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Epidemiology of diabetes.

Medicine (Abingdon, England : UK ed.)

Forouhi NG, Wareham NJ.
PMID: 25568613
Medicine (Abingdon). 2014 Dec;42(12):698-702. doi: 10.1016/j.mpmed.2014.09.007.

The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes...

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Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine (Abingdon). 2014;42(12):698-702doi: 10.1016/j.mpmed.2014.09.007.
Forouhi, N. G., & Wareham, N. J. (2014). Epidemiology of diabetes. Medicine (Abingdon, England : UK ed.), 42(12), 698-702. https://doi.org/10.1016/j.mpmed.2014.09.007
Forouhi, Nita Gandhi, and Wareham, Nicholas J. "Epidemiology of diabetes." Medicine (Abingdon, England : UK ed.) vol. 42,12 (2014): 698-702. doi: https://doi.org/10.1016/j.mpmed.2014.09.007
Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine (Abingdon). 2014 Dec;42(12):698-702. doi: 10.1016/j.mpmed.2014.09.007. PMID: 25568613; PMCID: PMC4282306.
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Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight.

Genes & nutrition

Meidtner K, Fisher E, Angquist L, Holst C, Vimaleswaran KS, Boer JM, Halkjær J, Masala G, Ostergaard JN, Mortensen LM, van der A DL, Tjønneland A, Palli D, Overvad K, Wareham NJ, Loos RJ, Sørensen TI, Boeing H.
PMID: 24496996
Genes Nutr. 2014 Mar;9(2):385. doi: 10.1007/s12263-014-0385-7. Epub 2014 Feb 05.

We analysed single nucleotide polymorphisms (SNPs) tagging the genetic variability of six candidate genes (ATF6, FABP1, LPIN2, LPIN3, MLXIPL and MTTP) involved in the regulation of hepatic lipid metabolism, an important regulatory site of energy balance for associations with...

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Meidtner K, Fisher E, Angquist L, et al. Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight. Genes Nutr. 2014;9(2):385doi: 10.1007/s12263-014-0385-7.
Meidtner, K., Fisher, E., Angquist, L., Holst, C., Vimaleswaran, K. S., Boer, J. M., Halkjær, J., Masala, G., Ostergaard, J. N., Mortensen, L. M., van der A, D. L., Tjønneland, A., Palli, D., Overvad, K., Wareham, N. J., Loos, R. J., Sørensen, T. I., & Boeing, H. (2014). Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight. Genes & nutrition, 9(2), 385. https://doi.org/10.1007/s12263-014-0385-7
Meidtner, Karina, et al. "Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight." Genes & nutrition vol. 9,2 (2014): 385. doi: https://doi.org/10.1007/s12263-014-0385-7
Meidtner K, Fisher E, Angquist L, Holst C, Vimaleswaran KS, Boer JM, Halkjær J, Masala G, Ostergaard JN, Mortensen LM, van der A DL, Tjønneland A, Palli D, Overvad K, Wareham NJ, Loos RJ, Sørensen TI, Boeing H. Variation in genes related to hepatic lipid metabolism and changes in waist circumference and body weight. Genes Nutr. 2014 Mar;9(2):385. doi: 10.1007/s12263-014-0385-7. Epub 2014 Feb 05. PMID: 24496996; PMCID: PMC3968289.
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Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals.

Diabetology & metabolic syndrome

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ.
PMID: 24669786
Diabetol Metab Syndr. 2014 Mar 26;6(1):43. doi: 10.1186/1758-5996-6-43.

BACKGROUND: There is a well-established association between type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) secondary to excess accumulation of intrahepatic lipid (IHL), but the mechanistic basis for this association is unclear. Emerging evidence suggests that in addition...

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Finucane FM, Sharp SJ, Hatunic M, et al. Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetol Metab Syndr. 2014;6(1):43doi: 10.1186/1758-5996-6-43.
Finucane, F. M., Sharp, S. J., Hatunic, M., Sleigh, A., De Lucia Rolfe, E., Aihie Sayer, A., Cooper, C., Griffin, S. J., & Wareham, N. J. (2014). Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetology & metabolic syndrome, 6(1), 43. https://doi.org/10.1186/1758-5996-6-43
Finucane, Francis M, et al. "Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals." Diabetology & metabolic syndrome vol. 6,1 (2014): 43. doi: https://doi.org/10.1186/1758-5996-6-43
Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ. Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. Diabetol Metab Syndr. 2014 Mar 26;6(1):43. doi: 10.1186/1758-5996-6-43. PMID: 24669786; PMCID: PMC3974597.
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Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring?.

Frontiers in endocrinology

Kunutsor SK, Abbasi A, Apekey TA.
PMID: 25408682
Front Endocrinol (Lausanne). 2014 Nov 04;5:189. doi: 10.3389/fendo.2014.00189. eCollection 2014.

No abstract available.

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Kunutsor SK, Abbasi A, Apekey TA. Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring?. Front Endocrinol (Lausanne). 2014;5:189doi: 10.3389/fendo.2014.00189.
Kunutsor, S. K., Abbasi, A., & Apekey, T. A. (2014). Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring?. Frontiers in endocrinology, 5189. https://doi.org/10.3389/fendo.2014.00189
Kunutsor, Setor K, et al. "Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring?." Frontiers in endocrinology vol. 5 (2014): 189. doi: https://doi.org/10.3389/fendo.2014.00189
Kunutsor SK, Abbasi A, Apekey TA. Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring?. Front Endocrinol (Lausanne). 2014 Nov 04;5:189. doi: 10.3389/fendo.2014.00189. eCollection 2014. PMID: 25408682; PMCID: PMC4219379.
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The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort.

BMJ open

Khawaja AP, Chan MP, Hayat S, Broadway DC, Luben R, Garway-Heath DF, Sherwin JC, Yip JL, Dalzell N, Wareham NJ, Khaw KT, Foster PJ.
PMID: 23516272
BMJ Open. 2013 Mar 19;3(3). doi: 10.1136/bmjopen-2013-002684.

OBJECTIVES: To summarise the methods of the European Prospective Investigation of Cancer (EPIC)-Norfolk Eye Study, and to present data on the prevalence of visual impairment and associations with visual impairment in the participants.DESIGN: A population-based cross-sectional study nested within...

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Khawaja AP, Chan MP, Hayat S, et al. The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort. BMJ Open. 2013;3(3)doi: 10.1136/bmjopen-2013-002684.
Khawaja, A. P., Chan, M. P., Hayat, S., Broadway, D. C., Luben, R., Garway-Heath, D. F., Sherwin, J. C., Yip, J. L., Dalzell, N., Wareham, N. J., Khaw, K. T., & Foster, P. J. (2013). The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort. BMJ open, 3(3), . https://doi.org/10.1136/bmjopen-2013-002684
Khawaja, Anthony P, et al. "The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort." BMJ open vol. 3,3 (2013). doi: https://doi.org/10.1136/bmjopen-2013-002684
Khawaja AP, Chan MP, Hayat S, Broadway DC, Luben R, Garway-Heath DF, Sherwin JC, Yip JL, Dalzell N, Wareham NJ, Khaw KT, Foster PJ. The EPIC-Norfolk Eye Study: rationale, methods and a cross-sectional analysis of visual impairment in a population-based cohort. BMJ Open. 2013 Mar 19;3(3). doi: 10.1136/bmjopen-2013-002684. PMID: 23516272; PMCID: PMC3612817.
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Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study.

Diabetes care

Rolandsson O, Hampe CS, Wennberg P, Radtke J, Langenberg C, Wareham N.
PMID: 26207060
Diabetes Care. 2015 Aug;38(8):e114-5. doi: 10.2337/dc15-0305.

No abstract available.

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Rolandsson O, Hampe CS, Wennberg P, et al. Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study. Diabetes Care. 2015;38(8):e114-5doi: 10.2337/dc15-0305.
Rolandsson, O., Hampe, C. S., Wennberg, P., Radtke, J., Langenberg, C., Wareham, N. (2015). Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study. Diabetes care, 38(8), e114-5. https://doi.org/10.2337/dc15-0305
Rolandsson, Olov, et al. "Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study." Diabetes care vol. 38,8 (2015): e114-5. doi: https://doi.org/10.2337/dc15-0305
Rolandsson O, Hampe CS, Wennberg P, Radtke J, Langenberg C, Wareham N. Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study. Diabetes Care. 2015 Aug;38(8):e114-5. doi: 10.2337/dc15-0305. PMID: 26207060; PMCID: PMC4512134.
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Mendelian Randomisation Study of Childhood BMI and Early Menarche.

Journal of obesity

Mumby HS, Elks CE, Li S, Sharp SJ, Khaw KT, Luben RN, Wareham NJ, Loos RJ, Ong KK.
PMID: 21773002
J Obes. 2011;2011:180729. doi: 10.1155/2011/180729. Epub 2011 May 18.

To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established "BMI-increasing" genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from...

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Mumby HS, Elks CE, Li S, et al. Mendelian Randomisation Study of Childhood BMI and Early Menarche. J Obes. 2011;2011:180729doi: 10.1155/2011/180729.
Mumby, H. S., Elks, C. E., Li, S., Sharp, S. J., Khaw, K. T., Luben, R. N., Wareham, N. J., Loos, R. J., & Ong, K. K. (2011). Mendelian Randomisation Study of Childhood BMI and Early Menarche. Journal of obesity, 2011180729. https://doi.org/10.1155/2011/180729
Mumby, Hannah S, et al. "Mendelian Randomisation Study of Childhood BMI and Early Menarche." Journal of obesity vol. 2011 (2011): 180729. doi: https://doi.org/10.1155/2011/180729
Mumby HS, Elks CE, Li S, Sharp SJ, Khaw KT, Luben RN, Wareham NJ, Loos RJ, Ong KK. Mendelian Randomisation Study of Childhood BMI and Early Menarche. J Obes. 2011;2011:180729. doi: 10.1155/2011/180729. Epub 2011 May 18. PMID: 21773002; PMCID: PMC3136158.
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Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.

International journal of endocrinology

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ.
PMID: 23737780
Int J Endocrinol. 2013;2013:870487. doi: 10.1155/2013/870487. Epub 2013 May 02.

Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression...

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Finucane FM, Sharp SJ, Hatunic M, et al. Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol. 2013;2013:870487doi: 10.1155/2013/870487.
Finucane, F. M., Sharp, S. J., Hatunic, M., Sleigh, A., De Lucia Rolfe, E., Sayer, A. A., Cooper, C., Griffin, S. J., Savage, D. B., & Wareham, N. J. (2013). Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. International journal of endocrinology, 2013870487. https://doi.org/10.1155/2013/870487
Finucane, Francis M, et al. "Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals." International journal of endocrinology vol. 2013 (2013): 870487. doi: https://doi.org/10.1155/2013/870487
Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ. Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals. Int J Endocrinol. 2013;2013:870487. doi: 10.1155/2013/870487. Epub 2013 May 02. PMID: 23737780; PMCID: PMC3659510.
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The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort.

BMJ open

Sahlqvist S, Goodman A, Simmons RK, Khaw KT, Cavill N, Foster C, Luben R, Wareham NJ, Ogilvie D.
PMID: 24231462
BMJ Open. 2013 Nov 14;3(11):e003797. doi: 10.1136/bmjopen-2013-003797.

OBJECTIVES: To investigate associations between modest levels of total and domain-specific (commuting, other utility, recreational) cycling and mortality from all causes, cardiovascular disease and cancer.DESIGN: Population-based cohort study (European Prospective Investigation into Cancer and Nutrition study-Norfolk).SETTING: Participants were recruited...

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Sahlqvist S, Goodman A, Simmons RK, et al. The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort. BMJ Open. 2013;3(11):e003797doi: 10.1136/bmjopen-2013-003797.
Sahlqvist, S., Goodman, A., Simmons, R. K., Khaw, K. T., Cavill, N., Foster, C., Luben, R., Wareham, N. J., & Ogilvie, D. (2013). The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort. BMJ open, 3(11), e003797. https://doi.org/10.1136/bmjopen-2013-003797
Sahlqvist, Shannon, et al. "The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort." BMJ open vol. 3,11 (2013): e003797. doi: https://doi.org/10.1136/bmjopen-2013-003797
Sahlqvist S, Goodman A, Simmons RK, Khaw KT, Cavill N, Foster C, Luben R, Wareham NJ, Ogilvie D. The association of cycling with all-cause, cardiovascular and cancer mortality: findings from the population-based EPIC-Norfolk cohort. BMJ Open. 2013 Nov 14;3(11):e003797. doi: 10.1136/bmjopen-2013-003797. PMID: 24231462; PMCID: PMC3831097.
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Unraveling the role for genetics in enabling precision prescription for weight loss-scaling up for success.

Obesity (Silver Spring, Md.)

Scott RA.
PMID: 26692577
Obesity (Silver Spring). 2016 Jan;24(1):12-3. doi: 10.1002/oby.21380.

No abstract available.

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Scott RA. Unraveling the role for genetics in enabling precision prescription for weight loss-scaling up for success. Obesity (Silver Spring). 2016;24(1):12-3doi: 10.1002/oby.21380.
Scott, R. A. (2016). Unraveling the role for genetics in enabling precision prescription for weight loss-scaling up for success. Obesity (Silver Spring, Md.), 24(1), 12-3. https://doi.org/10.1002/oby.21380
Scott, Robert A. "Unraveling the role for genetics in enabling precision prescription for weight loss-scaling up for success." Obesity (Silver Spring, Md.) vol. 24,1 (2016): 12-3. doi: https://doi.org/10.1002/oby.21380
Scott RA. Unraveling the role for genetics in enabling precision prescription for weight loss-scaling up for success. Obesity (Silver Spring). 2016 Jan;24(1):12-3. doi: 10.1002/oby.21380. PMID: 26692577.
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Mind the gap: efficacy versus effectiveness of lifestyle interventions to prevent diabetes.

The lancet. Diabetes & endocrinology

Wareham NJ.
PMID: 25652128
Lancet Diabetes Endocrinol. 2015 Mar;3(3):160-1. doi: 10.1016/S2213-8587(15)70015-X. Epub 2015 Feb 02.

No abstract available.

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Wareham NJ. Mind the gap: efficacy versus effectiveness of lifestyle interventions to prevent diabetes. Lancet Diabetes Endocrinol. 2015;3(3):160-1doi: 10.1016/S2213-8587(15)70015-X.
Wareham, N. J. (2015). Mind the gap: efficacy versus effectiveness of lifestyle interventions to prevent diabetes. The lancet. Diabetes & endocrinology, 3(3), 160-1. https://doi.org/10.1016/S2213-8587(15)70015-X
Wareham, Nicholas J. "Mind the gap: efficacy versus effectiveness of lifestyle interventions to prevent diabetes." The lancet. Diabetes & endocrinology vol. 3,3 (2015): 160-1. doi: https://doi.org/10.1016/S2213-8587(15)70015-X
Wareham NJ. Mind the gap: efficacy versus effectiveness of lifestyle interventions to prevent diabetes. Lancet Diabetes Endocrinol. 2015 Mar;3(3):160-1. doi: 10.1016/S2213-8587(15)70015-X. Epub 2015 Feb 02. PMID: 25652128.
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