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Showing 1 to 12 of 21 entries
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Co-Presence of Multimorbidity and Disability with Frailty: An Examination of Heterogeneity in the Frail Older Population.

The Journal of frailty & aging

Aarts S, Patel KV, Garcia ME, Van den Akker M, Verhey FR, Metsemakers JF, Van Boxtel MP, Gudnason V, Jonsdottir MK, Siggeirsdottir K, Jonsson PV, Harris TB, Launer LJ.
PMID: 27030941
J Frailty Aging. 2015;4(3):131-8. doi: 10.14283/jfa.2015.45.

BACKGROUND: Frailty is often associated with multimorbidity and disability.OBJECTIVES: We investigated heterogeneity in the frail older population by characterizing five subpopulations according to quantitative biological markers, multimorbidity and disability, and examined their association with mortality and nursing home admission.DESIGN:...

Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study.

Journal of nutritional science

Imai CM, Halldorsson TI, Eiriksdottir G, Cotch MF, Steingrimsdottir L, Thorsdottir I, Launer LJ, Harris T, Gudnason V, Gunnarsdottir I.
PMID: 26688723
J Nutr Sci. 2015 Nov 20;4:e37. doi: 10.1017/jns.2015.27. eCollection 2015.

Low vitamin D status may be associated with depression. Few studies have examined vitamin D and depression in older adults living at northern latitudes. The present study cross-sectionally investigated serum 25-hydroxyvitamin D (25(OH)D) status and depression among 5006 community-dwelling...

Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations.

NPJ microgravity

Michalski AS, Amin S, Cheung AM, Cody DD, Keyak JH, Lang TF, Nicolella DP, Orwoll ES, Boyd SK, Sibonga JD.
PMID: 30886891
NPJ Microgravity. 2019 Mar 14;5:6. doi: 10.1038/s41526-019-0066-3. eCollection 2019.

Concerns raised at a 2010 Bone Summit held for National Aeronautics and Space Administration Johnson Space Center led experts in finite element (FE) modeling for hip fracture prediction to propose including hip load capacity in the standards for astronaut...

Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study.

Blood advances

Thorsteinsdottir S, Lund SH, Lindqvist EK, Thordardottir M, Sigurdsson G, Costello R, Burton D, Steingrimsdottir H, Gudnason V, Eiriksdottir G, Siggeirsdottir K, Harris TB, Landgren O, Kristinsson SY.
PMID: 29296931
Blood Adv. 2017 Dec 21;1(27):2790-2798. doi: 10.1182/bloodadvances.2017010454. eCollection 2017 Dec 26.

Previous studies have shown that individuals with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of fractures, although the underlying mechanisms remain unknown. Our aim was to analyze bone mineral density (BMD), bone volume, and risk of...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease.

Genes & nutrition

Liu H, Zhang Y, Hu Y, Zhang H, Wang T, Han Z, Gao S, Wang L, Liu G.
PMID: 34715780
Genes Nutr. 2021 Oct 29;16(1):19. doi: 10.1186/s12263-021-00700-9.

OBJECTIVE: Until now, observational studies have explored the impact of vitamin C intake on Alzheimer's disease (AD) risk, however, reported ambiguous findings. To develop effective therapies or prevention, the causal link between vitamin C levels and AD should be...

Defining functional variants associated with Alzheimer's disease in the induced immune response.

Brain communications

Harwood JC, Leonenko G, Sims R, Escott-Price V, Williams J, Holmans P.
PMID: 33959712
Brain Commun. 2021 Apr 19;3(2):fcab083. doi: 10.1093/braincomms/fcab083. eCollection 2021.

Defining the mechanisms involved in the aetiology of Alzheimer's disease from genome-wide association studies alone is challenging since Alzheimer's disease is polygenic and most genetic variants are non-coding. Non-coding Alzheimer's disease risk variants can influence gene expression by affecting...

Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation.

Circulation. Genomic and precision medicine

Yang Y, Bartz TM, Brown MR, Guo X, Zilhão NR, Trompet S, Weiss S, Yao J, Brody JA, Defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dörr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B.
PMID: 34732054
Circ Genom Precis Med. 2021 Dec;14(6):e003460. doi: 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 04.

BACKGROUND: Elevated cardiac troponin levels in blood are associated with increased risk of cardiovascular diseases and mortality. Cardiac troponin levels are heritable, but their genetic architecture remains elusive.METHODS: We conducted a transethnic genome-wide association analysis on high-sensitivity cTnT (cardiac...

Exploratory assessment of pineal gland volume, composition, and urinary 6-sulfatoxymelatonin levels on prostate cancer risk.

The Prostate

Bazzi LA, Sigurdardottir LG, Sigurdsson S, Valdimarsdottir U, Torfadottir J, Aspelund T, Czeisler CA, Lockley SW, Jonsson E, Launer L, Harris T, Gudnason V, Mucci LA, Markt SC.
PMID: 33860950
Prostate. 2021 Jun;81(8):487-496. doi: 10.1002/pros.24130. Epub 2021 Apr 16.

INTRODUCTION: Melatonin levels are partially driven by the parenchyma volume of the pineal gland. Low urinary levels of 6-sulfatoxymelatonin have been associated with increased risk of advanced prostate cancer, but the relationship between pineal gland volume and composition and...

Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study.

Blood advances

Thordardottir M, Lindqvist EK, Lund SH, Costello R, Burton D, Korde N, Mailankody S, Eiriksdottir G, Launer LJ, Gudnason V, Harris TB, Landgren O, Kristinsson SY.
PMID: 29296866
Blood Adv. 2017 Nov 01;1(24):2186-2192. doi: 10.1182/bloodadvances.2017007609. eCollection 2017 Nov 14.

All multiple myeloma (MM) cases are preceded by the premalignant state monoclonal gammopathy of undetermined significance (MGUS). Results from previous studies show a positive association between obesity and MM; however, the association between obesity and MGUS is controversial. The...

Showing 1 to 12 of 21 entries