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Showing 1 to 12 of 60 entries
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Cloning and expression of full-length human insulin-like growth factor binding protein 3 (IGFBP3) in the Escherichia coli.

Advanced biomedical research

Khodadadi E, Panjepour M, Abbasian M, Broujeni ZK, Mofid MR.
PMID: 25878991
Adv Biomed Res. 2015 Mar 25;4:66. doi: 10.4103/2277-9175.153886. eCollection 2015.

BACKGROUND: The effect of the growth hormone on target cells is mediated by the insulin-like growth factor 1 (IGF-1). IGF-1 binds to the insulin-like growth factor binding proteins (IGFBPs) in blood and biological fluids. Considering the important application of...

Advanced colorectal adenoma related gene expression signature may predict prognostic for colorectal cancer patients with adenoma-carcinoma sequence.

International journal of clinical and experimental medicine

Li B, Shi XY, Liao DX, Cao BR, Luo CH, Cheng SJ.
PMID: 26131062
Int J Clin Exp Med. 2015 Apr 15;8(4):4883-98. eCollection 2015.

BACKGROUND: There are still no absolute parameters predicting progression of adenoma into cancer. The present study aimed to characterize functional differences on the multistep carcinogenetic process from the adenoma-carcinoma sequence.METHODS: All samples were collected and mRNA expression profiling was...

Differential regulation of collagen gene expression in granulation tissue and non-repair connective tissues in vitamin C-deficient guinea pigs.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Kipp D, Wilson S, Gosiewska A, Peterkofsky B.
PMID: 17173648
Wound Repair Regen. 1995 Apr-Jun;3(2):192-203. doi: 10.1046/j.1524-475X.1995.30211.x.

Poor wound healing during vitamin C deficiency is thought to be due to decreased hydroxylation of proline residues in collagen. In non-repair connective tissues of guinea pigs, however, procollagen gene expression is not decreased until weight loss occurs during...

Regulatory Actions of Insulin-like Growth Factor-binding Proteins.

Trends in endocrinology and metabolism: TEM

Rechler MM, Clemmons DR.
PMID: 18406262
Trends Endocrinol Metab. 1998 Jul;9(5):176-83. doi: 10.1016/s1043-2760(98)00047-2.

The six insulin-like growth factor-binding proteins (IGFBPs) are important regulators of insulin-like growth factor (IGF) action. Circulating high molecular weight complexes that contain IGF and IGFBP-3 restrict IGF bioavailability, and excess IGFBPs inhibit IGF action by forming biologically inactive...

Insulin-Like Growth Factors and Their Binding Proteins in Tumors and Ascites of Ovarian Cancer Patients: Association With Response To Neoadjuvant Chemotherapy.

Asian Pacific journal of cancer prevention : APJCP

Yunusova NV, Villert AB, Spirina LV, Frolova AE, Kolomiets LA, Kondakova IV.
PMID: 28125879
Asian Pac J Cancer Prev. 2016 Dec 01;17(12):5315-5320. doi: 10.22034/APJCP.2016.17.12.5315.

Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and...

Impaired kidney structure and function in spinal muscular atrophy.

Neurology. Genetics

Nery FC, Siranosian JJ, Rosales I, Deguise MO, Sharma A, Muhtaseb AW, Nwe P, Johnstone AJ, Zhang R, Fatouraei M, Huemer N, Alves CRR, Kothary R, Swoboda KJ.
PMID: 31517062
Neurol Genet. 2019 Aug 12;5(5):e353. doi: 10.1212/NXG.0000000000000353. eCollection 2019 Oct.

OBJECTIVE: To determine changes in serum profiles and kidney tissues from patients with spinal muscular atrophy (SMA) type 1 compared with age- and sex-matched controls.METHODS: In this cohort study, we investigated renal structure and function in infants and children...

Loggerhead sea turtle Caretta caretta plasma biochemistry and proteome profile modulation during recovery.

Journal of proteomics

Jakšić Ž, Mrljak V, Horvatić A, Gelemanović A, Mičić M.
PMID: 34839037
J Proteomics. 2021 Nov 26;252:104433. doi: 10.1016/j.jprot.2021.104433. Epub 2021 Nov 26.

The aim of the study was to monitor and analyse injured and diseased loggerhead sea turtles (Caretta caretta) plasma proteome profiles and biochemistry parameters during their recovery period in rescue centre within different age and recovery period groups, and...

Growth Factors and Their Roles in Multiple Sclerosis Risk.

Frontiers in immunology

Lu H, Wu PF, Ma DL, Zhang W, Sun M.
PMID: 34745143
Front Immunol. 2021 Oct 21;12:768682. doi: 10.3389/fimmu.2021.768682. eCollection 2021.

BACKGROUND: Previous studies have suggested essential roles of growth factors on the risk of Multiple Sclerosis (MS), but it remains undefined whether the effects are causal.OBJECTIVE: We applied Mendelian randomization (MR) approaches to disentangle the causal relationship between genetically...

Loggerhead sea turtle Caretta caretta plasma biochemistry and proteome profile modulation during recovery.

Journal of proteomics

Jakšić Ž, Mrljak V, Horvatić A, Gelemanović A, Mičić M.
PMID: 34839037
J Proteomics. 2021 Nov 26;252:104433. doi: 10.1016/j.jprot.2021.104433. Epub 2021 Nov 26.

The aim of the study was to monitor and analyse injured and diseased loggerhead sea turtles (Caretta caretta) plasma proteome profiles and biochemistry parameters during their recovery period in rescue centre within different age and recovery period groups, and...

Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer.

Cancers

Thomas D, Radhakrishnan P.
PMID: 32414222
Cancers (Basel). 2020 May 13;12(5). doi: 10.3390/cancers12051228.

Pancreatic cancer (PC) is the utmost stroma-rich cancer, which is accompanied by fibrotic reactions that stimulate interactions between tumor cells and stroma to promote tumor progression. Considerable research evidence denotes that insulin-like growth factor (IGF)/IGF binding proteins (IGFBP) signaling...

Profiling of Insulin-Like Growth Factor Binding Proteins (IGFBPs) in Obesity and Their Association With Ox-LDL and Hs-CRP in Adolescents.

Frontiers in endocrinology

Rahman A, Hammad MM, Al Khairi I, Cherian P, Al-Sabah R, Al-Mulla F, Abu-Farha M, Abubaker J.
PMID: 34394011
Front Endocrinol (Lausanne). 2021 Jul 28;12:727004. doi: 10.3389/fendo.2021.727004. eCollection 2021.

Insulin-like growth factor binding proteins (IGFBPs) are critical modulators of metabolism. In adults, IGFBPs are associated with obesity and insulin resistance. However, the association of IGFBPs with metabolic homeostasis in children and adolescents is not yet fully characterized. In...

Different temporal expressions of Tilapia (Oreochromis mossambicus) insulin-like growth factor-I and IGF binding protein-3 after growth hormone induction.

Marine biotechnology (New York, N.Y.)

Cheng R, Chang KM, Wu JL.
PMID: 14961256
Mar Biotechnol (NY). 2002 Jun;4(3):218-25. doi: 10.1007/s10126-002-0014-0.

In vertebrates the insulin-like growth factor-I (IGF-I) is well recognized for its important roles in prenatal and postnatal processes. Liver is the major endocrine organ in mammals to produce IGF-I and its modulators, the insulin-like growth factor binding proteins...

Showing 1 to 12 of 60 entries