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Showing 1 to 12 of 114 entries
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Pre-test metyrapone impairs memory recall in fear conditioning tasks: lack of interaction with β-adrenergic activity.

Frontiers in behavioral neuroscience

Careaga MB, Tiba PA, Ota SM, Suchecki D.
PMID: 25784866
Front Behav Neurosci. 2015 Mar 03;9:51. doi: 10.3389/fnbeh.2015.00051. eCollection 2015.

Cognitive processes, such as learning and memory, are essential for our adaptation to environmental changes and consequently for survival. Numerous studies indicate that hormones secreted during stressful situations, such as glucocorticoids (GCs), adrenaline and noradrenaline, regulate memory functions, modulating...

Conversion from Tryptophan Precursor into Violacein Pigments by a Cell-free System from Chromobacterium violaceum.

Bioscience, biotechnology, and biochemistry

Hoshino T, Yamamoto M.
PMID: 27396892
Biosci Biotechnol Biochem. 1997 Jan;61(12):2134-6. doi: 10.1271/bbb.61.2134.

A cell-free system for converting tryptophan precursor into violacein pigments is reported. Crucial factors were the requirements of the reduced nicotinamides as a cofactor and Zn(2+) as a metal ion. Optimal pHs were in the range of 8.5-9.5. The...

Gallium-68 DOTA-TATE Positron Emission Tomography/Computed Tomography: Scintigraphic Changes of Adrenal Glands Following Management of Ectopic Cushing's Syndrome by Steroidogenesis Inhibitors.

World journal of nuclear medicine

Huang YT, Aziz SI, Ravi Kumar AS.
PMID: 25538494
World J Nucl Med. 2014 Sep;13(3):201-4. doi: 10.4103/1450-1147.144823.

In the era of emerging functional imaging techniques, an understanding of the effects of hormonal therapies on the scintigraphic appearance of endocrine organs is desirable to minimize the erroneous scan interpretation. The mechanisms by which changes in the scintigraphic...

Differential toxicity of an inhibitor of mitochondrial respiration in canine hepatocytes and adrenocortical cell cultures.

Toxicology in vitro : an international journal published in association with BIBRA

Vernetti LA, Macdonald JR, Pegg DG.
PMID: 20650182
Toxicol In Vitro. 1996 Feb;10(1):51-7. doi: 10.1016/0887-2333(95)00102-6.

PD132301-2, a novel inhibitor of acyl-CoA: cholesterol acyltransferase, was previously shown to be an inhibitor of mitochondrial respiration and an adrenal toxicant in several species. To investigate potential mechanisms of tissue-specific toxicity in vivo, dog adrenocortical and hepatocyte cell...

Response of hepatic metallothionein to iron administration : Lack of correlation with serum corticosterone.

Biological trace element research

Petro A, Hill CH.
PMID: 24254827
Biol Trace Elem Res. 1987 Dec;14(3):255-63. doi: 10.1007/BF02795692.

Female broiler chicks receiving an ip injection of Fe (10 mg/kg bw) were found to have a greatly increased level of hepatic metallothionein. The increase in metallothionein was not correlated with changes in serum corticosterone. Attempts to vary serum...

Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-Solutions?.

Toxicology in vitro : an international journal published in association with BIBRA

Skett P.
PMID: 20692944
Toxicol In Vitro. 1994 Jun;8(3):491-504. doi: 10.1016/0887-2333(94)90174-0.

Isolated and cultured hepatocytes would seem to be an ideal model for the study of hepatic xenobiotic metabolism and metabolism-based hepatotoxicity. However, a serious drawback with this system of testing is the loss of xenobiotic-metabolizing capacity in a reaction-dependent...

Extra-adrenal glucocorticoids contribute to the postprandial increase of circulating leptin in mice.

Journal of cell communication and signaling

Tomabechi Y, Tsuruta T, Saito S, Wabitsch M, Sonoyama K.
PMID: 28744834
J Cell Commun Signal. 2018 Jun;12(2):433-439. doi: 10.1007/s12079-017-0403-9. Epub 2017 Jul 25.

Leptin, an adipokine secreted by white adipocytes, is known for its function in regulating food intake and energy expenditure, but the mechanisms regulating its circulating levels is not fully understood. Our previous findings suggest that as yet unidentified humoral...

Psychosis as a sequelae of paraneoplastic syndrome in Small- Cell Lung Carcinoma: A psycho-neuroendocrine interface.

Clinical schizophrenia & related psychoses

Wilkins CM, Johnson VL, Fargason RE, Birur B.
PMID: 29164929
Clin Schizophr Relat Psychoses. 2017 Nov 22; doi: 10.3371/CSRP.CWVJ.111717. Epub 2017 Nov 22.

In 2013 more than 150,000 Americans died from all types of lung cancer. Small cell lung cancer (SCLC) represents about 13% of all lung cancers and is notoriously associated with paraneoplastic syndromes (PNS). Here we present an interesting case...

Multiple Salivary Cortisol Measurements Are a Useful Tool to Optimize Metyrapone Treatment in Patients with Cushing's Syndromes Treatment: Case Presentations.

Frontiers in endocrinology

Yoshida K, Fukuoka H, Odake Y, Nakajima S, Tachibana M, Ito J, Hosokawa Y, Yamada T, Miura H, Suematsu N, Matsumoto R, Bando H, Suda K, Nishizawa H, Iguchi G, Ogawa W, Takahashi Y.
PMID: 29375480
Front Endocrinol (Lausanne). 2018 Jan 11;8:375. doi: 10.3389/fendo.2017.00375. eCollection 2017.

Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol...

Metyrapone as treatment in the neonatal McCune-Albright syndrome.

Journal of pediatric endocrinology & metabolism : JPEM

de Mingo C, Brugada M, León S, Moreno F, Vila N, Palanques-Pastor T, Poveda JL, Orti C, García-Robles A.
PMID: 32697759
J Pediatr Endocrinol Metab. 2020 Jul 22; doi: 10.1515/jpem-2020-0036. Epub 2020 Jul 22.

Objectives To present a case report of succesfully metyrapone treatment of a neonatal patient with McCune-Albrigth syndrome (MAS), a rare disease caused by a genetically mosaic disorder and is characterized by variable hyperfunctional endocrinopathies, bone dysplasia, and café-au-lait spots....

The Role of Inflammatory Proteins in Anti-Glucocorticoid Therapy for Treatment-Resistant Depression.

Journal of clinical medicine

Strawbridge R, Jamieson A, Hodsoll J, Ferrier IN, McAllister-Williams RH, Powell TR, Young AH, Cleare AJ, Watson S.
PMID: 33669254
J Clin Med. 2021 Feb 16;10(4). doi: 10.3390/jcm10040784.

BACKGROUND: Optimising treatments for patients with treatment-resistant depression (TRD) is key to reducing the burden of this severe illness. The anti-glucocorticoid medication metyrapone has mixed evidence supporting a role as a possible augmentation treatment in TRD. The degree of...

Permissive influence of stress in the expression of a U-shaped relationship between serum corticosterone levels and spatial memory errors in rats.

Dose-response : a publication of International Hormesis Society

Park CR, Campbell AM, Woodson JC, Smith TP, Fleshner M, Diamond DM.
PMID: 18648634
Dose Response. 2006 Jun 20;4(1):55-74. doi: 10.2203/dose-response.004.01.005.Park.

The relationship between glucocorticoids (GCs) and memory is complex, in that memory impairments can occur in response to manipulations that either increase or decrease GC levels. We investigated this issue by assessing the relationship between serum corticosterone (the primary...

Showing 1 to 12 of 114 entries