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Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants

k-12

[No authors listed]
GSID: Yzj3Ml19nQcJ
A Jaffé, YA Chabbert, E Derlot - Antimicrobial Agents and …, 1983 - Am Soc Microbiol

… (3-Lactam-resistant mutants ofEscherichia coli K-12 were selected by using 12 different … In a previous report (10), we described mutants of Eicherchia coi K-12 that are resistant to the -… coli K-12 towards P-lactams (2, 9, 10, 19)....

Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion.

Organic & biomolecular chemistry

Sapegin A, Osipyan A, Krasavin M.
PMID: 28321443
Org Biomol Chem. 2017 Apr 05;15(14):2906-2909. doi: 10.1039/c7ob00535k.

Imidazoline-fused [1,4]oxazepines (prepared in two simple steps from methyl 2-hydroxyaroates, ethylene diamine and bis-electrophilic aromatics) undergo a facile, good-yielding hydrolytic imidazoline ring expansion (HIRE) upon N-alkylation and treatment with aqueous K

Infections Caused by Stenotrophomonas maltophilia in Recipients of Hematopoietic Stem Cell Transplantation.

Frontiers in oncology

Al-Anazi KA, Al-Jasser AM.
PMID: 25202682
Front Oncol. 2014 Aug 25;4:232. doi: 10.3389/fonc.2014.00232. eCollection 2014.

Stenotrophomonas maltophilia (S. maltophilia) is a globally emerging Gram-negative bacillus that is widely spread in environment and hospital equipment. Recently, the incidence of infections caused by this organism has increased, particularly in patients with hematological malignancy and in recipients...

Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides.

Organic letters

Pace V, Rae JP, Procter DJ.
PMID: 24350760
Org Lett. 2014 Jan 17;16(2):476-9. doi: 10.1021/ol4033623. Epub 2013 Dec 18.

The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.

Synthesis of novel N-cyclopentenyl-lactams using the Aubé reaction.

Beilstein journal of organic chemistry

Shinde MV, Ople RS, Sangtani E, Gonnade R, Reddy DS.
PMID: 26199661
Beilstein J Org Chem. 2015 Jun 23;11:1060-7. doi: 10.3762/bjoc.11.119. eCollection 2015.

A novel and convenient method utilizing the Aubé reaction to access a new class of compounds that are similar to carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes the Aubé reaction with various cyclic ketones...

Carbamate-catalyzed enantioselective bromolactamization.

Angewandte Chemie (International ed. in English)

Cheng YA, Yu WZ, Yeung YY.
PMID: 26314397
Angew Chem Int Ed Engl. 2015 Oct 05;54(41):12102-6. doi: 10.1002/anie.201504724. Epub 2015 Aug 28.

A highly facile, efficient, and enantioselective bromolactamization of olefinic amides was effected by a carbamate catalyst and ethanol additive. The amide substrates underwent N-cyclization predominantly to give a diverse range of enantioenriched bromolactam products containing up to two stereogenic...

Synthesis of Pyrrolidines and Pyrrolizidines with α-Pseudoquaternary Centers by Copper-Catalyzed Condensation of α-Diazodicarbonyl Compounds and Aryl γ-Lactams.

Angewandte Chemie (International ed. in English)

Goudedranche S, Besnard C, Egger L, Lacour J.
PMID: 27701808
Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13775-13779. doi: 10.1002/anie.201607574. Epub 2016 Oct 04.

N-aryl γ-lactams react intermolecularly with acceptor-acceptor diazo reagents, usually dicarbonyl compounds, in a copper-catalyzed process to yield functionalized pyrrolidines with α-pseudoquaternary centers. As 1,2-acyl or -phosphoryl migration is preferred, single regioisomers are obtained. Furthermore, in the presence of a...

Diastereoselective Synthesis of and Mechanistic Understanding for the Formation of 2-Piperidinones from Imines and Cyano-Substituted Anhydrides.

Chemistry (Weinheim an der Bergstrasse, Germany)

Di Maso MJ, Snyder KM, De Souza Fernandes F, Pattawong O, Tan DQ, Fettinger JC, Cheong PH, Shaw JT.
PMID: 26929008
Chemistry. 2016 Mar 24;22(14):4794-801. doi: 10.1002/chem.201504424. Epub 2016 Mar 01.

2-Piperidinones are synthesized in a single step from imines and 2-cyano glutaric anhydrides. The reaction provides the products in good diastereoselectivity and generates a quaternary stereogenic center. Substitutions on the anhydride skeleton are well tolerated to provide 2-piperidinones with...

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014.

Hepatology international

Sarin SK, Kedarisetty CK, Abbas Z, Amarapurkar D, Bihari C, Chan AC, Chawla YK, Dokmeci AK, Garg H, Ghazinyan H, Hamid S, Kim DJ, Komolmit P, Lata S, Lee GH, Lesmana LA, Mahtab M, Maiwall R, Moreau R, Ning Q, Pamecha V, Payawal DA, Rastogi A, Rahman S, Rela M, Saraya A, Samuel D, Saraswat V, Shah S, Shiha G, Sharma BC, Sharma MK, Sharma K, Butt AS, Tan SS, Vashishtha C, Wani ZA, Yuen MF, Yokosuka O.
PMID: 26202751
Hepatol Int. 2014 Oct;8(4):453-71. doi: 10.1007/s12072-014-9580-2. Epub 2014 Sep 26.

The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. Due to the rapid advancements in...

Smaller, faster, better: modular synthesis of unsymmetrical ammonium salt-tagged NHC-gold(I) complexes and their application as recyclable catalysts in water.

Organic & biomolecular chemistry

Belger K, Krause N.
PMID: 26175224
Org Biomol Chem. 2015 Aug 21;13(31):8556-60. doi: 10.1039/c5ob01286d.

Facile access towards a small library of unsymmetrical ammonium salt-tagged N-heterocyclic carbene gold(i) complexes is described, and their application as recyclable catalysts in cyclization reactions of acetylenic carboxylic acids and amides to lactones and lactams, respectively, in aqueous media...

Prolonged versus Intermittent Infusion of β-Lactams for the Treatment of Nosocomial Pneumonia: A Meta-Analysis.

Infection & chemotherapy

Lal A, Jaoude P, El-Solh AA.
PMID: 27433378
Infect Chemother. 2016 Jun;48(2):81-90. doi: 10.3947/ic.2016.48.2.81. Epub 2016 Jun 30.

BACKGROUND: The primary objective of this meta-analysis is aimed at determining whether β-lactams prolonged infusion in patients with nosocomial pneumonia (NP) results in higher cure rate and improved mortality compared to intermittent infusion.MATERIALS AND METHODS: Relevant studies were identified...

The emergence of multidrug-resistant .

Lung India : official organ of Indian Chest Society

AbdulWahab A, Zahraldin K, Sid Ahmed MA, Jarir SA, Muneer M, Mohamed SF, Hamid JM, Hassan AAI, Ibrahim EB.
PMID: 29098998
Lung India. 2017 Nov-Dec;34(6):527-531. doi: 10.4103/lungindia.lungindia_39_17.

INTRODUCTION: Multidrug-resistant Pseudomonas aeruginosa (MDR-PA) is an important and growing issue in the care of patients with cystic fibrosis (CF), and a major cause of morbidity and mortality.OBJECTIVE: The objective of the study was to describe the frequency of...

Showing 1 to 12 of 1586 entries