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Showing 1 to 12 of 206 entries
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PO-20 - Crosstalk between the lectin pathway and haemostasis in patients with pulmonary cancer.

Thrombosis research

Larsen JB, Christensen TD, Hvas CL, Hvas AM.
PMID: 27161707
Thromb Res. 2016 Apr;140:S183. doi: 10.1016/S0049-3848(16)30153-0. Epub 2016 Apr 08.

INTRODUCTION: Recent research has focused on the complement system in cancer, including the lectin pathway of complement activation. Mannose-binding lectin (MBL), a key activator of the lectin pathway, can bind to tumor cell surfaces in vitro, and lectin pathway...

A Bifunctional Spin Label for Ligand Recognition on Surfaces.

Angewandte Chemie (International ed. in English)

Hollas MA, Webb SJ, Flitsch SL, Fielding AJ.
PMID: 28570782
Angew Chem Int Ed Engl. 2017 Aug 01;56(32):9449-9453. doi: 10.1002/anie.201703929. Epub 2017 Jul 06.

In situ monitoring of biomolecular recognition, especially at surfaces, still presents a significant technical challenge. Electron paramagnetic resonance (EPR) of biomolecules spin-labeled with nitroxides can offer uniquely sensitive and selective insights into these processes, but new spin-labeling strategies are...

The lectin pathway of complement and rheumatic heart disease.

Frontiers in pediatrics

Beltrame MH, Catarino SJ, Goeldner I, Boldt AB, de Messias-Reason IJ.
PMID: 25654073
Front Pediatr. 2015 Jan 21;2:148. doi: 10.3389/fped.2014.00148. eCollection 2014.

The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry. The effector components of innate immunity include epithelial...

Association of Single-Nucleotide Polymorphisms of the .

Annals of dermatology

Kim JS, Lee SY, Hahn HJ, Lee YB, Yu DS, Kim JW.
PMID: 28966513
Ann Dermatol. 2017 Oct;29(5):571-577. doi: 10.5021/ad.2017.29.5.571. Epub 2017 Aug 25.

BACKGROUND: Human mannose-binding lectin (MBL) is a serum lectin taking part in the innate immunity by opsonizing various microorganisms for phagocytosis. The MBL serum concentration is affected by several single-nucleotide polymorphisms (SNPs) in the promoter region of the OBJECTIVE:...

Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM.

Data in brief

Liu Y, Cecílio NT, Carvalho FC, Roque-Barreira MC, Feizi T.
PMID: 26793748
Data Brief. 2015 Nov 18;5:1035-47. doi: 10.1016/j.dib.2015.11.014. eCollection 2015 Dec.

This article contains data related to the researc.h article entitled "Yeast-derived ArtinM shares structure, carbohydrate recognition, and biological effects with native ArtinM" by Cecílio et al. (2015) [1]. ArtinM, a D-mannose-binding lectin isolated from the seeds of Artocarpus heterophyllus,...

A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene.

SpringerPlus

Kalia N, Sharma A, Kaur M, Kamboj SS, Singh J.
PMID: 27390651
Springerplus. 2016 Jun 21;5(1):811. doi: 10.1186/s40064-016-2543-4. eCollection 2016.

Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. Mannose binding lectin gene 2 (MBL2) polymorphisms are reported to be associated with various diseases. In spite of being exhaustively studied molecule,...

Complement activity is associated with disease severity in multifocal motor neuropathy.

Neurology(R) neuroimmunology & neuroinflammation

Vlam L, Cats EA, Harschnitz O, Jansen MD, Piepers S, Veldink JH, Franssen H, Stork AC, Heezius E, Rooijakkers SH, Herpers BL, van Strijp JA, van den Berg LH, van der Pol WL.
PMID: 26161430
Neurol Neuroimmunol Neuroinflamm. 2015 Jun 25;2(4):e119. doi: 10.1212/NXI.0000000000000119. eCollection 2015 Aug.

OBJECTIVE: To investigate whether high innate activity of the classical and lectin pathways of complement is associated with multifocal motor neuropathy (MMN) and whether levels of innate complement activity or the potential of anti-GM1 antibodies to activate the complement...

Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis.

Frontiers in microbiology

Rosentul DC, Delsing CE, Jaeger M, Plantinga TS, Oosting M, Costantini I, Venselaar H, Joosten LA, van der Meer JW, Dupont B, Kullberg BJ, Sobel JD, Netea MG.
PMID: 25295030
Front Microbiol. 2014 Sep 23;5:483. doi: 10.3389/fmicb.2014.00483. eCollection 2014.

OBJECTIVE: Approximately 5% of women suffer from recurrent vulvovaginal candidiasis (RVVC). It has been hypothesized that genetic factors play an important role in the susceptibility to RVVC. The aim of this study was to assess the effect of genetic...

Serum protein biomarkers screening in patients with ischemic stroke by LC-MS/MS.

The International journal of neuroscience

Wei XJ, Li F, Yang FY, Duan CH.
PMID: 26000912
Int J Neurosci. 2016 Aug;126(8):692-9. doi: 10.3109/00207454.2015.1033713. Epub 2015 Aug 17.

BACKGROUND: The purpose of this study was to investigate the serum proteins biomarkers by label-free liquid chromatography coupled to tandem mass spectrometry quantification methods in the Chinese patients with acute ischemic stroke (AIS).METHOD: In the study period, sera from...

Differences in properties of peanut seed lectin and purified galactose- and mannose-binding lectins from nodules of peanut.

Planta

Law IJ, Haylett T, Strijdom BW.
PMID: 24220730
Planta. 1988 Nov;176(1):19-27. doi: 10.1007/BF00392475.

Two lectins were purified by affinity chromatography from mature peanut (Arachis hypogaea L.) nodules, and compared with the previously characterised seed lectin of this plant. One of the nodule lectins was similar to the seed lectin in its molecular...

Mannose binding lectin deficiency: more than meets the eye.

Clinical medicine insights. Pediatrics

Halbrich M, Ben-Shoshan M, McCusker C.
PMID: 23641170
Clin Med Insights Pediatr. 2012 Nov 05;6:89-94. doi: 10.4137/CMPed.S9860. Print 2012.

This case report describes a 5-year-old boy who presented to the emergency department with clinical symptoms and chest X-ray findings suggestive of pneumonia. Further history revealed multiple other infections, and workup for immunodeficiency revealed a deficiency of mannose-binding lectin...

Rapid identification of pathogens responsible for necrotizing fasciitis on an integrated microfluidic system.

Biomicrofluidics

Yu JC, Hsieh PH, Tsai HW, Chang WH, Liu TH, Lee MS, Peng KT, Huang KC, Lee GB.
PMID: 29282420
Biomicrofluidics. 2017 Dec 12;11(6):064108. doi: 10.1063/1.5007081. eCollection 2017 Nov.

Necrotic fasciitis (NF) is a particularly aggressive and serious infection of the fascia that can penetrate into the musculature and internal organs, resulting in death if not treated promptly. In this work, an integrated microfluidic system composed of micropumps,...

Showing 1 to 12 of 206 entries