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Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Human molecular genetics

Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE.
PMID: 34165540
Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166.

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central...

Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation.

PloS one

Winkler TW, Justice AE, Cupples LA, Kronenberg F, Kutalik Z, Heid IM.
PMID: 28749953
PLoS One. 2017 Jul 27;12(7):e0181038. doi: 10.1371/journal.pone.0181038. eCollection 2017.

Genome-wide association meta-analyses (GWAMAs) conducted separately by two strata have identified differences in genetic effects between strata, such as sex-differences for body fat distribution. However, there are several approaches to identify such differences and an uncertainty which approach to...

Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes.

BMC proceedings

Justice AE, Howard AG, Fernández-Rhodes L, Graff M, Tao R, North KE.
PMID: 30275878
BMC Proc. 2018 Sep 17;12:22. doi: 10.1186/s12919-018-0118-9. eCollection 2018.

Even though there has been great success in identifying lipid-associated single-nucleotide polymorphisms (SNPs), the mechanisms through which the SNPs act on each trait are poorly understood. The emergence of large, complex biological data sets in well-characterized cohort studies offers...

Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Human molecular genetics

Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE.
PMID: 34165540
Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166.

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central...

Showing 1 to 4 of 4 entries