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Imai CM, Halldorsson TI, Eiriksdottir G, et al. Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study. J Nutr Sci. 2015;4:e37doi: 10.1017/jns.2015.27.
Imai, C. M., Halldorsson, T. I., Eiriksdottir, G., Cotch, M. F., Steingrimsdottir, L., Thorsdottir, I., Launer, L. J., Harris, T., Gudnason, V., & Gunnarsdottir, I. (2015). Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study. Journal of nutritional science, 4e37. https://doi.org/10.1017/jns.2015.27
Imai, Cindy M, et al. "Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study." Journal of nutritional science vol. 4 (2015): e37. doi: https://doi.org/10.1017/jns.2015.27
Imai CM, Halldorsson TI, Eiriksdottir G, Cotch MF, Steingrimsdottir L, Thorsdottir I, Launer LJ, Harris T, Gudnason V, Gunnarsdottir I. Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study. J Nutr Sci. 2015 Nov 20;4:e37. doi: 10.1017/jns.2015.27. eCollection 2015. PMID: 26688723; PMCID: PMC4678766.
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J Nutr Sci. 2015 Nov 20;4:e37. doi: 10.1017/jns.2015.27. eCollection 2015.

Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes - AGES-Reykjavik Study.

Journal of nutritional science

Cindy M Imai, Thorhallur I Halldorsson, Gudny Eiriksdottir, Mary F Cotch, Laufey Steingrimsdottir, Inga Thorsdottir, Lenore J Launer, Tamara Harris, Vilmundur Gudnason, Ingibjorg Gunnarsdottir

Affiliations

  1. Unit for Nutrition Research , Landspitali - The National University Hospital of Iceland and Faculty of Food Science and Nutrition , School of Health Sciences , University of Iceland , Eiriksgata 29 , 101 Reykjavik , Iceland.
  2. Unit for Nutrition Research , Landspitali - The National University Hospital of Iceland and Faculty of Food Science and Nutrition , School of Health Sciences , University of Iceland , Eiriksgata 29 , 101 Reykjavik , Iceland ; Department of Epidemiology Research , Centre for Fetal Programming , Statens Serum Institut , 5, Artillerivej , 2300 Copenhagen S , Denmark.
  3. Icelandic Heart Association , Holtasmari 1 , 201 Kopavogur , Iceland.
  4. Division of Epidemiology and Clinical Applications , National Eye Institute , 10 Center Drive , MSC 1204 , Bethesda , MD 20892-1204 , USA.
  5. National Institute on Aging, Laboratory of Epidemiology, and Population Sciences , 7201 Wisconsin Avenue , Bethesda , MD 20892-9205 , USA.
  6. Icelandic Heart Association , Holtasmari 1 , 201 Kopavogur , Iceland ; Faculty of Medicine , School of Health Sciences , University of Iceland , Vatnsmyrarvegur 16 , 101 Reykjavik , Iceland.

PMID: 26688723 PMCID: PMC4678766 DOI: 10.1017/jns.2015.27

Abstract

Low vitamin D status may be associated with depression. Few studies have examined vitamin D and depression in older adults living at northern latitudes. The present study cross-sectionally investigated serum 25-hydroxyvitamin D (25(OH)D) status and depression among 5006 community-dwelling older persons (66-96 years) living in Iceland (latitudes 64-66°N). Depressive symptoms were measured by the fifteen-item Geriatric Depression Scale (GDS-15). Current major depressive disorder was assessed according to Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria. Serum 25(OH)D was analysed using chemiluminescence immunoassay and categorised into three groups: deficient (<30 nmol/l); inadequate (30-49·9 nmol/l); and adequate (≥50 nmol/l). There were twenty-eight (2 %) men and fifty (1 %) women with current major depressive disorder. Mean GDS-15 scores for men and women with adequate vitamin D concentrations were 2·1 and 2·2, respectively. Men and women with deficient v. adequate vitamin D status had more depressive symptoms (higher GDS-15 scores) (difference 0·7 (95 % CI 0·4, 0·9) and 0·4 (95 % CI 0·1, 0·6), respectively). Furthermore, men with deficient vitamin D status were more likely to have current major depressive disorder (adjusted OR 2·51; 95 % CI 1·03, 6·13) compared with men with adequate vitamin D status. Associations among women were not significant. In this older population living at northern latitudes, deficient vitamin D status may be associated with depression. Further investigations are warranted to evaluate the pathways that may be associated with risk of depression among older adults.

Keywords: 25(OH)D, 25-hydroxyvitamin D; AGES-Reykjavik, Age, Gene/Environment Susceptibility–Reykjavik; Cross-sectional analyses; Depression; GDS, Geriatric Depression Scale; MINI, Mini-International Neuropsychiatric Interview; Nutritional epidemiology; Older adults; Vitamin D

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