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Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression.

Ophthalmology and eye diseases

Blalock EL, Chien H, Dix RD.
PMID: 23650460
Ophthalmol Eye Dis. 2012 Sep 25;4:79-90. doi: 10.4137/OED.S10294. Print 2012.

Interleukin-4 (IL-4) and interleukin-10 (IL-10) are key cytokines whose increased production during systemic HIV infection has been associated with decreased cellular immunity during AIDS. We examined whether HIV-induced stimulation of IL-4 or IL-10 production leads to increased susceptibility to...

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Blalock EL, Chien H, Dix RD. Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. Ophthalmol Eye Dis. 2012;4:79-90doi: 10.4137/OED.S10294.
Blalock, E. L., Chien, H., & Dix, R. D. (2012). Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. Ophthalmology and eye diseases, 479-90. https://doi.org/10.4137/OED.S10294
Blalock, Emily L, et al. "Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression." Ophthalmology and eye diseases vol. 4 (2012): 79-90. doi: https://doi.org/10.4137/OED.S10294
Blalock EL, Chien H, Dix RD. Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. Ophthalmol Eye Dis. 2012 Sep 25;4:79-90. doi: 10.4137/OED.S10294. Print 2012. PMID: 23650460; PMCID: PMC3619657.
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Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells.

Iranian journal of public health

Arjomand Fard N, Tabrizian N, Mirzaei R, Hadjati J, Tofighi Zavareh F, Salehi Nodeh AR, Mirshafiey A.
PMID: 28451557
Iran J Public Health. 2017 Feb;46(2):216-221.

BACKGROUND: The expanse of dendritic cells (DC) differentiation plays an important role in determining immune response. DC-based immunosuppressive drugs have notable side effects in increasing the risk of infectious diseases and cancers. G2013, as a novel anti-inflammatory and immunosuppressive...

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Arjomand Fard N, Tabrizian N, Mirzaei R, et al. Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iran J Public Health. 2017;46(2):216-221
Arjomand Fard, N., Tabrizian, N., Mirzaei, R., Hadjati, J., Tofighi Zavareh, F., Salehi Nodeh, A. R., & Mirshafiey, A. (2017). Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iranian journal of public health, 46(2), 216-221.
Arjomand Fard, Nazanin, et al. "Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells." Iranian journal of public health vol. 46,2 (2017): 216-221.
Arjomand Fard N, Tabrizian N, Mirzaei R, Hadjati J, Tofighi Zavareh F, Salehi Nodeh AR, Mirshafiey A. Efficacy and Safety of G2013 as a Novel Immunosuppressive Agent on Differentiation, Maturation and Function of Human Dendritic Cells. Iran J Public Health. 2017 Feb;46(2):216-221. PMID: 28451557; PMCID: PMC5402780.
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Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis.

Annals of medicine and surgery (2012)

Wang T, Tian L, Gao M, Song H, Wei Y, Xue Y.
PMID: 27284401
Ann Med Surg (Lond). 2016 May 18;9:1-5. doi: 10.1016/j.amsu.2016.05.011. eCollection 2016 Aug.

Gastric cancer (GC) is a common cancer affecting patients around the world. The pathogenesis of gastric cancer has not been understood completely. Genetic mutations and the inflammation induced by Helicobacter pylori (HP) seem to play important roles. The cytokine...

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Wang T, Tian L, Gao M, et al. Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis. Ann Med Surg (Lond). 2016;9:1-5doi: 10.1016/j.amsu.2016.05.011.
Wang, T., Tian, L., Gao, M., Song, H., Wei, Y., & Xue, Y. (2016). Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis. Annals of medicine and surgery (2012), 91-5. https://doi.org/10.1016/j.amsu.2016.05.011
Wang, Tie, et al. "Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis." Annals of medicine and surgery (2012) vol. 9 (2016): 1-5. doi: https://doi.org/10.1016/j.amsu.2016.05.011
Wang T, Tian L, Gao M, Song H, Wei Y, Xue Y. Interleukin (IL)-4 -590C>T polymorphism is not associated with the susceptibility of gastric cancer: An updated meta-analysis. Ann Med Surg (Lond). 2016 May 18;9:1-5. doi: 10.1016/j.amsu.2016.05.011. eCollection 2016 Aug. PMID: 27284401; PMCID: PMC4887560.
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Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice.

Central-European journal of immunology

Jiang YQ, Zhou ZX, Ji YL.
PMID: 26155138
Cent Eur J Immunol. 2014;39(3):294-8. doi: 10.5114/ceji.2014.45938. Epub 2014 Oct 14.

Severe and life-threatening side effects can occur in patients receiving allergen-specific immunotherapy (SIT), and recombinant allergens made from cDNA have been used in clinical trials for ten years and appear promising for SIT. The aim of this study is...

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Jiang YQ, Zhou ZX, Ji YL. Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice. Cent Eur J Immunol. 2014;39(3):294-8doi: 10.5114/ceji.2014.45938.
Jiang, Y. Q., Zhou, Z. X., & Ji, Y. L. (2014). Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice. Central-European journal of immunology, 39(3), 294-8. https://doi.org/10.5114/ceji.2014.45938
Jiang, Yong-Qian, et al. "Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice." Central-European journal of immunology vol. 39,3 (2014): 294-8. doi: https://doi.org/10.5114/ceji.2014.45938
Jiang YQ, Zhou ZX, Ji YL. Effects of the recombinant allergen rDer f 2 on neuro-endocrino-immune network in asthmatic mice. Cent Eur J Immunol. 2014;39(3):294-8. doi: 10.5114/ceji.2014.45938. Epub 2014 Oct 14. PMID: 26155138; PMCID: PMC4440009.
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Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner.

Molecular medicine (Cambridge, Mass.)

Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, McKay DM.
PMID: 26701314
Mol Med. 2016 May;21(1):924-936. doi: 10.2119/molmed.2015.00193. Epub 2015 Dec 09.

The adoptive transfer of alternatively activated macrophages (AAMs) has proven to attenuate inflammation in multiple mouse models of colitis; however, the effect of cryopreservation on AAMs, the ability of previously frozen AAMs to block dinitrobenzene sulfonic acid (DNBS) (Th1)...

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Leung G, Petri B, Reyes JL, et al. Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Mol Med. 2015;21(1):924-936doi: 10.2119/molmed.2015.00193.
Leung, G., Petri, B., Reyes, J. L., Wang, A., Iannuzzi, J., & McKay, D. M. (2016). Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Molecular medicine (Cambridge, Mass.), 21(1), 924-936. https://doi.org/10.2119/molmed.2015.00193
Leung, Gabriella, et al. "Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner." Molecular medicine (Cambridge, Mass.) vol. 21,1 (2016): 924-936. doi: https://doi.org/10.2119/molmed.2015.00193
Leung G, Petri B, Reyes JL, Wang A, Iannuzzi J, McKay DM. Cryopreserved Interleukin-4-Treated Macrophages Attenuate Murine Colitis in an Integrin β7 - Dependent Manner. Mol Med. 2016 May;21(1):924-936. doi: 10.2119/molmed.2015.00193. Epub 2015 Dec 09. PMID: 26701314; PMCID: PMC4818268.
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Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease.

Asia Pacific allergy

Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara T.
PMID: 29094020
Asia Pac Allergy. 2017 Oct;7(4):221-226. doi: 10.5415/apallergy.2017.7.4.221. Epub 2017 Oct 23.

BACKGROUND: Kimura disease (KD) is a systemic soft-tissue disease that leads to formation of painless masses in lymph nodes, with the highest predilection for the head and neck and especially the parotid gland. KD lesions are characterized by marked...

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Nonaka M, Sakitani E, Ono E, et al. Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. Asia Pac Allergy. 2017;7(4):221-226doi: 10.5415/apallergy.2017.7.4.221.
Nonaka, M., Sakitani, E., Ono, E., Yamamura, Y., Seo, Y., Shibata, N., Pawankar, R., & Yoshihara, T. (2017). Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. Asia Pacific allergy, 7(4), 221-226. https://doi.org/10.5415/apallergy.2017.7.4.221
Nonaka, Manabu, et al. "Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease." Asia Pacific allergy vol. 7,4 (2017): 221-226. doi: https://doi.org/10.5415/apallergy.2017.7.4.221
Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara T. Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease. Asia Pac Allergy. 2017 Oct;7(4):221-226. doi: 10.5415/apallergy.2017.7.4.221. Epub 2017 Oct 23. PMID: 29094020; PMCID: PMC5663750.
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Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy.

International journal of hepatology

Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K.
PMID: 24868471
Int J Hepatol. 2014;2014:584650. doi: 10.1155/2014/584650. Epub 2014 Apr 27.

It is known that the interleukin-4 receptor α (IL-4R α ) is highly expressed on the surface of various human solid tumors. We previously designed novel IL-4R α -lytic hybrid peptide composed of binding peptide to IL-4R α and...

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Seto K, Shoda J, Horibe T, et al. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Int J Hepatol. 2014;2014:584650doi: 10.1155/2014/584650.
Seto, K., Shoda, J., Horibe, T., Warabi, E., Kohno, M., Yanagawa, T., Bukawa, H., Nakanuma, Y., & Kawakami, K. (2014). Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. International journal of hepatology, 2014584650. https://doi.org/10.1155/2014/584650
Seto, Kahori, et al. "Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy." International journal of hepatology vol. 2014 (2014): 584650. doi: https://doi.org/10.1155/2014/584650
Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami K. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Int J Hepatol. 2014;2014:584650. doi: 10.1155/2014/584650. Epub 2014 Apr 27. PMID: 24868471; PMCID: PMC4020457.
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Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk.

Cancer cell international

Duan Y, Pan C, Shi J, Chen H, Zhang S.
PMID: 25484626
Cancer Cell Int. 2014 Nov 30;14(1):131. doi: 10.1186/s12935-014-0131-7. eCollection 2014.

BACKGROUND: Interleukin-4(IL-4) is a critical inflammatory cytokine and has been involved in pathogenesis of cancer. To date, several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans;...

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Duan Y, Pan C, Shi J, et al. Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk. Cancer Cell Int. 2014;14(1):131doi: 10.1186/s12935-014-0131-7.
Duan, Y., Pan, C., Shi, J., Chen, H., & Zhang, S. (2014). Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk. Cancer cell international, 14(1), 131. https://doi.org/10.1186/s12935-014-0131-7
Duan, Yin, et al. "Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk." Cancer cell international vol. 14,1 (2014): 131. doi: https://doi.org/10.1186/s12935-014-0131-7
Duan Y, Pan C, Shi J, Chen H, Zhang S. Association between interleukin-4 gene intron 3 VNTR polymorphism and cancer risk. Cancer Cell Int. 2014 Nov 30;14(1):131. doi: 10.1186/s12935-014-0131-7. eCollection 2014. PMID: 25484626; PMCID: PMC4258052.
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Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial.

Allergy, asthma & immunology research

Yang HJ, Min TK, Lee HW, Pyun BY.
PMID: 24843795
Allergy Asthma Immunol Res. 2014 May;6(3):208-15. doi: 10.4168/aair.2014.6.3.208. Epub 2013 Dec 12.

PURPOSE: To evaluate a therapeutic efficacy of probiotics mixture (probiotics) in the treatment of children with mild-to-moderate atopic dermatitis (AD).METHODS: Randomized, double-blind, placebo-controlled, parallel trial with a washout period of 2 weeks and an intervention period for 6 weeks,...

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Yang HJ, Min TK, Lee HW, et al. Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial. Allergy Asthma Immunol Res. 2013;6(3):208-15doi: 10.4168/aair.2014.6.3.208.
Yang, H. J., Min, T. K., Lee, H. W., & Pyun, B. Y. (2014). Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial. Allergy, asthma & immunology research, 6(3), 208-15. https://doi.org/10.4168/aair.2014.6.3.208
Yang, Hyeon-Jong, et al. "Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial." Allergy, asthma & immunology research vol. 6,3 (2014): 208-15. doi: https://doi.org/10.4168/aair.2014.6.3.208
Yang HJ, Min TK, Lee HW, Pyun BY. Efficacy of Probiotic Therapy on Atopic Dermatitis in Children: A Randomized, Double-blind, Placebo-controlled Trial. Allergy Asthma Immunol Res. 2014 May;6(3):208-15. doi: 10.4168/aair.2014.6.3.208. Epub 2013 Dec 12. PMID: 24843795; PMCID: PMC4021238.
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2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation.

Frontiers in immunology

Zhao Q, Chu Z, Zhu L, Yang T, Wang P, Liu F, Huang Y, Zhang F, Zhang X, Ding W, Zhao Y.
PMID: 28620389
Front Immunol. 2017 Jun 01;8:637. doi: 10.3389/fimmu.2017.00637. eCollection 2017.

As important effector cells in inflammation, macrophages can be functionally polarized into either inflammatory M1 or alternatively activated anti-inflammatory M2 phenotype depending on surroundings. The key roles of glycolysis in M1 macrophage polarization have been well defined. However, the...

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Zhao Q, Chu Z, Zhu L, et al. 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation. Front Immunol. 2017;8:637doi: 10.3389/fimmu.2017.00637.
Zhao, Q., Chu, Z., Zhu, L., Yang, T., Wang, P., Liu, F., Huang, Y., Zhang, F., Zhang, X., Ding, W., & Zhao, Y. (2017). 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation. Frontiers in immunology, 8637. https://doi.org/10.3389/fimmu.2017.00637
Zhao, Qingjie, et al. "2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation." Frontiers in immunology vol. 8 (2017): 637. doi: https://doi.org/10.3389/fimmu.2017.00637
Zhao Q, Chu Z, Zhu L, Yang T, Wang P, Liu F, Huang Y, Zhang F, Zhang X, Ding W, Zhao Y. 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation. Front Immunol. 2017 Jun 01;8:637. doi: 10.3389/fimmu.2017.00637. eCollection 2017. PMID: 28620389; PMCID: PMC5451502.
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Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization.

Journal of traditional and complementary medicine

Minami M, Konishi T, Jiang Z, Arai T, Makino T.
PMID: 27419089
J Tradit Complement Med. 2015 Jun 21;6(3):252-6. doi: 10.1016/j.jtcme.2015.06.001. eCollection 2016 Jul.

Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine ( rì běn hàn yī) and traditional Chinese medicine (TCM; zhōng yī), has been used for the treatment of chronic sinusitis. The...

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Minami M, Konishi T, Jiang Z, et al. Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization. J Tradit Complement Med. 2015;6(3):252-6doi: 10.1016/j.jtcme.2015.06.001.
Minami, M., Konishi, T., Jiang, Z., Arai, T., & Makino, T. (2016). Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization. Journal of traditional and complementary medicine, 6(3), 252-6. https://doi.org/10.1016/j.jtcme.2015.06.001
Minami, Masaaki, et al. "Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization." Journal of traditional and complementary medicine vol. 6,3 (2016): 252-6. doi: https://doi.org/10.1016/j.jtcme.2015.06.001
Minami M, Konishi T, Jiang Z, Arai T, Makino T. Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization. J Tradit Complement Med. 2015 Jun 21;6(3):252-6. doi: 10.1016/j.jtcme.2015.06.001. eCollection 2016 Jul. PMID: 27419089; PMCID: PMC4936765.
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One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats.

Toxicology reports

Francis AP, Ganapathy S, Palla VR, Murthy PB, Ramaprabhu S, Devasena T.
PMID: 28962343
Toxicol Rep. 2015 Feb 07;2:111-120. doi: 10.1016/j.toxrep.2015.02.003. eCollection 2015.

We have investigated the time-dependent effect of multi-walled carbon nanotubes (MWCNTs) in rats upon single inhalation exposure followed by intermittent sacrifice. The effects were monitored by analyzing the bronchoalveolar lavage fluid (BALF) and histopathological analysis. Cell count, neutrophils, lymphocytes,...

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Francis AP, Ganapathy S, Palla VR, et al. One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats. Toxicol Rep. 2015;2:111-120doi: 10.1016/j.toxrep.2015.02.003.
Francis, A. P., Ganapathy, S., Palla, V. R., Murthy, P. B., Ramaprabhu, S., & Devasena, T. (2015). One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats. Toxicology reports, 2111-120. https://doi.org/10.1016/j.toxrep.2015.02.003
Francis, Arul Prakash, et al. "One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats." Toxicology reports vol. 2 (2015): 111-120. doi: https://doi.org/10.1016/j.toxrep.2015.02.003
Francis AP, Ganapathy S, Palla VR, Murthy PB, Ramaprabhu S, Devasena T. One time nose-only inhalation of MWCNTs: Exploring the mechanism of toxicity by intermittent sacrifice in Wistar rats. Toxicol Rep. 2015 Feb 07;2:111-120. doi: 10.1016/j.toxrep.2015.02.003. eCollection 2015. PMID: 28962343; PMCID: PMC5598153.
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Showing 1 to 12 of 680 entries