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The effect of hydrogen bonding propensity and enantiomeric composition on the dynamics of supercooled ketoprofen - dielectric, rheological and NMR studies.

Physical chemistry chemical physics : PCCP

Adrjanowicz K, Kaminski K, Tarnacka M, Szutkowski K, Popenda L, Bartkowiak G, Paluch M.
PMID: 27035123
Phys Chem Chem Phys. 2016 Apr 21;18(15):10585-93. doi: 10.1039/c6cp00578k. Epub 2016 Apr 01.

The aim of this work is to analyze in detail the effect of small hydrogen bonding (HB) structures and enantiomeric composition on the dynamics of glass-forming liquid ketoprofen. For that purpose dielectric relaxation, rheological and NMR studies were performed....

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Adrjanowicz K, Kaminski K, Tarnacka M, et al. The effect of hydrogen bonding propensity and enantiomeric composition on the dynamics of supercooled ketoprofen - dielectric, rheological and NMR studies. Phys Chem Chem Phys. 2016;18(15):10585-93doi: 10.1039/c6cp00578k.
Adrjanowicz, K., Kaminski, K., Tarnacka, M., Szutkowski, K., Popenda, L., Bartkowiak, G., & Paluch, M. (2016). The effect of hydrogen bonding propensity and enantiomeric composition on the dynamics of supercooled ketoprofen - dielectric, rheological and NMR studies. Physical chemistry chemical physics : PCCP, 18(15), 10585-93. https://doi.org/10.1039/c6cp00578k
Adrjanowicz, K, et al. "The effect of hydrogen bonding propensity and enantiomeric composition on the dynamics of supercooled ketoprofen - dielectric, rheological and NMR studies." Physical chemistry chemical physics : PCCP vol. 18,15 (2016): 10585-93. doi: https://doi.org/10.1039/c6cp00578k
Adrjanowicz K, Kaminski K, Tarnacka M, Szutkowski K, Popenda L, Bartkowiak G, Paluch M. The effect of hydrogen bonding propensity and enantiomeric composition on the dynamics of supercooled ketoprofen - dielectric, rheological and NMR studies. Phys Chem Chem Phys. 2016 Apr 21;18(15):10585-93. doi: 10.1039/c6cp00578k. Epub 2016 Apr 01. PMID: 27035123.
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Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study.

Journal of pain research

Olczak B, Kowalski G, Leppert W, Bienert A, Teżyk A, Adamski M, Rzymski S, Wieczorowska-Tobis K.
PMID: 29026333
J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017.

BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA).PATIENTS...

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Olczak B, Kowalski G, Leppert W, et al. Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. J Pain Res. 2017;10:2303-2309doi: 10.2147/JPR.S144799.
Olczak, B., Kowalski, G., Leppert, W., Bienert, A., Teżyk, A., Adamski, M., Rzymski, S., & Wieczorowska-Tobis, K. (2017). Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. Journal of pain research, 102303-2309. https://doi.org/10.2147/JPR.S144799
Olczak, Bogumił, et al. "Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study." Journal of pain research vol. 10 (2017): 2303-2309. doi: https://doi.org/10.2147/JPR.S144799
Olczak B, Kowalski G, Leppert W, Bienert A, Teżyk A, Adamski M, Rzymski S, Wieczorowska-Tobis K. Analgesic efficacy and safety of epidural oxycodone in patients undergoing total hip arthroplasty: a pilot study. J Pain Res. 2017 Sep 27;10:2303-2309. doi: 10.2147/JPR.S144799. eCollection 2017. PMID: 29026333; PMCID: PMC5627752.
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A photoreducible copper(II)-tren complex of practical value: generation of a highly reactive click catalyst.

Chemistry (Weinheim an der Bergstrasse, Germany)

Harmand L, Lambert R, Scarpantonio L, McClenaghan ND, Lastécouères D, Vincent JM.
PMID: 24127367
Chemistry. 2013 Nov 25;19(48):16231-9. doi: 10.1002/chem.201302032. Epub 2013 Oct 14.

A detailed study on the photoreduction of the copper(II) precatalyst 1 to generate a highly reactive cuprous species for the copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) click reaction is presented. For the photoactive catalyst described herein, the activation is driven by...

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Harmand L, Lambert R, Scarpantonio L, et al. A photoreducible copper(II)-tren complex of practical value: generation of a highly reactive click catalyst. Chemistry. 2013;19(48):16231-9doi: 10.1002/chem.201302032.
Harmand, L., Lambert, R., Scarpantonio, L., McClenaghan, N. D., Lastécouères, D., & Vincent, J. M. (2013). A photoreducible copper(II)-tren complex of practical value: generation of a highly reactive click catalyst. Chemistry (Weinheim an der Bergstrasse, Germany), 19(48), 16231-9. https://doi.org/10.1002/chem.201302032
Harmand, Lydie, et al. "A photoreducible copper(II)-tren complex of practical value: generation of a highly reactive click catalyst." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 19,48 (2013): 16231-9. doi: https://doi.org/10.1002/chem.201302032
Harmand L, Lambert R, Scarpantonio L, McClenaghan ND, Lastécouères D, Vincent JM. A photoreducible copper(II)-tren complex of practical value: generation of a highly reactive click catalyst. Chemistry. 2013 Nov 25;19(48):16231-9. doi: 10.1002/chem.201302032. Epub 2013 Oct 14. PMID: 24127367.
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Reducing postoperative pain from tonsillectomy using monopolar electrocautery by cooling the oropharynx.

International archives of otorhinolaryngology

Vieira L, Nissen L, Sela G, Amara Y, Fonseca V.
PMID: 25992083
Int Arch Otorhinolaryngol. 2014 Apr;18(2):155-8. doi: 10.1055/s-0033-1363783. Epub 2014 Jan 06.

Objective Evaluate intraoperative cooling of the oropharynx to reduce postoperative pain in tonsillectomy using monopolar electrocautery. Methods Sixty-six patients, age 1 to 12 years, were selected for the study, 33 in the control group and 33 in the experimental...

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Vieira L, Nissen L, Sela G, et al. Reducing postoperative pain from tonsillectomy using monopolar electrocautery by cooling the oropharynx. Int Arch Otorhinolaryngol. 2014;18(2):155-8doi: 10.1055/s-0033-1363783.
Vieira, L., Nissen, L., Sela, G., Amara, Y., & Fonseca, V. (2014). Reducing postoperative pain from tonsillectomy using monopolar electrocautery by cooling the oropharynx. International archives of otorhinolaryngology, 18(2), 155-8. https://doi.org/10.1055/s-0033-1363783
Vieira, Lucas, et al. "Reducing postoperative pain from tonsillectomy using monopolar electrocautery by cooling the oropharynx." International archives of otorhinolaryngology vol. 18,2 (2014): 155-8. doi: https://doi.org/10.1055/s-0033-1363783
Vieira L, Nissen L, Sela G, Amara Y, Fonseca V. Reducing postoperative pain from tonsillectomy using monopolar electrocautery by cooling the oropharynx. Int Arch Otorhinolaryngol. 2014 Apr;18(2):155-8. doi: 10.1055/s-0033-1363783. Epub 2014 Jan 06. PMID: 25992083; PMCID: PMC4297033.
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Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt.

Drug development and industrial pharmacy

Cerciello A, Auriemma G, Del Gaudio P, Cantarini M, Aquino RP.
PMID: 27237337
Drug Dev Ind Pharm. 2016 Dec;42(12):2063-2069. doi: 10.1080/03639045.2016.1195401. Epub 2016 Jun 14.

CONTEXT: Ketoprofen lysinate (KL) is one of the most widely used non-steroidal anti-inflammatory drugs in the symptomatic treatment of some chronic inflammatory diseases. Compared to ketoprofen, KL shows better pharmacokinetics and tolerability. However, due to its short half-life of...

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Cerciello A, Auriemma G, Del Gaudio P, et al. Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt. Drug Dev Ind Pharm. 2016;42(12):2063-2069doi: 10.1080/03639045.2016.1195401.
Cerciello, A., Auriemma, G., Del Gaudio, P., Cantarini, M., & Aquino, R. P. (2016). Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt. Drug development and industrial pharmacy, 42(12), 2063-2069. https://doi.org/10.1080/03639045.2016.1195401
Cerciello, Andrea, et al. "Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt." Drug development and industrial pharmacy vol. 42,12 (2016): 2063-2069. doi: https://doi.org/10.1080/03639045.2016.1195401
Cerciello A, Auriemma G, Del Gaudio P, Cantarini M, Aquino RP. Natural polysaccharides platforms for oral controlled release of ketoprofen lysine salt. Drug Dev Ind Pharm. 2016 Dec;42(12):2063-2069. doi: 10.1080/03639045.2016.1195401. Epub 2016 Jun 14. PMID: 27237337.
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Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat.

Journal of clinical pharmacology

Cabré F, Fernández MF, Zapatero MI, Arañó A, García ML, Mauleón D.
PMID: 29023865
J Clin Pharmacol. 1998 Dec;38:27S-32S. doi: 10.1002/jcph.1998.38.s1.27.

Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit prostaglandin synthesis in the gastrointestinal mucosa, which can lead not only to stomach ulcers but also ulcers in the small and large intestines. Ulcers of the small intestine are less common than those of...

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Cabré F, Fernández MF, Zapatero MI, et al. Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat. J Clin Pharmacol. 1998;38:27S-32Sdoi: 10.1002/jcph.1998.38.s1.27.
Cabré, F., Fernández, M. F., Zapatero, M. I., Arañó, A., García, M. L., & Mauleón, D. (1998). Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat. Journal of clinical pharmacology, 3827S-32S. https://doi.org/10.1002/jcph.1998.38.s1.27
Cabré, Francesc, et al. "Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat." Journal of clinical pharmacology vol. 38 (1998): 27S-32S. doi: https://doi.org/10.1002/jcph.1998.38.s1.27
Cabré F, Fernández MF, Zapatero MI, Arañó A, García ML, Mauleón D. Intestinal Ulcerogenic Effect of S(+)-Ketoprofen in the Rat. J Clin Pharmacol. 1998 Dec;38:27S-32S. doi: 10.1002/jcph.1998.38.s1.27. PMID: 29023865.
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Conformational Change in the Mechanism of Inclusion of Ketoprofen in β-Cyclodextrin: NMR Spectroscopy, Ab Initio Calculations, Molecular Dynamics Simulations, and Photoreactivity.

The journal of physical chemistry. B

Guzzo T, Mandaliti W, Nepravishta R, Aramini A, Bodo E, Daidone I, Allegretti M, Topai A, Paci M.
PMID: 27689813
J Phys Chem B. 2016 Oct 20;120(41):10668-10678. doi: 10.1021/acs.jpcb.6b07913. Epub 2016 Oct 11.

Inclusion of drugs in cyclodextrins (CDs) is a recognized tool for modifying several properties such as solubility, stability, bioavailability, and so on. The photoreactive behavior of the β-CD/ketoprofen (KP) complex upon UV exposure showed a significant increase in photodecarboxylation,...

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Guzzo T, Mandaliti W, Nepravishta R, et al. Conformational Change in the Mechanism of Inclusion of Ketoprofen in β-Cyclodextrin: NMR Spectroscopy, Ab Initio Calculations, Molecular Dynamics Simulations, and Photoreactivity. J Phys Chem B. 2016;120(41):10668-10678doi: 10.1021/acs.jpcb.6b07913.
Guzzo, T., Mandaliti, W., Nepravishta, R., Aramini, A., Bodo, E., Daidone, I., Allegretti, M., Topai, A., & Paci, M. (2016). Conformational Change in the Mechanism of Inclusion of Ketoprofen in β-Cyclodextrin: NMR Spectroscopy, Ab Initio Calculations, Molecular Dynamics Simulations, and Photoreactivity. The journal of physical chemistry. B, 120(41), 10668-10678. https://doi.org/10.1021/acs.jpcb.6b07913
Guzzo, T, et al. "Conformational Change in the Mechanism of Inclusion of Ketoprofen in β-Cyclodextrin: NMR Spectroscopy, Ab Initio Calculations, Molecular Dynamics Simulations, and Photoreactivity." The journal of physical chemistry. B vol. 120,41 (2016): 10668-10678. doi: https://doi.org/10.1021/acs.jpcb.6b07913
Guzzo T, Mandaliti W, Nepravishta R, Aramini A, Bodo E, Daidone I, Allegretti M, Topai A, Paci M. Conformational Change in the Mechanism of Inclusion of Ketoprofen in β-Cyclodextrin: NMR Spectroscopy, Ab Initio Calculations, Molecular Dynamics Simulations, and Photoreactivity. J Phys Chem B. 2016 Oct 20;120(41):10668-10678. doi: 10.1021/acs.jpcb.6b07913. Epub 2016 Oct 11. PMID: 27689813.
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Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI.

Magnetic resonance in chemistry : MRC

Emoto MC, Sato S, Fujii HG.
PMID: 26990690
Magn Reson Chem. 2016 Sep;54(9):705-711. doi: 10.1002/mrc.4431. Epub 2016 Mar 15.

Theranostic probes provide both therapeutic and diagnostic imaging capabilities in one molecule and show significant promise for use in magnetic resonance imaging (MRI) examinations. The present study describes for the first time the synthesis and utility of nitroxide-based contrast...

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Emoto MC, Sato S, Fujii HG. Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI. Magn Reson Chem. 2016;54(9):705-711doi: 10.1002/mrc.4431.
Emoto, M. C., Sato, S., & Fujii, H. G. (2016). Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI. Magnetic resonance in chemistry : MRC, 54(9), 705-711. https://doi.org/10.1002/mrc.4431
Emoto, Miho C, et al. "Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI." Magnetic resonance in chemistry : MRC vol. 54,9 (2016): 705-711. doi: https://doi.org/10.1002/mrc.4431
Emoto MC, Sato S, Fujii HG. Development of nitroxide-based theranostic compounds that act both as anti-inflammatory drugs and brain redox imaging probes in MRI. Magn Reson Chem. 2016 Sep;54(9):705-711. doi: 10.1002/mrc.4431. Epub 2016 Mar 15. PMID: 26990690.
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The application of co-melt-extruded poly(ε-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies.

Results in pharma sciences

Gardyne SJ, Mucalo MR, Rathbone MJ.
PMID: 25755986
Results Pharma Sci. 2011 Nov 25;1(1):80-7. doi: 10.1016/j.rinphs.2011.11.002. eCollection 2011 May.

Eight bioactive drug compounds (abamectin, amoxicillin, dexamethasone, dexamethasone valerate, ketoprofen, melatonin, oestradiol 17β, and oestradiol benzoate) were combined via melt extrusion and disc pressing processes with a polycaprolactone (PCL) matrix and were then evaluated and compared via membrane diffusion...

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Gardyne SJ, Mucalo MR, Rathbone MJ. The application of co-melt-extruded poly(ε-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies. Results Pharma Sci. 2011;1(1):80-7doi: 10.1016/j.rinphs.2011.11.002.
Gardyne, S. J., Mucalo, M. R., & Rathbone, M. J. (2011). The application of co-melt-extruded poly(ε-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies. Results in pharma sciences, 1(1), 80-7. https://doi.org/10.1016/j.rinphs.2011.11.002
Gardyne, Stephen J, et al. "The application of co-melt-extruded poly(ε-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies." Results in pharma sciences vol. 1,1 (2011): 80-7. doi: https://doi.org/10.1016/j.rinphs.2011.11.002
Gardyne SJ, Mucalo MR, Rathbone MJ. The application of co-melt-extruded poly(ε-caprolactone) as a controlled release drug delivery device when combined with novel bioactive drug candidates: Membrane permeation and Hanson dissolution studies. Results Pharma Sci. 2011 Nov 25;1(1):80-7. doi: 10.1016/j.rinphs.2011.11.002. eCollection 2011 May. PMID: 25755986; PMCID: PMC4150627.
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[2-Arylpropionic acids. Role in pain therapy].

Schmerz (Berlin, Germany)

Brune K, Hinz B.
PMID: 12799951
Schmerz. 1998 Dec 09;12(6):383-8. doi: 10.1007/s004829800037.

The antipyretic analgesics still comprise the most widely used group of analgesic compounds. Until twenty years ago, aspirin, phenazone derivatives and acetaminophen had been used as standard remedies for intercurrent harmless pain conditions in connection with infections, trauma, small...

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Brune K, Hinz B. 2-Arylpropionsäuren. Stellenwert in der Schmerztherapie. [2-Arylpropionic acids. Role in pain therapy]. Schmerz. 1998;12(6):383-8doi: 10.1007/s004829800037.
Brune, K., & Hinz, B. (1998). 2-Arylpropionsäuren. Stellenwert in der Schmerztherapie. [2-Arylpropionic acids. Role in pain therapy]. Schmerz (Berlin, Germany), 12(6), 383-8. https://doi.org/10.1007/s004829800037
Brune, K, and Hinz, B. "2-Arylpropionsäuren. Stellenwert in der Schmerztherapie." [2-Arylpropionic acids. Role in pain therapy]. Schmerz (Berlin, Germany) vol. 12,6 (1998): 383-8. doi: https://doi.org/10.1007/s004829800037
Brune K, Hinz B. 2-Arylpropionsäuren. Stellenwert in der Schmerztherapie. [2-Arylpropionic acids. Role in pain therapy]. Schmerz. 1998 Dec 09;12(6):383-8. doi: 10.1007/s004829800037. German. PMID: 12799951.
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Ketoprofen for add-on pain treatment to paracetamol after strabismus surgery in children.

Clinical drug investigation

Kokki H, Purhonen S, Teräsvirta M, Ylönen P.
PMID: 17516708
Clin Drug Investig. 2004;24(4):237-44. doi: 10.2165/00044011-200424040-00005.

OBJECTIVE: To evaluate whether combining ketoprofen, a nonsteroidal anti-inflammatory analgesic, with paracetamol would provide better postoperative analgesia than paracetamol alone in children undergoing strabismus surgery.STUDY DESIGN: A prospective, double-blind, randomised clinical trial.PATIENTS AND METHODS: 56 generally healthy children, aged...

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Kokki H, Purhonen S, Teräsvirta M, et al. Ketoprofen for add-on pain treatment to paracetamol after strabismus surgery in children. Clin Drug Investig. 2004;24(4):237-44doi: 10.2165/00044011-200424040-00005.
Kokki, H., Purhonen, S., Teräsvirta, M., & Ylönen, P. (2004). Ketoprofen for add-on pain treatment to paracetamol after strabismus surgery in children. Clinical drug investigation, 24(4), 237-44. https://doi.org/10.2165/00044011-200424040-00005
Kokki, Hannu, et al. "Ketoprofen for add-on pain treatment to paracetamol after strabismus surgery in children." Clinical drug investigation vol. 24,4 (2004): 237-44. doi: https://doi.org/10.2165/00044011-200424040-00005
Kokki H, Purhonen S, Teräsvirta M, Ylönen P. Ketoprofen for add-on pain treatment to paracetamol after strabismus surgery in children. Clin Drug Investig. 2004;24(4):237-44. doi: 10.2165/00044011-200424040-00005. PMID: 17516708.
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Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain.

Clinical drug investigation

Seymour RA, Kelly PJ, Hawkesford JE.
PMID: 18370482
Clin Drug Investig. 1998;15(4):279-84. doi: 10.2165/00044011-199815040-00003.

A double-blind, randomised trial was carried out to investigate the relationship between efficacy and various pharmacokinetic variables after single doses of racemic ketoprofen 12.5 and 25mg in patients with postoperative pain after third molar surgery over a 4-hour investigation...

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Seymour RA, Kelly PJ, Hawkesford JE. Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain. Clin Drug Investig. 1998;15(4):279-84doi: 10.2165/00044011-199815040-00003.
Seymour, R. A., Kelly, P. J., & Hawkesford, J. E. (1998). Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain. Clinical drug investigation, 15(4), 279-84. https://doi.org/10.2165/00044011-199815040-00003
Seymour, R A, et al. "Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain." Clinical drug investigation vol. 15,4 (1998): 279-84. doi: https://doi.org/10.2165/00044011-199815040-00003
Seymour RA, Kelly PJ, Hawkesford JE. Pharmacokinetics and efficacy of low-dose ketoprofen in postoperative dental pain. Clin Drug Investig. 1998;15(4):279-84. doi: 10.2165/00044011-199815040-00003. PMID: 18370482.
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