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Showing 1 to 5 of 5 entries
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Multiple sclerosis, relapses, and the mechanism of action of adrenocorticotropic hormone.

Frontiers in neurology

Ross AP, Ben-Zacharia A, Harris C, Smrtka J.
PMID: 23482896
Front Neurol. 2013 Mar 08;4:21. doi: 10.3389/fneur.2013.00021. eCollection 2013.

Relapses in multiple sclerosis (MS) are disruptive and frequently disabling for patients, and their treatment is often a challenge to clinicians. Despite progress in the understanding of the pathophysiology of MS and development of new treatments for long-term management...

Melanocortin Regulation of Inflammation.

Frontiers in endocrinology

Wang W, Guo DY, Lin YJ, Tao YX.
PMID: 31649620
Front Endocrinol (Lausanne). 2019 Oct 09;10:683. doi: 10.3389/fendo.2019.00683. eCollection 2019.

Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system. The clinical use of ACTH in the treatment of rheumatoid...

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective.

Frontiers in endocrinology

Heyder N, Kleinau G, Szczepek M, Kwiatkowski D, Speck D, Soletto L, Cerdá-Reverter JM, Krude H, Kühnen P, Biebermann H, Scheerer P.
PMID: 31417496
Front Endocrinol (Lausanne). 2019 Jul 31;10:515. doi: 10.3389/fendo.2019.00515. eCollection 2019.

The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses ligand-independent basal signaling activity (orexigenic effects). Binding...

Melanocortins and their implication in melanoma.

Trends in endocrinology and metabolism: TEM

Siegrist W, Eberle AN.
PMID: 18406692
Trends Endocrinol Metab. 1995 May-Jun;6(4):115-20. doi: 10.1016/1043-2760(95)00017-c.

The melanocortins (MCs), that is, the melanocyte-stimulating hormones (MSHs) and ACTH, are a group of related peptides containing the typical melanotropin core sequence, His-Phe-Arg-Trp, and are derived from a common precursor, pro-opiomelanocortin. They are pleiotropic molecules that occur in...

The role of proopiomelanocortin (POMC) neurones in feeding behaviour.

Nutrition & metabolism

Millington GW.
PMID: 17764572
Nutr Metab (Lond). 2007 Sep 01;4:18. doi: 10.1186/1743-7075-4-18.

The precursor protein, proopiomelanocortin (POMC), produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin. The MSHs and ACTH bind to the extracellular G-protein coupled...

Showing 1 to 5 of 5 entries