsterdam, Netherlands), 4(2), 165-178. https://doi.org/10.1080/10245332.1999.11746440
Stewart, A. K., et al. "Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia." Hematology (Amsterdam, Netherlands) vol. 4,2 (1999): 165-178. doi: https://doi.org/10.1080/10245332.1999.11746440
Stewart AK, Gupta H, Cappe D, Sutherland DR. Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia. Hematology. 1999;4(2):165-178. doi: 10.1080/10245332.1999.11746440. PMID: 11399561.
Copy Download .nbib Format: NLM
[The construction and expression of phage display library of anti human lung adenocarcinoma monoclonal antibody 5F-11].

Zhongguo fei ai za zhi = Chinese journal of lung cancer

Yue W, Lai B, Wang H, Zhan X, Zhang C, Yang X.
PMID: 21320404
Zhongguo Fei Ai Za Zhi. 2002 Apr 20;5(2):119-22. doi: 10.3779/j.issn.1009-3419.2002.02.12.

BACKGROUND: To construct and express a phage display library of anti human lung cancer monoclonal antibody 5F-11.METHODS: Immunoglobulin variable regions (VH,VL) were amplified from 5F-11 hybridrom by RT-PCR. ScFv genes consisting of VH DNA and VL DNA joined together...

Cite
Yue W, Lai B, Wang H, et al. [The construction and expression of phage display library of anti human lung adenocarcinoma monoclonal antibody 5F-11]. Zhongguo Fei Ai Za Zhi. 2002;5(2):119-22doi: 10.3779/j.issn.1009-3419.2002.02.12.
Yue, W., Lai, B., Wang, H., Zhan, X., Zhang, C., & Yang, X. (2002). [The construction and expression of phage display library of anti human lung adenocarcinoma monoclonal antibody 5F-11]. Zhongguo fei ai za zhi = Chinese journal of lung cancer, 5(2), 119-22. https://doi.org/10.3779/j.issn.1009-3419.2002.02.12
Yue, Wentao, et al. "[The construction and expression of phage display library of anti human lung adenocarcinoma monoclonal antibody 5F-11]." Zhongguo fei ai za zhi = Chinese journal of lung cancer vol. 5,2 (2002): 119-22. doi: https://doi.org/10.3779/j.issn.1009-3419.2002.02.12
Yue W, Lai B, Wang H, Zhan X, Zhang C, Yang X. [The construction and expression of phage display library of anti human lung adenocarcinoma monoclonal antibody 5F-11]. Zhongguo Fei Ai Za Zhi. 2002 Apr 20;5(2):119-22. doi: 10.3779/j.issn.1009-3419.2002.02.12. Chinese. PMID: 21320404.
Copy Download .nbib Format: NLM
Showing 1 to 12 of 18 entries