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Showing 1 to 12 of 998 entries
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Multimorbidity among people with HIV in regional New South Wales, Australia.

Sexual health

Edmiston N, Passmore E, Smith DJ, Petoumenos K.
PMID: 26144504
Sex Health. 2015 Oct;12(5):425-32. doi: 10.1071/SH14070.

UNLABELLED: Background Multimorbidity is the co-occurrence of more than one chronic health condition in addition to HIV. Higher multimorbidity increases mortality, complexity of care and healthcare costs while decreasing quality of life. The prevalence of and factors associated with...

Synthesis of novel N-cyclopentenyl-lactams using the Aubé reaction.

Beilstein journal of organic chemistry

Shinde MV, Ople RS, Sangtani E, Gonnade R, Reddy DS.
PMID: 26199661
Beilstein J Org Chem. 2015 Jun 23;11:1060-7. doi: 10.3762/bjoc.11.119. eCollection 2015.

A novel and convenient method utilizing the Aubé reaction to access a new class of compounds that are similar to carbocyclic nucleosides is reported. The azido alcohol derived from Vince lactam undergoes the Aubé reaction with various cyclic ketones...

Tautomerization lowers the activation barriers for N-glycosidic bond cleavage of protonated uridine and 2'-deoxyuridine.

Physical chemistry chemical physics : PCCP

Wu RR, Rodgers MT.
PMID: 27536972
Phys Chem Chem Phys. 2016 Sep 21;18(35):24451-9. doi: 10.1039/c6cp03620a. Epub 2016 Aug 18.

The gas-phase conformations of protonated uridine, [Urd+H](+), and its 2'-deoxy form, protonated 2'-deoxyuridine, [dUrd+H](+), have been examined in detail previously by infrared multiple photon dissociation action spectroscopy techniques. Both 2,4-dihydroxy tautomers and O4 protonated conformers of [Urd+H](+) and [dUrd+H](+)...

A Positive Selection for Nucleoside Kinases in E. coli.

PloS one

Shelat NY, Parhi S, Ostermeier M.
PMID: 27677184
PLoS One. 2016 Sep 27;11(9):e0162921. doi: 10.1371/journal.pone.0162921. eCollection 2016.

Engineering heterologous nucleoside kinases inside E. coli is a difficult process due to the integral role nucleosides play in cell division and transcription. Nucleoside analogs are used in many kinase screens that depend on cellular metabolization of the analogs....

TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy.

Beilstein journal of organic chemistry

Gophane DB, Sigurdsson ST.
PMID: 25815073
Beilstein J Org Chem. 2015 Feb 09;11:219-27. doi: 10.3762/bjoc.11.24. eCollection 2015.

Three 2´-deoxynucleosides containing semi-flexible spin labels, namely (T)A, (U)A and (U)C, were prepared and incorporated into deoxyoligonucleotides using the phosphoramidite method. All three nucleosides contain 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) connected to the exocyclic amino group; (T)A directly and (U)A as well...

Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by .

Beilstein journal of organic chemistry

Stepchenko VA, Miroshnikov AI, Seela F, Mikhailopulo IA.
PMID: 28144328
Beilstein J Org Chem. 2016 Dec 01;12:2588-2601. doi: 10.3762/bjoc.12.254. eCollection 2016.

The

Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.

Scientific reports

Saladino R, Bizzarri BM, Botta L, Šponer J, Šponer JE, Georgelin T, Jaber M, Rigaud B, Kapralov M, Timoshenko GN, Rozanov A, Krasavin E, Timperio AM, Mauro ED.
PMID: 29116184
Sci Rep. 2017 Nov 07;7(1):14709. doi: 10.1038/s41598-017-15392-8.

The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2'-deoxy-ribonucleosides from sugars and purine nucleobases under proton...

Complex Thermodynamic Behavior of Single-Stranded Nucleic Acid Adsorption to Graphene Surfaces.

Langmuir : the ACS journal of surfaces and colloids

Ranganathan SV, Halvorsen K, Myers CA, Robertson NM, Yigit MV, Chen AA.
PMID: 27219463
Langmuir. 2016 Jun 21;32(24):6028-34. doi: 10.1021/acs.langmuir.6b00456. Epub 2016 Jun 06.

In just over a decade since its discovery, research on graphene has exploded due to a number of potential applications in electronics, materials, and medicine. In its water-soluble form of graphene oxide, the material has shown promise as a...

Efficient microwave-assisted solid phase coupling of nucleosides, small library generation and mild conditions for release of nucleoside derivatives.

Tetrahedron letters

Paritala H, Suzuki Y, Carroll KS.
PMID: 23794759
Tetrahedron Lett. 2013 Apr 01;54(14):1869-1872. doi: 10.1016/j.tetlet.2013.01.109.

Nucleosides are essential bio-molecules that participate in a wide array of biological processes involved in maintaining physiologic homeostasis. Recent efforts geared towards the synthesis of nucleoside analogues and development of nucleoside combinatorial libraries using solid phase synthesis has contributed...

Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation.

Frontiers in cellular neuroscience

Cavaliere F, Donno C, D'Ambrosi N.
PMID: 26082684
Front Cell Neurosci. 2015 Jun 02;9:211. doi: 10.3389/fncel.2015.00211. eCollection 2015.

Extracellular ATP, related nucleotides and adenosine are among the earliest signaling molecules, operating in virtually all tissues and cells. Through their specific receptors, namely purinergic P1 for nucleosides and P2 for nucleotides, they are involved in a wide array...

Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides.

ACS medicinal chemistry letters

Meščić A, Harej A, Klobučar M, Glavač D, Cetina M, Pavelić SK, Raić-Malić S.
PMID: 26617970
ACS Med Chem Lett. 2015 Oct 05;6(11):1150-5. doi: 10.1021/acsmedchemlett.5b00298. eCollection 2015 Nov 12.

A series of novel N-acyclic uracil analogs with linear, branched, aromatic, and cyclopropyl-alkynyl as well as heteroaryl moieties at C-5 were prepared using palladium catalyzed Sonogashira and Stille cross-coupling and evaluated against malignant tumor cell lines. C-5-Furan-2-yl uracil derivative...

A SURVEY OF NONXANTHINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS.

Nucleosides & nucleotides

Siddiqi SM, Ji XD, Melman N, Olah ME, Jain R, Evans P, Glashofer M, Padgett WL, Cohen LA, Daly JW, Stiles GL, Jacobson KA.
PMID: 27043138
Nucleosides Nucleotides. 1996;15(1):693-717. doi: 10.1080/07328319608002416.

The binding affinities at rat A

Showing 1 to 12 of 998 entries