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Showing 1 to 12 of 26 entries
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Associations between Blood Metabolic Profile at 7 Years Old and Eating Disorders in Adolescence: Findings from the Avon Longitudinal Study of Parents and Children.

Metabolites

Santos Ferreira DL, Hübel C, Herle M, Abdulkadir M, Loos RJF, Bryant-Waugh R, Bulik CM, De Stavola BL, Lawlor DA, Micali N.
PMID: 31546923
Metabolites. 2019 Sep 19;9(9). doi: 10.3390/metabo9090191.

Eating disorders are severe illnesses characterized by both psychiatric and metabolic factors. We explored the prospective role of metabolic risk in eating disorders in a UK cohort (

Future Directions for Integrative Objective Assessment of Eating Using Wearable Sensing Technology.

Frontiers in nutrition

Skinner A, Toumpakari Z, Stone C, Johnson L.
PMID: 32714939
Front Nutr. 2020 Jul 02;7:80. doi: 10.3389/fnut.2020.00080. eCollection 2020.

Established methods for nutritional assessment suffer from a number of important limitations. Diaries are burdensome to complete, food frequency questionnaires only capture average food intake, and both suffer from difficulties in self estimation of portion size and biases resulting...

Pregnancy and risk of COVID-19: a Norwegian registry-linkage study.

BJOG : an international journal of obstetrics and gynaecology

Magnus MC, Oakley L, Gjessing HK, Stephansson O, Engjom HM, Macsali F, Juliusson PB, Nybo Andersen AM, Håberg SE.
PMID: 34657368
BJOG. 2022 Jan;129(1):101-109. doi: 10.1111/1471-0528.16969. Epub 2021 Nov 01.

OBJECTIVE: To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist healthcare services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.POPULATION OR SAMPLE: All women ages 15-45 living in Norway on...

Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes.

Wellcome open research

Walker VM, Davies NM, Hemani G, Zheng J, Haycock PC, Gaunt TR, Davey Smith G, Martin RM.
PMID: 31448343
Wellcome Open Res. 2019 Nov 07;4:113. doi: 10.12688/wellcomeopenres.15334.2. eCollection 2019.

Mendelian randomization (MR) estimates the causal effect of exposures on outcomes by exploiting genetic variation to address confounding and reverse causation. This method has a broad range of applications, including investigating risk factors and appraising potential targets for intervention....

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation.

Molecular psychiatry

Sammallahti S, Cortes Hidalgo AP, Tuominen S, Malmberg A, Mulder RH, Brunst KJ, Alemany S, McBride NS, Yousefi P, Heiss JA, McRae N, Page CM, Jin J, Pesce G, Caramaschi D, Rifas-Shiman SL, Koen N, Adams CD, Magnus MC, Baïz N, Ratanatharathorn A, Czamara D, Håberg SE, Colicino E, Baccarelli AA, Cardenas A, DeMeo DL, Lawlor DA, Relton CL, Felix JF, van IJzendoorn MH, Bakermans-Kranenburg MJ, Kajantie E, Räikkönen K, Sunyer J, Sharp GC, Houtepen LC, Nohr EA, Sørensen TIA, Téllez-Rojo MM, Wright RO, Annesi-Maesano I, Wright J, Hivert MF, Wright RJ, Zar HJ, Stein DJ, London SJ, Cecil CAM, Tiemeier H, Lahti J.
PMID: 33414500
Mol Psychiatry. 2021 Jun;26(6):1832-1845. doi: 10.1038/s41380-020-00976-0. Epub 2021 Jan 07.

Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis...

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.

Genome biology

Cousminer DL, Wagley Y, Pippin JA, Elhakeem A, Way GP, Pahl MC, McCormack SE, Chesi A, Mitchell JA, Kindler JM, Baird D, Hartley A, Howe L, Kalkwarf HJ, Lappe JM, Lu S, Leonard ME, Johnson ME, Hakonarson H, Gilsanz V, Shepherd JA, Oberfield SE, Greene CS, Kelly A, Lawlor DA, Voight BF, Wells AD, Zemel BS, Hankenson KD, Grant SFA.
PMID: 33397451
Genome Biol. 2021 Jan 04;22(1):1. doi: 10.1186/s13059-020-02207-9.

BACKGROUND: Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by modeling longitudinal bone accrual across 11,000...

Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium.

Epigenetics

Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Estrada Gutierrez G, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler AG, Annesi-Maesano I, Bustamante M, Huang RC, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin MR, Felix JF, Sebert S.
PMID: 33331245
Epigenetics. 2021 Jan 11;1-13. doi: 10.1080/15592294.2020.1864171. Epub 2021 Jan 11.

Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences....

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.

Nature communications

Gordillo-Marañón M, Zwierzyna M, Charoen P, Drenos F, Chopade S, Shah T, Engmann J, Chaturvedi N, Papacosta O, Wannamethee G, Wong A, Sofat R, Kivimaki M, Price JF, Hughes AD, Gaunt TR, Lawlor DA, Gaulton A, Hingorani AD, Schmidt AF, Finan C.
PMID: 34675202
Nat Commun. 2021 Oct 21;12(1):6120. doi: 10.1038/s41467-021-25731-z.

Drug target Mendelian randomization (MR) studies use DNA sequence variants in or near a gene encoding a drug target, that alter the target's expression or function, as a tool to anticipate the effect of drug action on the same...

The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile.

Wellcome open research

Lawlor DA, Lewcock M, Rena-Jones L, Rollings C, Yip V, Smith D, Pearson RM, Johnson L, Millard LAC, Patel N, Skinner A, Tilling K.
PMID: 31984238
Wellcome Open Res. 2019 Feb 20;4:36. doi: 10.12688/wellcomeopenres.15087.2. eCollection 2019.

No abstract available.

Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health.

Hypertension (Dallas, Tex. : 1979)

Wang G, Bhatta L, Moen GH, Hwang LD, Kemp JP, Bond TA, Åsvold BO, Brumpton B, Evans DM, Warrington NM.
PMID: 34784738
Hypertension. 2022 Jan;79(1):170-177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Epub 2021 Nov 17.

Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether this association represents a causal relationship through intrauterine mechanisms. We used...

Pregnancy and risk of COVID-19: a Norwegian registry-linkage study.

BJOG : an international journal of obstetrics and gynaecology

Magnus MC, Oakley L, Gjessing HK, Stephansson O, Engjom HM, Macsali F, Juliusson PB, Nybo Andersen AM, Håberg SE.
PMID: 34657368
BJOG. 2022 Jan;129(1):101-109. doi: 10.1111/1471-0528.16969. Epub 2021 Nov 01.

OBJECTIVE: To compare the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and contact with specialist healthcare services for coronavirus disease 2019 (COVID-19) between pregnant and non-pregnant women.POPULATION OR SAMPLE: All women ages 15-45 living in Norway on...

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations.

International journal of epidemiology

Hartwig FP, Tilling K, Davey Smith G, Lawlor DA, Borges MC.
PMID: 33619569
Int J Epidemiol. 2021 Nov 10;50(5):1639-1650. doi: 10.1093/ije/dyaa266.

BACKGROUND: Two-sample Mendelian randomization (MR) allows the use of freely accessible summary association results from genome-wide association studies (GWAS) to estimate causal effects of modifiable exposures on outcomes. Some GWAS adjust for heritable covariables in an attempt to estimate...

Showing 1 to 12 of 26 entries