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Showing 1 to 12 of 19 entries
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Which antibiotic is better for the treatment of infections of the lower respiratory tract?.

International journal of antimicrobial agents

Schwigon CD, Gabor M, Hartmann J, Mössinger R, Oberling M, Schubert U, Schwarck H, Springsklee M, Zinndorf J.
PMID: 18611724
Int J Antimicrob Agents. 1996 Apr;6:S73-7.

The efficacy and tolerance of mezlocillin and ampicillin/sulbactam were investigated in an open, comparative, multicentre study involving 96 patients. The high levels of efficacy of both ampicillin/sulbactam and mezlocillin, as previously documented in comprehensive in vitro studies, were confirmed...

Evolution of the antimicrobial susceptibility of B. fragilis group at the university hospital of Seville (Spain) between 1977 and 1995.

International journal of antimicrobial agents

Borobio MV, Pascual A, Dominguez MC, Suarez AI, Ramirez E, Conejo MC, Pallarés JA, Moreno R, Perea EJ.
PMID: 18611728
Int J Antimicrob Agents. 1996 May;7(1):1-7. doi: 10.1016/0924-8579(96)00002-7.

A susceptibility survey of the B. fragilis group divided into three periods was carried out between 1977 and 1995 at the University Hospital of Seville (Spain) using the agar dilution method. No chloramphenicol, imipenem or meropenem-resistant strains were found....

Development and Validation of a UPLC-MS/MS Method for Ultra-Trace Level Determination of Acyl Chloride Potential Genotoxic Impurity in Mezlocillin.

Journal of chromatographic science

Chen Y, Huang L, Yuan X, Luo F, Pu H.
PMID: 34718453
J Chromatogr Sci. 2021 Oct 27; doi: 10.1093/chromsci/bmab119. Epub 2021 Oct 27.

3-Chlorocarbonyl-1-methanesulfonyl-2-imidazolidinone (CMI) is a critical intermediate used in the synthesis of mezlocillin drug substance and also a potential genotoxic impurity with acyl chloride moiety. The content of CMI in mezlocillin should be

Prevalence of Extended Spectrum β-lactamase-Producing Klebsiella pneumoniae in Clinical Isolates.

Jundishapur journal of microbiology

Ali Abdel Rahim KA, Ali Mohamed AM.
PMID: 25774279
Jundishapur J Microbiol. 2014 Nov;7(11):e17114. doi: 10.5812/jjm.17114. Epub 2014 Nov 01.

BACKGROUND: Extended spectrum β-lactamase (ESBL) are gram-negative bacteria that produce the enzyme, β-lactamase, which can break down commonly used antibiotics, such as penicillin and cephalosporins, making infections with ESBL producing bacteria more difficult to treat. Extended spectrum β-lactamase-producing Klebsiella...

The penicillins.

Mayo Clinic proceedings

Wright AJ, Wilkowske CJ.
PMID: 1921489
Mayo Clin Proc. 1991 Oct;66(10):1047-63. doi: 10.1016/s0025-6196(12)61730-3.

The penicillin family of antibiotics remains an important part of our antimicrobial armamentarium. In general, these agents have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections caused by susceptible bacteria. The initial introduction of...

Frequency of Class 1 Integron and Genetic Diversity of .

Journal of natural science, biology, and medicine

Eghbalimoghadam M, Farahani A, Akbar FN, Mohajeri P.
PMID: 28781486
J Nat Sci Biol Med. 2017 Jul-Dec;8(2):193-198. doi: 10.4103/0976-9668.210007.

MATERIALS AND METHODS: A total of 100 isolates of RESULTS: The maximum drug resistance was observed against cefotaxime, ceftriaxone, mezlocillin, imipenem, and ceftazidime and piperacillin. Twenty-nine isolates were multidrug resistant (MDR); about 21 isolates were extensively-drug resistant and none...

Analysis of polymerized impurities in mezlocillin sodium and sulbenicillin sodium using two chromatographic separation mechanisms coupled to tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis

Ren X, Tang K, Zhou P, Wang J.
PMID: 35026591
J Pharm Biomed Anal. 2022 Jan 07;210:114584. doi: 10.1016/j.jpba.2022.114584. Epub 2022 Jan 07.

To effectively control the polymerized impurities in mezlocillin sodium and sulbenicillin sodium, a HPSEC method with TSK-gel G2000SWxl column and a RP-HPLC method with C18 analytical column were established to replace the classical gel filtration chromatography with Sephadex G-10...

Emergence of .

Infection and drug resistance

Patil S, Chen H, Guo C, Zhang X, Ren PG, Francisco NM, Wen F.
PMID: 34511949
Infect Drug Resist. 2021 Sep 02;14:3581-3588. doi: 10.2147/IDR.S324018. eCollection 2021.

AIM: We investigated the clonal diversity of carbapenemase-producing METHODS: From January 2014 to December 2018, a total number of 36 unique carbapenemase-producing clinical isolates of RESULTS: The isolates showed resistance to ceftazidime, ertapenem, ampicillin, cefazolin, ceftriaxone, cefotetan, ticarcillin, cefaclor,...

The value of serum procalcitonin in the anti-infection therapy of acute stroke patients.

Pakistan journal of medical sciences

Wang HL, Li YL, Li XF, Wang ZZ.
PMID: 34290800
Pak J Med Sci. 2021 Jul-Aug;37(4):1155-1160. doi: 10.12669/pjms.37.4.3932.

OBJECTIVES: To investigate the value of dynamic monitoring of serum procalcitonin (PCT) in anti-infective therapy of patients with acute stroke.METHODS: This is a case control retrospective study of acute stroke patients conducted from July 2016 to October 2018, in...

Sulbactam and clavulanic acid: enzyme kinetics and synergy with ampicillin and mezlocillin.

International journal of antimicrobial agents

Cullmann W, Binder S, Stieglitz M.
PMID: 18611714
Int J Antimicrob Agents. 1996 Apr;6:S1-7.

The two beta-lactamase inhibitors, sulbactam and clavulanic acid, exhibit high affinity (K(I) < 10(-6)mol/l) for the beta-lactamases of Gram-negative organisms with predominantly penicillinase activity and much less affinity (especially clavulanic acid) for organisms with predominantly cephalosporinase activity. In tests...

Development of a high performance liquid chromatographic assay measuring mezlocillin in serum or tissue.

Infectious diseases in obstetrics and gynecology

Mya S, Gain RE, Larsen B.
PMID: 18476212
Infect Dis Obstet Gynecol. 1993;1(1):71-5. doi: 10.1155/S1064744993000171.

OBJECTIVE: This study evaluated the blood and uterine tissue concentration of mezlocillin, a broadspectrum penicillin.METHODS: We adapted a liquid chromatographic method to measure mezlocillin in serum and tissue. Mezlocillin reference standard was diluted in water, chromatographed on a reversed...

Randomized trial of antibiotics in addition to tocolytic therapy to treat preterm labor.

Infectious diseases in obstetrics and gynecology

Watts DH, Krohn MA, Hillier SL, Eschenbach DA.
PMID: 18472878
Infect Dis Obstet Gynecol. 1994;1(5):220-7. doi: 10.1155/S106474499400013X.

OBJECTIVE: The objective of this study was to assess whether antibiotic therapy plus tocolysis given to women in preterm labor would prolong pregnancy compared with tocolysis alone.METHODS: A randomized, double-blind trial of intravenous mezlocillin and oral erythromycin therapy vs....

Showing 1 to 12 of 19 entries