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Evaluation of comparative protein modeling by MODELLER

evaluation

Šali A.
GSID: OnSA2h_RAhcJ
A Šali, L Potterton, F Yuan… - Proteins: Structure …, 1995 - Wiley Online Library

We evaluate 3D models of human nucleoside diphosphate kinase, mouse cellular retinoic acid binding protein I, and human eosinophil neurotoxin that were calculated by MODELLER, a program for comparative protein modeling by satisfaction of spatial restraints. The models …

NADH Oxidase Activity of Plasma Membranes of Soybean Hypocotyls Is Activated by Guanine Nucleotides.

Plant physiology

Morre DJ, Brightman AO, Barr R, Davidson M, Crane FL.
PMID: 12231849
Plant Physiol. 1993 Jun;102(2):595-602. doi: 10.1104/pp.102.2.595.

The activity of an auxin-stimulated NADH oxidase of the plasma membrane of hypocotyls of etiolated soybean (Glycine max Merr.) seedlings responded to guanine and other nucleotides, but in a manner that differed from that of enzymes coupled to the...

Reconsideration of the significance of substrate-level phosphorylation in the citric acid cycle*.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

Lambeth DO.
PMID: 21638627
Biochem Mol Biol Educ. 2006 Jan;34(1):21-9. doi: 10.1002/bmb.2006.49403401021.

For nearly 50 years, students of metabolism in animals have been taught that a substrate-level phosphorylation in the Krebs citric acid cycle produces GTP that subsequently undergoes a transphosphorylation with ADP catalyzed by nucleoside diphosphate kinase. Research in the...

Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells.

Cytotechnology

E L Omri A, Han J, Ben Abdrabbah M, Isoda H.
PMID: 21861121
Cytotechnology. 2012 May;64(3):231-40. doi: 10.1007/s10616-011-9352-y. Epub 2011 Aug 23.

Polyphenols are known to exhibit wide spectrum of benefit for brain health and to protect from several neurodegenerative diseases. The present study was sought to determine the neuroprotective effects of Rosmarinus officinalis' polyphenols (luteolin, carnosic acid, and rosmarinic acid)...

A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure.

Nanomaterials (Basel, Switzerland)

Ray A, Macwan I, Singh S, Silwal S, Patra P.
PMID: 29360759
Nanomaterials (Basel). 2018 Jan 23;8(2). doi: 10.3390/nano8020057.

During a heart failure, an increased content and activity of nucleoside diphosphate kinase (NDPK) in the sarcolemmal membrane is responsible for suppressing the formation of the second messenger cyclic adenosine monophosphate (cAMP)-a key component required for calcium ion homeostasis...

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T-cell lymphoma, not otherwise specified.

Oncology letters

Huang W, Cao Z, Zeng L, Guo L, Liu X, Lv N, Feng X.
PMID: 31516591
Oncol Lett. 2019 Oct;18(4):3803-3810. doi: 10.3892/ol.2019.10703. Epub 2019 Aug 02.

Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is an aggressive lymphoma associated with a poor outcome. To date, the factor consistently associated with prognosis is the International Prognostic Index (IPI) score; however, it is considered that the IPI score...

Anti-metastatic effects of isolinderalactone via the inhibition of MMP-2 and up regulation of NM23-H1 expression in human lung cancer A549 cells.

Oncology letters

Chuang CH, Wang LY, Wong YM, Lin ES.
PMID: 29541242
Oncol Lett. 2018 Apr;15(4):4690-4696. doi: 10.3892/ol.2018.7862. Epub 2018 Jan 25.

Metastatic lung cancer is a leading cause of mortality and has a mortality rate of ≥90%. Isolinderalactone (ILL) is a sesquiterpene lactone compound that has been used in traditional Chinese medicine. Research has demonstrated that ILL has anti-inflammatory and...

Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.

Oncology letters

Tang M, Wang S, Wei Y, Fu J.
PMID: 30655894
Oncol Lett. 2019 Jan;17(1):1267-1273. doi: 10.3892/ol.2018.9673. Epub 2018 Nov 07.

Traditional Chinese medicine applied to cancer therapy has a long history. This study aimed to investigate the effect and underlying mechanism of the traditional Chinese medicine, Yuxiao San, in combination with cisplatin, on Lewis lung cancer mice. Lewis lung...

Crystal structure and characterization of nucleoside diphosphate kinase from Vibrio cholerae.

Biochimie

Agnihotri P, Shakya AK, Mishra AK, Pratap JV.
PMID: 34242727
Biochimie. 2021 Nov;190:57-69. doi: 10.1016/j.biochi.2021.07.003. Epub 2021 Jul 07.

Nucleoside diphosphate kinases (NDK) are ubiquitous enzymes that catalyse the transfer of the γ phosphate from nucleoside triphosphates (NTPs) to nucleoside diphosphate (NDPs), to maintain appropriate NTP levels in cells. NDKs are associated with signal transduction, cell development, proliferation,...

The impact of genetic variations in sofosbuvir metabolizing enzymes and innate immunity mediators on treatment outcome in HCV-infected patients.

Microbial pathogenesis

Ibrahim MK, AbdElrahman M, Bader El Din NG, Tawfik S, Abd-Elsalam S, Omran D, Barakat AZ, Farouk S, Elbatae H, El Awady MK.
PMID: 34843922
Microb Pathog. 2021 Nov 26;162:105311. doi: 10.1016/j.micpath.2021.105311. Epub 2021 Nov 26.

Hepatitis C virus (HCV) is the leading cause of liver diseases worldwide. At present, combinations of different classes of direct-acting antiviral agents (DAAs) are used as treatment options for HCV, in which sofosbuvir (SOF) is the common DAA among...

The impact of genetic variations in sofosbuvir metabolizing enzymes and innate immunity mediators on treatment outcome in HCV-infected patients.

Microbial pathogenesis

Ibrahim MK, AbdElrahman M, Bader El Din NG, Tawfik S, Abd-Elsalam S, Omran D, Barakat AZ, Farouk S, Elbatae H, El Awady MK.
PMID: 34843922
Microb Pathog. 2021 Nov 26;162:105311. doi: 10.1016/j.micpath.2021.105311. Epub 2021 Nov 26.

Hepatitis C virus (HCV) is the leading cause of liver diseases worldwide. At present, combinations of different classes of direct-acting antiviral agents (DAAs) are used as treatment options for HCV, in which sofosbuvir (SOF) is the common DAA among...

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.

Science signaling

Ernst O, Sun J, Lin B, Banoth B, Dorrington MG, Liang J, Schwarz B, Stromberg KA, Katz S, Vayttaden SJ, Bradfield CJ, Slepushkina N, Rice CM, Buehler E, Khillan JS, McVicar DW, Bosio CM, Bryant CE, Sutterwala FS, Martin SE, Lal-Nag M, Fraser IDC.
PMID: 34344832
Sci Signal. 2021 Aug 03;14(694). doi: 10.1126/scisignal.abe0387.

Noncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in macrophages is preceded by a Toll-like receptor (TLR) priming signal required to induce transcription of inflammasome components...

Showing 1 to 12 of 89 entries